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Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

The catalytic enantioconvergent N-alkylation of hydrazine derivatives with alkyl halides offers an attractive route to chiral hydrazines, but remains challenging due to the lack of efficient asymmetric catalytic systems and the difficulty in achieving regioselectivity. Herein, the authors report the copper-catalyzed enantioconvergent N-alkylation of hydrazine derivatives with racemic α-haloamides.

Here they establish an NTR-based genetic ablation tool in axolotls to investigate the function of specific cells. They use this system to demonstrate the capacity of ependymoglial cells for central nervous system regeneration.

The function of intermediate epithelial states in pulmonary fibrosis unknown. This study used RNA sensing technology to show selectively removal of alveolar epithelial stem cells trapping in an intermediate state reduced lung fibrosis.

Acne is a common skin disease caused by the anaerobic Cutibacterium acnes. Here, the authors report a microneedles patch loaded with near infrared-driven self-oxygenating ZnO₂@PDA-MnO₂ nanomotors for photothermal therapy of acne.

This study reports graphene–amorphous carbon with interwoven networks, achieving a flexural strength of 203 MPa. Microscopy shows that crack deflection at graphene/amorphous interfaces underlies its superior performance.

A membrane system operating without electricity and inspired by natural fractal transport patterns achieves exceptional nanofiltration performance, offering a simple and reliable source of potable water for decentralized communities.

Bicyclo[2.1.1]hexanes (BCHs), three-dimensional benzene bioisosteres characterized by high sp3-carbon content, hold great promise for diverse applications in medicinal chemistry. Here, authors report a secondary amine–catalyzed asymmetric [2π + 2σ] cycloaddition of bicyclo[1.1.0]butanes (BCBs) with α,β-unsaturated aldehydes.

Efforts to develop P2X7 drugs are hampered by species differences. Here, authors reveal the structural basis for these disparities and show that transgenic mice provide a powerful model for testing selective inhibitors with greater clinical relevance.

Memristor arrays based on molecular crystal with van der Waals-linked cages are fabricated, enabling ultralow energy switching, high endurance and seamless integration into neuromorphic computing hardware.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

PanoSpace enhances low-resolution spatial transcriptomics data to reconstruct continuous tissue maps at single-cell resolution. In cancer tissues and mouse brain, it refines cell localization, identity, gene expression and microenvironmental interactions.

Self-organized growth often suffers from a lack of long-range order in preparing large-area nanostructures. Here, the authors develop a direct electrochemical growth technique for preparing ordered magnetic networks without the use of templates.

Administrative-driven hierarchical management (ADHM) encourages general practitioners to act as voluntary gatekeepers in China’s non-mandatory medical system. Here the authors show that ADHM lowers cardiovascular events, mortality, and healthcare costs in atrial fibrillation patients compared with usual care.

The combination of plasmon-mediated electron enrichment and a continuous-flow reactor overcomes key challenges in selective methane oxidation, achieving a methanol production rate of over 6.5 mmol·g-1·h-1 with the selectivity of 100% and sustained stability over 100 h under ambient pressure.

Li-metal batteries suffer from sluggish kinetics at low temperatures. Here, authors propose a guideline for rational electrolyte solvent screening and design a class of asymmetric ethers, which bestows the Li metal pouch cell with a high specific energy of 345.3 Wh kg⁻¹ over 40 cycles at −40 °C.

Cas9-based genome editing tools face challenges for efficient in vivo delivery due to their large size. Here, the authors present a set of compact genome-editing tools engineered from a CRISPR-associated IscB system which exhibit robust editing efficiency in human cells and mouse embryos.

The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

Stem cells are highly resistant to viral infection, irrespective of any interferon response. Here the authors discover that VAMP5 as a potent cell-autonomous defense factor protects ESCs from various viruses’ infection, including SARS-CoV-2 by interacting with RNA replication complexes to defend against viral infection.

Zhao et al. demonstrate that ZmCRY1s, blue-light receptors in maize, interact with GL2 in blue light to promote C32 aldehyde accumulation thereby modulating epidermal wax composition and enhancing UV-B tolerance, revealing a light-regulated wax biosynthetic mechanism critical for maize stress adaptation.

In this clinical trial, the authors demonstrate that recombinant gE-Fc Fusion Protein Vaccine LZ901 for herpes zoster induces superior cellular immunogenicity and exhibits a better safety profile than HZ/su in adults ≥50 years, supporting its potential as vaccine candidate.

Therapeutic options for patients with renal medullary carcinoma (RMC) are limited. Here the authors report the results of a phase II clinical trial of anti-PD1 nivolumab plus anti-CTLA4 ipilimumab in RMC, associating the activation of a myeloid mimicry program in tumor cells to the rapid disease progression and hyper-progression observed in treated patients.

