Search

Wan et al. identify MEA1 as a chaperone that promotes assembly of the AP1 adaptor complex and is essential for cargo transport. MEA1 and AAGAB cooperate through a dual-chaperone mechanism that may be broadly applicable to protein complex assembly.

Tools for precisely manipulating phase-separated condensates remain limited. Here authors present an engineered system based on the androgen receptor, where clinically used drugs can be used to control the formation and dissolution of synthetic condensates, subsequently allowing control over various cellular processes.

Improving catalysts for producing carbonates remains a challenge due to limited activity and durability. This study shows a bismuth–ceria catalyst that enhances reaction steps through remote electronic effects and can be easily regenerated.

An approach that integrates electrochemical CO₂ reduction and biological denitrification provides a new solution for nitrogen removal, where the formate obtained from CO₂ is used directly as the carbon source in the denitrification process in wastewater treatment.

An atomically thin high-κ gate dielectric of Bi₂SeO₅ can be formed via layer-by-layer oxidization of an underlying two-dimensional semiconductor, allowing high-performance field-effect transistors and inverters to be fabricated.

A new architecture based on high-valence sulfur/sulfur tetrachloride cathode chemistry is described for manufacturing high-voltage anode-free sodium–sulfur batteries, demonstrating promise for applications in grid energy storage and wearable electronics.

A nanobody was identified that targets the N-terminal fragment of the adhesion G-protein-coupled receptor ADGRG2, allosterically enhances activation by the natural agonist dehydroepiandrosterone and restores signaling in mutant receptors.

Interwoven magnetic and non-magnetic layers in TbTi₃Bi₄ overcome kagome frustration, producing coupled elliptical-spiral magnetic and spin-density-wave orders and a very large anomalous Hall effect driven by strong electron–magnetic field interactions.

Here the authors report that some aspects of clinical heterogeneity in type 2 diabetes vary across populations. Using a deep-learning–based tree model built from over 32,000 patients, they document disease patterns and risks specific for the Chinese population, potentially enabling more precise prediction and personalized care.

The role of RNA-binding protein (RBP) phase separation in transcriptional regulation and its contribution to tumorigenesis remains to be characterised. Here, the authors show that RBP AKAP95 physically co-condenses with the mixed lineage leukemia 1 (MLL1) translocated fragment commonly found in MLL rearranged (MLLr) leukemia to promote leukemogenesis.

A short peptide derived from a commensal-fungal-secreted protein promotes repair in models of colon epithelial damage when delivered directly or via probiotic microbes.

The magnetic field is an effective tool for inducing topological phase transitions. Here, the authors tune the direction and strength of the magnetic field in an ideal Dirac semimetal, Bi₄(Br_0.27I_0.73)₄, to demonstrate multiple Weyl modes.

Examples of materials with non-trivial band topology in the presence of strong electron correlations are rare. Now it is shown that quantum fluctuations near a quantum phase transition can promote topological phases in a heavy-fermion compound.

This study reports that genomic signatures composed of the loss of pluripotency inhibitors, expansion of pluripotency activators and maintenance of an epigenetically permissive state contribute to the plantlet formation in Kalanchoe.

In Bi₂O₂Se thin films, the local inversion-symmetry breaking in two sectors of the [Bi₂O₂]²⁺ layer yields opposite Rashba spin polarizations, which compensate each other and give rise to the hidden Rashba effect. Hence, the films exhibit only even-integer quantum Hall states, but there is no sign of odd-integer states.

High-quality, non-layered 2D β-Bi₂O₃ crystals are grown using a vapour–liquid–solid–solid growth technique. These crystals demonstrate promising properties for p-channel field-effect transistors.

The authors find that the plasticity of magnesium bismuthide (α-Mg₃Bi₂) arises from helical dislocation-driven interlayer slip, and the dispersion of lightweight Mg atoms also plays a pivotal role in facilitating strain redistribution during plastic deformation.

This work on 90 angiosperm tree species presents a trait-based root ‘acquisition-defence-decomposition’ framework. In support, the study shows how tree root economics strategy and mycorrhizal strategy strongly correlate with root litter chemical defences that define root decomposability, with multiple potential consequences feeding back on tree nutrition.

The micro-thermoelectric coolers face challenges in high-performance material preparation and high-density device integration. Here, the authors combine Bi₂Te₃-based film prepared by powder direct molding with micro-thermoelectric cooler integrated via phase-change batch transfer.

By utilizing an AI-accelerated silicon photonic slow-light technology, researchers demonstrate a record 400 Gbps/λ PAM-4 transmission based on pure silicon modulators, paving the way for next-generation optical interconnects in computing centers.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Floating gate memories (FGMs) hold potential for neuromorphic computing, but their single-device state capacity is normally insufficient for precision computing. Here, the authors report the realization of high-performance 11-bit 2D MoS₂ FGMs by using Schottky-barrier free Bi contacts and a dual-pulse state editing scheme.

The authors propose a phase-boundary and bandgap co-engineering strategy by incorporating BiFeO₃ into 0.97(K_0.5Na_0.5)(Nb_0.96Sb_0.04)O₃-0.03(Bi_0.5Na_0.5)0.85(Li_0.5Nd_0.5)_0.15ZrO₃, greatly improving the output current performance.

