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CRISPR–Cas tools enable genome regulation but are often too large for efficient AAV delivery. Here, authors engineer a compact enhanced TnpB–ωRNA system (enTnpB) as a versatile genome regulation platform and develop a single-AAV regimen, ImmunAct, to activate endogenous cytokines and enhance cancer immunotherapy.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

MicroRNAs are promising disease biomarkers, yet accurately measuring them remains challenging. Here, the authors develop SE-SPTM-PCR, a method which improves sensitivity 100-fold and eliminates false signals, showing improved diagnostic performances for cancer and viral reactivation.

Chern ferromagnetism is established in twisted bilayer MoTe₂ devices at large twist angles. Here, the authors observe evidence of antiferromagnetic ground states with zero Hall resistance at an intermediate twist angle around three degrees, demonstrating the sensitivity of the magnetic ground state.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

A MoSe₂ piezocatalyst with lattice strain upcycles wastewater pollutants into value-added chemicals, offering an environmental and energy solution by accelerating carbon reduction and lowering reaction energy barriers.

This study delineates lifespan changes in the sensorimotor-association gradient using multimodal neuroimaging data from 33,247 participants, revealing a pattern aligned with evolutionary, structural, and cognitive hierarchies within a unified neurodevelopmental framework.

The MFS-type tripartite efflux pump EmrAB-TolC mediates resistance to multiple antimicrobial drugs. Here the authors report the high-resolution structure of the EmrAB TolC pump, along with functional data that support a model for one-step drug transport across the entire envelope of Gram-negative bacteria.

Adsorption of trace transition-metal cations endows common Ca/Mg-carbonates and phyllosilicates with catalytic activity for electrochemical CO2 reduction under planetary conditions, potentially promoting prebiotic chemistry and the origin of life.

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

A vapour post-treatment strategy enables fully printed carbon-electrode perovskite solar modules with an area of about 50 cm² and a certified power conversion efficiency of 19.26%. The modules show no performance decay after 1,000 h of continuous operation at 65 °C.

Quantum computers often exhibit a bias in the type of error that is the most common or severe. Entanglement has now been demonstrated for qubits encoded with an error correction code that is designed to efficiently handle biased errors.

Magnetic fields affect astrophysical processes throughout the Universe. This Review explores how the generation, amplification and transport of astrophysical magnetic fields can be investigated in terrestrial experiments, using high-energy-density plasmas generated by intense lasers.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic platform for treating cardiac remodelling and heart failure.

Sweat sensors are important in personalized healthcare using natural oxidase to target biomolecules but these reactions are susceptible to external interference. Here, the authors report tryptophan- and histidine-treated copper metal-organic frameworks which show highly selective activity for ascorbate oxidation and can serve as an efficient ascorbate oxidase-mimicking material in sensitive sweat sensors.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be potentially targeted for improved immunotherapy.

Dong and colleagues report that blockade of T cell-expressed cytotoxic and regulatory T cell molecule results in selective mitigation of immune-related toxicities without affecting antitumor efficacy of immune checkpoint inhibitors.

A photochemical regeneration strategy achieves repeated capture and release of diverse precious metals by integrating a phenol–quinone redox cycle into a nanocarbon aerogel scaffold, offering a practical and sustainable pathway for metal recovery.

Most estimates of air pollutant emissions and associated health burdens from global food systems focus on local food production. By integrating four advanced global models, this study estimates the impacts of food trade and consumption across distant regions.

Improving the elongation of stretchable organic electronics typically increases flexibility at the expense of ductility. Here, authors construct a covalent network, reinforced by silica filler, for improving crack-onset strain and modulus, achieving efficiency of 16.5% for stretchable solar cells.

A chip-less, self-powered electronic patch uses friction-induced electromagnetic waves to achieve wearable motion sensing and long-range wireless communication.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Pei et al. overcome desorption of passivating molecules under photothermal stress in wide-bandgap perovskites and achieve perovskite/Cu(In,Ga)Se₂ tandem solar cells with a certified efficiency of 27.35%.