Confining high-entropy nanoparticles in molecular sieves enhances catalytic performance but lacks scalable synthesis methods. This study presents a versatile quenching strategy, producing uniform HE-NPs@MSs with high propane dehydrogenation activity.

Polar skyrmions are a topological polarization texture. While they have now been detected in numerous material systems, near universally these have required careful strain engineering. Here, Xue, Zhang, Zheng, Tong, Wang and coauthors observe polar skyrmions in the van der Waals ferroelectric CuInP2S6, without strain-engineering.

cAMP export by ABCC4 is critical for localized signaling. Here, the authors revealed that PKA activation drives ABCC4 to the plasma membrane and organizes a PDZ-dependent protein network with actin cytoskeleton and scaffolds, like SCRIB, that stabilize the transporter and optimize cAMP efflux. Furthermore, the authors show that the potent ABCC4 inhibitor Ceefourin 2 disrupts this network, revealing a non-canonical mechanism of ABCC4 inhibition.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Graphene is often used as parts of electrodes in batteries and stacking of graphene layers is problematic. Here, Zhao et al.synthesize graphene on mesoporous layered double oxide flakes so that the stacking is effectively prevented, and show high-rate performance when used in Li–S batteries.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

Allenes are versatile substrates in synthetic chemistry. Now an iron catalyst enables unusual regioselectivity by mediating an electrophilicity reversal of allenes for stereoselective alkenylzincation reactions affording 1,4-diene zinc products.

Wang and colleagues report the clinical results and immunological correlates of a phase 2 clinical trial of cryoablation plus lenvatinib and sintilimab in persons with advanced or metastatic intrahepatic cholangiocarcinoma.

The 64-plex fluorescence imaging of RNA in tissues is achieved in one imaging cycle

It is highly desired to explore cheap, non-toxic transition metals catalysts for semihydrogenation of acetylene. Here, isolated Cu atoms anchored onto a defective nanodiamond-graphene support exhibit robust catalytic performance in acetylene semihydrogenation in comparison with supported Cu clusters.

A reference-quality genome assembly of hexaploid oat variety ‘Sanfensan’ and genome assemblies of its diploid and tetraploid Avena ancestors provide insights into the evolutionary history of allohexaploid oat.

Electrosynthesis of acetate from CO using renewable electricity faces low selectivity. Here, the authors report a cerium single atom modulated copper catalyst, where cerium atoms tailor the interfacial water structure, enabling highly selective CO-to-acetate conversion under pulsed electrolysis.

This study reveals that ion displacement–induced antiferroelectricity in CuBiP₂Se₆ enables polymorphic functionalization, allowing a single device to achieve multilevel conductance and synaptic behavior for energy-efficient neuromorphic computing.

The cryo-electron microscopy structure of the GPR101–Gs complex reveals the mechanism for its constitutive activity and facilitates the screening and identification of GPR101 ligands with rejuvenating potential.

Twisted-stacking MOF patterns with high g_lum (~ 0.4) and tailorable CPL performance by the combination of brush coating, heteroepitaxial growth and twisted-stacking techniques were developed, favoring the application in information encryption.

A hybrid cathode interfacial layer (AZnO-F3N) is developed, delivering 21.0% efficiency along with excellent stability, mechanical robustness and broad versatility, highlighting its potential to advance organic solar cells.

Methods for asymmetric alkyl–alkyl bond formation between sp³-hybridized carbon atoms, C(sp³)–C(sp³), are limited yet highly desirable. Now an approach for asymmetric alkyl–alkyl bond formation by Ni-catalysed cross-coupling between alkenes has been developed to construct tertiary stereogenic carbon centres with head-to-tail regioselectivity and excellent chemo- and enantioselectivity.

Allylic alcohols and ethers are key functional motifs widely found in various bioactive molecules, pharmaceuticals, and natural products. Here, the authors report the synthesis of (E)-allyl ethers from internal alkenes and alcohols or phenols via copper catalyzed selective allylic C–H oxidation.

This work presents a wide-FOV, high-spatiotemporal-resolution LiDAR with astigmatic metalens (AML) coordinated spectral-acousto-optic scanning. A frame-wise point acquisition rate of 36.6 MHz and a FOV of 102° are simultaneously achieved.

Developing skeletal editing tools, especially to realize the single-atom transmutation in a ring system without altering the ring size is challenging. Here, the authors introduce a skeletal editing strategy that enables polycyclic arenols to be readily converted into N-heteroarenes through carbon–nitrogen transmutation.