Search

This work develops an atomic-level coordination engineering strategy that strengthens key intermediate adsorption to promote C–C coupling, enabling highly selective photocatalytic CO₂ conversion to ethylene.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Seed size plays an important role in determining soybean yield. Here, the authors report GmSW17, encoding a homolog of Arabidopsis UBP22 that plays a role in deubiquitination, as a positive regulator of soybean seed width and seed weight through inhibition of the G1-to-S transition by interacting with GmSGF11 and GmENY2.

Metastatic cancer cells rely on metabolic flexibility to survive. Here, the authors show that metastatic breast cancer cells use lactate for mitochondrial oxidation via the CD147/MCT1/LDHB complex to sustain stemness and promote metastasis.

Insertion of a long DNA sequence into the host genome is challenging in mammalian cells. Here, the authors develop a recombinase (Redα/β)-enhanced DNA integration approach, which enables efficient and precise kilobase-scale DNA insertion in both primary cells and mouse embryos.

The chemical complexity of post-consumer ‘mixed’ plastic waste limits its use as a feedstock for biomanufacturing. Here the authors combine transition-metal-free plastic deconstruction with a microbial consortium platform to upcycle real-world mixed plastic waste into value-added chemicals.

Here authors show loss of AKAP11, a strong genetic risk factor for bipolar disorder and schizophrenia, disrupts PKA proteostasis and signaling, leading to widespread transcriptomic alterations across the brain, particularly in striatal neurons, as well as altered behavior.

Shoot branching is critical in determining soybean yield. Here, the authors report natural variation of Dt2 in controlling soybean branching number and the interaction of Dt2 with GmAgl22 and GmSoc1a to activate transcription of GmAp1a and GmAp1d.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

This study provides prognostic models for clinical translation and reveals methylation biomarkers and mechanisms of CAD adverse outcomes.

This study reports a conjugated polymer photocatalyst, TPM-DADK, that enables light-driven hydrogen peroxide production via stable ketyl radicals, achieving efficient electron storage and dynamic exfoliation for enhanced solar-to-chemical conversion.

Based on an immunogenicity screen of monkeypox virus (MPXV) surface proteins, the authors develop an mRNA vaccine with 12 antigens, which they combine with T cell epitope-rich regions to achieve protection through coordinated activation of humoral and cellular immune responses.

The mitochondrial membranes present a formidable barrier to the delivery of exogenous genes. Here, the authors report on the development of fluorinated lipid nanoparticles to efficiently introduce therapeutic genes into mitochondria, for the correction of mitochondrial genomic defects.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondria-enriched extracellular vesicles, which offer high-quality, abundant mitochondrial material for transplantation.

Tertiary lymphoid structures (TLS) within the tumour microenvironment are important for prognostic and immunotherapeutic indications in cancer. Here the authors use a spatial and single cell transcriptomics analysis of gastric cancer (GC) samples and show transcriptomic differences grouped by types of TLS and generate a prognostic transcriptomic signature to help predict outcome in GC patients.

The authors integrate single-cell transcriptomic data with prior gene graphs to produce a biologically meaningful cell state manifold that can predict driver genes for genetic perturbations and differentiation events across diverse cell types.

Lu et al. characterize cis-regulatory element dynamics at different stages of colorectal cancer progression and identify a functional variant associated with increased colorectal cancer risk because of selective transcription factor binding.

Here, based on single-pass intestinal perfusion platform, the authors establish a microbiota-based drug permeability screening framework to compare perfusion and metabolomic profiles of 32 orally administered drugs in germ-free rats, and show that increased permeability of N-Acetylcysteine is mediated by cysteine-3-ketosphinganine of Bacteroides.

It is uncertain how much life expectancy of the Chinese population would improve under current and greater policy targets on lifestyle-based risk factors for chronic diseases and mortality behaviours. Here we report a simulation of how improvements in four risk factors, namely smoking, alcohol use, physical activity and diet, could affect mortality. We show that in the ideal scenario, that is, all people who currently smokers quit smoking, excessive alcohol userswas reduced to moderate intake, people under 65 increased moderate physical activity by one hour and those aged 65 and older increased by half an hour per day, and all participants ate 200 g more fresh fruits and 50 g more fish/seafood per day, life expectancy at age 30 would increase by 4.83 and 5.39 years for men and women, respectively. In a more moderate risk reduction scenario referred to as the practical scenario, where improvements in each lifestyle factor were approximately halved, the gains in life expectancy at age 30 could be half those of the ideal scenario. However, the validity of these estimates in practise may be influenced by population-wide adherence to lifestyle recommendations. Our findings suggest that the current policy targets set by the Healthy China Initiative could be adjusted dynamically, and a greater increase in life expectancy would be achieved.

Rab5 GTPases deliver RopGEF8 from endosomes to the pollen plasma membrane, establishing polarity for germination. This crosstalk between trafficking and signalling GTPases is crucial for the reproductive success of flowering plants.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Researchers demonstrate all-collinear antiferromagnetic tunnel junctions achieving up to 75% magnetoresistance through van der Waals interface effects, enabling spintronics with layer-tunable volatile or non-volatile behavior.

Hydroxysafflor yellow A, a quinochalcone di-C-glycoside, is clinically used for acute ischemic stroke. Here, authors elucidate its biosynthetic pathway, revealing that CtCGT and Ct2OGD1 coordinately catalyze di-C-glycosylation and dearomatization in the final step.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Membranes selective to ions of the same charge are sought for water waste processing and valuable element recovery. Here authors show that ions intercalated into vermiculite laminate membranes become effectively unexchangeable, creating stable channels that exhibit robust and tuneable ion selectivity.

