Nature Search

Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis

Cao et al. provide a comprehensive immune landscape of sepsis, delineating anatomical-specific and age-dependent programs.

Qian Ye
Xiaofei Lai
Ju Cao
Research03 Dec 2025
Nature Immunology

Volume: 27, P: 150-165
Mechanisms of rectified gap junctional coupling enhancing pacemaking activity of biologically engineered pacemaker cells

Yacong Li
Jun Liu
Henggui Zhang
ResearchOpen Access12 Jan 2026
npj Systems Biology and Applications

P: 1-13
The evolution of digital twins from reactive to agentic systems

Digital twins are evolving into self-learning, autonomous systems that link models, data and human interaction. Realizing their full potential depends on interoperability, standardization and the integration of artificial intelligence and advanced computational reasoning across sectors.

Omer San
Adil Rasheed
Jun Deng
Comments & Opinion29 Jan 2026
Nature Computational Science

Volume: 6, P: 6-10
Experimental determination of structural motifs of interference-free water undecamer cluster (H₂O)₁₁

Using size-specific infrared spectroscopy and quantum-chemical calculations, structural motifs of interference-free neutral water undecamer (H₂O)₁₁ were characterized, revealing three isomer families and insights into hydrogen-bonding networks essential for understanding solvation processes.

Tiantong Wang
Yang-Yang Zhang
Xueming Yang
ResearchOpen Access13 Dec 2025
Nature Communications

Volume: 16, P: 1-8
Structural basis for pharmacotherapeutic action of triple reuptake inhibitors

Most current antidepressants target SERT and NET but often have limited efficacy or side effects. Here, authors reveal how five triple reuptake inhibitors bind to DAT, offering structural insights to guide development of more effective antidepressants.

Yue Li
Yufei Meng
Yan Zhao
ResearchOpen Access14 Dec 2025
Nature Communications

Volume: 17, P: 1-13
Constructing a prognostic signature of tumor-associated B lymphocytes in hepatocellular carcinoma via machine learning integration

Shengjie Zhang
Jun Qian
Li Jin
ResearchOpen Access14 Dec 2025
Scientific Reports

Volume: 16, P: 1-16
Lung ultrasound B-line quantification in CTD-ILD: a cross-sectional single-center observational study

Mengru Du
Jie Wang
Lingyun Sun
ResearchOpen Access24 Jan 2026
Scientific Reports

P: 1-12
Development and validation of a nomogram prediction model for thyroid dysfunction in patients with type 2 diabetes mellitus

Yinghao Niu
Zhihua Chen
Dan Song
ResearchOpen Access24 Jan 2026
Scientific Reports

P: 1-12
Observation and extended Weiss modeling of multi-step type-II spin switching in Mn doped YbFeO₃

Due to the strong exchange interactions between the rare-earth and iron sublattices, rare-earth orthoferrites, such as YbFeO₃, offer a rich platform for exploring spin dynamics and spin transport phenomena. Here, the authors report multi-step type-II spin switching in Mn-doped YbFeO₃ and investigate the underlying mechanism using an extended Weiss model.

Wanting Yang
Haohuan Peng
Shixun Cao
ResearchOpen Access24 Jan 2026
Communications Physics

P: 1-7
Structure Of Lysozyme: An X-ray Investigation of Lysozyme Chloride Crystals containing Complex Ions of Niobium and Tantalum : Three-dimensional Fourier Plot obtained from Data extending to a Minimum Spacing of 5 Å

R. H. STANFORD JUN.
R. E. MARSH
R. B. COREY
Research22 Dec 1962
Nature

Volume: 196, P: 1176-1178
Subpolar North Atlantic decadal cooling may have aggravated recent Eastern Siberian wildfires

This study shows that the recent escalation of wildfires in Eastern Siberia is primarily driven by a decline in fire-season precipitation, which is likely partially linked to concurrent unforced decadal cooling in the subpolar North Atlantic.

Yuhao Zeng
Jun Wang
Quansheng Ge
ResearchOpen Access24 Dec 2025
Nature Communications

Volume: 17, P: 1-12
Developmental variations in recurrent spatiotemporal brain propagations from childhood to adulthood

Here, the authors show that brain dynamics mature from childhood to adulthood with increased hierarchical propagation and reduced visual-somatomotor dynamics. Top-down hierarchical flow strengthens throughout this developmental period.

