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The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

The authors demonstrate a generative model-based inverse design strategy that synergistically optimizes the composition and polarization configurations in Bi_0.5Na_0.5TiO₃-based ceramics, achieving enhanced energy-storage performance under low fields.

Pulmonary arterial hypertension (PAH) is a fatal disease involving disrupted metabolic and mitochondrial regulation. Here the authors show that REV-ERBα protects against PAH by repressing BNIP3-driven mitophagy in pulmonary vascular smooth muscle cells, revealing a potential circadian-based therapeutic target.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

Researchers demonstrate a minimalist terahertz wireless transceiver in integrated photonics. They break the longstanding constraint between source purity and DSP complexity, realizing 144 Gbps high-speed transmission at subterahertz frequency.

Photocatalytic CO₂ reduction is fundamentally limited by inefficient utilization of solar energy, particularly low-energy photons. Here, the authors report a nanoscale greenhouse structure (Bi@Fe₂O₃) that enables cascaded full-spectrum solar utilization and enhances solar-driven CO₂ reduction with water to CH₄.

This randomized open-label trial shows that hemoadsorption combined with hemodialysis reduces all-cause and cardiovascular mortality, and cardiovascular events in patients with end-stage kidney disease compared to hemodialysis (mainly low-flux hemodialysis plus intermittent hemodiafiltration) alone.

In vanadium flow batteries, crossovers are critical challenges for membrane design. Here, authors propose a balanced state electrolyte strategy that overcomes crossovers, thereby circumventing existing membrane-related constraints and establishing a new framework for advanced electrolyte design.

This study explores the role of protein hyperacetylation in heart failure with preserved ejection fraction (HFpEF). It identifies Dlat as a key regulator of mitochondrial fatty acid oxidation, offering insights for clinical HFpEF interventions.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

The manufacture of nitriles is critical to various industrial applications, but poor selectivity results in the significant release of CO₂, NO_x and toxic cyanide. Here, the authors report the electroconversion of aromatic and aliphatic aldehydes to valuable nitriles at near-unity selectivities.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

Extrachromosomal circular DNA (eccDNA) is a regulatory element involved in genomic stability and gene regulation. This study identifies widespread eccDNA in early mammalian embryos. These eccDNAs arise from active genomic regions, increase during a major wave of gene activation, and can regulate key developmental genes.

Reduced expression of STING in cancer cells due to ER and Golgi dysfunction enables tumor immune escape and limits STING targeted therapies. The authors here develop a cell membrane derived nanodisc system ND-cGAMP-HP that delivers activated STING directly to tumor cells bypassing ER Golgi translocation which activates the IFN-I signaling pathway and induces potent cellular immune responses.

This work proposes a strategy to fabricate textured piezoelectric ceramics with greatly reduced grain size (~7.8 μm), enabling to maintain high piezoelectric and dielectric properties of textured ceramics at the sample thickness below 100 μm.

Wang and colleagues present GEASO, a network-based tool that aligns, stitches, and reconstructs 3D structures from spatial slices. GEASO handles complex deformations to integrate diverse spatial datasets, offering biologists a powerful tool for spatial omics analysis.

The authors propose an asynchronous sublattice distortion mechanism to elucidate the complex phase transitions in HfO₂-based materials. The phase transitions among the orthorhombic, tetragonal, and monoclinic phases are governed by the orientation of the orthorhombic phase.

Large language models appear aligned, yet harmful pretraining knowledge persists as latent patterns. Here, the authors prove current alignment creates only local safety regions, leaving global adversarial paths intact, and empirically show widespread vulnerability across leading aligned models.

Alternative splicing may help explain genetic risk for joint diseases. Here, the authors generate cartilage and synovium sQTL maps, revealing tissue‑specific splicing variants and pinpointing effector genes for osteoarthritis, rheumatoid arthritis, and height

Authors present a specialized diagnostic tool called ClinDiag-GPT trained on real-world cases. It outperformed baseline models of existing large language models and could serve as a clinical assistant to physicians.

Although ketenes are important intermediates in chemical synthesis, the high reactivity of difluoroketene has impeded its controlled generation and practical application. Here, the authors report a transition-metal-free strategy for its mild, in situ production from difluorobromoacetylsilane, enabling cycloadditions, rearrangements and difluoroacetylations.

This work reports the discovery of a giant in-plane Hall effect in a nonmagnetic half Heusler compound, demonstrating magneto-cubic behavior over a wide temperature range and identifying extrinsic mechanisms as the dominant origin.

