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The flammability of the Li electrode impedes its safe application in a battery. Here, the authors develop a layered Li electrode design to eliminate corrosion between Li metal and fire retardant, and smart release fire retardant against Li combustion during heating conditions, enabling a safe Li metal battery.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

The authors find that reconstructing the Moδ+ active site via multi-field coupling effectively boosts ammonia borane hydrolysis. They provide key insights into the plasmon polarization-induced carrier kinetics and hydrolysis mechanism.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Conversion-type batteries face performance decay under high loading due to shuttle effects and sluggish kinetics. Here, authors introduce an f-d orbital tag-team catalysis mechanism using cerium single-atom catalysts, achieving a competitive iodine loading of 44.7 mg cm⁻² and an areal capacity of 10.2 mAh cm⁻² in zinc–iodine batteries.

Practical use of covalent organic framework-based solid electrolytes is hindered by their mediocre ionic conduction. Here, authors engineer the pore structure via incorporation of alternating oxyethylene and perfluoroalkyl chains, suppressing anion migration and improving Li⁺ ion transport, achieving 1.06mS·cm^-1 at 25 °C and transference number of 0.9.

The authors reveal intrinsic long-range-order noncollinear electric dipole order in the van der Waals crystal WO₂Br₂, enabling pressure-driven 90° polarization rotation via multiple transition pathways and distinctive ultrafast phonon dynamics.

The core downstream mediator of the Norrin/β-catenin pathway remain elusive, hindering the treatment of familial exudative vitreoretinopathy. Here, the authors show that KIF11 acts as a key effector of this axis by preventing phosphorylation-driven PRDX1 phase separation and subsequent ferroptosis.

Achieving simultaneous flexibility, thermal stability and strong absorption in conventional X-ray sensors is challenging. Here, the authors develop an all-inorganic fabric X-ray sensor working from 80 K to 1373 K, enabling real-time imaging of molten metals and superconducting magnets.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

Most kiwifruit species are vulnerable to high levels of heat stress. Here, the authors report natural variation at the GATA transcription factor binding site of EGY3 gene mediates chloroplastic ROS homeostasis to confer kiwifruit thermotolerance.

High yield and wide adaptation rice are crucial for grain supply and food security. Here the authors report OsPI4Kγ7 which contributes to different “adaptability-yield” trade-offs in japonica and indica, and provides an alternative breeding strategy for raising grain yield in different latitudes.

In maize, ZmDapF1 suppresses the activity of ZmMDH6 in chloroplasts, exacerbating oxidative damage under drought. Knocking out ZmDapF1 or using its favourable allele with lower gene expression enhances drought resilience without yield penalty.

The role of long non-coding RNAs (lncRNAs) in regulating cancer progression remains to be explored. Here, the authors identify an antisense lncRNA in the IGF1R locus (IGF1RAS1) which strongly interacts with super enhancers and modulates MYC expression in metastatic prostate cancer.

Traditional von Neumann electronic textiles rely on rigid chips for logic and memory, limiting wear comfort and integration. Here, the authors present stretchable fibres that integrate tuneable logic and memory functions, positioning each fibre as a building block for computing-capable textiles.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

Self-aggregation in self-assembled monolayers adversely affects on hole transport performance in inverted perovskite solar cells. To address this issue, Shen et al. propose an indole/carbazole co-adsorption strategy to construct phase-homogeneous monolayers featuring alternating molecular arrangements.

Capacitive sensors based on electronic polarization typically exhibit low sensitivity as their dielectric modulation is confined to a single mode. Here, the authors develop a dielectric-gradient all-fiber non-ionic electronic skin that converts interfacial impedance into signal amplification for tactile sensing.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Flexible displays face challenges in power use, resolution, and durability. This work presents a flexible micro-LED display driven by HZO-based FeMFETs, achieving low power, high resolution, and strong mechanical reliability.

Slow ion transport limits Li-ion battery performance under fast charging and low temperature. This work establishes an electrolyte design framework based on intermolecular interactions and molecule volume to reshape Li+ solvation structure, enabling Li-ion battery to operate stably at −50 °C and 6 C

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

Pulmonary arterial hypertension (PAH) is a fatal disease involving disrupted metabolic and mitochondrial regulation. Here the authors show that REV-ERBα protects against PAH by repressing BNIP3-driven mitophagy in pulmonary vascular smooth muscle cells, revealing a potential circadian-based therapeutic target.

Mutations in the follicle-stimulating hormone receptor (FSHR) cause spontaneous ovarian hyperstimulation syndrome (OHSS). Here, the authors report that estrildid finches naturally carry an analogous pathogenic mutation found in patients but avoid the syndrome by lowering a related receptor’s activity. Blocking this receptor successfully treats OHSS in mice.

