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In conventional s-wave superconductors, ferromagnetism is strongly suppressed, due to the singlet pairing of the electrons. Here, Xiang, He, Lin, and coauthors find a long-range ferromagnetic order among impurity sites in the spin-orbit coupled Fe(Se,Te) using scanning superconducting quantum interference device microscopy.

Membrane bioreactors face sustainability issues due to waste. Here, authors propose upcycling end-of-life membranes into curtain-type dynamic membranes, reducing carbon emissions and environmental costs while maintaining filtration performance, offering a sustainable solution for water treatment.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Extrachromosomal circular DNA (eccDNA) is a regulatory element involved in genomic stability and gene regulation. This study identifies widespread eccDNA in early mammalian embryos. These eccDNAs arise from active genomic regions, increase during a major wave of gene activation, and can regulate key developmental genes.

The study introduces manifold topological deep learning (MTDL) that extends topological deep learning to data on differentiable manifolds through de Rham-Hodge theory. MTDL outperforms competing methods on various biomedical imaging benchmarks.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Using artificial intelligence, authors model how air pollution may increase susceptibility to SARS-CoV-2. NPC1 is identified via genetic and laboratory analyses as a key pathway that enhances viral entry after exposure to fine particulate matter.

MIR photothermal detection can be limited under weak irradiation due to insufficient thermal sensitivity. Here, the authors show ligand-capped lanthanide nanoparticles enable broadband mid-IR detection through localized heating that modulates visible emission.

Xiang, Wang, Tian et al. report that during nutrient insufficiency, inflammatory cytokines promote a ZBTB5-mediated mechanism to activate mTORC1 signalling, thereby enhancing amino acid uptake in tumour cells and restricting antitumour immune response.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

IMiD-based PROTACs may degrade IKZF1/3 with hematologic effects. This study profiles these liabilities using hematopoietic assays showing stem cell rewiring and interferon activation and introduces a CRBN ligand that reduces them.

MicroRNAs are promising disease biomarkers, yet accurately measuring them remains challenging. Here, the authors develop SE-SPTM-PCR, a method which improves sensitivity 100-fold and eliminates false signals, showing improved diagnostic performances for cancer and viral reactivation.

Hydrogen spillover enhances hydrogen production but is hindered by electronic barriers at phase interfaces. Here, the authors report a Ni₁₇W₃-WO₂ with a built-in strain gradient and directional electron transfer to enable non-interfacial hydrogen spillover, delivering high activity and durability.

Taurine transporter TauT is a key drug target for multiple diseases. Here, authors reveal structure of human TauT in four states, showing how inhibitors mimic taurine and guiding future TauT-targeted drug design.

This study reveals that Amphotericin B activates glucocerebrosidase to remodel late endosomal lipid and protein composition, promoting respiratory viral entry. This highlights a risk of secondary viral infections during antifungal therapy.

3Snet-CLID integrates signal-preserving deep learning denoising with direct Richardson–Lucy deconvolution to achieve over 5-fold resolution improvement on standard microscopes, enabling artifact-free nanoscale imaging of live-cell organelles and structures.

XA-Novo is a mass spectrometry–only de novo antibody sequencing workflow that reconstructs full-length antibodies from single samples or mixtures, enabling rapid sequence recovery and functional re-expression for antibody research and drug discovery.

Converting metal nanoparticles into single-atom catalysts remains a challenge. This light-driven method uses chlorine radicals to disperse noble metals at room temperature, dramatically boosting the activity of industrial catalysts.

Grain chalkiness is an undesirable trait that severely compromises rice quality. Here, the authors report the cloning of an E3 ubiquitin ligase encoding gene Chalk9 and reveal its crucial role in regulating grain chalkiness through mediating the ubiquitination-dependent degradation of OsEBP89.

How behavioral constraints re-organize functionally-defined HD (head direction) cells within the wider entorhinal network is not fully understood. Here authors show the complementary role of learning and self-organization in some entorhinal subpopulations, enabling animals to adaptively represent themselves within their environment, shaped by ongoing behavioral constraints.

Japonica subspecies has a lower nitrogen use efficiency (NUE) than that of indica rice. Here, the authors show that natural variations in the NIN-like protein 4 (OsNLP4) encoding gene are responsible for the divergence and introgression of the indica OsNLP4 allele into elite japonica cultivar can increase NUE and grain yield.

The authors reveal how two insect-selective animal peptide toxins engage distinct sites on an insect sodium channel to disrupt fast inactivation and leverage these structural insights to AI-design a more potent toxin for biopesticide development.