Enhancing utilization of single atoms is crucial but challenging in electrocatalysis. Here, the authors present a surfactant-assisted freezecasting method to optimize nanocarbon micro- and macrostructures, achieving near-100% site utilization and enhancing single-atom catalyst performance.

Solving the interlayer charge transfer issue of Bi₃TiNbO₉ is crucial for overcoming its limitation in photocatalytic overall water splitting. Here, the authors introduced gradient doping to promote the separation and transfer of photogenerated charges and enhance the photocatalytic activity.

Identifying genetic variants using long-read RNA sequencing (lrRNA-seq) is useful but hampered by high error rates and biological complexities. Here, the authors developed Clair3-RNA, a deep-learning tool that improves variant calling accuracy in lrRNA-seq data and accurately identifies RNA editing sites.

The authors synthesize rock-salt-structured LiMnSbTe₃, in which Sb₂Te₃-type van der Waals-like gaps are embedded as ordered local structures that both scatter phonons and enhance charge-carrier transport.

Heusler compounds have been predicted to host topological order with other emergent properties, which yet awaits for experimental evidence. Here, Liu et al. report a direct observation of topological surface states on half-Heusler compounds LnPtBi.

HOM formation from a same VOC can vary by over a factor of three depending on chemical conditions. A RO₂ oxidation fraction concept explains this variability and cautions against directly applying lab yields to the atmosphere.

Surface frustrated Lewis pairs (SFLPs) provide a unique class of active sites that enable efficient gas-phase CO₂ photocatalysis. How to tailor the reactivity of the SFLPs represents a major challenge, which the authors address here by single-site Bi³⁺ ion substitution of the SFLPs.

Achieving high pure formic acid production from CO₂ electroconversion is of high interest yet challenging. Here the authors report vitamin C functionalized Bi₃S₂ nanowire catalyst to achieve selective, active, and stable formic acid production.

Many of the most sensitive X-ray detectors are based on toxic elements such as lead, limiting their safe applications. Here, the authors report the realization of sensitive X-ray detectors based on solution-grown thick BiI/BiI3/BiI van der Waals heterostructures, showing a detection limit down to 34 nGy s⁻¹ and high stability.

Quantum anomalous Hall junctions show great promise for advancing next-generation electronic circuits. Here, the authors demonstrate a scalable method for synthesizing heterostructures of magnetic topological insulators with regions of distinct Chern numbers and characterize the chiral interface modes that emerge at the interface.

Polar ordering in materials enables fascinating properties; however, achieving beyond binary responses remains a challenge. Here, the authors demonstrate control on the polar-to antipolar transition and multiple polarization states in BiFeO₃ thin films.

Vaccinations against the SARS-CoV-2 KP.2 variant were introduced for the 2024-25 season in the United States. Here, the authors investigate the effectiveness of these vaccines up to April 2025 through a target trial emulation study using electronic health record data.

Here, trace detection of NO2 is achieved with a 2D Schottky-junction Bi₂O₂Se gas sensor. Simultaneous signals allow for detection in the ppt range, and impedance angle analysis allows for molecular specificity.

The authors study (Bi,Sb)₂Te₃/FeTe bilayers, which feature emergent superconductivity at the interface with T_c ~ 12 K. Through angle-resolved photoemission spectroscopy and electrical transport measurements, they argue that the Dirac-fermion-mediated Ruderman-Kittel-Kasuya-Yosida-type interaction weakens antiferromagnetic order in FeTe layer, allowing for superconductivity.

Ferromagnetic systems rarely display a large or non-saturating magnetoresistance, due to the low Fermi velocity of the predominant charge carrier. Here, the authors show that MnBi, a ferromagnet, bucks this trend, showing both large and non-saturating magnetoresistance, and high charge carrier motilities.

Reconfigurable elastic properties are essential for functional mechanical metamaterials. Here, the authors propose a 3D metamaterial with engineered zero modes, and experimentally demonstrate its transformability covering all seven extremal metamaterial types, leading to programmable wave functions.

Electrochemical CO₂ reduction in acidic media offers a promising route for CO₂ valorization but faces challenges owing to competing hydrogen evolution and sluggish C–C coupling. Here the authors demonstrate that surface-adsorbed iodide ions enhance performance on Cu-based catalysts, doubling ethylene selectivity and reducing overpotentials.

Mixing the fundamental (ω) and the second harmonic (2ω) waves in the gas phase is a widely used technique for generating terahertz pulses. The authors experimentally present an enhanced terahertz emission through the temporal-spatial manipulation of bi-focal bi-chromatic fields, and the THz radiation mainly originates from the plasma created by the 2ω pulses instead of the ω pulses, which cannot be explained only using photocurrent model.

A band-hybridized selenium contact is developed for nanoscale p-type field-effect transistors (WSe₂, black phosphorus and carbon nanotubes), achieving a low contact resistance through a scalable fabrication process.

A trial that used a master randomized design found that the skills commonly found in smartphone-based cognitive behavioral therapy, when tested alone or in combination with behavioral activation, were differentially efficacious in improving mental health symptoms in adults with subthreshold depression.