Convenient and sustainable photoactivated room temperature phosphorescent (RTP) materials exhibit great potential in a wide ranging of applications but are difficult to obtain. Here the authors develop a photoactivated RTP materials by covalently attaching lignin to polylactic acid.

The complete biosynthetic pathway of Prim-O-Glucosylcimifugin and 5-O-Methylvisamminoside in Saposhnikovia divaricata is resolved and their de novo biosynthesis is reconstructed in Nicotiana benthamiana leaves. The evolutionary mechanisms of furochromone biosynthesis among Apiaceae plants is further analyzed.

How RNA polymerase II transcription of tandemly repetitive satellite DNAs is regulated is poorly understood. Here, the authors identify Topoisomerase I as an evolutionary key regulator for satellite DNA transcription under both normal and DNA double-stranded break conditions.

Quantum dots with a fine size dispersion offer attractive levels of functional control and manipulation. In this study, Yang et al. report an environmentally friendly top–down synthesis technique, based on laser irradiation of a polydisperse of lead sulphide nanocrystals.

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with C. difficile infection. Here, Tian et al. show that several TcdB subtypes do not recognize the established FZD receptors, and identify a different host protein (TFPI) as a receptor for subtypes TcdB4 and TcdB10.

Combining expansion microscopy (ExM) with lightsheet imaging can enable fast 3D visualisation of biological structures at high-resolution, but such approaches can be hindered by several limitations. By using potassium acrylate-based hydrogels, the authors perform large-volume ExM with Bessel lightsheet microscopy, achieving high-resolution imaging of cellular structures within the fly brain.

The rapid expansion of agricultural irrigation raises concerns about exacerbating water scarcity, but land–atmosphere interactions are often overlooked. This study isolates irrigation impacts from other drivers using a multi-model framework to reveal that historical irrigation expansion substantially reduces net atmospheric water influx, intensifying drying trends and accelerating terrestrial water storage depletion, urging immediate mitigation strategies.

Spider-silk-mimicking microfibers often suffer from low efficiency and durability in water collection. Here, the authors fabricate robust microfibers with spindle cavity-knots and different topological fiber-networks with improved water-collecting performance

Here, the authors report that SARS-CoV-2 M protein interacts with host ARF1 to facilitate viral assembly at the ER-Golgi intermediate compartment and demonstrate that targeting ARF1 or its interaction with the M protein disrupts virus production in vitro and in vivo, proposing a potential broad-spectrum therapeutic approach.

Palladium-catalyzed β-carbon elimination for selective synthesis of diverse heterocyclic skeletons has been a persistent challenge. Here, the authors achieve switchable chemoselective synthesis of C4-carbamoylated indoles and C10-aminophenanthridinones by controlling β-carbon elimination using chlorocarbamates.

The ongoing uncoordinated emission abatement of anthropogenic volatile organic compounds and NO_x has increased condensable oxygenated organic vapor concentrations and in turn promoted atmospheric new particle growth in Beijing.

The molecular mechanisms that regulate postnatal termination of neurogenesis remain poorly described. Here authors report Prdm16 deletion leads to the retention of radial glia in adulthood and prolonged postnatal neuroblast production.

Embryo development is critical to seed development and grain yield in rice. Here, the authors show that mutation of brassinazole-resistance 4 (OsBZR4) cause embryoless phenotype with the possible involvement of auxin signaling and the penetration of the phenotype depending on genetic background and temperature.

The decarbonization of energy systems requires access to minerals that are critical for manufacturing low-carbon technologies. Here researchers show that meeting climate targets could be impeded by material shortages, revealing the importance of diverse solutions that balance mitigation, equity and resource constraints.

Brain glucose induces in vivo tolerance of Cryptococcus neoformans to amphotericin B, limiting fungicidal efficacy against meningitis in a mouse model, and aureobasidin A inhibits brain glucose-induced tolerance, improving therapeutic outcome.

Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show early-life exercise in mice extends healthspan, though it does not affect lifespan.

Two new methods, target chromatin indexing and tagmentation (TACIT) and combined TACIT (CoTACIT), enabled single-cell profiling of the epigenome and lineage tracing from mouse zygotes to blastocysts.

Serotonin is important in depression-like behavior. Here the authors show that dorsal raphe neurons that project to the ventral tegmental area are involved in regulating stress responses in mice.

Gao and colleagues report a structure-guided chimeric antigen based on the A35 and M1 antigens of the mpox virus (MPXV) that induces strong MPXV-specific antibody responses and protection against lethal doses of vaccinia virus in mice.

Despite the importance of G-protein-coupled receptors in many cellular functions, their intracellular organisation is largely unknown. The authors identified periodically repeating clusters of cannabinoid receptor 1 hotspots within neuronal axons that are dynamically regulated by CB₁ agonists.

Partial oxidation of methane to value-added C₁ products remains challenging due to the favorable formation of fully-oxidized CO₂. Here, the authors show supported B₂O₃ catalysts with tri-coordinated BO₃ units as the active site are highly selective in oxidizing methane to HCHO and CO.

Chemodynamic therapy (CDT) uses Fenton chemistry to covert hydrogen peroxide in cancer cells to toxic hydroxyl radicals, but endogenous hydrogen peroxide is insufficient to drive sustainable CDT. Here, the authors report a water oxidation CoFe Prussian blue nanoframe to provide sustained, external energy free self-supply of hydroxyl radicals for CDT.