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This study reports coherent Aharonov–Bohm interference, including statistical phase contributions, in a Fabry–Pérot interferometer at two even-denominator fractional quantum Hall states in high-mobility bilayer-graphene van der Waals heterostructures is reported.

Division of embryonic cells with an incomplete contractile ring occurs by a ratchet mechanism with repeated cycles of cytoplasmic stiffening, which stabilizes the contractile actin band, and fluidization, which enables band ingression.

Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

An optoelectronic device that converts light into a postsynaptic signal after two stages of cascaded potentiation can mimic the synaptic facilitation function of the human retina and could be used to create a curvy neuromorphic imager.

Replication-dependent histone mRNA decay involves the RNA helicase UPF1, the histone stem-loop binding protein SLBP and the exoribonuclease 3’hExo. Here, the authors present evidence for assembly of a degradosome-like complex involving the three proteins and delineate the mechanism that drives their concerted action to achieve histone mRNA decay.

A genetic study of natural variation in potato tuberization onset, an important phenotype for breeding potatoes adapted to different global day lengths, has revealed a role for StCDF1, a member of the DOF family of transcription factors.

ALMA has captured exquisitely detailed images of bowshock shells in the outflow of an outbursting protostar. These provide important insights into the variable nature of the ejections from protostars, which play a key role in star and planet formation.

Adipose CoA handling is critical for lipid metabolism and homeostasis. Here, the authors identify TMEM120A as an ER-resident CoA binding protein enriched in adipocytes that promotes fatty acid recycling to support energy metabolism and limit lipotoxic stress, while its loss leads to adipose inflammation and metabolic dysfunction under high-fat diet conditions.

The origin of blue straggler stars (BSSs) is still unclear. Here the authors show that the BSS and binary fractions correlate with the host cluster parameters, indicating that BSSs have a binary-related origin mediated by the environment.

Cell fate transitions rely on dynamic regulatory programs that RNA velocity often blurs. Here, the authors show that MoFlow integrates multi-omic data to infer locally adaptive, single-cell-resolved velocities that illuminate fine-scale regulatory dynamics.

Here, the authors show that brain dynamics mature from childhood to adulthood with increased hierarchical propagation and reduced visual-somatomotor dynamics. Top-down hierarchical flow strengthens throughout this developmental period.

Addressing how the nitrogen-induced changes in plant diversity differ from those in soil organisms is critical. This global meta-analysis suggests that nitrogen enrichment has stronger negative effects on plant diversity but modest to negligible effects on soil bacterial and fungal diversity.

Gravitational lens modelling of a million-solar-mass dark object reveals that it cannot be a free-floating black hole or dark-matter halo as predicted by cold dark matter, instead indicating a peculiar and highly concentrated mass distribution.

Cation effects have been rigorously studied in electrochemical charge transfer, but their role in mass transport remains unexplored. Now, it has been shown that the structural entropy of cation hydration quantitatively explains how cations regulate reactant diffusion during the chlorine evolution reaction.

The study reports the discovery of a persistent bow shock around a diskless magnetic accreting white dwarf, revealing a powerful energy-loss mechanism that challenges current models of accretion and compact binary evolution.

Recent MPXV outbreaks underscore the need for better vaccines and treatments. Here, the authors isolate and structurally characterize potent antibodies interacting with A28 that they identify as a key viral surface protein essential for viral entry and that induces strong, protective antibody response in mice.

Ferroptosis is an iron-dependent lipid peroxidation-mediated form of cell death that holds promise for targeting treatment-resistant cancer cells. Here, the authors show that AMPK-mediated lipid droplet dynamics modulates the response to ferroptosis inducers in melanoma.

Grazing affects plant diversity, but plant diversity in turn may modulate the effect of grazing on the plant community. This global analysis explores the association between plant species richness and plant cover resistance to grazing intensity in drylands.

A clinical cohort-based biomarker study in patients with metastatic renal cell carcinoma demonstrates that blood levels of soluble mucosal addressin cell adhesion molecule-1 are prognostic for survival in patients treated with tyrosine kinase inhibitors and immune checkpoint inhibitors and may serve as a surrogate marker for gut dysbiosis based on integrated data from three clinical trials.

In the phase 1/2 CASTLE basket trial, autologous CD19 CAR-T cell therapy in patients with treatment-refractory systemic lupus erythematosus, systemic sclerosis or idiopathic inflammatory myopathy was safe, with improved disease activity and patient-reported global health in most patients.

Analysis of the 3D chromatin architecture and cis-regulatory elements in a sea urchin and a sea star reveals mechanisms of 3D chromatin organization in echinoderms and the long-term evolutionary dynamics of cis-regulatory elements in animals.

We enhanced the scintillation performance of Sb³⁺-based halides by introducing H₂O to enhance lattice distortion and restrict free degrees, and realized real-time and 3D X-ray imaging using the flexible film.

Centennial-scale variations in methane carbon isotope ratios are attributed to changes in pyrogenic and biogenic sources that can be correlated with anthropogenic activities, such as varying levels of biomass burning during the period of the Roman empire and the Han dynasty, and changes in natural climate variability.

Electrochemical dechlorination provides a sustainable method to treat chlorinated volatile organic compounds polluted water and produce value-added hydrocarbon. Here, the authors report cobalt phthalocyanine grafted on sulfur-doped graphene for efficient CH₂Cl₂ dechlorination at moderate potentials.

