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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

CRISPR-Cas12a diagnostics are limited by strict PAM requirements. Here, authors show that higher temperatures activate numerous noncanonical PAMs, enabling a versatile one-pot platform that improves sensitivity, specificity, and rapid on-site pathogen detection.

Here, the authors identify DspII, a functionally equivalent and indispensable partner of DspI in mediating the chronic-to-acute virulence switch in Pseudomonas aeruginosa, which is a key adaptive strategy that facilitates response to the host.

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Gas diffusion electrodes enable electrochemical H₂O₂ production, but fused binders and disordered pores restrict mass transport. Here, the authors report a non-fused gradient catalyst layer that supports directional self-transport and stable high efficiency at industrial current densities.

By analyzing the structures of the Polycomb repressive deubiquitinase complex, which catalyzes the deubiquitination of H2AK119Ub on nucleosomes, Zhang, Zheng, Tong and Deng et al. reveal that ubiquitin acts as a proteinaceous glue to fasten the intersubunit interaction within the complex to allosterically enhance its activity.

A four-qubit quantum error detection circuit with stabilizers can be implemented with spin qubits in a donor-based silicon quantum processor.

Flexible electronics need to balance conductivity and material performance. Here the authors report a PDMS based conductor using in-situ silver nanoparticle formation to optimize these properties.

HOXA2 expression was inhibited by aberrant hypermethylation, leading to decreased SIRT1 levels, which could increase ATF6 acetylation and activation as well as subsequent ER stress, resulting in renal damage in CKD-related fibrosis.

Topological metamaterial clothing based on metallic conductive textiles can be used to create robust biosensing networks on the human body that can monitor vital signs during exercise.

Programable coatings are promising for information encryption, though it is challenging to design stimuli-responsive materials. Here the authors integrate a photochromic switch into a polymer system for programmable encryption.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Cellular fate decisions are governed by the equilibrium between inhibitor of apoptosis proteins (IAPs) and pro-apoptotic proteins (PAPs). Li et al. reveal that histone acetylation homeodynamics orchestrates this critical decision-making process by shifting the balance toward either survival or apoptosis.

Genome mining identified bacterial P450 that cleave cholesterol side-chains via dual C-H activation, differing from mammalian P450scc. Engineered CYP204A5 efficiently converts cholestenone to progesterone for biocatalysis.

Prokaryotic defense-associated reverse transcriptase (DRT) systems confer resistance to viral infection through DNA synthesis. Here, the authors dissect DRT4 mechanism of function and show that ORF55, a phage-encoded DNA-binding protein, protects the 3’ end of the DRT4- synthesized ssDNA, activating the anti-phage defense program.

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

Acetylene hydrochlorination produces polyvinyl chloride (PVC) precursors but relies on toxic Hg-based catalysts. Here a Hg free cascade system is used to electrochemically generate C₂H₄ and Cl₂ and thermocatalytically convert them into high-purity PVC precursor with near-complete C₂H₂ conversion.

The paper demonstrates a ferroelectric photosensor array that integrates image memorization, low-level processing, and high-level computing. It uses dynamic and switchable photovoltages to perform image tasks, leveraging the bulk photovoltaic effect for enhanced precision and reliability.

Layered black phosphorous has gained significant attention in the 2D materials community, and dynamical control of its bandgap is key to enable novel applications. Here, the authors demonstrate continuous electrical bandgap tuning using moderate displacement fields.

Sustainable food production under climate change requires farming practices that support plant–soil–microbe interactions. This study suggests that conservation agriculture with warming enhances wheat nitrogen uptake by reducing microbial competition.

Chiral 1,2-diamines are useful chemicals used as ligands in asymmetric catalysis. Here, the authors report a copper(I)-catalyzed asymmetric α-addition of ketimines derived from trifluoroacetophenone and 2- or 4-NO2-benzylamines to aldimines, affording a series of chiral anti-1,2-diamine derivatives.

In this work, the authors report that citronellal stimulates skin renewal by promoting keratinocyte proliferation through the activation of TRPV3. Structural and functional analysis elucidate that essential oil ligands activate TRPV3 channels by competitively displacing endogenous lipids from the vanilloid site. These findings can help move skin healthcare forward.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Developing efficient non-precious catalysts is key to advancing water electrolysis. Here, the authors report a microbial vulcanization strategy that co-dopes cobalt hydroxide with sulfur and organic molecules to optimize O–O coupling and accelerate the electrocatalytic oxygen evolution reaction.

Using supramolecular chemistry principles, thermodynamically metastable, yet kinetically stable, poly(disulfide)s with tunable mechanical properties can be recycled into crystalline monomers with quantitative yields and monomer purity >90%.

Self-assembled monolayers targeting wide-bandgap perovskite solar cells are essential to reduce the open-circuit voltage loss. Here, the authors report the stepwise tuning of interfacial energy level through inductive effect, achieving perovskite/TOPCon tandem solar cells with efficiency over 31%.

Conditional knockout of LARP4 in naive CD4⁺ T cells leads to attenuated quiescence exit and clonal expansion.

Here, Li et al. develop a human liver organoid model to elucidate Dengue virus infection dynamics and identify oxyresveratrol as a potential antiviral candidate, highlighting the NRF2 pathway’s crucial role in mitigating mitochondrial damage and enhancing cellular resistance.

The realization of 2D photodetectors with simultaneous high sensitivity to light polarization and intensity is challenging. Here, the authors report the fabrication of broadband black phosphorus meta-polarization detectors combining polarization extinction ratio tending to +/- ∞ and high specific detectivity also under blackbody radiation.

Formic acid (FA) is a promising CO2-equivalent feedstock for onecarbon biorefinery, but microbial host that can efficiently utilize FA is unavailable. Here, the authors engineer a non-native closed loop in Vibrio natriegens and demonstrate its application in promoting FA utilization.

We fabricated silicon heterojunction back-contact solar cells using laser patterning, producing cells that exceeded 27% power-conversion efficiency.

In response to high fluid shear stress, KLF2-mediated induction of the BMP inhibitor BMPER improves outward arterial remodeling. This knowledge is translated into a preclinical model showing that BMP9 and BMP10 neutralizing antibodies enhance flow recovery and arterialization in ischemia in diabetic mice.

Quantum state engineering necessitates transfer between quantum states. Here the authors demonstrate coherent population transfer between un- or weakly-coupled states of solid state systems, superconducting Xmon and phase qutrits, using stimulated Raman adiabatic passage and microwave driving.