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Showing 51–100 of 24625 results
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  • While the pathogenesis of Alzheimer’s disease (AD) has been extensively studied, the predominant focus has traditionally been on gray matter alterations. Here, authors use single-nucleus and spatial transcriptomic profiling of the human brain’s temporal cortex and white matter to uncover cell type specific changes and their associations with Alzheimer’s pathology.

    • Pallavi Gaur
    • Julien Bryois
    • Vilas Menon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • The authors analytically determine how neuronal correlations and geometry collectively determine readout generalization across tasks and show how these geometric features follow distinct trajectories over the course of learning.

    • Albert J. Wakhloo
    • Will Slatton
    • SueYeon Chung
    ResearchOpen Access
    Nature Neuroscience
    P: 1-11
  • The bacterial protein H-NS prevents costly expression of horizontally acquired genes such as those in Salmonella pathogenicity islands (SPIs), which are essential for infection. Here, Kortebi et al. show that the expression of SPI-1 is associated with Salmonella chromatin remodelling and with the repositioning of this region toward the nucleoid periphery.

    • Mounia Kortebi
    • Mickaël Bourge
    • Virginia S. Lioy
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-17
  • Using infant fMRI, the authors show that, by 2 months of age, representations in high-level visual cortex encode visual categories that align with deep neural networks, and lateral object-selective regions are later to develop.

    • Cliona O’Doherty
    • Áine T. Dineen
    • Rhodri Cusack
    ResearchOpen Access
    Nature Neuroscience
    P: 1-10
  • The relationship between brain development and smoking behaviour is not well understood. Here, the authors show an association between volume of the left ventromedial prefrontal cortex and smoking initiation in adolescents.

    • Shitong Xiang
    • Tianye Jia
    • Jianfeng Feng
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-13
  • Three-component Fermi gases represent a versatile platform for quantum simulation, including quantum chromodynamics-like physics, pairing and few-body effects. Here the authors demonstrate control of spin imbalances and an unexpected asymmetric decay due to different three-body losses for each component, and whose microscopic mechanism remains to be understood.

    • Grant L. Schumacher
    • Jere T. Mäkinen
    • Nir Navon
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-11
  • Membrane ion channels can be responsive to a variety of stimuli such as pressure, temperature, or pH. Here, the authors show that simply shining 365 nm light activates a native potassium channel in rodent pain-sensing neurons, delivering powerful analgesia without drugs or genetic manipulations.

    • Marion Bied
    • Arnaud Landra-Willm
    • Guillaume Sandoz
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-18
  • HORBEC are protein complexes involved in the regulation of redox balance and energy conservation. The authors develop a bioinformatic tool for HORBEC annotation in bacterial and archaeal genomes and reconstruct the evolutionary history of these fundamental enzymes.

    • Pierre Simon Garcia
    • Valerie De Anda
    • Guillaume Borrel
    Research
    Nature Ecology & Evolution
    P: 1-16
  • Five-year survival data and biomarker analysis of the PRADO extension cohort of the phase 2 OpACIN-neo trial, in which patients with high-risk stage III melanoma received neoadjuvant ipilimumab and nivolumab and underwent pathologic response-directed surgery and adjuvant therapy, show 71% event-free survival and 88% overall survival, with tumor mutational burden, IFNγ signature and PD-L1 expression associated with favorable outcomes.

    • Lotte L. Hoeijmakers
    • Petros Dimitriadis
    • Christian U. Blank
    Research
    Nature Medicine
    P: 1-12
  • The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior.

    • Zhen Li
    • Himanshi Chawla
    • Benjamin Schumann
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-10
  • Targeting neurons that regulate energy balance may offer new approaches for obesity treatment. Here, authors show that chemogenetic and pharmacological manipulation of GABAergic neurons in the DRN/vlPAG increases adaptive thermogenesis and reduces weight gain in mice fed a highfat diet.

    • Alexandre Moura-Assis
    • Kaja Plucińska
    • Marc Schneeberger
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-13
  • Microglial states throughout remyelination are incompletely understood. Here, the authors show that microglia form several states during the early stages of remyelination that coalesce into a partially resolved state that is dysregulated with age.

    • Sameera Zia
    • Marianela E. Traetta
    • Jason R. Plemel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24
    • P. J. FODOR
    • S. KUK
    • J. DIAMANTE-LICHTENSTEIN
    Research
    Nature
    Volume: 151, P: 280
  • The study shows that the HIV-1 Nef protein stabilizes actin, thereby preventing R12C release and priming of RIG-I–like receptors. HIV-1 containing a mutant Nef unable to bind the actinmodulating kinase PAK2, triggers enhanced interferon responses.

    • Alexandre Laliberté
    • Caterina Prelli Bozzo
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Here the authors perform longitudinal sampling of lymphoid organs along with fate mapping and matched single-cell RNA sequencing and TCR sequencing to define the developmental dynamics of follicular regulatory T (TFR) cells. They find that TFR cells undergo clonal expansion and progressive differentiation in a process that requires follicular helper T cells.