This study identifies key neurocognitive domains that distinguish patients with schizophrenia from healthy individuals using machine learning. Analyzing data from 1,304 participants, it demonstrates that verbal learning and emotion identification effectively classify conditions, promoting efficient neurocognitive profiling strategies.

Yersinia pseudotuberculosis senses fungal tyrosol signalling through EnvZ–OmpR which triggers T6SS activation and antifungal effector release to reduce fungal competitors in the mouse gut.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Neonatal brain injury from intermittent hypoxemia increases fatty acid oxidation and causes long-term changes in hippocampal lipid profile. Here authors demonstrate oral treatment with glycerol-triacetate restores lipid fatty acid profile and promotes functional recovery.

Ribosomes convert chemical energy to mechanical work. Here, the authors monitor ribosome binding to the GTPase EF-G and the ensuing mechanical work on mRNA in real time, uncovering a major energetic contribution from EF-G binding, rather than GTP hydrolysis, to the mechanical work.

Mutations in VPS13B cause Cohen syndrome, but its cellular role is not fully understood. Here, the authors show that VPS13B promotes mitochondrial fission and mitophagy by facilitating local enrichment of vesicle-derived lipids.

Whether high-order frontal lobe areas receive raw speech input in parallel with early speech areas in the temporal lobe is unclear. Here, the authors show that frontal lobe areas get fast low-level speech information in parallel with temporal lobe speech areas.

The variability in clinical outcomes of SARS-CoV-2 infection is partly due to deficiencies in production or response to type I interferons (IFN). Here, the authors describe a FIP200-dependent lysosomal degradation pathway, independent of canonical autophagy and type I IFN, that restricts SARS-CoV-2 replication, offering insights into critical COVID-19 pneumonia mechanisms.

Malaria parasites specifically target red blood cells for invasion. Here, the authors investigate how Plasmodium falciparum exploits host CD44, showing that CD44 crosslinking promotes invasion in two ways: by altering the cell membrane to enhance critical ligand-receptor interactions, and by regulating signaling internally to the host cell cytoskeleton.

Decadal-scale observations reveal that plant diversity stabilizes ecosystem productivity over time. Phylogenetic diversity is the key driver of long-term stability, whereas plant height shapes short-term productivity dynamics.

Electrochemical synthesis of solid compounds is an emerging frontier in electrocatalysis. Here, the authors report a Pt catalyst whose surface-coordinated halogens alleviate the scaling effect by regulating the local environment and enable simultaneous Mg(OH)₂ and H₂ production from natural seawater.

Reconfigurable all-liquid optical fibers enable gigabit-speed communication while offering softness, rapid self-healing, and on-demand reconfiguration, providing a resilient alternative to brittle quartz fibers in dynamic application environments.

Small-scale vorticity dynamics are central to turbulence, but their transient and chaotic nature makes direct measurement and control extremely challenging. By using magnetically driven particles, authors uncover stochastic resonance and a symmetry-breaking mechanism that may enable both control of particle dynamics and a magnetic resonance- based method for probing turbulence at its smallest scales.

The reactive nitrogen (Nr)-driven atmospheric multiphase buffering can induce unintended Concomitant Pollution. Given the importance of NH₃ in this process, rising global NH₃ emissions has positioned Concomitant Pollution as an urgent challenge.

This research developed and compared firearm-specific and method-agnostic machine-learning models using data from 800,579 Army veterans, revealing that model choice and intervention thresholds impact predictive accuracy and fairness, guiding tailored suicide prevention efforts.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

Large informal settlements reflect inequalities in Latin America, where transport interventions can build social capital. TransMiCable increased the probability of individuals transitioning to bridging social capital networks, suggesting an increase in trust among neighbors and an improvement in bridging community networks.

Mechanism of CD8 T cell dysfunction in tumor microenvironment requires continuous investigation. The authors here show that Lypd6b expression is increased in CD8 T cells of colorectal cancer tissue and its absence inhibits MC38 or CMT-93 tumor growth associated with upregulated glycolysis and reduced oxidative phosphorylation.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

Yakut communities, with Trans-Baikal admixture during the Mongol expansion, preserved genomic diversity and oral microbiomes despite the Russian conquest, which introduced cereals, pathogens and Christianity, whereas marital practices preserved low consanguinity except in one late case of traditional shamanism.

The West Antarctic Ice Sheet responded to different natural forcing mechanisms than the East Antarctic Ice Sheet through the mid-Pliocene due to a greater sensitivity to oceanic feedbacks, according to iceberg-rafted debris records and ice-sheet modelling experiments.

Here the authors show that mitochondrial RNA leaks into the cytosol of senescent cells through sublethal apoptosis, driving inflammation. Blocking this pathway improves outcomes in Metabolic Dysfunction-Associated Steatohepatitis.

Leukemic stem cells (LSCs) drive relapse and therapy resistance in acute myeloid leukemia (AML). Here, the authors show that increasing the stiffness of LSCs reduces their stemness and enhances their susceptibility to natural killer cell-mediated immunotherapy in AML.

Multi-omics profiling of diverse cancer cachexia models uncovers a multi-tissue metabolite-coordinated response associated with disease progression and links multi-tissue one-carbon metabolism to wasting.

Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.