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China’s carbon neutrality and clean-air policies cause global warming from reduced aerosols that nearly offsets cooling from reduced CO2 before 2060, with warming emerging afterwards, calling for early carbon neutrality and more mitigation strategies.

Fast reendothelialisation of vascular grafts is important for maintain patency. Here, the authors report on a vascular graft that regenerates the neo-adventitia with lymphatic endothelial cells, which increases the recruitment of circulatory progenitor cells, achieving 90% patency in small-diameter arterial grafts.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

CrPS₄, a 2D van der Waals A-type antiferromagnet, is shown to exhibit ideal characteristics of Stoner–Wohlfarth antiferromagnets, such as ferromagnet-like binary switching rather than layer-by-layer flipping as in other 2D A-type antiferromagnets.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Rechargeable zinc batteries are hindered by sluggish ion transport and unstable interfaces. Here, the authors design a zwitterionic gel-ligand-channel where molecular crowding promotes ion liberation, enabling fast ion migration and interfacial kinetics even at −60 °C.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Intermittent hypobaric pressure extends the lifespan and rescues the osteoporosis phenotype in aged mice by activating the ion channel transmembrane protein 59 (TMEM59) and eliminating senescent cells via lysosome-dependent cell death.

Tree ectomycorrhizal colonization in aridity regions is supported by microbial cooperation, where bacteria attach to fungal hyphae and reduce inhibitory soil metabolites, suggesting a microbiome-based strategy for tree restoration.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

Lampreys are jawless vertebrates that can offer unique insights into vertebrate evolution. Here they generate a comprehensive cell atlas of the lamprey, uncovering 70 distinct cell types across 14 tissues, and identify pancreas-like cells in the lamprey small intestine.

This study benchmarks four cutting-edge spatial transcriptomics platforms using human tumour tissues, performs multi-metric evaluation with multi-omics references, and presents the SPATCH portal for visualisation and download.

Variations in the valence states of nickel oxide hinder the growth of a uniform self-assembled monolayer (SAM). Here, authors develop a SAM with the oxidized product forming S−O−Ni bond at Ni³⁺-rich regions, achieving maximum device efficiency of 26.5% in operationally stable perovskite solar cells.

The olfactory epithelium (OE) undergoes changes during aging and this may affect inflammatory responses and immune cell infiltration. Here the authors look at the effect of aging on OE and how this involves cross talk between T cells and horizontal basal cells involving Il17a expression in OE which is increased in aging and inhibition of IL-17a function reduces respiratory metaplasia.

Achieving high output-power-density in Gallium-nitride transistors is challenging due to high thermal resistances and thick nitride layers. Here, the authors propose ion-implantation on silicon-carbide substrates, achieving high performance and reduced thermal resistance.

Graphene film-based metamaterials are applied for polarization manipulation of electromagnetic shielding effectiveness, achieving high performance in polarization sensitivity, full polarization shielding, and switching efficiency.

The intrinsic instability of non-fullerene acceptors caused by exocyclic vinyl linkages hampers operational lifetime of organic solar cells. Here, authors introduce F···H interaction in fluoroacetonitrile-containing terminal group for a more planar structure, achieving device efficiency of 19.31%.

KP.3.1.1 S S31del confers enhanced immune escape and increased infectivity, which is counterbalanced by NSP10 S33C. The opposing effects of these mutations highlight the complex interplay of viral genomic elements in shaping their overall fitness.

Streptococcus equi subsp. zooepidemicus imports glucose via the bacterial mannose phosphotransferase system (PTS_man), which inhibits stringent response, supports growth in cerebrospinal fluid and promotes brain damage during meningitis.

Engineering the perovskite–electrical contact interface with sodium heptafluorobutyrate reduces interfacial defects and improves charge transport in perovskite solar cells. Functionalized devices deliver a certified power conversion efficiency of 26.96%, which is fully retained after 1,200 h of continuous operation under 1-sun illumination.