This study reveals an sRNA-centered signaling pathway that activates nitrate respiration and enhances Cronobacter sakazakii virulence in oxygen-limited host environments, offering important insights into therapeutic strategies.

Traditional flexible sensors struggle with synchronized multimodal perception and robustness, limiting their performance in extreme environments. Baijin Mao and colleagues propose an ultra-robust bionic distributed multimodal flexible sensor inspired by tiger-shark skin.

Coulomb explosion imaging provides real space/time resolution of molecular processes. Here the authors develop a generative model to reconstruct molecular geometries from ion momentum measurements which extends the system size accessible with this technique.

In neuromorphic computing, time-series prediction is a significant challenge to recurrent neural network architecture. Here, the authors present ambipolar transistors implementing a physical echo-state network for efficient time-series and image tasks, achieving high accuracy via static and dynamic computing modes.

Novel treatments are needed for type 2 diabetes mellitus which target insulin resistance, lipid metabolism dysregulation, and gut microbiome dysbiosis. Here the authors engineered a probiotic to tolerate oxidative stress, an alleviate type 2 diabetes in mice by activating host metabolic pathways.

Covalent organic frameworks are promising for desalinations; however, it is challenging to control pore size for efficient desalination. Here the authors design an ultra-microporous membrane by introducing hydrogen bonding networks that enhance the crystallinity and desalination performance.

Oncolytic viruses are an approved therapeutic approach for glioblastoma, but, unfortunately, they are efficacious only in some patients. Here, the authors discover that LRRK2 inhibitors enhance viral infection and oncolysis by oncolytic herpes simplex virus (oHSV) in glioblastoma.

NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.

RNA-sequencing’s conversion of molecules to reads confines analysis to relative fold-changes, a metric unreliable across batches. Here, the authors introduce TranScale, a spike-in method with 100 biomimetic standards that converts reads into absolute quantities to resolve systemic biases.

Solar-driven biosynthesis using semiconductor biohybrids has the potential to achieve sustainable chemical production, but often it is hindered by inefficient solar energy conversion. Here the authors develop design strategies to tackle this technical challenge.

The Template-Independent Genome Editing for Restoration (TIGER) platform enables efficient and precise correction of frameshift mutations in vivo, incorporates algorithms to score therapeutic guide RNAs and demonstrates restored hearing in a mouse model.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Random access memory has multiple data registers and uses addresses to specify which register should be read or modified. Now a quantum random access memory has been demonstrated that uses quantum addresses to return data in superposition.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

A fully self-powered wireless arm interface converts human motion into electrical signals and wireless commands using a compact triboelectric nanogenerator, enabling battery-free, real-time robotic arm control for industrial and human–machine applications.

Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks and pathologists in lymph node metastasis detection.

Negative regulator of thermotolerance 1 (NAT1) is identified as a negative regulator of thermotolerance in rice through the NAT1–bHLH110–CER1/CER1L module. Modifying NAT1 by targeted gene editing increases wax deposition and enhances thermotolerance in rice.

Hong-Xuan Lin, Ji-Ping Gao, Jun-Xiang Shan and colleagues show that natural variation in a proteasome α2 subunit gene contributes to thermotolerance in African rice. Their follow-up studies suggest that the variant allele protects cells from heat stress by enhancing the elimination of cytotoxic denatured proteins and maintaining heat-response processes.

Native crystallographic defects are often introduced during synthesis of battery materials, but has been overlooked. Here, using in situ synchrotron X-ray probes and electron microscopy, the authors have revealed their adverse effect during battery operation.

Achieving robustness against a dynamic physiological environment is a challenge for neuromorphic prostheses. An interface made of a self-healing hydrogel and electrodes acts as a physical reservoir of a neuromorphic prosthesis, achieving minimal susceptibility to physical damage.

Aging boosts diabetic kidney disease risk via shared renal pathology. Renal RORγ is downregulated in diabetes/aging; its tubule-specific loss worsens injury, and overexpression protects. RORγ stabilizes INSIG1 via YOD1/CAB39, blocking SREBP2/STING.

On-surface synthesis recently enabled access to generate a series of cyclo[n]carbons via delicately designed precursors but for large cyclocarbons, synthesis of the corresponding precursors is challenging. Here, the authors report a strategy for synthesizing larger cyclocarbons via the coupling and ring-opening reactions from smaller ones.

Hot climates erode children’s sleep, threatening cognitive development with likely socioeconomic consequences. A global analysis finds potential links between future sleep losses and trillions of dollars in economic costs that disproportionately burden poorer regions.