Search

Chen et al. report a tailored self-assembled monolayer to create a localized 2D/3D perovskite heterojunction. This strategy reduces interfacial loss, achieving photovoltages >90% of thermodynamic limit for wide-bandgap cells, and enables perovskite-organic tandem solar cells with efficiency of 27.11%.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Osteoarthritis (OA) involves joint inflammation and degeneration, but its underlying causes are not fully understood. Here, the authors show that cholesterol triggers intercellular mitochondrial transfer to activate inflammatory chain reaction in joints and targeting this process can alleviate OA.

The authors demonstrate that a cell’s external environment can physically control its genes. Osmotic pressure alters intranuclear crowding, shifting the equilibrium of proteins binding to dCas9-SunTag complex and thereby regulating gene expression.

Nuclear Factor IA is important for development and metabolism. Here, the authors present high-resolution molecular structures of Nuclear Factor IA, and detail how it recognizes the TGGCA DNA motif.

Conventional battery electrodes exhibit high tortuosity, impeding ion transport. Here, authors report the use of a temporally shaped ultraviolet femtosecond laser to create an array of high-density through-holes, reducing tortuosity in thick electrodes with low material loss (> 1%) in up to 280 μm-thick LiFePO4 electrodes, improving gravimetric energy density and power capabilities.

Neoadjuvant chemoradiotherapy has become the standard of care in patients with resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). Here, authors present a randomised phase II trial reporting the non-inferiority of neoadjuvant camrelizumab (anti-PD-1) and chemotherapy (nab-paclitaxel and cisplatin) compared to chemoradiation (nab-paclitaxel, cisplatin, and radiotherapy in patients with resectable LA-ESCC.

Advancements in spin-orbit-torque magnetic random-access memory require solutions for achieving high density and low power consumption. Here, the authors achieve a significant and simultaneous enhancement of perpendicular magnetic anisotropy and spin-orbit-torque conductivity by inserting an ultrathin gadolinium layer at the β-W/CoFeB interface, positioning rare-earth elements as key multifunctional regulators for efficient spintronic devices.

In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

Authors in this study discover a CCKBR agonist MF-8 with β-arrestin bias. This biased agonist can reduce other CCKBR signaling pathways, including Gαs-induced cAMP and Gαq/11-induced calcium signaling, thereby inhibiting the CCKBR-LTP. This discovery provides us with new ideas for developing drugs targeting CCKBR.

Sulfoquinovosyl diacylglycerols are produced by photosynthetic organisms and serve as sources of carbon and sulfur for bacteria. This work characterizes a sulfoquinovosidase, unveils a reservoir of organosulfur compounds in the ocean and elucidates their critical role in marine carbon cycling.

This study provides a de novo resequencing of 802 Camellia accessions and a genome-wide variation map. Genome-wide association study (GWAS) and metabolite GWAS identify genes responsible for crucial agronomic and flavor traits.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Helical polythiophene and polypyrrole are synthesized using a chiral iron-based metal–organic framework template. Single-handed helices are formed within the framework’s narrow channels, enhancing the chirality-induced spin polarization of the metal–organic framework to 94%.

Bi, Mo, Liu et al. carry out high-throughput screening and analysis to profile genome-wide pro-tumour enhancers and uncover enhancer connectomes in glioma. In particular, they identify specific single-nucleotide polymorphisms associated with glioma risk and progression.

This work presents a crystal-in-glass composite doped with rare-earth ions to create a WGM microcavity that simultaneously enables efficient upconversion and broadband frequency-doubled lasing.

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Pharmacological inhibition of the prolyl isomerase PIN1, highly expressed in cancer cells and cancer associated fibroblasts (CAF), has been proposed for cancer therapy. Here the authors report the design of a DNA-barcoded micellular system functionalized with antibodies targeting CAFs and a T cell recruiting aptamer to deliver the PIN1 inhibitor AG17724, showing antitumor response in preclinical models of pancreatic cancer.

