Search

Emerging evidence underscores biophysical characteristics of cancer cells as key modulators of cancer metastasis. Here, the authors reported a single-cell mechanophenotyping chip that screens deformable CTCs to reveal the hematogenous metastatic potential of bacteria-infected breast cancer.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Tea plant has a highly complex and heterozygous genome, and can produce abundant beneficial metabolites. Here, the authors report the haplotype-resolved genome of cultivar Fuding Dabaicha and reveal structural variations associated with secondary metabolism diversity through QTL and mGWAS analyses.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Achieving photo-thermal stability and device operational stability of tin-lead perovskite solar cells remains a major challenge. Here, authors replace tin fluoride additive by lead powders followed by lead fluoride post-treatment, achieving efficiency of 24.07% in stable tin fluoride-free devices.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Multi-omics profiling of the mucosal mycobiome in individuals with Crohn’s disease identifies C. sphaerospermum as a protective fungal species that counteracts intestinal inflammation and reinforces the intestinal barrier.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

An analogue memory built from a two-dimensional material with antimony contacts enables very high, energy-efficient in-memory searches and k-nearest-neighbour classification, offering a scalable, low-power hardware platform for real-time edge artificial intelligence applications.

The ecological role of viruses for CPR bacteria and DPANN archaea remains understudied. Here, the authors apply metagenomic approaches to study the biogeographic distribution of CPR and DPANN viruses in acid mine drainage sediments and elucidate their complex interplays.

Eosinophils are involved in eosinophilic airway inflammation such as type 2 asthmatic responses. Here the authors investigate how lysosomes and cathepsin L affect the function and activation of eosinophils and that inhibition of cathepsin L reduces the pathology of allergic asthma in mice models.

Nanometer-wide lateral heterostructures between 2D semiconductors are still rare. Here the authors report the valley-selective hole state transmission between ferroelectric SnTe monolayers separated by a PbTe barrier with the width of merely 2 nm.

Electrofusion enables membrane fusion but struggles with lipid nanoparticles. Here, the authors present a nanofabrication platform that combines microfluidics with microelectrode arrays, achieving efficient, controlled nanoscale electrofusion of LNPs for effective siRNA delivery

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Electrochemical synthesis of solid compounds is an emerging frontier in electrocatalysis. Here, the authors report a Pt catalyst whose surface-coordinated halogens alleviate the scaling effect by regulating the local environment and enable simultaneous Mg(OH)₂ and H₂ production from natural seawater.

Elevated intracellular Cu converts CTR1 trimers to monomers at Rab5⁺ sites prior to endocytosis, rapidly halting Cu uptake; an endocytosis-deficient mutant fails to mount this response.

Transition metal compounds provide a versatile platform for tailoring Mott physics. Here, the authors reveal that hybridization between the lower Hubbard band and the chalcogen band stabilizes the Mott state through bandwidth tuning in the 1T-MX₂ (M = Nb, Ta; X = S, Se) family.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Electrolysis of dirty water is an attractive route to clean hydrogen, but fluctuating surface pH quickly ruins electrodes. Here, the authors report an ion-selective polymer gate that steadies surface pH, bars harmful ions and lets seawater-fed cells run 1500 h with pure-water durability.

Liquid films are essential in semiconductor lithography but microscopic behaviors of photoresist within these films remain unclear. This study uses cryo-electron tomography to reconstruct photoresist structures, achieving 99% defect reduction.

Atomically dispersed metals can improve sodium deposition control. Here, authors show that tin single atoms on carbon films enhance sodium-ion adsorption and activate surrounding atoms, leading to uniform deposition and stable cycling in sodium batteries with improved capacity retention.

High-power, tunable accelerator-based terahertz radiation is demonstrated. By electron-beam manipulation through laser heater beating, tunable capability from 7.8 to 30.8 THz, narrow spectral bandwidths (ranging from 7.7% to 14.7%) and pulse energies up to 385 μJ are obtained.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Effective lossless compression requires that frequent patterns in the data can be identified. Li et al. explore using deep learning models to more effectively compress text, audio and video data.