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The electron-phonon coupling in organic semiconductors is key to improving performance for devices. Here, the authors show that modulating the penetrated donor-acceptor interface with low electron-phonon coupling, reduces non-radiative voltage loss for high-performance organic solar cell devices.

Gravitationally induced stratification during self-assembly often leads to density driven vertical segregation limiting the synthesis of metastable nanofilms. Here, the authors address this limitation with an antigravity confined interfacial self-assembly synthesis where capillary forces dominate and enable precise molecular organization resulting in ordered and stable nanofilms.

Here, the authors report an exome-wide association study for multi-organ imaging traits by leveraging recent bioinformatic tools such as AlphaMissense. The identified signals elucidate the genetic effects from rare variants on human organs and their connections to complex diseases

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

The pathophysiologic functions of small nucleolar RNAs (snoRNAs) remain to be studied. Here the authors report that snoRNA SNORA49 suppresses liver cancer stem cell renewal through transcriptional inhibition of the stemness factor SOX9.

Elevated adipocyte-derived AFABP in obesity disrupts iron homeostasis in intestinal stem cells (ISCs), which impairs PPARα signalling and blocks ISC differentiation after injury.

Affordable public housing in Singapore enables intergenerational upward mobility for lower-income families by easing budget constraints. Children of public housing residents have 9.5% higher probability of surpassing their parents’ housing ranks through increased investment in education.

LncRNA P4HA2-AS1 drives renal fibrosis by stabilizing TRIM32 to promote K63-linked ubiquitination of ULK1.

Photon noise fundamentally limits 3D fluorescence imaging performance. Lu et al. proposed LF-denoising, a self-supervised transformer leveraging spatial-angular redundancy for denoising without temporal dependence, enabling high-fidelity intravital imaging.

There is an unmet medical need for endometrial cancer patients with mismatch-repair proficient disease. Here, the authors report the primary analysis of the FRUSICA-1 phase Ib/II trial evaluating fruquintinib plus sintilimab in this population, showing an ORR of 32.7%, a median PFS of 8.6 months, and manageable toxicity.

Researchers have resolved cryo-EM structures of the bacterial TamAB machinery in two distinct states: a non-hybrid and a novel hybrid barrel. These structures suggest each state enables a distinct function, facilitating outer membrane protein folding and phospholipid transport, respectively.

The perceived toxicity of organometallic reagents has limited their use in living systems. Now it has been shown that balancing flexible chelation with biocompatible ligands without precluding chemical reactivity enables organonickel-mediated S-arylation inside cells. This reaction enables deep chemical surveys of reactive proteins and covalent tracking of intracellular viral and bacterial pathogens.

Future development aims to meet hot data storage demands for data modification. Here, authors present a DNA origami nanostructure-enabled linked data storage system that uses distinct DNA origami as data-storing nodes, enabling parallel storage, and supporting data insertion/removal.

A library preparation method using anchored random reverse primer sequencing for quantitative analysis of novel gene fusions from low-input samples.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Insights from surface science studies on model catalysts very often do not translate to practical catalytic systems due to the so-called pressure and materials gaps. Now, a combination of in situ microscopy, spectroscopy and computational modelling is used to bridge the knowledge from surface science and powder catalysts for FeO–Pt during CO oxidation.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

Molecular organometallic catalysts typically struggle to activate only one of two identical C–H bonds in arenes for mono-selective C–H activation. Now mono-selectivity has been achieved for Pd(II)-catalysed ortho- or meta-C–H activations using commercial proteins or designed peptides as ligands.

In this work, authors show that micro- and nanoplastics at environmentally relevant levels promote conjugative transfer of antibiotic resistance genes between bacteria by altering oxidative stress, membrane permeability and energy metabolism.

Candidatus Liberibacter asiaticus promotes ovarian development and mating in Diaphorina citri by upregulating ATPSyn-β, which enhances ATP production, nutrient supply, and vitellogenin entry into ovaries.

Wang et al. propose a 3D meta-holographic zoom micro-projector, integrating a high-resolution metasurface with a tailored liquid lens, resulting in a 3D zoom micro-projector of only 0.18 cm³, small enough to fit on a fingertip.

Climate limits where insects can live and which species can coexist. Using thermal tolerances of 653 moths on Asian mountains, this study shows warmer temperatures broaden thermal tolerance traits diversity; daily variation has little influence, and strong seasonality mildly weakens this pattern.

The regulation of ferroelectric photovoltaic properties has been challenging. Here, authors substitute the p-site of cations with halogen for tuning distortion degree of inorganic layer and electric dipole moment of aromatic spacer, achieving ferroelectric anomalous photovoltaic effect of 38.2 V.

Syntaxin-1A, a SNARE protein mediating membrane fusion for neurotransmission, forms clusters with unclear functions. Using light-controlled clustering, the authors found that phase-separation-driven clusters, regulated by Munc18, suppress fusion, revealing a new phase-separation-based mechanism.

The spatiotemporal relationship between neuromodulator and neurotransmitter dynamics and neuronal activity remains unclear. Here, the authors performed dual-color imaging of calcium and ACh/5-HT signals across the fly brain, revealing a key role of ACh dynamics in stable odor representation.

In this study, the authors present that deep brain stimulation of lateral hypothalamic area activates a hypothalamic-pontine-spinal pathway, promoting locomotor initiation and functional recovery after spinal cord injury in mice.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Environmental Li pollution and health problems have been becoming an important concern worldwide. Here, the authors show that Li exposure causes trophoblast cell ferroptosis and thus induces unexplained miscarriage through a non-canonical MBOAT1 pathway.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

Resistance to KRAS-targeted therapies is a challenge, especially with co-mutations like KEAP1. Here, the authors show that increasing polyamine metabolism enhances KRAS-targeted therapy efficacy but requires also increasing the polyamine-metabolism SAT1 enzyme in KEAP1-mutant context.

T cells have been shown to have a function in chronic lung inflammation in COPD. Here the authors characterise the single cell transcriptional profile of T cells after smoke inhalation in mouse models showing changes in TCR repertoire and Il17a expression in γδ T cells, suggesting smoke-associated γδ T cells are involved in COPD inflammation and implicating γδT17 cells as a possible target for early prevention and treatment of COPD.

Over the past decade, the previously declining trend in coronary heart disease burden has reversed, with a concerning rise among younger populations and growing challenges for prevention. Here, the authors show that addressing modifiable factors could prevent an estimated 40–62% of disease cases.

Growth factor signalling has been shown to alleviate tissue fibrosis and promote repair. Here, the authors use fibroblast growth factor 7 (FGF7) knockout mice and an FGF7-loaded hydrogel to show that this factor can promote functional regeneration of tendon.

Semi-metallic single crystals of antimony can be deposited using molecular beam epitaxy on molybdenum disulfide to create ohmic contacts with resistance of under 100 Ω µm at a contact length of 18 nm.

Previous clinical studies suggested that Insulin-like growth factor binding-protein 7 (IGFBP7) is elevated in early stages of diabetes. Here authors showed tubule and glomerular-specific IGFBP7 promotes diabetic kidney disease.

Immune checkpoint inhibitors have shown promise in tumour immunotherapy but resistance has been seen. Here using pre-treatment hepatocellular carcinoma patient biopsies from patients scheduled for immunotherapy, the authors implicate BCL9 and show that a BCL9-targeting peptide promotes anti-tumour immunity in mouse models through targeting macrophages and promoting anti-tumour T cell responses.

Drought, fires, and human activities have reversed the accumulation of live biomass carbon in the Northern Hemisphere, with total biomass shifting from a positive to a negative trend around 2016.