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Distributed multiparameter quantum metrology allows to probe multiple spatially distributed parameters across networked quantum systems. Here, the authors demonstrate distributed multiparameter quantum metrology in a modular superconducting quantum processor network.

Chromatin profiling methods are often limited by a lack of suitable antibodies. Here, authors present Af-CUT&Tag, a chromatin profiling strategy based on CRISPR-integrated peptide tags which enables sensitive bulk and single-cell mapping of transcriptional regulators.

The scaffold protein AXIN can promote the formation of two opposing complexes: the Wnt signalosome and a degradation complex that inhibits Wnt. Here, the authors show that mechanical compression and the presence/absence of Wnt ligand are inputs in a circuit that acts as a logic gate to control which complex is formed.

The tolerogenic activity of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and induces antigen-specific FOXP3-expressing regulatory T cells.

Wearable silent speech systems hold potential for restoring communication in patients suffering from speech impairments. Tang et al. report an AI-driven silent speech system for dysarthria patients, which enables zero-time-delay expression and context-aware emotion decoding-based sentence expansion.

A modular nanobody-based approach assembles combination vaccines by stably attaching diverse antigens to hepatitis E virus-like particles, preserving native immunogenicity and inducing broad protection against respiratory pathogens.

Using size-specific infrared spectroscopy and quantum-chemical calculations, structural motifs of interference-free neutral water undecamer (H₂O)₁₁ were characterized, revealing three isomer families and insights into hydrogen-bonding networks essential for understanding solvation processes.

Sustainable food production under climate change requires farming practices that support plant–soil–microbe interactions. This study suggests that conservation agriculture with warming enhances wheat nitrogen uptake by reducing microbial competition.

Freezing-induced enrichment of organic solutes within ice has been hypothesized to play an essential role in the origins of life, yet direct evidence for the in-ice aggregation of dilute, water-soluble organics has remained elusive. Here, the authors employ a conformation-sensitive organic phosphor, 2- phenylbenzothiazole iodide, to uncover the formation of amino acid nanoaggregates in water ice.

A gallium-based, iron-embedded liquid metal catalyst enables reversible, magnetic-field-controlled switching between atomically dispersed and clustered iron states, achieving tunable production of CH₃OOH and CH₃COOH under ambient conditions.

Developmental programs are frequently co-opted in glioblastoma. Here, the authors show the role of transcription factors Olig1/2 in fate specification of tri-potential intermediate progenitor cells and their connection with gliomagenesis in mouse models; they also show that Olig1/2 deletion can reprogram such stem cell differentiation and inhibit tumour growth.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

A flat stanene layer can be grown on Cu (111) by MBE growth, exhibiting topological properties as revealed by a combination of ARPES, STM and DFT calculations.

The high performance of two-dimensional (2D) channel membranes is generally achieved by preparing ultrathin or forming short channels with less tortuous transport through self-assembly of small flakes. Here, the authors report the construction of vertical channels in graphene oxide membranes based on a substrate template with asymmetric pores demonstrating high flux and metal ion rejection.

XPR1 is the only known protein that exports inorganic phosphate from cells. This study demonstrates that XPR1 uses a channel-like mechanism for phosphate transport, offering insights into potential therapeutic strategies for XPR1-linked diseases.

Whether the spin-degenerate counterpart of Lorentz-violating Weyl fermions, the Dirac fermions, can be realized remains as an open question. Here, Yan et al. report experimental evidence of such type-II Dirac fermions in bulk PtTe₂ single crystal with a pair of strongly tilted Dirac cones.

The mechanism by which the chromatinized HBV genome is transcribed remains poorly understood. In this study, Liu et al. demonstrate how HBx exploits Spindlin1, a histone methylation reader, to overcome heterochromatin barriers and enhance HBV transcription from the cccDNA minichromosome.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

Noise-induced synchronization is known in classical systems and has recently been proposed in quantum many-body settings. Here, the authors experimentally demonstrate stable and entangled synchronized oscillations at the ends of a superconducting qubit chain by applying Gaussian noise to a single qubit.

