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Hole–electron resonance in WTe2 unlocks Coulomb-unconstrained spin transfer across WTe2/Fe3GaTe2, producing a giant 289% unusual anisotropic magnetoresistance and chiral transverse transport beyond conventional spin-transport models.

Modifying the light-absorbing or catalytic properties of a photocatalyst typically requires tedious preparation, resulting in a lengthy development process. Here, the authors address this limitation by achieving manganese-based low-energy photoredox catalysis through the in-situ assembly of simple Mn salts with inexpensive coordinating chemicals.

Spin transport properties of magnetically ordered materials have been well studied. Here, the authors report an anomalous spin signal exhibiting spin transport over 480 microns in the frustrated hyperkagome magnetic insulator Gd₃Ga₅O₁₂.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

In this study, the authors present an fMRI‑based signature of corticospinal connections, which predicts individual pain sensitivity, generalizes to patient cohorts, and tracks changes after brain stimulation, suggesting a biomarker to guide personalized pain care.

A telomere-to-telomere gap-free pig genome assembly (T2T-pig1.0) for a Wuzhishan boar highlights Y chromosome structure and genomic regions potentially associated with body stature.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

Cuticular wax is crucial for plant development and environmental interaction. This study reveals the negative impact of nitrogen on cuticular wax via MdBT2–MdMYB106–MdCER2L1, thus uncovering a novel pathway for N-mediated wax biosynthesis in apple.

Tissue Contribution Index (TCI): quantifies tissue contributions to plasma cfDNA by leveraging transcription start site (TSS) coverage profiles.

The development of catalysts for practical asymmetric hydrogenation of ketones remains an important goal of synthetic organic chemistry. Here, an anionic iridium catalyst with excellent activity is reported and used in a hundred-kilogram-scale reduction as part of a route to chiral nicotine.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

Creating different pore environments within a covalent organic framework (COF) leads to useful multicompartment structure and multiple functions. Here, the authors propose a strategy to construct amphiphilic COFs with separated hydrophilic and hydrophobic nanochannels by precisely controlling the distribution of hydrophilic and hydrophobic segments in two different kinds of pores.

An electrostatic-repulsion-enabled advanced transfer technique based on ammonia solution is introduced for separating van der Waals thin-film materials from their substrates, demonstrating suitability for its use in the complementary metal–oxide–semiconductor (CMOS) industry.

In this clinical trial, the authors demonstrate that recombinant gE-Fc Fusion Protein Vaccine LZ901 for herpes zoster induces superior cellular immunogenicity and exhibits a better safety profile than HZ/su in adults ≥50 years, supporting its potential as vaccine candidate.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Traditional electrorefining process is limited by deposition potential of the metal itself. Here, the authors explore an in-situ anodic precipitation process based on different solubility of target metal chlorides that can efficiently separate components of aluminum alloys.

Receptor tyrosine kinases play a key role in the regulation of intracellular signal transduction revealing their potential for targeted therapy. Here this group reports an aptamer-directed phosphatase recruiting chimeras for direct dephosphorylation of tyrosine residues on the receptor targets thereby inhibiting transmission of phosphorylation signals both in vitro/vivo.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Artificial photosynthetic diluted CO₂ reduction from fuel gas is promising but challenging for carbon neutrality. Here, the authors report a host-guest system by integrating CO₂-enriching ionic liquids and photoactive metal-organic frameworks, greatly enhancing CO₂-to-CO conversion efficiency.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

Artificial photosynthesis of urea from NH₃ and CO₂ remains difficult to achieve. Herein, by three altering the number of heterocyclic N atoms within a series of covalent organic frameworks, the authors report an increase in urea photosynthesis yields and efficiencies.

The authors describe a new mechanism of AD pathogenesis in which the histone methylase G9a regulates translation of hippocampal proteins associated with AD pathology. Targeting this mechanism with a brain-penetrant inhibitor of G9a helped rescue brain pathology in AD mouse models.

Ferroelectric ordering of water has been at the heart of intense debates due to its importance in enhancing our understanding of the condensed matter. Here, the authors observe ferroelectric properties of water ice in a two dimensional phase under confinement between two graphene layers.

Although transition metal-based complexes featuring metal atoms in formally negative oxidation states are known, their stabilization without an organic ligand remains challenging. Now, lanthanide–nickel intermetallic complexes featuring an organic-ligand-free Ni²⁻ ion bound to electropositive lanthanides have been stabilized in fullerenes.

Acute kidney injury (AKI) frequently arises as a complication of hepatic ischemia reperfusion injury (HIRI), yet simultaneous optical imaging of both remains challenging. Here, the authors develop a unimolecular cascaded activatable reporter with dual responses and pharmacokinetic conversion for non-invasive multiplex chemiluminescence imaging and fluorescent urinalysis of HIRI and associated AKI.

The authors introduce a loss-enhanced magneto-optical effect and sublinearly amplify the frequency response of a non-Hermitian optical cavity under different background magnetic fields. This effect is exploited to detect subtle magnetic field variations against a strong background with enhanced system response and sensitivity.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Achieving sustainability in wireless communications is crucial yet poses significant challenges. To address this, the authors propose and demonstrate a solar-powered programmable metasurface enabling hybrid light-to-microwave wireless communications.

SARS-CoV-2-related coronaviruses are identified in Malayan pangolins (Manis javanica); these pangolin-associated coronaviruses belonged to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2.

Xue et al. develop a foundation model for spectral analysis. It excels in multiple tasks, such as denoising spectra and quantifying trace molecules, and is especially promising in identifying metabolic biomarkers of diseases such as stroke, Alzheimer’s disease and prostate cancer.

Here the authors study diet-induced weight gain/loss to identify chromatin architectures in adipose tissue (AT) associated obesity in a pig model. They found parallels and species-specific regulatory elements in humans and pigs that underpin AT specialization.

Here the authors investigate the involvement of the immune modulator ILF3 in abdominal aortic aneurysm, showing that macrophage ILF3 promotes aneurysm progression by increasing NF-kB activity and inhibiting Keap1-Nrf2 signaling.