The reconstruction and control of supramolecular ropes using minimalist building units remains a fundamental challenge. Here the authors demonstrate self-assembly of cyclo-tryptophan-proline dipeptide stereoisomers into crystalline supramolecular triple-helical structures with tunable S- or Z- twists governed by the configuration of tryptophan residues.

Strong optical anisotropy is commonly achieved by complex engineered materials. Here, authors synthesize elemental crystals of type-II red phosphorus made of wavy tubular structures, exhibiting strong birefringence in the visible and near-infrared spectral region. They demonstrate anisotropic photoluminescence, Raman scattering and second-harmonic generation.

Maintaining nanocatalysts under extreme heat is a major challenge due to structural disintegration. Pre-filling support vacancies creates a confinement field that anchors rhodium nanoparticles, preserving their integrity and activity during methane oxidation.

Here the authors present a photoinduced Mn(II)-bipyridine catalyzed cross-coupling reaction between aryl halides, particularly less-reactive aryl chlorides, and nucleophiles containing nitrogen, oxygen, and sulfur.

Maize cultivar evolution boosts maize yield, yet the response pattern of maize to extreme climates is unclear. This study clarifies the synergy and trade-off mechanisms underlying the increase of yield per unit area and adaptation to extreme climates.

The study reveals that GPX4 protects against myocardial ischemia/reperfusion injury by maintaining mitochondrial quality control. By stabilizing BNIP3 through USP20, GPX4 enhances mitophagy and reduces cardiac damage.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Efficient cryogenic electronics are essential for quantum computing at millikelvin temperatures. Yang et al. report a SiC-based negative differential resistance device with high on/off ratio at millikelvin and demonstrate programmable cryogenic neuromorphic circuits including sensory, logic and spiking neurons.

How do avian eyes fulfill the intense metabolic activity of thick, high-acuity retinas in the absence of direct vascular support? The study finds that birds’ rapid, oscillating saccadic eye movements pump glucose from the pecten to the avascular retina, sustaining nutrient supply and boosting visual responses in the brain; especially when driven by dynamic visual stimuli.

Vegetation productivity resilience to fast and slow developing droughts remains poorly understood. This study reports lower resilience, greater sensitivity, and weaker CO₂ fertilization effects under flash drought, indicating limited ecosystem resilience.

A genome-wide association study in rice identifies variation in SBRR1 associated with sheath blight resistance. Introducing the SBRR1-R allele into a commercial rice variety reduces yield loss under severe exposure to sheath blight disease.

Methanotrophic growth on methane and N₂-derived ammonia is inhibited by a toxic intermediate, hydroxylamine, generated via ammonia oxidation. Here the authors ameliorate this toxicity through genetically engineering M. sanxanigenens and feed the biomass to mice to reduce colitis symptoms.

Spatial omics maps cell positions, but how they hierarchically assemble into functional tissues remains unclear. Here, the authors present HRCHY-CytoCommunity, a tool that decodes these multi-level organisations, linking them to biological mechanisms and clinical outcomes.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

Thermochromic materials are promising for optical switching devices, though many examples are sensitive to environmental conditions. Here the authors report a phase-separating thermochromic ionogel with a wide temperature stability and enhanced mechanical properties.

Converting methane into valuable chemicals is challenging due to its stable bonds and inefficient C–C coupling. Herein, a dual-site catalyst with high-valent metals to selectively converts methane to acetic acid with high efficiency and stability.

SERS analysis at higher temperatures, such as during photothermal processes, is challenging due to enhancement losses. Here, the authors demonstrate a heat-induced increase in SERS activity mechanistically attributed to assisted hot-hole transfer.

Controlling mitochondrial ROS has potential to regulate inflammatory responses, however targeting it in macrophages can be difficult. Here, the authors create hybrid membrane extracellular vesicles capable of targeted delivery to macrophages to modulate mitochondrial ROS, promoting diabetic wound healing.

The authors showcase a lateral Si–Ge avalanche photodiode in the O-band. With low dark current, high gain–bandwidth product of 7564 GHz, it supports 100 Gbps NRZ and 200 Gbps PAM4 signals for high-speed optical communication applications.

Ming et. al. reports a memristor with an intrinsic ionic gradient that enables stable second-order dynamics and physically modulated learning rates. The device supports stable, energy-efficient continual reinforcement learning and adaptive decision-making.

Tumors remain difficult to map. Here, the authors developed a 2.5 mm magnetic-driven multifunctional optoelectronic catheter that enables minimally invasive tumor mapping, targeted drug delivery, in situ sensing, and photodynamic therapy.

ANNEVO advances accurate and scalable ab initio gene annotation of evolutionarily diverse genomes using deep learning approach modeling sequence evolution and long-range dependencies and mixture of experts (MoE) architecture.

When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.