Kyoungseob Byeon
Hyunjin Park
Ting Xu
ResearchOpen Access10 Jan 2026
Nature Communications

Volume: 17, P: 1-14
Extreme temperature events reshuffle the ecological landscape of the Southern Ocean

Satellite records reveal that Southern Ocean phytoplankton responds in contrasting ways to marine heatwaves and cold spells. These opposing impacts vary sharply by region, exposing distinct ecological sensitivity to climate-driven extremes.

Zhimin Bai
Lin Deng
Jun Zhao
ResearchOpen Access30 Dec 2025
Nature Communications

Volume: 17, P: 1-12
LorBin: efficient binning of long-read metagenomes by multiscale adaptive clustering and evaluation

Here, the authors present LorBin, an unsupervised long-read metagenomic binning tool that improves recovery of high-quality metagenome-assembled genomes and uncovers new taxa, advancing insights into diverse and complex natural microbiomes.

Wei Xue
Zuo Liu
Zhong Wei
ResearchOpen Access24 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Novel DCAT plans in stereotactic body radiotherapy for stage I/II centrally located non-small-cell lung cancer

Yangyang Huang
Jun Yang
Yibao Liu
ResearchOpen Access14 Jan 2026
Scientific Reports

P: 1-13
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation

This study presents LoopID, which profiles proteins at targeted interacting enhancer–promoter (E-P) pairs, identifying the histone demethylase JMJD2 as a regulator of E-P interactions through biomolecular condensate formation independent of its catalytic activity.

Shaoshuai Jiang
Xinyi Liu
Junjun Ding
Research16 Dec 2025
Nature Genetics

P: 1-14
Ion-selective interface engineering for durable electrolysis of impure water

Electrolysis of dirty water is an attractive route to clean hydrogen, but fluctuating surface pH quickly ruins electrodes. Here, the authors report an ion-selective polymer gate that steadies surface pH, bars harmful ions and lets seawater-fed cells run 1500 h with pure-water durability.

Fei-Yue Gao
Jun Xu
Shi-Zhang Qiao
ResearchOpen Access25 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Nociceptive sensory neuron-derived NGF orchestrates a fibrotic mesenchymal stromal cell neurogenic niche to drive tendon pathological fibrosis

Nociceptive sensory nerves infiltrate the peripheral trauma area, mediating the biased repair response due to the formation of fibrotic mesenchymal stromal cells (MSCs) neurogenic niche. Nociceptive sensory neuron-derived nerve growth factor activates the TrkA receptors in MSCs and triggers the Hif1α-Twist1 pathway, driving the differentiation of MSCs into myofibroblasts to mediate fibrosis. TPX-0005 exerts therapeutic effects by inhibiting TrkA to reverse fibrosis.

Yanhao Li
Sa Pang
Shen Liu
ResearchOpen Access10 Dec 2025
Nature Communications

Volume: 17, P: 1-20
A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice

Rancid odors trigger retching and aversion. Here, authors show a nose-to-brain axis whereby such odors activate olfactory-piriform circuits that diverge to mediodorsal thalamic nucleus and nucleus accumbens to mediate retching-like behavior and aversion.

Wan-Ying Dong
Ping-Kai Cheng
Xia Zhu
ResearchOpen Access03 Jan 2026
Nature Communications

Volume: 17, P: 1-15
Pangenome analyses of tea plants reveal structural variations driving gene expression alterations and agronomic trait diversification

The regulatory roles of structural variations (SVs) in transcriptional networks and agronomic traits of tea plants are largely unexplored. Here, the authors assemble the pangnome from 22 representative tea accessions and their wild relative and reveal SVs driving gene expression alteration and agronomic traits diversification.

Lingling Tao
Junyan Zhu
Chaoling Wei
ResearchOpen Access06 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Parvovirus B19 targets hematopoietic stem cells to disrupt multilineage differentiation and drive pancytopenia

Xu-Ying Pei
Zhuo-Jun Liu
Xiao-Jun Huang
Research28 Jan 2026
Cell Death & Differentiation

P: 1-11
Acceleration of Sinking Rates of Radionuclides in the Ocean

CHARLES OSTERBERG
ANDREW G. CAREY JUN.
HERBERT CURL JUN.
Research28 Dec 1963
Nature

Volume: 200, P: 1276-1277
HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein

Jun Matsumoto
Takayuki Ohshima
Kunitada Shimotohno
Research13 Dec 2004
Oncogene

Volume: 24, P: 1001-1010
Prospective randomized trial of triple port laparoscopic cholecystectomy combined with choledochoscopic common bile duct exploration and primary closure for acute abdominal pain

