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The efficient mass transport is the key factor to advancing the flow-electrocatalytic chemosynthesis. Here, the authors design a flow-through architecture in flow electrolyzer, reinforcing mass transport in the electrolyte to achieve the high efficiency of continuous oxime electrosynthesis.

Diagnosing breast cancer through MRI is limited by high false-positive rates and inter- reader variability, leading to unnecessary biopsies. In here, the authors find that the BI-RADS 4 Lesions Analysis System (BL4AS) model improves diagnostic accuracy and reduces unnecessary biopsies as well as inter-reader variability

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

This study reports a Ag₂(Se_1-xS_x)_1.05-based fully printed origami thermoelectric generators, achieving a high power density of 21 W m⁻² at a temperature difference of 80 K. It enables low-cost, battery-free wearables and Internet-of-Things applications.

Tip-focused radiofrequency perforation enables soft, bloodless implantation of flexible electronic hairs, advancing semi-implantable electrophysiology for prosthetics and human–machine interfaces.

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

This work reports the growth of inch-scale diamond wafers with a hardness of 208.3 GPa via high-frequency pulsed local non-equilibrium CVD, revealing a stacking-fault-driven ultrahard mechanism.

The insufficient structure and biofunction of cartilaginous implant impede cartilage regeneration. Here, the authors develop anti-swelling and self-activating artificial proteoglycan assemblies for post-microfracture healing by downregulate calcium signaling pathway and reducing ossification.

Realizing the 1.5 °C target could advance WHO Air Quality Guidelines compliance by decades, preventing over one million deaths and delivering significant benefits. The monetized health co-benefits will exceed mitigation costs in most regions.

Two-dimensional perovskites enable high efficiency in perovskite photovoltaics but compromise operational stability. Yaghoobi Nia et al. form two-dimensional perovskite co-crystals with neutral templating molecules, improving the stability of perovskite solar modules.

A groundbreaking study reveals how physical confinement triggers ferroptosis. It finds the nucleus acts as a mechanosensor, orchestrating Drp1 and cPLA2 that leads to mitochondrial dysfunction and ultimately, cell death.

Accurately predicting immunotherapy efficacy remains challenging. Here, the authors report a multiplexed blood-based assay using self-assembled, dual-target responsive DNA hydrogels for detection of soluble programmed death-ligand 1 and lactate dehydrogenase which can be used as a tool to help evaluate and predict immunotherapy response.

Receptor engagement is a determinant of alphavirus entry. This work reveals how Western Equine Encephalitis Virus uses very-low-density lipoprotein receptor (VLDLR) to invade our cells and finds that a single polymorphism in the E2 glycoprotein determines the receptor’s tropism.

SWI/SNF chromatin-remodeling complexes regulate gene expression and division in zoonotic parasite Toxoplasma gondii. Loss of the core ATPases restricts chromatin access, rewires cell cycle programs, impairs growth, and causes abnormal division.

This study demonstrates that a single antibody exhibits distinct binding modes with SARS-CoV-2 WT and Omicron variants, correlating with neutralization loss. The underlying mechanisms offer insights into enhanced neutralization.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

Even though chiroptical luminophores have high potential for optoelectronic innovation and precision bioimaging, their rational engineering remains constrained by synthetic limitations. Here, the authors report a streamlined and programmable asymmetric synthesis platform enabling systematic construction of boron-stereogenic boron dipyrromethenes (BODIPYs) with near-infrared chiroptical activity.

The paper presents an enhanced framework for predicting flight paths using wavelet transform. It improves accuracy by addressing error accumulation and capturing multi scale flight patterns, achieving significant error reduction in multi-horizon predictions compared to previous methods.

SARS-CoV-2 mainly transmits via respiratory droplets. Here Deng et al. show that SARS-CoV-2 can infect rhesus macaques via ocular conjunctival inoculation.

Peripheral nerve transfer can restore motor functions of the upper limbs after peripheral nerve injuries. Here, the authors developed an implantable multisite optogenetic stimulation system for wireless evaluation of peripheral nerve plexus with sub nerve resolution.

Snail is involved in the regulation of epithelial-mesenchymal transition and metastasis. Here, the authors show that the metabolite β-hydroxybutyrate promotes pancreatic cancer metastasis through protecting Snail from degradation.

Drosophila oenocytes accumulate fat during periods of starvation similar to the liver. This study shows that oenocytes regulate fat metabolism during starvation via Desat1-dependent secretion of ImpL2, linking lipid desaturation to lipoprotein trafficking, insulin signaling and fat body triacylglycerol storage for survival.

Activation of genes depends on transcription factors and chromatin remodelers. Here, the authors show ARID1A organizes these components through phase separation, co-condensing with specific transcription factors to maintain chromatin accessibility and drive gene expression.

WNT-signaling activation is a promising strategy for adult tissue and organ rejuvenation. The authors report an efficient approach to generate exosomes carrying WNTs and RSPONDINs family ligands that can achieve strong activation of the pathway to regenerate diseased and aged livers.

Proton exchange membrane water electrolysis promises green hydrogen production but safety risks in industrial operations remain unexplored. Here, the authors identify water-starvation as the cause of water electrolysis stack deflagration and establish safety precautions for industrial scale-up.

Microbial iron cycling can enhance the accumulation of rare earth elements and yttrium in host minerals by facilitating their release from iron oxides back into the pore water, according to an integrated geochemical, magnetic, and microscopic analysis.

DNA damage from chemotherapy can activate cGAS–STING and interferon pathways. Here, the authors show that cGAS–STING signaling is specific to DNA rich in CA repeats, whereas DNA not rich in CA repeats is detected by AIM2, resulting in opposing tumor immune responses.

Regulating oxidative phosphorylation and restoring redox homeostasis are crucial in neurological disorders. Here, the authors develop a top-down membrane self-assembly strategy to develop stem cell-derived artificial organelles (SAOs) that mimic mitochondrial oxidative phosphorylation without the risks associated with stem cell therapy.

The fast skin-permeable polyzwitterion poly[2-(N-oxide-N,N-dimethylamino)ethyl methacrylate] may enable non-invasive transdermal delivery of insulin, and potentially facilitate the use of other protein- and peptide-based therapeutics through transdermal delivery.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

The underlying mechanisms for drug resistance in Acute Myeloid Leukemia (AML) are not completely understood. Here, the authors show that succinate accumulation, associated with succinate dehydrogenase deficiency, impairs the activity of the ubiquitin-conjugating enzyme UBC12 leading to tumor-promoting protein accumulation and drug resistance in AML.

The red fluorescent protein mScarlet3-H is bright, photostable and very robust to high temperature, chaotropic conditions and oxidative environments. mScarlet3-H works well in correlative light and electron microscopy, tissue clearing and time-lapse super-resolution microscopy.

Lu et al. characterize cis-regulatory element dynamics at different stages of colorectal cancer progression and identify a functional variant associated with increased colorectal cancer risk because of selective transcription factor binding.

RSV hijacks cholesterol or autophagy pathways to facilitate optimal replication. Here, the authors show that RSV-mediated changes in lysosomal cholesterol metabolism promote RSV-F accumulation in lysosomes by blocking autophagy flux, thereby facilitating viral replication.