High-resolution FAST observations of a very-high-velocity cloud in the warm neutral medium reveal a network of hierarchical filaments formed by shock compression. These findings suggest a viable mechanism for early structure formation in the interstellar medium.

The RNA-binding protein SAIR1 forms phosphorylation-regulated condensates in guard cells, which link PAMP–MPK3/6 signalling to stomatal immunity. This finding reveals how biomolecular condensates regulate spatially specific immune responses in plants.

N-oxidation of N-heterocycles is essential in the synthesis of natural products and intermediates for pharmaceuticals and pesticides but challenging due to low efficacy and poor regioselectivity. Here, the authors employ structure-guided directed evolution of Bacillus megaterium P450BM3 to obtain variants with expanded N-oxidation selectivity for the synthesis of N-heterocyclic N-oxides.

The coupling of acetonitrile into succinonitrile via a dehydrogenative route is highly attractive in terms of valuable chemical synthesis and green hydrogen energy production. Here, the authors report succinonitrile synthesis with high selectivity and rate via a light driven dehydrogenative coupling reaction of CH₃CN over the anatase TiO₂ supported Pt catalyst.

A large-scale single-cell transcriptomic atlas of the non-human primate Macaca fascicularis encompasses over 1 million cells from 45 adult tissues.

Intestinal motility disorders that can occur following small intestine resection often require regular monitoring. This study reports a biodegradable ultrasound contrast tape (BioUCT) that adheres to the intestine for high-contrast imaging for up to two weeks for non-invasive monitoring of postoperative intestinal motility.

This study reveals how pre-mRNA processing factors in Arabidopsis distinctly coordinate cleavage and transcription termination, highlighting complex roles of CPSF, CstF, PAPS1, BORDER proteins, and FPA in efficient mRNA maturation.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Zhao et al. identified a novel E3 ligase RED and its E2 partner UBC32 which mediates ethylene-induced degradation of ethylene receptors ETR3 via the ERAD pathway in Rosa hybrida and Solanum lycopersicum, providing new insights into controlling ethylene response through receptor turnover.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

An ex vivo model and pre-clinical study in a brain-dead recipient provide enzyme-converted O organs to avoid hyperacute rejection in ABO-incompatible kidney transplant patients.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Pollen tube growth is guided towards ovules. Here the authors show that a bHLH transcriptional factor CsALC functions in pollen tube emergence towards ovules to regulate female fertility in cucumber and promotes the expression of two rapid alkalinization factors CsRALF4/19 in the ovary.

An extreme Einstein ring ~10,000 times as bright as the Milky Way in the infrared is studied with VLT/ERIS and ALMA, and the authors find that the lensed galaxy is a starburst with a fast-rotating disk, rather than being driven by a major merger.

A ketogenic diet can reduce calorie absorption and protect against obesity by inducing changes to the gut microbiota and the bile acid pool.

The realization of efficient perovskite/organic tandem solar cells has been challenging due to large voltage deficits and severe non-radiative recombination. Here, the authors introduce sandwiched hole transport configuration for more balanced carrier transport, achieving efficiency of 26.05%.

A telomere-to-telomere genome assembly of allohexaploid bread wheat cv. Chinese Spring (CS-IAAS), along with transcriptomic and proteomic data, highlights wheat genome complexity and its structural and functional features.

The introduction of ethylenediammonium diiodide reduces defects but also leads to severe hysteresis caused by excessive mobilized ions. Here, authors employ hydrazine monohydrochloride as a bulk passivator to mitigate such hysteresis, achieving maximum efficiency of 28.55% for tandem solar cells.

This work proposes a wet-chemical etching assisted aberration-enhanced single-pulsed femtosecond laser nanolithography, named “WEALTH”, for manufacturing small-size, large-area, deep holey nanostructures, promising for emerging nanophotonic devices.

Natural photosynthesis converts H₂O and CO₂ into carbohydrates through all-weather reactions based on enzymes and coenzymes. Here, the authors report an artificial photosynthesis system under intermittent light irradiation by integrating nanozyme complexes and ubiquinone on a copper nanocluster.