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Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.

Interwoven magnetic and non-magnetic layers in TbTi₃Bi₄ overcome kagome frustration, producing coupled elliptical-spiral magnetic and spin-density-wave orders and a very large anomalous Hall effect driven by strong electron–magnetic field interactions.

Spatially variable surface-elevation changes across 40 global deltas using interferometric synthetic aperture radar are reported.

The long-term existence of diverse virulent phages within cultures of Escherichia coli and others challenges the virulent–temperate dichotomy and points to non-canonical phage lifestyles.

How is specific ribosomal RNA expression precisely controlled in the malaria parasite? Dr. Couble et al. show that a switch between distinct energy-generating pathways during parasite development directly impacts the accessibility to rDNA chromatin.

Microwave observations of Jupiter’s moon Europa reveal subsurface properties of the ice shell covering a purported global ocean. The shell is 29 ± 10 km thick, with fractures or pores a few centimetres across that extend hundreds of metres deep.

Central charge, a key quantity in conformal field theories, is crucial in the study of critical phenomena, yet its measurement has remained elusive. Here, the authors extract the central charge of several quantum critical models by accurately preparing their ground states on a superconducting quantum processor.

The development of robust catalysts that could work under high current densities brings promise but is a challenge in CO₂ electroreduction. Here, the authors report a wettability-engineered electrode design for ethylene electrosynthesis that operates over 1000 h without salt precipitation.

How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

Organic heterojunction nanoparticles composed of all-small-molecule photovoltaic materials achieve (sub)nanometer-scale diameters, overcoming the size constraints of widely used polymer nanoparticles and enabling enhanced photocatalytic performance.

Oriented growth is an important pathway for crystal growth. Here, the authors show that gibbsite nanoplates form mesocrystals through directed sliding and staggered stacking, as demonstrated by in situ microscopy and molecular simulations.

Nuclear pore complexes control selective transport between the nucleus and cytoplasm. Here, the authors show how FG-Nups and transport receptors form a dynamic interface that enables selective and efficient transport.

A new technique for ML-driven atomic simulations produces differentiable free energy estimates, allowing computational phase diagram predictions to be fine-tuned against experimental data and equipped with robust uncertainty quantification.

This research developed and compared firearm-specific and method-agnostic machine-learning models using data from 800,579 Army veterans, revealing that model choice and intervention thresholds impact predictive accuracy and fairness, guiding tailored suicide prevention efforts.

Extrachromosomal circular DNAs (ecDNAs) are prevalent in human cancers and are thought to drive tumor evolution and drug resistance by amplifying oncogenes. Here, authors develop ec3D to reconstruct three-dimensional ecDNA structures, revealing how their spatial organization rewires regulatory circuits.

Coupling an optogenetic lipid-modifying enzyme with proximity labeling reveals protein networks and mechanisms regulating lipid homeostasis in the membranes of target organelles.

The defossilization platform offers a competitive approach to produce sustainable hydrocarbon fuels directly from biomass-derived feedstocks. Here, the authors report an integrated electrochemical strategy for converting renewable fatty acids into liquid alkanes under mild and scalable conditions.

GaitDynamics is a generative foundation model for accurately and efficiently estimating the motion and forces of human gaits from kinematic data, which will have impacts in injury prevention, therapies and performance coaching.

Recently there has been interest in using the orbital Hall effect to drive the magnetization of an adjacent ferromagnet. One metal, Tantalum, has been proposed a strong source of orbital current. Here, Liu and Zhu argue that the claimed orbital torques in Tantalum arise instead from self-induced spin-orbit torques in the adjacent ferromagnet.

Ultrafast, low-pressure CO₂-hydrate formation occurs in 2.3-nm channels of mesoporous zeolite ZMQ-1, verified by FTIR; at Rw=2 and 275 K it starts in 2 min and stores up to 151 wt.% (176 v/v), showcasing pore confinement for scalable carbon capture, usage, and storage.

Trends in global H₂ sources and sinks are analysed from 1990 to 2020, and a comprehensive budget for the decade 2010–2020 is presented.

Vinyard et al. present a generative method to model cell dynamics using neural stochastic differential equations that learn state-dependent drift and diffusion, outperforming existing approaches and enabling perturbation studies of development and disease.

The authors reveal distinct atomic-scale mechanisms underlying phase boundary engineering formation and explain the different electrical properties of two (K, Na)NbO₃ based materials with the similar phase boundary, providing a new mechanistic insight.

Phase-shift engineering of triboelectric nanogenerators (TENGs) is a strategy for modulating the phase shifts of electrical output from multiple TENG units to achieve continuous constant voltage/current output. This Review summarizes the principles of phase shift engineered TENGs, and how it might further boost energy utilization efficiency and practicality.

Fine-scale field analysis and modelling of the spatial dynamics of infection of Darwin’s frogs with Batrachochytrium dendrobatidis fungus identifies highly localized transmission dynamics that generate clustered epidemics and can drive collapse of local subpopulations.

High-voltage, anode-free sodium metal batteries combine high energy density and sustainability, but the lack of suitable electrolytes hinders their application. This work formulates an eco-friendly electrolyte design that supports exciting performance in such batteries.