Solid additives are typically used for improving morphology and efficiency in organic solar cells (OSC). Here, the authors present 3-AR, which optimizes the active layer morphology in all-small-molecule OSCs through selective interactions, achieving a PCE of 18.43% (certified 18.16%).

Formamidinium lead iodide perovskite holds promise for high-efficiency solar cells, but the kinetic instability of its α-phase crystallization remains an issue. He et al. report a strategy for directing the crystallization process in a n-i-p architecture and champion power conversion efficiency of 26.18%.

Analysis of embryo metabolites offers a promising non-invasive strategy for assessing preimplantation developmental potential. Here, the authors report a capillary-driven chemiluminescence microfluidic device equipped with three electrowetting valves that enables quantification of glucose, lactate and pyruvate from as little as 3 μL of spent blastocyst culture medium.

Zhuang, Zi et al. identify cyclin-dependent kinase 3 (CDK3) as a driver of neuron loss in Alzheimer’s disease that is associated with brain atrophy and memory decline in mice. Inhibition of CDK3 (BMX330) is shown to limit neuronal loss and improve cognition.

Two phase 2 trials, along with translational analysis of prospective cohorts and experimental analysis, indicate that immunosenescence as a mechanism of resistance to immunotherapy can be overcome with the senolytics dasatinib and quercetin in patients with head and neck squamous cell carcinoma.

Here they show that mitochondria-localized NEK7 couples mitochondrial complex II subunit SDHB to maintain the homeostasis of electron transport in hepatocytes, thereby impeding the progression of liver fibrosis.

Yin et al. report linear conjugated polymer donors with chlorinated backbone for modulating polymer aggregation and surface tension, and optimised compatibility with norfullerene acceptors. By using binary blends, a 20.42% efficiency is achieved for organic solar cells.

The rapid degradation during operation of perovskite solar cells may be caused by the limited durability of passivation by ammonium-terminated ligands. Here, the authors reveal the depassivation mechanism of perovskites induced by violet/ultraviolet light, validated in cells with 26.44% efficiency

Broad-spectrum host restriction factors against bacteria and viruses remain largely unclear. Here, the authors identify the small GTPase Rab14 as a restriction factor that promotes lysosomal acidification by delivering the V-ATPase to lysosomes.

LipoID profiles lipid droplet interactions and identifies interorganelle regulators.

Machine learning models using PacBio kinetic signals enable high-sensitivity detection of dZ-DNA and single-nucleotide A/Z base calling to explore the biological roles and biotechnological potential of 2,6-diaminopurine.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Xiaolu et al. evaluate the efficacy and safety of eribulin plus gemcitabine treatment for HER2-negative metastatic breast cancer patients. The combination treatment is effective in patients with HER2-negative metastatic breast cancer needing second-line or later treatment and has a predictable, manageable side effect profile.

A microwave quantum network that uses a 4-K-thermalized niobium–titanium transmission line provides coherent coupling between 2 superconducting qubits with a quantum state transfer process fidelity of 58.5% and a Bell entanglement fidelity of 52.3%.

AIaided diagnosis is an exciting area of cancer research, however, large scale training is limited by the availability of imaging datasets. Here, the authors develop FreeTumor as a generative AI framework to develop realistic tumor images for clinical application.

‘Ultrathin’ gold interlayers are shown to form nanoparticles that balance optical losses and electrical contact, enabling efficient perovskite–perovskite integration for scalable and durable triple-junction photovoltaics.

Viruses such as EBV use various mechanisms to avoid antiviral responses. Here the authors propose that the EBV protein BRRF2 is secreted via extracellular vesicles from NPC cells, disrupts the cGAS-STING pathway, reduces cGAS-DNA phase separation and the subsequent antiviral response.