Spin polarization in non-magnetic solids has mainly been limited to non-centrosymmetric materials. Here, the authors identify a helical spin texture in the centrosymmetric semiconductor platinum diselenide, and suggest it arises from a local dipole induced Rashba effect rather than the usual spin-splitting.

This study presents the difference in oxidation potential between metals and carbon as a thermodynamic factor for designing multielement heterostructures. A roll-to-roll carbothermal shock technology is developed to achieve one-step synthesis and continuous manufacturing of the multielement heterostructures.

Antibodies (Abs) targeting highly conserved epitopes are important tools against emerging virus variants. Here, the authors characterize Abs that recognize a cryptic epitope in the receptor-binding domain of SARS-CoV-2 spike that is well conserved and show that these Abs can neutralize several variants of concerns.

Here, the authors demonstrate topolectrical space-time circuits. These provide a practical platform for realizing multidimensional topological space-time crystals by integrating spatial and temporal modulations. These circuits open new avenues for exploring space-time topology and hold potential for advanced applications in wireless communication, non-reciprocal electronics, and beyond.

Circulating subtypes of Influenza viruses seasonally change and therefore vaccines need to be matched to these strains each year, which is why there is a need for next-generation vaccines that can elicit broad and cross-type protection. Here, Li et al. generate a human-mouse chimeric antibody with broad neutralizing activity against seasonal and pandemic H1N1 and some H5N1 viruses in vivo and identify residues on hemagglutinin relevant for its broad neutralization activity.

Through direct visualization of how the moiré potential enhances and modulates the topological flat band in rhombohedral graphene superlattice, this work provides key insights into the microscopic mechanism of the fractional quantum anomalous Hall effect

Li et al. show that maternal exposure to a Western-type diet accelerates atherosclerosis in adult offspring by inducing inflammatory memory in fetal endothelial cells through AP-1-mediated chromatin dynamics. This process, enhanced by 27-hydroxycholesterol, increases chromatin accessibility to inflammatory genes, which can be mitigated by inhibiting AP-1 binding.

The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn controls the expression of tumour suppressor protein, PML.

Inactivation of the ventral subiculum does not change existing schema cells in the orbitofrontal cortex (OFC) but aids their formation during new learning. This challenges the idea that the OFC relies on the hippocampus and suggests that these regions work in parallel to process different aspects of cognitive maps.

Rat hepatitis E virus (HEV) can infect humans, but the extent of spillover isn’t well studied. Here the authors develop a serological test that distinguishes exposure to rat HEV from other HEV infection and show substantial spillover in a biodiversity hotspot in China. The method can support surveillance of rat HEV.

The authors report an ultra-broadband ptychography method, suitable for dispersive samples, by exploiting structured illumination and a novel joint deconvolution algorithm.

An analysis of genomic, molecular and neuroanatomical traits across extant primates reveals early divergence in visual and olfactory systems of major primate lineages consistent with lineage-specific shifts in diel activity and dietary niche, providing support for a sensory ‘reallocation’ hypothesis.

Here, the authors observe room-temperature ferroelectricity in van der Waals layered GaSe down to monolayer with mirror symmetric structures and attribute it to the intralayer sliding of the Se atomic sublayers.

Layers of transition metal dichalcogenides (TMDs) are generally formed by covalently bonded atoms, enabling mechanical exfoliation only in the out-of-plane direction. Here, the authors show the fabrication of fractional 2/3-layers of WTe₂ and other TMDs by applying local scanning tunneling microscopy tip pulses and controllably removing the topmost chalcogen atoms.

Dynamic cell walls enable stomata rapidly responding to the environment. Here the authors report that a maize epimerase is involved in cell wall polysaccharide biosynthesis and glycosylation modulation during stomatal morphogenesis.