    • Jeong-Mi Lee
    • Paulo Lisboa Raeder
    • Peter T. Sage
    ResearchOpen Access
    Nature Immunology
    Volume: 27, P: 336-347
  • Engineering polymerases to synthesize alternative genetic polymers remains a challenging problem in synthetic biology. The current study offers insights into the structural and biochemical changes responsible for improving the fidelity and catalytic activity of a laboratory evolved TNA polymerase.

    • Mohammad Hajjar
    • Victoria A. Maola
    • John C. Chaput
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-14
  • This study uses single-cell DNA sequencing to analyze genomic evolution in pancreatic cancer using a cohort of multiregionally and longitudinally sampled patients’ tissues across various clinical contexts.

    • Haochen Zhang
    • Palash Sashittal
    • Christine A. Iacobuzio-Donahue
    ResearchOpen Access
    Nature Genetics
    P: 1-11
  • How the pulvinar represents complex visual information, its functional topography, and its relationship to cortical processing of visually presented objects remains unclear. Here authors show that responses to natural scenes in the human pulvinar reveal organized spatial maps for both low-level visual features, such as local contrast, as well as high-level visual features, such as bodies and faces.

    • Daniel R. Guest
    • Emily J. Allen
    • Michael J. Arcaro
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12
  • Results from the phase ELAD 2 trial reveal that liraglutide is safe and well tolerated in people with mild to moderate Alzheimer’s disease but does not significantly slow brain metabolism decline.

    • Paul Edison
    • Grazia Daniela Femminella
    • Clive Ballard
    ResearchOpen Access
    Nature Medicine
    Volume: 32, P: 353-361
  • Early life RSV infection contributes to risk of childhood asthma. Here, the authors develop a statistical model to predict age at first RSV infection in the United States based on birthdate, demographics, and RSV surveillance data which could be used to identify groups at risk of chronic respiratory sequalae like asthma.

    • Chris G. McKennan
    • Tebeb Gebretsadik
    • Tina V. Hartert
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-10
  • Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

    • Jay J. Van Bavel
    • Aleksandra Cichocka
    • Paulo S. Boggio
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14
  • GIANT, a genetically informed brain atlas, integrates genetic heritability with neuroanatomy. It shows strong neuroanatomical validity and surpasses traditional atlases in discovery power for brain imaging genomics.

    • Jingxuan Bao
    • Junhao Wen
    • Li Shen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Single-cell RNA sequencing and assay for transposase-accessible chromatin using sequencing profiling of human retinal samples from diverse ancestries create an epitranscriptomic atlas characterizing over 130 cell types. Integration with genome-wide association study and expression quantitative trait loci data provides further insights into gene regulation and disease etiology.

    • Jin Li
    • Jun Wang
    • Rui Chen
    Research
    Nature Genetics
    P: 1-16
  • Here, the authors examine the mechanisms behind cheatgrass’s successful invasion of North American ecosystems. Their genetic analyses and common garden experiments demonstrate that multiple introductions and migrations facilitated cheatgrass local adaptation.

    • Diana Gamba
    • Megan L. Vahsen
    • Jesse R. Lasky
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors characterize the LPS translocon holo-complex, LptDEMY, uncovering conformational translocon state transitions that might explain how LPS is assembled at the outer membrane surface.

    • Haoxiang Chen
    • Axel Siroy
    • Raffaele Ieva
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • This study reveals high-spin state formation and quintet-mediated emission in diphenylhexatriene oligomers. Quintet states dominate delayed fluorescence up to room temperature, establishing a spin-selective platform for quantum technologies.

    • Jeannine Grüne
    • Steph Montanaro
    • Neil C. Greenham
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-10
  • Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.

    • Raphael Reher
    • Allegra T. Aron
    • Daniel Petras
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • The evolutionary dynamics of aneuploidy in solid tumors are challenging to study. Here the authors introduce a method, ALFA-K, which estimates karyotype fitness and predicts emergent karyotypes before experimental detection, and test its performance on synthetic and empirical data.

    • Richard J. Beck
    • Tao Li
    • Noemi Andor
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-11
  • iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

    • Abhi Aggarwal
    • Adrian Negrean
    • Kaspar Podgorski
    ResearchOpen Access
    Nature Methods
    P: 1-9
  • Disease heterogeneity complicates precision medicine, which focuses on single conditions and ignores shared mechanisms. Here the authors introduce ‘pan-disease’ analysis using a deep learning model on multi-organ data, identifying 11 AI-derived biomarkers that reveal new therapeutic targets and pathways, enhancing patient stratification for disease risk monitoring and drug discovery.

    • Junhao Wen
    • Christos Davatzikos
    • Junhao Wen
    ResearchOpen Access
    Nature Mental Health
    P: 1-28
  • In this work, authors show how the enterotoxigenic Escherichia coli (ETEC) protease EatA cleaves the human mucus protein MUC2 at a C-terminal site, allowing bacteria to cross the intestinal mucus, reach epithelial cells, and promote infection, as demonstrated using a human MUC2 transgenic mouse model.

    • Sergio Trillo-Muyo
    • Brendan Dolan
    • Sjoerd van der Post
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-12