Xirang Wang
Jian Kang
Zhen Ban
ResearchOpen Access22 Jan 2026
Scientific Reports

P: 1-7
Significance of Induced In Vivo Synthesis of Diphosphopyridine Nucleotide

LOUIS SHUSTER
THOMAS A. LANGAN jun.
ABRAHAM GOLDIN
Research23 Aug 1958
Nature

Volume: 182, P: 512-515
A paraventricular hypothalamic control of social stress susceptibility by targeting brown adipose tissue β3 adrenoceptor

Brown adipose tissue β3AR plays a functional role in regulating susceptibility to social stress, which is controlled by neural inputs from the paraventricular hypothalamus.

Xinyu Du
Jin Zhang
Zhou Wu
ResearchOpen Access23 Jan 2026
Communications Biology

P: 1-13
Reconstruction of temperature, precipitation, and identification of extreme climate events in high mountain Asia over 500 years using multi-method EnKF

Jun Zhou
Feng Chen
Shiyin Liu
ResearchOpen Access17 Jan 2026
Scientific Reports

P: 1-14
In vitro Malignant Transformation of Cells by Friend Virus

T. OSATO
E. A. MIRAND
F. PRICE
Research01 Feb 1966
Nature

Volume: 209, P: 779-782
Effect of Acridine Orange on Living Bull Spermatozoa

C. VAN DUIJN JUN.
Research17 Sept 1960
Nature

Volume: 187, P: 1006-1008
Evaluation of large language models for diagnostic impression generation from brain MRI report findings: a multicenter benchmark and reader study

Ming-Liang Wang
Rui-Peng Zhang
Yue-Hua Li
ResearchOpen Access22 Jan 2026
npj Digital Medicine

P: 1-14
Transatlantic Migration of Juvenile Sooty Terns

W. B. ROBERTSON jun
Research17 May 1969
Nature

Volume: 222, P: 632-634
Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

Extrachromosomal circular DNAs (ecDNAs) are prevalent in human cancers and are thought to drive tumor evolution and drug resistance by amplifying oncogenes. Here, authors develop ec3D to reconstruct three-dimensional ecDNA structures, revealing how their spatial organization rewires regulatory circuits.

Biswanath Chowdhury
Kaiyuan Zhu
Vineet Bafna
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 17, P: 1-20
Versatile cardiovascular signal generation with a unified diffusion transformer

UniCardio is a unified framework for versatile multimodal cardiovascular signal generation, enabling robust signal restoration and cross-modal translation to detect abnormal conditions and estimate vital signs in real-time health monitoring.

Zehua Chen
Yuyang Miao
Jun Zhu
Research29 Dec 2025
Nature Machine Intelligence

Volume: 8, P: 6-19
Synthesis of incommensurate moiré structures with short-range-ordered charge density modulation

Moiré structures often exhibit long-range order. Here, the authors use scanning tunneling microscopy to identify an incommensurate moiré structure with a short-range-ordered charge density modulation.

Hui Guo
Zihao Huang
Hong-Jun Gao
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-9
Transferrin-phosphatidylserine liposomes target TDP-43 and neuroinflammation in male mice with neuropathic pain

Neuropathic pain is driven by chronic neuroinflammation involving dysfunction of microglia and astrocytes. Here, the authors develop nanoparticles that block TDP-43 aggregation and suppress glial activation via the cGAS-STING pathway in a mouse model, highlighting a promising therapeutic strategy.

Yingxin Liu
Yue Wu
Jiamin Miao
ResearchOpen Access12 Dec 2025
Nature Communications

Volume: 16, P: 1-20
Diffusional dynamic process of irreversible ferroelectric to antiferroelectric phase transition and the rate limit

The authors reveal that the ferroelectric to antiferroelectric phase transition in Pb(Zr_0.97Ti_0.03)O₃-1wt%Nb₂O₅ at low temperatures is an irreversible process exhibiting relaxation behavior and diffusional kinetics.

Mingyue Ge
Bing Han
Zhipeng Gao
ResearchOpen Access31 Dec 2025
Nature Communications

Volume: 17, P: 1-11
RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.

Shivendra Singh
Jie Fang
Jun Yang
ResearchOpen Access17 Sept 2025
Nature Communications

Volume: 16, P: 1-26
A brain-to-small intestine circuit mediates morphine-induced constipation in male mice

Neural mechanisms mediating opioid-induced constipation are not fully understood. Here authors find that morphine-induced constipation is mediated by a neural circuit from the paraventricular nucleus of hypothalamus to the dorsal motor nucleus of the vagus, and subsequently to the small intestine in male mice.

