Nucleosides, nucleotides and nucleic acids with N6 modified adenosine are important for the areas of disease diagnosis and treatment, biological chemistry, and nanotechnology, but challenging to synthesize. Here, the authors develop a practical alkylation at the N6-position of adenines in adenosine and its analogues, as well as late-stage functionalization of nucleotides/oligonucleotides through photoredox and copper co-catalyzed decarboxylative C(sp3)-N cross-coupling reaction.
- Ruoqian Xie
- Guolan Xiao
- Gang Chen