Wang, He, Gong and colleagues identify an age-related decline in the palmitoyltransferase ZDHHC11 in chondrocytes that leads to senescence and the pathogenesis of osteoarthritis, highlighting the potential of targeted ZDHHC11 delivery as a therapeutic strategy for osteoarthritis.

Lancelot, a compute-efficient federated learning framework using homomorphic encryption to prevent information leakage, is presented, achieving 20 times faster processing speeds through advanced cryptographic and encrypted sorting techniques.

Methane emissions from mangrove tree stems offset about 17% of the carbon buried in sediments in global mangroves, highlighting the need to incorporate tree-mediated methane fluxes into blue carbon budgets, according to a global quantification of methane emissions from mangrove tree stems.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

EMO integrates DNA sequence and chromatin accessibility data to predict how noncoding variants regulate gene expression across tissues and single cells, enabling context-aware personalized insights into genetic effects for precision medicine.

Late-stage acute liver failure (ALF) has limited therapies. The authors show that the bioactive compound SCM-198 extends the ALF treatment window from 3 to 24 hours in mice by selectively targeting the identified AdipoR2-CaM-CaMKII-NOS3-NO axis.

Metastasis of pancreatic cancer has been associated with epithelial-mesenchymal transition (EMT). Here, the authors identify STN1 as a regulator of pancreatic cancer metastasis by promoting transcription of EMT-activator ZEB1, which is independent of its known role in telomere maintenance.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

A Cu-Au-Ag medium-entropy alloy with Damascus-style hierarchical layers provides balanced strength–ductility combination, enabling greener and more mechanically reliable metallic materials for advanced electronic packaging.

In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and deletion of the PD-1 (PDCD1) gene were safe and associated with reduced disease activity.

Ischemic injury induces a partial mesenchymal shift in endothelial cells. Here, the authors show that circATXN1 regulates angiogenesis and partial endothelial-to-mesenchymal transition by controlling SLUG mRNA methylation via ALKBH5, offering a potential therapeutic target for ischemic diseases.

Cu metal suffers from unavoidable and uncontrollable surface reconstruction during electrocatalysis. The authors here guide the reconstruction process in a favorable direction using trace amount of electrolyte additives, promoting CO₂ electroreduction to CH₄.

Clinical calculators play a vital role in healthcare, but their utilization remains to be optimized. The authors present AgentMD, an AI agent that can autonomously curate clinical calculators from medical literature and apply them to various use cases.

The tissue-specific accumulation patterns of pathogenic mtDNA mutations during aging remain incompletely understood. In this study, the researchers developed three mouse models with distinct mitochondrial tRNA mutations, revealing age-dependent accumulation of these mutations in the kidneys, leading to mitochondrial kidney disease.

This trial evaluated the immunogenicity and safety profiles of a bivalent aerosolized adenovirus-vectored COVID-19 vaccine and an intramuscular bivalent mRNA booster. The mRNA booster induced higher neutralizing antibody levels and a distinct memory B cell response, yet was associated with a higher incidence of adverse reactions.

The origin of high-temperature superconductivity in iron-based materials remains a challenging task to solve, but the concept of orbital differentiation of the charge carriers may be a crucial ingredient to the answer. Here, the authors identify an orbital-selective metal–insulator transition and the opening of a gap in the material Rb_1−xFe_2−ySe₂.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

A fibre-structured bandage converts the temperature gradient between the wound and dressing into an electric stimulus to generate an electric field that accelerates wound healing.

PTX3 alleviates glucocorticoid-induced osteonecrosis by downregulating FGF21 via TLR4/NF-κB pathway, revealing a potential therapeutic strategy

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

Protein C receptor (PROCR) has been proposed as a cancer stem cell marker in different types of cancer. Here the authors report that PROCR upregulation in cancer cells is associated with resistance to radiotherapy and reduced anti-tumour immunity.