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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and selective destruction of cancer cells.

Using single-cell transcriptomics and functional analyses, the authors identify a specialized neural network in the male schistosome gynecophoric canal and show that lsamp maintains its integrity, enabling intersex communication and female reproductive maturation.

The development of sustainable water oxidation catalysts is crucial for hydrogen production, yet cobalt-based materials often suffer from instability. Here, the authors report that co-doping LiCoO₂ with nickel, iron, and palladium yields a durable electrode with stability of over 2,000 hours.

STING–type-I interferon pathway regulates the immunogenicity of several cancer types, including head and neck squamous cell carcinoma. Here the authors describe that glutamine metabolism in the tumour microenvironment dampens the STING–type-I interferon pathway by epigenetically silencing the expression of BATF2, which functions as a tumour suppressor.

Defect formation and phase instability remain critical challenges for perovskite/organic tandem solar cells. Jiang et al. address this by designing an additive to modulate the crystallization thermodynamics of wide-bandgap perovskite, achieving a record efficiency of 22.1% in a flexible cell.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

Cryo-electron microscopy structures of the bile acid transporter OSTα–OSTβ, which has a key role in bile acid homeostasis, provide insight into its distinct architecture and mechanism of substrate translocation.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

The precise molecular and physiological functions of the iron transporter Slc22a17 remain poorly understood. Here authors report mice lacking Slc22a17 expression in the brain suffer from iron overload, oxidative stress, and learning deficits.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Cross-dehydrogenative coupling (CDC) allows the efficient construction of C−C and C−heteroatom bonds. Now, single-platinum-atom-decorated graphitic carbon nitride is applied as a heterogeneous photocatalyst for CDC reactions between (hetero)arenes and nucleophiles without external oxidants.

Paraoxonase-1 (PON1) is a liver-specific glycoprotein that has been shown to be a tumor suppressor in hepatocellular carcinoma (HCC). Here, the authors show that PON1 reduces HCC tumor growth due to regulation of lactic acid production and regulatory T cell-mediated immunosuppression.

Existing methods for the modification of exosomes adversely impact structures and functions of exosomal proteins and membranes. Here, the authors develop a chemically engineered platform by leveraging the synergistic interplay between CD38’s catalytic activity and the covalent inhibitor 2'-Cl-araNAD⁺.

Achieving high output-power-density in Gallium-nitride transistors is challenging due to high thermal resistances and thick nitride layers. Here, the authors propose ion-implantation on silicon-carbide substrates, achieving high performance and reduced thermal resistance.

The authors developed a CRISPR-based proximity labelling system to profile DNA-binding proteins in plants, especially the transcription factors of target genes, as exemplified by studies on the regulators of PIF4 in Arabidopsis, cabbage and rice.

The retina offers a window into systemic health, but its molecular links to cardiometabolic disease remain unclear. Here, the authors show that metabolomic profiling on retinal nerve fibre layer combined with machine learning reveals shared metabolic states that predict cardiometabolic risk and bridge health inequities.

Here, with multi-omics analyses of human cohorts and murine models, the authors identify Odoribacter splanchnicus depletion to impair intestinal P-glycoprotein function via loss of microbial, GDP-L-fucose, which in turn promotes eIF4E phosphorylation and c-Jun–driven ABCB1 expression, maintaining xenobiotic efflux.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

The anomalous in-plane Hall effect is predicted to arise in topological magnetic materials when an external magnetic field is applied within the sample plane. Here, the authors observe the anomalous in-plane Hall effect at room temperature in Fe₃Sn.

Metabolic syndrome (MS) is associated with enhanced risk to develop endometrial cancer (EC). Here, the authors show that oleic acid, increased in MS, promotes endometrial cancer by supporting the stability of the rate-limiting enzyme in polyamine metabolism ODC1 and polyamine accumulation.

Identifying genetic variants using long-read RNA sequencing (lrRNA-seq) is useful but hampered by high error rates and biological complexities. Here, the authors developed Clair3-RNA, a deep-learning tool that improves variant calling accuracy in lrRNA-seq data and accurately identifies RNA editing sites.

A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

Environmental gradients in temperature and productivity jointly, yet asymmetrically, shape the structure and resilience of coral reef food webs, according to analysis of environmental DNA data from the South China Sea.

Long-range dependency benchmarks for DNA foundation models are scarce. Here, the authors present DNALONGBENCH to fill this gap, showing that current foundation models still lag behind expert models in capturing long-range genomic dependencies.

Diabetic retinopathy is a major cause of blindness, yet ways to predict who will be affected remain limited. Here, the authors show that patterns of blood proteins can reveal disease mechanisms and enable powerful early prediction across diverse populations.

To overcome the transverse wrinkles and voids between MXene nanosheets, the authors fabricated MXene fibers via a combination of static filling and dynamic thermal drawing, achieving optimized mechanical and electrical performance.

Self-supervised reconstruction structured illumination microscopy (SSR-SIM) is a reconstruction approach for SIM that improves image reconstruction by including light modulation priors and information on reconstruction artifacts, while simultaneously eliminating the need for ground-truth images. The improvements allow long-term imaging of sensitive cellular processes.

Gut microbiota influence bone health, but the genetic and metabolic mechanisms are unclear. Here, the authors show that specific bifidobacterial taxa causally reduce bone mineral density, partly via n-3 fatty acid metabolism, highlighting host-microbe interactions with potential therapeutic implications.

Green hydrogen production often needs Pt-based electrolysers; however, their high cost and lack of scalability hinder uptake. Here a core–shell Ru-based electrolyser is demonstrated for acidic hydrogen evolution and demonstrates a low overpotential and Pt-like stability, as well as scalability to a 200 cm² device.

Achieving generality in asymmetric catalysis with highly reactive radicals is a challenge. Now it is shown that a sequential copper-catalysed approach enables the efficient, enantioselective cross-coupling of over 50 diverse radicals, providing unified access to C-, P- and S-chiral products and advancing the asymmetric synthesis of challenging molecular architectures.

The function and regulatory mechanism of mRNA acetylation modification in cancer progression remains largely unknown. Here the authors identify that targeting tumor N4-acetylcytidine (ac4C) RNA acetyltransferase NAT10 improves anti-tumor response via MYC/CDK2/DNMT1/dsRNA/type I IFN pathway, and show the synergic anti-tumor effect of NAT10 inhibition with aPD-1.

Cryosection pathology is essential for intraoperative diagnosis of diffuse midline gliomas (DMGs), but often requires re-sampling for an accurate assessment. Here, the authors develop CryoAID, an AI-augmented framework for rapid and accurate molecular outcome prediction during surgery for DMG, reducing re-biopsy rates in clinical cohorts.

Biomolecular condensates can adopt complex architectures, including hollow structures linked to disease. Here, the authors combine biochemical assays with mathematical modeling to reveal how the fusion oncoprotein FUS–ERG and DNA drive the formation of hollow condensates.