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CLASSIC is a high-throughput genetic profiling platform that combines long- and short-read next-generation-sequencing modalities to quantitatively assess pools of constructs of arbitrary length containing diverse genetic part compositions.

Indigo is an extremely popular molecule in dye industry, however, its use in photochemical transformations is surprisingly scarce. This report explores its photocatalytic activity over an unusually wide excited-state redox window.

In this work, researchers show how laser annealing is used to create complex 2D gradients in magnetic properties, which can steer spin waves and domain walls. This fast, maskless method enables the development of next-generation computing devices.

Urban soils are exposed to numerous human-driven stressors that can interact in unpredictable ways. This study concludes that the impact of adding one factor does not correspond to the impact of removing it from a set of interacting stressors.

Cavity-mediated interactions lead to collective effects and ordering in ultracold atomic systems. Here, the authors demonstrate the interplay of different ordered states of ultracold Fermi gases in a cavity, resulting from an intriguing coexistence of photon coupling with both atoms and atom-pairs.

Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

A widely applicable, cost-effective, easily accessible and handleable, highly active, and recyclable d3-methylation reagent remains has not yet been reported. Here, the authors design a thianthrene-based organic polymer that shows the ability of capturing and releasing a d3-methyl reagent.

By integrating macro-scale and nano-scale experiments that reproduce the seismic cycle, this study reveals that feldspars, very common minerals, reduce the rate at which faults heal after a seismic rupture under certain hydrothermal conditions.

Yang et al. identify RHOA, a GTP hydrolyzing enzyme, as a key regulator of contact sites between mitochondria and the endoplasmic reticulum. It controls contact sites by modulating a tethering complex between the two organelles.

Murphy et al. reveal a unifying pathogenetic mechanism according to which diverse mutations in the muscle-specific ribosomal protein RPL3L cause severe neonatal dilated cardiomyopathy, establishing a framework for interpreting the growing spectrum of RPL3L variants.

Ionizing radiation can cause simultaneous charge noise in multi-qubit superconducting devices. Here, the authors measure space- and time-correlated charge jumps in a four-qubit system in a low-radiation underground facility, achieving operation with minimal correlated events over 22 h at qubit separations beyond 3 mm.

Nitazenes are potent synthetic opioids that are difficult to detect. Here, authors computationally redesign a plant receptor to create sensitive sensors capable of detecting diverse nitazenes and their metabolites in biological samples.

Electron tomography enables high-resolution 3D imaging but is limited by radiation sensitivity. Here, the authors demonstrate a phase retrieval method using multiple tilted HRTEM focal series, achieving 1.6 Å resolution with improved dose efficiency and elemental sensitivity.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Terahertz switches that are based on a zero-change silicon-on-insulator process—and operate through the electrical control of displacement fields and tunnelling currents in the interface between polycrystalline and bulk silicon—can achieve sub-30-ps switching.

How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

The genetic basis of chronic prostatitis/chronic pelvic pain syndrome remains poorly understood. Here, the authors present a multi-ancestry GWAS of this syndrome, identifying eight loci linked with higher risk.

Here, the authors create a high-quality-factor chiral metasurface that enables record-high room-temperature valley-selective emission in MoSe₂ monolayers, independent of excitation polarization.

Tropical cyclone rain rates rise by over 20% in the 60 hours before landfall, which is driven by land–sea thermal and friction contrasts, heightening coastal flood risk. In addition, this enhancement has implications for forecasting and preparedness.

The authors identify flip probability as a universal quantity in random explorations. Here, the authors show it follows a simple inverse law across Markovian, non-Markovian, and real-world systems.

The authors use femtosecond-timed Coulomb explosion to study in real time the bimolecular reaction of a single lithium ion diffusing toward a benzene dimer inside a liquid helium nanodroplet until formation of an ion-molecule complex.

Plant Augmin cryo-EM structures reveal a 40-nm hetero-octameric fork with coiled-coil interfaces, dual CH domains at V-junction switch for microtubule binding and NEDD1 β-propeller binding to the V-junction boosts anti-parallel Augmin dimerization, recruiting γ-TuRC for branch nucleation.

The ~500-metre-thick Prudhoe Dome in northwestern Greenland completely deglaciated 7,000 years ago, highlighting the sensitivity of the ice sheet to mid-Holocene warming, according to luminescence and geochemical data from sub-ice sediments and ice cores.

