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Hepatitis C virus remains a health burden due to the lack of an effective vaccine, hindered by difficulties in replicating the native E1E2 antigen structure. Here, the authors engineer a stabilized E1E2 heterodimer using cryo-EM-guided modifications, enhancing immunogenicity and paving the way for future HCV vaccine development.

The authors report that Ta-doped PbTiO₃ films with a p-i-n structure can generate a high photovoltaic current, offering the opportunity to advanced optoelectronic and imaging devices.

Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

FLT3-ITD mutations drive relapse in acute myeloid leukemia (AML) despite targeted therapies. This group studies therapeutic potential and resistance mechanisms of FLT3-ITD inhibition with QUIZartinib and Omacetaxine Mepesuccinate (QUIZOM) in preclinical and clinical AML specimens.

High blood pressure is regulated by natriuretic peptide signaling through the GC-A receptor. Here, authors show that antibodies can activate GC-A, and that XX16 locks an active state without hormone and lowers blood pressure in obese mice.

The authors identify Npr1 as a nucleophagy receptor in fission yeast that acts redundantly with Epr1 to degrade nuclear components. Tethering chromatin to the inner nuclear membrane blocks nucleophagy, suggesting a genome protection mechanism.

He et al. model electrification of airport ground support equipment across more than 300 U.S. airports, estimating energy consumption, peak power demand, charging infrastructure requirements, and potential cost savings from battery storage and solar integration.

Assembling cellulose into hydroplastics through water-enhanced effects remains challenging. Here the authors demonstrate that modulating the polarity by using thioctic acid leads to a reconfigured network with enhanced mechanical properties and reversible adhesion.

In this work, authors present genetic and atomic insights of the Mycobacterium abscessus cytochrome bcc:aa₃, enabling the design of ND-011458 as a potent QcrB inhibitor, with the inhibitor bound enzyme structure paving the way for the development of a lead compound.

The authors report a metamaterial robot that integrates mechanical intelligence into robotics through embodied versatile computing. The robot performs analog and logic tasks, supports serial and parallel operations, and enables flexible spatiotemporal modulation and self-regulating locomotion.

Cardiovascular surgery and haemodialysis urgently need durable vascular grafts. Here, authors develop a decellularized polymer skeleton-reinforced biotube as a readily-available vascular graft and demonstrate utility in vivo across multiple large animal preclinical models.

Fe3GaTe2 is a room temperature van der Waals ferromagnet, which, despite having a centrosymmetric crystal structure, has both a large Dzyaloshinskii-Moriya interaction and hosts topological spin textures. Here, Xia, Luo, Malik and coauthors unravel this mystery, showing the critical role of field cooling in the breaking of inversion symmetry in Fe3GaTe2.

Here, they develop optimized mouse testicular organoids that recapitulate key testicular functions and generate functional haploid germ cells, enabling the generation of normal fertile F2 offspring. These organoids can be used to model male infertility and screen for drugs that may prevent germ cell loss after chemotherapy.

A link between the oral microbiome and oesophageal squamous cell carcinoma (ESCC) has previously been reported but whether it has a causal role is unclear. Here, the authors identify oral Veillonella-derived valeric acid as having a tumour suppressive function in ESCC via interaction with the elongation translational factor, eEF1A1.

Susceptibility of Nasopharyngeal carcinoma (NPC), associated with Epstein-Barr virus infection, is linked with HLA gene region with mechanisms unclear. The authors here show that the high-risk EBV subtype BALF2 upregulates HLA-DP, leading to CD8⁺ T cell exhaustion, and combined anti-LAG-3 and anti-PD-1 therapy improves anti-cancer efficacy.

This study introduces a total atmospheric energy proxy into precipitation forecasts, improving extreme precipitation prediction at sub-seasonal and longer timescales. Moreover, it shows that the predictive value added by total energy has grown substantially in recent years.

Here the authors show that marine diatoms produce tryptophanol, a molecule that at extremely low concentrations rapidly activates nitrogen assimilation genes and enzymes. This facilitates acquisition of nitrogen, a vital ocean nutrient.

Authors present a specialized diagnostic tool called ClinDiag-GPT trained on real-world cases. It outperformed baseline models of existing large language models and could serve as a clinical assistant to physicians.

Large language models appear aligned, yet harmful pretraining knowledge persists as latent patterns. Here, the authors prove current alignment creates only local safety regions, leaving global adversarial paths intact, and empirically show widespread vulnerability across leading aligned models.

Metabolic reprogramming toward glycolysis is a hallmark of pathological cardiac hypertrophy, but the regulatory mechanisms remain unclear. Here the authors show that the adipokine, asprosin, drives hypertrophic metabolic remodeling by stabilizing PFKP and activating a YY1–asprosin–PFKP–PDK4–PDH axis.

The PD-1/PD-L1 pathway is central to immunotherapy, but PD-L1 recycling limits durable responses. This study identifies TM9SF2 as a key regulator of PD-L1 trafficking and shows that disrupting its PGK1-dependent complex depletes PD-L1 and enhances antitumor immunity.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

The unfolded protein response is activated at the ER due to protein misfolding. Here the authors show that in Magnaporthe oryzae, the plasma membrane localized MoPh1 protein perceives stress through ER-PM contact sites and stimulates autophagy to support stress relief.

CBP phosphorylation keeps intestinal homeostasis by restraining CBP–p53 binding to allow sufficient versican expression. Its impairment suppresses versican, disrupting the stem cell niche to drive UC and highlighting versican as a therapeutic target.

Using thermodynamically favourable organic oxidations instead of oxygen evolution enables energy-efficient cathodic reactions, but rates are limited by slow anodic kinetics. Here, the authors report decoupled charge‒discharge electrolysis using a solid redox reservoir to overcome this limitation.

