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Reconciling broad substrate generality with high enantioselectivity remains a core limitation of enantioselective catalysis. In this study, the authors design a new-to-nature photoenzyme that unlocks enzymatic deracemization of structurally diverse allenes, an entropically disfavored process inaccessible to natural biocatalysts.

Distributed multiparameter quantum metrology allows to probe multiple spatially distributed parameters across networked quantum systems. Here, the authors demonstrate distributed multiparameter quantum metrology in a modular superconducting quantum processor network.

Dearomatization offers a route towards three dimensional spirocyclic architectures, which are essential in bioactive molecules and pharmaceuticals, but biocatalytic dearomatization for obtaining these spirocyclic frameworks is underexplored. Here, the authors report a photoenzymatic platform synergizing visible-light activation with engineered nicotinamide-dependent ketoreductase catalysis to achieve highly enantioselective dearomative spirocyclization of N-hydroxyphthalimide esters.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after injury.

Graphene film-based metamaterials are applied for polarization manipulation of electromagnetic shielding effectiveness, achieving high performance in polarization sensitivity, full polarization shielding, and switching efficiency.

Adsorbate-mediated strong metal–support interaction is important but mechanistically hard to tune. Facet-resolved Ni/TiO₂ reveals adsorbates trigger and stabilise TiO_2-x overlayers, allowing CO vs CH₄ selectivity control via interfacial electronic effects.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

The treatment of lung cancer with checkpoint inhibitors is limited by the emergence of complications, including immunotherapy-induced pneumonitis (CIP). However, the immunological changes accompanying CIP are poorly characterized. Here, the authors perform single-cell analysis of CIP samples isolated from lung cancer patients and identify IFNγ-producing CD8 Tissue-resident T cells, IgG isotype class switching in B cells, and GSDME-mediated macrophage pyroptosis as central players in CIP.

Squeezed states are key resources in quantum technologies, but generating high squeezing usually requires strong nonlinearity. Here, the authors propose and demonstrate a displacement-enhanced squeezing approach that uses weak Kerr nonlinearity and off-resonant driving to generate and amplify squeezing inside a superconducting microwave cavity, reaching 14.6 dB of intracavity squeezing.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

This study shows that the transcriptional targets of NANOG recruits UTP15 to gene promoters in mESCs. There, UTP15 supports the formation of Pol II condensates, thereby activating pluripotency gene transcription independently of its classic role.

DNA is a transformative storage medium, but flexible encoding and secure encryption remain challenging. Here, the authors present a DNA condensate-based system capable of writing, erasing, rewriting, replicating, and repairing information, while supporting versatile encryption.

Acetylene hydrochlorination produces polyvinyl chloride (PVC) precursors but relies on toxic Hg-based catalysts. Here a Hg free cascade system is used to electrochemically generate C₂H₄ and Cl₂ and thermocatalytically convert them into high-purity PVC precursor with near-complete C₂H₂ conversion.

Authors report the assembly of the haplotype-resolved and telomere-to-telomere genome of a key rubber tree variety and uncover major structural variations. It is also revealed that jasmonic acid enhances rubber yield by activating the mevalonate pathway during tapping.

Silicon solar cells with hybrid interdigitated back contacts have a power conversion efficiency approaching 95% of the theoretical limit and a fill factor approaching 98% of the theoretical limit.

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

Ethanol steam reforming (ESR) promises green H₂, but tangled networks hide controlling intermediates. In-situ SVUV-PI-MBMS with DFT/microkinetics on Ni/La₂O₃ pinpoints vinyloxy (CH₂CHO), not acetyl, as the chain carrier, steering most flux and redefining ESR mechanisms.

Chiral 1,2-diamines are useful chemicals used as ligands in asymmetric catalysis. Here, the authors report a copper(I)-catalyzed asymmetric α-addition of ketimines derived from trifluoroacetophenone and 2- or 4-NO2-benzylamines to aldimines, affording a series of chiral anti-1,2-diamine derivatives.

Monolayer amorphous carbon (a-C) has attracted attention due to its structural and electronic properties, but its synthesis has so far required the use of metal substrates. Here, the authors report the Te-assisted growth of large-scale 2D a-C patterns on various insulating substrates, confirming their insulating properties in quantum tunnelling devices.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

This work describes FX-Cell and its derivatives to achieve single-cell RNA sequencing from challenging and cryopreserved plant tissues, expanding the scope of single-cell genomics across field-grown samples.

Yuan et al. present S2-omics, an end-to-end workflow that automatically identifies regions of interest in histology images to maximize molecular information capture in spatial omics experiments.

This study identifies TriDTCs as a family of terpene cyclases responsible for harzianol I and wickerol A biosynthesis in Trichoderma fungi and are found to regulate Trichoderma’s chlamydospore and Aspergillus oryzae’s sclerotia formation through producing harzianol I.

Glioblastoma stem cells (GSCs) contribute to tumor recurrence and resistance to therapy. Here, the authors show that ICAM1 enhances GSC stemness and promotes immune evasion through the β-catenin/PD-L1 signaling pathway.

Low-frequency quasiperiodic oscillations in X-ray data are thought to trace the accretion flow in X-ray binaries. Here, the detection of 200 keV oscillations probes the innermost regions of MAXI J1820+070, revealing the precession of a small-scale jet.

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Metabotropic glutamate receptor 4 (mGluR4) is a neurotransmitter receptor receiving signals from the central nervous system. Here authors show a non-neuronal, tumour-autonomous role for mGluR4 in suppressing dendritic cell maturation and function in multiple murine cancers, and that inhibiting mGluR4 chemically by Forskolin or via genomic deletion enhances the immune response against tumours.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.