Core excitons are strongly localised excitonic states impacting x-ray absorption and resonant inelastic scattering (RIXS) spectra. Here, the authors demonstrate an application of free electron laser-driven ultrafast RIXS spectroscopy to study previously unclear aspects of core exciton-phonon interactions in graphite.

The intestinal microbiome is shaped by genetics and environment. Here, the authors show in rats that host genetic effects, including indirect social effects, influence microbiome composition, identify replicated loci, and reveal mechanisms contributing to microbiome heritability.

Peripartum cardiomyopathy (PPCM) is a potentially fatal heart condition with poorly understood molecular causes. Here, the authors show that loss of the protein PTRH2 in female mice leads to postpartum heart failure, identifying it as a potential therapeutic target.

The authors present the results of a phase I/II clinical trial using autologous CD133+ bone marrow stem cell therapy to restore fertility in patients with Asherman Syndrome. The intervention was safe and showed promising results for the restoration of menstruation and reproductive function.

The study presents a generative spike-based framework to re-establish functional connectivity across pathway-damaged brain regions, enabling biomimetic neural prostheses and closed-loop brain stimulation.

Photonic time crystals (PTCs) have unveiled unusual band structures and phenomena due to temporal modulation of optical properties. Here, the authors address non-Hermitian features of PTCs within a purely Hermitian Hamiltonian description, bridging classical and quantum approaches.

The authors show that babies conceived during the COVID-19 pandemic have a different parental socioeconomic composition than expected had the pandemic not occurred.

Reduced GC-related content in the influenza A virus genome may be a necessary condition for sustained mammalian transmission and should be included in risk assessment tools for pandemic influenza.

The authors present scRR-seq, a single-cell multi-omics tool that directly links DNA changes to gene expression and enables simultaneous analysis of DNA replication, DNA copy number variation, and transcription.

In this study, authors employ fragment-based lead discovery to identify WRN inhibitors. The fragment hits reveal an additional allosteric pocket and uncover a previously uncharacterized structural conformation of the WRN helicase domain with unique orientations of the ATPase domains

De novo and inherited dominant variants in genes encoding U4 and U6 small nuclear RNAs are identified in individuals with retinitis pigmentosa. The variants cluster at nucleotide positions distinct from those implicated in neurodevelopmental disorders.

Metagenomics shows that viral diversity and community structure are shaped by geography and ecosystem health status, positioning viruses as unexpected players in peatland restoration.

This combined experimental and theoretical study of a collinear antiferromagnet reveals a large magnetic exchange driven structural shift and non-coplanar domain wall junctions, which exhibit a topological orbital magnetization.

This study shows that historical precipitation variability shapes current and future record-breaking precipitation probabilities, with regions with low current records being more at risk. High-risk regions are abundant around the world, leading to a quarter billion people facing potential precipitation disasters by 2050.

Mechanical recycling of incompatible mixed plastics is challenging, as it often downcycles plastics into brittle materials. Here the authors develop a multi-arm topological universal dynamic crosslinker platform to enable mechanical upcycling of incompatible mixed plastics.

Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through immunoediting.

This study provides new insights into the role of endoglin (ENG) as a co-receptor in endothelial cells and addresses a gap-in-knowledge on how ENG could be involved in both TGF-β and BMP9 signalling. Such knowledge greatly facilitates therapeutic targeting of ENG-related pathways.

Resting human CD56^Dim natural killer cells utilize exogenous pyruvate to support energy metabolism. A new study shows that these cells take up exogenous pyruvate, which regenerates cytosolic NAD⁺ via metabolism to lactate to support glycolysis and fuels oxidative phosphorylation via the mitochondrial citrate–malate shuttle.

Colloidal particles experience capillary interactions at liquid interfaces, but modifying these interactions is challenging as shape change is required. Here, the authors report polymer particles that change shape with polarised light, and therefore create flow patterns with unusual paths.

This research developed and compared firearm-specific and method-agnostic machine-learning models using data from 800,579 Army veterans, revealing that model choice and intervention thresholds impact predictive accuracy and fairness, guiding tailored suicide prevention efforts.

Multi-plane light converters (MPLCs) rely on complex nonlinear design optimisation and are challenging to physically realise with high fidelity. Here the authors develop a self-configuring free-space MPLC for linear optical information processing.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Here, the authors use meta-analysis to examine factors that are associated with the successful inclusion of migrants. They find that the strongest correlates of migrant adaptation are the presence of stressors and the availability of social resources.

Bessler et al. developed a human organoid model for H3.3K27M-altered diffuse midline glioma that recapitulates key tumor features and demonstrated its utility for modeling CAR T cell and microglia functions.