Accurate projections of heating and cooling needs are vital for planning energy use and achieving the sustainable development goals. A global dataset now maps global heating and cooling degree days, finding future hotspots, rising cooling demand and early shifts in energy needs with major global impacts.

Spent LiCoO₂ batteries pose challenges for sustainable recycling. Here, the authors develop a flash Joule heating method to upcycle spent LiCoO₂ into a sulfur-stabilized Li₆CoO₄ lithium donor, enabling efficient lithium replenishment and improving full-cell durability.

The authors prepare single-domain SrAl_11-δTiO₁₉ ferroelectric thin films with a magnetoplumbite structure through a solid-state reaction. This thin film not only exhibits high remnant polarization but also demonstrates excellent polarization retention characteristics.

Gas-phase actinium monofluoride (AcF) has been produced and spectroscopically studied at the CERN-ISOLDE radioactive ion beam facility; the results highlight the potential of ²²⁷AcF for exceptionally sensitive searches of CP violation.

This study investigates a calcium-permeable AMPAR–gated microcircuit in the nucleus accumbens during social bonding in prairie voles. By showing that disrupting calcium-permeable AMPAR signaling impairs ensemble-level encoding despite increasing single-neuron selectivity, the work reveals how coordinated ensemble dynamics transform social interaction into enduring attachment.

Interactions between dark matter and neutrinos would leave observable imprints on cosmic structures. Combining cosmic microwave background and weak lensing data shows a nearly three-sigma preference for such interactions.

Koala retroviruses are models of transposable element colonization of germlines. By mapping their integration sites in koala pedigrees, this study provides genetic risk scoring for breeding decisions and documents rates of acquisition and loss of retroviral integrations across generations.

Laser shock experiments on an iron-water phase reveal its density, melting, and electronic changes under extreme pressures. The results suggest dense deep magma oceans and show that iron-water reactions can greatly shrink and densify super-Earths.

This study reveals how the intrinsically disordered protein POSH undergoes stepwise folding upon binding to the GTPase Rac1. Each folding step is dependent on the successful completion of the previous one, revealing a hierarchical folding mechanism.

A closed-loop in-memory computing accelerator, implemented in a fully integrated chip with on-chip mixed-signal circuits, can be used to solve multiple inverse matrix–vector problems.

Large benthic oxygen isotope fluctuations in the Oligocene Southern Ocean primarily represent deep water temperature changes, suggesting the Antarctic ice sheet volume was relatively stable, according to a clumped isotope record.

Human metapneumovirus (hMPV) can cause severe acute respiratory illness in children but effective therapeutic monoclonal antibodies require further exploration. The authors here isolate a panel of monoclonal antibodies from children previously infected with hMPV, test their in vitro neutralizing potency, reveal their cryo-EM structures and manifest their in vivo prophylactic efficacy.

Inspired by dynamic textural modulation in cephalopod skin, polymer films whose colour and surface texture can be dynamically and independently controlled are developed and demonstrated using standard electron-beam patterning tools.

Electrically conductive hydrogels based on conducting polymers often rely on covalent and therefore irreversible crosslinking mechanisms. Here, the authors report a thermo-responsive conducting polymer that undergoes a fully reversible non-covalent crosslinking at 35 °C within less than a minute to form conductive hydrogels.

Here, the authors show that immotile bacteria degrade antibiotics to alter their environment and facilitate nearby motile competitors to expand. As expansion proceeds, the immotile degrader is outcompeted, becoming a hidden driver of community spread.

Ionizing radiation can cause simultaneous charge noise in multi-qubit superconducting devices. Here, the authors measure space- and time-correlated charge jumps in a four-qubit system in a low-radiation underground facility, achieving operation with minimal correlated events over 22 h at qubit separations beyond 3 mm.

Many studies assess which jobs risk automation, but less is known about how skill demands shift within surviving jobs. Here the authors show that U.S. lower-skilled occupations face the steepest upskilling requirements, especially in small firms and labor markets.

The discovery of a vast reservoir of primordial neutral hydrogen gas surrounding a young galaxy cluster just one billion years after the Big Bang offers new insight into how the first large cosmic structures assembled.

Reaching fundamental noise limits permits optimal extraction of spectroscopic information from an absorption measurement. Here, the authors demonstrate a quantum-limited spectrometer with which they can obtain an extremely accurate measurement of the excited-state hyperfine splitting in Cs.

Fermionic currents of opposing chirality can be spatially filtered without the need for a magnetic field using the quantum geometry of topological bands in single-crystal PdGa.

Complex infectious conditions, such as sepsis, requires rapid assessment of both pathogens and host responses. Here, the authors develop MIDAS, an assay platform that profiles bacterial RNA and inflammatory proteins simultaneously in under 4 hours.

Inhibitor-induced kinase degradation is a common event that positions supercharging of endogenous degradation circuits as an alternative to classical proximity-inducing degraders.

The success of Li batteries relies on electrolyte reduction at anodes for interphase formation, yet controlled interphase formation on high-energy cathodes has proven challenging. Now it has been shown that a bimolecular nucleophilic substitution-assisted strategy advances both primary and secondary batteries by regulating the electrolyte reduction potential and interphase passivation capability.