Jun Ma
Xiaoqi Peng
Peng Cao
ResearchOpen Access23 Dec 2025
Nature Communications

Volume: 17, P: 1-16
Metabolic syndrome promotes endometrial cancer by Oleic acid-mediated polyamine accumulation

Metabolic syndrome (MS) is associated with enhanced risk to develop endometrial cancer (EC). Here, the authors show that oleic acid, increased in MS, promotes endometrial cancer by supporting the stability of the rate-limiting enzyme in polyamine metabolism ODC1 and polyamine accumulation.

Lirong Zhai
Yuan Cheng
Jianliu Wang
ResearchOpen Access16 Dec 2025
Nature Communications

Volume: 17, P: 1-22
Clearance of Particulate Matter from the Tracheobronchial Tree in Patients with Tuberculosis

HENRY N. WAGNER jun.
VINCENT LOPEZ-MAJANO
JAMES K. LANGAN
Research16 Jan 1965
Nature

Volume: 205, P: 252-254
Adsorption of Polar Compounds on Amorphous Boron

J. S. GILLESPIE jun.
M. C. HOBSON jun.
HELEN M. GAGER
Research08 Oct 1966
Nature

Volume: 212, P: 137-139
Double training promotes retinotopic transfer of category learning

Jun-Ping Zhu
Xin-Yu Xie
Jun-Yun Zhang
ResearchOpen Access08 Jan 2026
npj Science of Learning

P: 1-10
The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD

Using human iPSC-derived motor and cortical neurons as well as Drosophila models, the authors have identified a dysregulated Ku80–p53–SIRT1 axis downstream of DNA damage repair as a common pathogenic mechanism in both sporadic ALS and familial FTD.

Yong-Woo Jun
Soojin Lee
Fen-Biao Gao
ResearchOpen Access20 Dec 2025
Nature Communications

Volume: 17, P: 1-12
Robust spin-qubit control in a natural Si-MOS quantum dot using phase modulation

Takuma Kuno
Takeru Utsugi
Hiroyuki Mizuno
ResearchOpen Access21 Jan 2026
npj Quantum Information

P: 1-8
Sharp subthreshold switching in interface-modified organic electrochemical transistors for millivolt-level signal sensing

Hanyu Sun
Masaki Ishii
Yu Yamashita
ResearchOpen Access07 Jan 2026
npj Soft Matter

Volume: 2, P: 1-6
Analysis of the risk of metachronous colorectal cancer and long-term prognosis in patients following gastrectomy for gastric cancer

Jun He
Bixian Luo
Weihua Gong
ResearchOpen Access24 Nov 2025
Scientific Reports

Volume: 15, P: 1-9
AP-1: a double-edged sword in tumorigenesis

Robert Eferl
Erwin F. Wagner
Reviews01 Nov 2003
Nature Reviews Cancer

Volume: 3, P: 859-868
Breathing mode in Nd-CoO_x for active and stable proton exchange membrane water electrolysis

Proton-exchange-membrane water electrolysis is crucial for advancing the green-hydrogen economy but is limited by the use of precious-metal catalysts. Here, the authors report a Nd-CoOx catalyst in which Nd confers long-term stability via a flexible atomic “breathing mode.”

Yong Feng
Jianhua Wang
Jun Zhong
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-12
Oxyanions stabilized low-coordinated nickel species for efficient and durable nucleophilic electrooxidation

Nucleophilic oxidation in electrosynthesis is hindered by slow dehydrogenation and the competing oxygen evolution reaction (OER). Here an oxyanion-stabilized low-coordinated Ni catalyst suppresses OER and Ni over-oxidation, enabling co-production of H₂ and valuable organic compounds.

Xiaokang Liu
Chengxiang Shi
Ji-Jun Zou
ResearchOpen Access18 Dec 2025
Nature Communications

Volume: 16, P: 1-12
Nanoarray-fortified ultra-durable nanofiber membrane via sequential crystallization

Polymeric nanofiber membranes are hindered by low mechanical strength and stability, especially under harsh conditions. Here, the authors report an approach to simultaneously enhance the tensile strength, stability and hydrophilicity by sequentially crystallizing covalent organic frameworks and poly(ether-etherketone).

Xiquan Cheng
Mi Zhou
Lu Shao
ResearchOpen Access19 Dec 2025
Nature Communications

Volume: 17, P: 1-9

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