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The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

TRIM37–PARP1–TET1 signalling preserves stem cell function and prevents osteoporosis by regulating DNMT1 splicing through 5hmC maintenance, revealing a mechanism linking epigenetic control to stem cell function and bone health.

Periodic marine oxygen oscillations occurred throughout the middle Ediacaran Gaskiers Glaciation, probably stemming from increased organic carbon burial destabilizing ocean redox systems, according to geochemical constraints and modelling.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Paired electrolysis converts industrial SO₂ directly into valuable cyclic sulfite esters, turning a common pollutant into useful chemicals. Mechanistic studies reveal key intermediates, offering a sustainable and versatile platform for green organosulfur synthesis and pollutant valorization.

The oxygen evolution reaction enables many clean energy technologies, but most acid-unstable catalysts still block deployment. Here the authors report a temperature dependent mechanistic evolution in RhRu3Ox that links reaction pathways to stability, enabling durable acidic water electrolysis.

This study introduces a nano-confined CuRu catalyst that leverages confinement effects to enhance CO₂–nitrate C–N coupling by improving reactant transport and strengthening the stabilization of key reaction intermediates, thereby achieving high urea yield and long-term operational stability.

The success of photocatalytic coupling of CH₄ has been limited by the low solar absorption of wide-bandgap semiconductors and the uncontrolled oxidation caused by radical oxygen species. Here a Pd/Co₃O₄ heterojunction derived from a metal–organic framework demonstrates the selective conversion of CH₄ to C₂H₆ by less reactive oxygen species under full-solar-spectrum irradiation.

The sluggish hydrogen oxidation reaction hinders the development of anion exchange membrane fuel cells. Here, the authors develop high-curvature RuIr CNCs that induce an O-down water orientation, thereby strengthening hydrogen-bond networks and reducing proton transfer barriers.

Cryogenic electron microscopy structures of human Ostα/β uncover a unique transport pathway featuring two substrate-binding sites connected by an amphipathic helix-gated conduit, and electrophysiological studies demonstrate voltage-sensitive, bidirectional transport, showing its efflux role in vivo.

A device for rectifying supercurrents at liquid-nitrogen temperature with high efficiency is demonstrated. This is a practical step towards implementing dissipationless electronics.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

Alcohol oxidation to carbonyl compounds is a very useful functional group transformation in organic synthesis. Here, the authors perform the direct electrochemical oxidation of various alcohols to the corresponding ketones in a continuous-flow reactor without external oxidants, base or mediators.

Optimizing the crystallization of the active materials in organic solar cells is challenging. Fu et al. use an acenaphthene additive to induce a two-step crystallization of the non-fullerene acceptor, achieving a certified 20.5% power conversion efficiency.

Authors report cryo-EM structures of AL amyloid fibrils from the kidney of a male patient with renal AL amyloidosis. Comparison to previous heart-derived fibrils reveals variations linked to sequence differences and insights into fibril assembly and organ tropism in AL amyloidosis.

SARS-CoV-2 variants with mutations in spike have emerged during the pandemic. Magaret et al. show that in Latin America, efficacy of the Ad26.COV2.S vaccine against moderate to severe–critical COVID-19 varied by sequence features, antibody escape scores, and neutralization impacting features of the SARS-CoV-2 variant.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Installing algal pyrenoids or cyanobacterial carboxysomes into plants to enhance photosynthetic efficiency remains a formidable challenge. Here, the authors report the construction of CO₂-fixing nanocompartments by encapsulating Rubisco using encapsulin from Quasibacillus thermotolerans.

Surface reconstruction during reactions often generates unique active sites that boost catalytic performance. Here, the authors show that supported Ni₃InC₀.₅ nanoparticles undergo CO₂-induced surface oxidation, forming defective In₂O₃₋ₓ layers and inverse In₂O₃₋ₓ/Ni interfaces during CO₂ hydrogenation.

METTL3 promotes healthy placenta function by regulating m⁶A methylation and histone epigenetics. Deficiency in METTL3 leads to premature senescence, inflammation activation of trophoblasts, contributing to pregnancy complications like preeclampsia.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Lithium metal batteries are susceptible to dendrite growth and interfacial instability, particularly at extreme temperatures. Here, authors propose an allyl ether electrolyte with a neighbouring group participation in lithium solvation regulation, inducing a dual-layer SEI and enabling stable cell operation from −40 to 60 °C.

MuSCs are vital for muscle renewal with unclear regulatory mechanisms. Here, the authors show that cytosolic TBC1D1 inhibits nuclear entry of the AS160-STAT3 complex and regulates MuSC proliferation. Deficiency of TBC1D1 improves muscle regeneration.

Incompatibility between organic electrodes and inorganic solid electrolytes limits the performance of solid-state organic batteries. Here, the authors introduce indigo natural dye as a redox-active material and molecular catalyst, enabling high capacity and long cycle life via synergistic redox reactions with sulfide electrolytes.

All-solid-state batteries require external high pressure for good contact between the solid electrolyte and electrodes. Here the authors introduce iodine anions into electrolytes to form interphases that adapt to morphology at the interface, lifting the dependence on high pressure.

The full exploitation of back contact silicon solar cells is crucial to achieve a high performance for potential industrialization. Here, authors incorporate a double-sided light management strategy to reduce optical losses, achieving a total-area efficiency of 27.03% for 350 cm2 solar cells.

Exploiting the high abundance of mutant p53 protein, a small molecule was developed that specifically binds to p53-Y220C mutants and delivers a mitosis blocker, killing TP53-mutant cancer cells while sparing healthy ones.

Most optical tools for cortex-wide imaging are focused on either neuronal physiology or hemodynamics. Here, the authors present a cortex-wide multimodal imaging approach that facilitates simultaneous observation of neural activity and hemodynamics in awake mice.

Electrochemical oxidative C–C bond cleavage and functionalization are rarely developed due to the inertness and weak electronic bias of C–C bonds. In this study, the authors report the electrochemical C–C bond cleavage and 1,3-difluorination, 1,3-oxyfluorination and 1,3-dioxygenation of arylcyclopropanes under catalyst-free and external-oxidant-free conditions.

Electrocatalytic co-reduction of CO₂ and nitrate to synthesize urea is a sustainable and promising option to the alternative conventional Bosch-Meiser. Here, the authors report a CeO_x-integrated diatomic electrocatalyst overcomes the traditional trade-off between urea yield and Faradaic efficiency.

Regular oscillations in early Triassic ocean chemistry are explored in a box model. Periodic fluctuations in C and U isotopes are attributed to internal feedbacks in the coupled carbon-phosphorus-oxygen system after the end Permian mass extinction.

Zhang, Ma et al. report that ROS-activated O-GlcNAc transferase promotes FOXK2 O-GlcNAcylation and nuclear translocation to upregulate SLC7A11 expression, thereby modulating ferroptosis sensitivity, tumour development and chemoradiotherapy efficacy.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Detecting early allopolyploidy events and understanding the specific subgenomic evolution contributing to the origin of adaptive innovations for species radiation are challenging. Here, the authors address these problems by analyzing nine newly assembled genomes of Salicaceae species from different genera.

The insertion of thin layers of cobalt can stabilize β-tungsten under back-end-of-line thermal constraints, allowing a 64-kb spin–orbit torque magnetic random-access memory to be fabricated that offers a spin–orbit torque switching of 1 ns, data retention of more than 10 years and a tunnelling magnetoresistance of 146%.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.