High-nickel layered positive electrodes suffer from lattice oxygen loss and inherent lattice strain. Here, authors report a self-derived subtractive strategy to form a coherent spinel-phase shell with tunable thickness to confine active oxygen intermediates and suppresses interfacial side reactions.

Combining distinct confinement mechanisms can enable the engineering of novel electronic states. Here, the authors integrate a moiré potential with vertical quantum confinement in a heterostructure composed of twisted bilayer MoS₂ on (111)-oriented Bi nanofilms, revealing experimental signatures of a Wigner crystal.

The reconstruction and control of supramolecular ropes using minimalist building units remains a fundamental challenge. Here the authors demonstrate self-assembly of cyclo-tryptophan-proline dipeptide stereoisomers into crystalline supramolecular triple-helical structures with tunable S- or Z- twists governed by the configuration of tryptophan residues.

This work develops DJX-A-KM, a small-molecule KRASG12C degrader that recruits E3 ligase FBXO28 via dual covalent binding, inducing potent degradation. This strategy can possibly be extended to pan-KRAS degraders against a broader spectrum of KRAS mutations.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

Here, the authors show that the PLA2G6 protein is a component of the IP3R1–GRP75–VDAC1 complex at the mitochondria-associated endoplasmic reticulum (ER) membrane, maintaining the integrity and function of ER–mitochondria contacts.

The authors present a concise synthesis of 19-norbufadienolide bufogargarizin B from inexpensive, commercially available dehydroepiandrosterone by means of a conformation-controlled skeletal reorganization approach.

Converting low-grade heat into electricity is promising to power electronic devices, though it is often limited due to weak ion selectivity and insufficient concentration gradients. Here the authors use a calix[4]pyrrole as an ion trap enhancing electronic properties for energy harvesting.

Multidrug resistant tuberculosis (MDR-TB) is a major global health concern. This study uses novel phylogeographic approaches to determine the origin and global dispersion of a highly transmissible MDR-TB lineage first identified in Eastern Europe.

The immunological events that correlate with latent Mycobacterium tuberculosis (Mtb) infection (LTBI) containment in immune suppressed hosts remain to be explored. The authors here show that CD8⁺ T cells are critical for BCG vaccination-induced prevention of Mtb dissemination in the absence of CD4⁺ T cells in a mouse model of contained tuberculosis.

The genomewide meta-analysis of lumbar spinal stenosis LSS identifies 73 previously unreported loci in addition to 15 known loci and highlights spinal degeneration as a key pathogenic mechanism. Overall, the findings expand knowledge of the genetic background of LSS.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Endocsymbiosis is known to fuel deep-sea life, while ectosymbiosis remains poorly understood. Analysing the genome of a cold-seep scallop, this study uncovers key adaptations to the deep sea and metabolic complementarity with chemosynthetic bacteria on its gill surface.

Direct C–N bond formation from nitroarenes offers an appealing alternative to conventional routes that rely on aniline intermediates. Here, the authors report a paired electrolysis strategy that enables highly selective para-C–H amination of phenols with nitroarenes, delivering unprotected p-hydroxy diphenylamines in a single step without transition-metal catalysts or external reductants.

Algal photosynthesis relies on a biomolecular condensate known as the pyrenoid, which sequesters the cell’s Rubisco. The pyrenoid constituent Rubisco activase partitions to the condensate via an element functionally involved in Rubisco activation.

Conventional dendritic cells (cDCs) are essential to generate effective anti-tumor immune responses; however, they are often dysfunctional within the tumor microenvironment. Here the authors report that the impaired function of cDCs in late-stage tumors is associated with a reduction of pentose phosphate pathway (PPP), suggesting strategies to augment PPP as a therapeutic option to increase cDC-mediated anti-tumor response.

This study shows that medial septal parvalbumin neurons causally control hippocampal place cell dynamics during memory encoding, thereby supporting object-place recognition and rescuing sleep deprivation-induced memory deficits.

Long‑range chromosome encounters in cells are hard to quantify. Here, the authors induce artificial contacts in yeast and show that intra‑chromosomal interactions form faster than inter‑chromosomal ones in G1 yeast, driven by condensin‑mediated loop extrusion.

Amino acid transport is essential for metabolism and cell signalling. Here, authors demonstrate that the gene SLC7A4 encodes a plasma membrane leucine transporter regulated by extracellular pH.

RNA editing influences gene regulation in cancer. Here, the authors show that EZH2 regulates RNA editing by ADAR1 through remodeling its interactome and nuclear transport, thereby promoting MDM2 expression and prostate cancer progression.

Metabolic profiling of extracellular vesicles for diagnostic applications remains challenging. Here authors develop ACTIVITY, a cascade-catalysis strategy to detect metabolically active extracellular vesicles, enabling macrophage phenotyping and differentiation of pneumonia patients from healthy controls.

Current recycling methods for polyurethane waste suffer from high reagent consumption, urethane byproduct generation, and limited economic value. Here, the authors demonstrate a selective cleavage—crosslink strategy using food-grade ethyl acetoacetate to break biuret crosslinks while preserving urethane/urea bonds in non-crosslinked regions intact.

The GABA_B receptor is a mandatory heterodimer. Here authors show the existence of GABA_B dimers of dimers in neurons, and their relevance in human health. By solving the structure of this tetramer, they show the structural basis for a negative cooperativity between the dimers within such a complex.

Exceptional points (EPs) in non-Hermitian systems offer a strong response to perturbations, offering a promising platform for sensing. By using a third-order EP of coherent perfect absorption, here, authors demonstrate signal-to-noise ratio enhancement in a passive cavity magnonic system, providing a step forward towards future developments of EP sensing.