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Zanubrutinib is a second-generation BTK inhibitor, reported to have fewer off-target toxicities while maintaining comparable efficacy to previous BTK inhibitors. Here, the authors report the phase II CHESS trial evaluating frontline Zanubrutinib (second-generation BTK inhibitor) plus rituximab (anti-CD20) induction, followed by chemoimmunotherapy in patients with mantle cell lymphoma.

Neuromorphic devices are currently constrained by their limited functionality. Zhi et al. report a ferroelectric heterostructure device that integrates Boolean, optoelectronic synaptic and photodetection operations, offering a pathway to realizing integrated sensing-memory-computing systems.

How behavioral constraints re-organize functionally-defined HD (head direction) cells within the wider entorhinal network is not fully understood. Here authors show the complementary role of learning and self-organization in some entorhinal subpopulations, enabling animals to adaptively represent themselves within their environment, shaped by ongoing behavioral constraints.

Clarifying how different acid sites function in zeolite catalysts is essential yet difficult due to their overlapping roles. This study uncovers distinct reaction pathways and a key trade-off that governs ethylene formation from ethanol.

Oncolytic viruses are an approved therapeutic approach for glioblastoma, but, unfortunately, they are efficacious only in some patients. Here, the authors discover that LRRK2 inhibitors enhance viral infection and oncolysis by oncolytic herpes simplex virus (oHSV) in glioblastoma.

Classical monocytes can differentiate into pro-inflammatory or pro-resolving macrophages. Here the authors characterise mouse macrophage differentiation and show that Ly6C^hi classical monocytes can differentiate into Ly6C^lo pro-resolving macrophages which are involved in the resolution of skin allergic inflammation.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

CD8⁺ T cell abundance in the tumor microenvironment is critical for immunotherapy success. This study shows that the STING–TOX axis suppresses CD8⁺ T cell antitumor activity by inducing ferroptosis. STING–TOX-deficient CD8⁺ T cells enhance outcomes when combined with checkpoint blockade or chemotherapy.

Combining generative AI and one round of wet lab evolution generates high-affinity RNA aptamers.

A two-dimensional/two-dimensional contact of metallic Nb_0.3W_0.7Se₂ and tungsten diselenide can be used to make p-type transistors with channel lengths of 100 nm and on-currents of over 1.1 mA µm⁻¹.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Wan, Li, Cao and colleagues report a feedback crosstalk between THY1⁺ cancer stem cells and neutrophils via migrasome-mediated release of mitochondria, which induces a pseudohypoxic state and promotes metastasis.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

An integrated photonics scheme is presented for the manufacture of communication systems supporting the use of fibre and wireless infrastructures simultaneously, addressing the long-standing bandwidth mismatch between the two domains and demonstrating ultrahigh data rates.

He et al. report a lanthanide-doping strategy for dual-halogen-alloyed perovskite microplates, which promotes phase segregation and facilitates ion migration in the alloyed case, while suppressing it in the phase-segregated state, resulting in dual-wavelength lasing in visible spectral region.

Using a regioirregular polymerization strategy, diverse polymer structures containing urethane, carbonate and urea linkages are synthesized from a single tetramethylene urethane monomer. Mixed polymers can be depolymerized to the starting monomer in a closed-loop manner.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Mechanical annealing is a process through which the dislocation density in submicrometre metal crystals can be removed purely by applying a mechanical stress. This study shows that mechanical annealing occurs in body centred cubic molybdenum, and not only in face centred crystals as previously thought.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Yang et al. compare neoadjuvant triple therapy versus direct hepatectomy in patients with resectable intermediate or advanced hepatocellular carcinoma. The findings indicate that the neoadjuvant regimen improves overall and event-free survival but is associated with a higher risk of serious adverse events and postoperative complications.

An artificial intelligence-driven robotic chemist that integrates generative machine-learning models incorporating spectroscopic descriptors with automated experimentation is developed, enabling the inverse design of high-entropy catalysts and offering a generalizable strategy for the design of diverse complex materials.

IRF3 initiates type I IFN transcription, and this is required for host defense. Here, Chen and colleagues show that RAD18 terminates the transcriptional activity of IRF3 and subsequently promotes the autophagic degradation of IRF3.

This study presents a structural N-glycoproteome atlas of 24 mouse tissues, revealing distinct tissue-specific glycan patterns, subcellular-related protein function remodeling, and non-random co-occurrence among glycan structural features.

The current unbalance between the performance of n-type and p-type 2D transistors limits their applications for next-generation electronics. Here, the authors report the realization of high-performance 2D MoTe₂ p-type transistors by depositing metallic tellurium contacts via thermal evaporation.

Using volatile vanadium oxide and non-volatile tantalum oxide/hafnium oxide memristor arrays, a first-principles Fourier transform system can be created that can outperform conventional Fourier transform hardware in terms of throughput and reduce memory cost.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Stem cell migration plays critical roles in the regeneration of adult tissue. Here, the authors demonstrate that Wnt5a-mediated activation of non-canonical Wnt signaling promotes migration of airway stem cells after epithelial injury.

The nature of localized interlayer excitons (LIXs) in moiré superlattices is still elusive Here, the authors propose a donor-acceptor pair mechanism for LIXs in MoSe₂/WSe₂ heterobilayers.

Using a molecular engineering approach, wafer-scale uniaxially oriented Te nanowire thin films are synthesized with excellent controllability and uniformity. The anchor-rope structural molecules form a periodic self-assembled supramolecular membrane, which facilitates the adsorption and well-arranged growth of Te nanowires on grooved sapphire.

High-resolution computed tomography is used to reconstruct and analyse fossils of the herbivorous tritylodontid Polistodon and a newly named morganucodontid species called Camurocondylus, providing key insights into the evolution of the mammalian jaw joint.

Catalytic asymmetric all-carbon-based inverse-electron-demand Diels–Alder reactions are challenging. Now, transition metal catalysts enable formal inverse-electron-demand [4+2] cycloaddition reactions of Morita–Baylis–Hillman carbonates with 1,3-unsaturated compounds to afford chiral cyclohexene derivatives.

East, South, and Southeast Asia are key regions in the dissemination of seasonal influenza viruses, but major perturbations (e.g., pandemics) may disrupt their role. Here, the authors demonstrate the impact of the 2009 H1N1 and COVID-19 pandemics on seasonal influenza circulation and evolution within Southeastern Asia.

Two-dimensional van der Waals ferromagnetic materials can achieve efficient integration with ferroelectric materials. The authors propose a strain-modulation strategy based on multiferroic heterostructure Fe₃GaTe₂/P(VDF-TrFE) to achieve low power operation.