The authors identify a KAT8 K145 lactylation switch that enhances TIP60 dependent p53 K120 acetylation and proapoptotic transcription, implicating this axis in doxorubicin cardiotoxicity and its mitigation by glimepiride.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

The unfolded protein response is activated at the ER due to protein misfolding. Here the authors show that in Magnaporthe oryzae, the plasma membrane localized MoPh1 protein perceives stress through ER-PM contact sites and stimulates autophagy to support stress relief.

A bioelectronic device incorporating triphylite (LiFePO₄) as electrode is used for lithium-ion-specific inhibition of peripheral and central nervous system activities in rats and in mice.

Hormone receptor-positive, HER2-negative advanced breast cancer lacks defined treatment options following CDK4/6 inhibitor (CDK4/6i) failure. Here, the authors present a phase Ib clinical trial where the CDK4/6i dalpiciclib is combined with the histone deacetylase inhibitor chidamide in this setting.

Systemic lupus erythematosus (SLE) is a complex autoimmune condition and treatment options have limited efficacy. Here, by analysis clinical samples and employing preclinical models, the authors show that cGAMP levels are elevated in the plasma of patients with SLE and that loss of cGAS ameliorates symptoms in an imiquimod-induced lupus model. Importantly, they identify prasugel as a cGAS inhibitor with promising therapeutic potential.

The properties of small-sized carbon dots have been exploited to generate theranostic agents for bioimaging and imaging-guided cancer therapies. Here the authors report the design and characterization of D-π-A sensitized carbon dots for type-I/II photodynamic therapy (PDT), showing PDT-induced anti-tumor activity in preclinical models.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

The role of gut microbiota–metabolism crosstalk in polycystic ovary syndrome (PCOS) remains unclear. Here, the authors revealed that sialic acid exacerbates PCOS pathogenesis by remodeling gut microbial bile acid metabolism and FXR activation.

Controlling plant metabolism to improve growth and disease resistance has huge potential. Here, the authors find a conserved pathway which promotes antiviral resistance and promotes plant growth and develop polyglutamate-loaded chitosan nanogels to manipulate this pathway.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Achieving high power scaling in ultrawide bandgap electronics remains challenging. Here, the authors present a Ga₂O₃ module using a high permittivity interface that enables fast megawatt pulsed switching with improved thermal performance.

Gel-based soft materials are attractive for flexible electronics, though are constrained by unfavorable mechanical properties. Here the authors design a geometry programmed self-wrinkling strategy for organo-hydrogels, enhancing mechanical and electronic properties.

Persistent luminescence is promising for photodynamic therapy in deep-seated tumors, but the uncontrollability of light within the body complicates precise spatiotemporal regulation. Here, the authors report X-ray preactivated elimusertib-loaded tumor-targeted photodynamic nanoparticles with controllable “on-off-on” afterglow properties for the treatment of deep-seated tumors.

Women with diminished ovarian reserve face persistently low success rates during in vitro fertilization. Here, the authors show that a modified letrozole protocol yields cumulative clinical pregnancy rates and cumulative live birth rates comparable to those of the GnRH antagonist protocol.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

By constructing tailored donor-acceptor structures in 3D COFs via artificial defects and electronic tuning, researchers overcame inherent limitations in conjugation and light absorption, achieving stable and efficient photocatalytic H₂O₂ production.

This work reports the discovery of a giant in-plane Hall effect in a nonmagnetic half Heusler compound, demonstrating magneto-cubic behavior over a wide temperature range and identifying extrinsic mechanisms as the dominant origin.

Immunosuppressive myeloid cells drive tumor progression and immune evasion. The authors here develop a nanomicelle platform that codelivers photosensitizers (IR825), anti-PD-L1 antibodies, and antagomiR-182 to tumor site, promotes DC maturation, repolarizes tissue associated macrophages, enhances CD8⁺ T cell functionality and antitumor efficacy in breast cancer models.

This study presents a mechanistic RO model to predict ammonia transport that explicitly distinguishes NH3 and NH4 + transport and explains the pH dependence of RO performance, providing insights for the reclamation of ammonia-rich wastewater.

Genome annotation typically requires costly experimental assays across diverse cell types, limiting its scalability. Here, authors introduce BioSeq2Seq, a deep learning framework that leverages DNA sequence and run-on sequencing (RO-seq) data to accurately predict histone modifications, functional elements, gene expression, and transcription factor binding sites.

Nanostructure fragility limits applications. The authors develop a tribochemical surface reconstruction strategy to build single-crystal nanostructures on sapphire, which retain bulk-level wear resistance and improve triboelectric device performance.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease of premature infants with unclear mechanisms. Here, the authors show that CD177⁺ neutrophil–platelet aggregates promote neutrophil extracellular trap (NET)-linked thromboinflammation in NEC and that blocking CD177/NET formation or low-molecular-weight heparin alleviates disease in mouse models.

Ischemic stroke involves complex peripheral and central pathologies. Here, authors develop a spatially tiered strategy using dual stiffness nanoparticles for compartment-specific drug delivery, offering a synergistic treatment paradigm.