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The authors investigate the heterogeneity of Toxoplasma bradyzoites prior to recrudescence. Tissue cysts from infected mice harbor multiple bradyzoite subtypes with distinct developmental fates as evidenced by single-bradyzoite RNAseq and FACS.

This study reports that de novo germline missense variants in SF3B1, distinct from the somatic variants frequently observed in cancer, cause a neurodevelopmental disorder and disrupt global RNA splicing.

Lipid nanoparticle based mRNA vaccines are known to induce robust CD4 + T cell responses. Here the authors establish a role of endogenously derived antigen processing in the optimal priming of CD4 + T cell responses to mRNA lipid nanoparticle vaccines.

Cosmological simulations show that tiny black holes that formed from the first stars can grow far faster than expected to become the seeds of the supermassive black holes now observed by JWST at cosmic dawn.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

This study introduces an ion mobility–mass spectrometry method for de novo glycan structure identification, using a self-expanding database that reduces reliance on synthetic reference standards.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Here the authors show that transient cell cycle arrest reprograms CD8⁺ T cells into a highly energized state, increasing proliferation and antitumor activity and boosting efficacy of immunotherapies in cancer models.

Cardiac ryanodine receptors (RyR2) are critical for heart contraction. Here, the authors use 3D MINFLUX microscopy to image receptor subunits and RyR2 orientation with nanometre resolution, thereby providing a molecular view of the organisation and clustering of these cardiac muscle receptors.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

By combining satellite observations with ground-based data and expert validation, this analysis demonstrates considerable misestimation of grassland extent and thereby carbon stock estimates in previous global assessments based on remote sensing.

Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

Bark decomposition could significantly affect global carbon and nutrient cycling. Here, the authors report the global trend of bark decomposition rates, identify the key drivers in different climate regions, and predict the response of bark decomposition to future climate change.

This study finds that native tree extinctions and alien naturalizations are pushing forests towards fast-growing, resource-demanding species. This global shift could affect carbon storage and ecosystem stability, highlighting the need to protect slow-growing trees.

There is a challenge of overestimation in figures of merit for organic electrochemical transistors due to a kink in the transistor current. Here, the authors investigate the origin of the kink and identify the charge transport phenomena that is impacted.

There are limited data on mpox immunity in West Africa. In this study, authors present serological and genomic evidence of residual smallpox vaccination immunity and possibly unrecognized mpox exposure among ostensibly healthy Nigerian adults.

Enhanced performance of offspring compared to their parents is termed heterosis. This study presents a powerful and computationally efficient tool for detecting heterotic quantitative trait loci. Applying it to a large hybrid wheat dataset reveals pervasive cumulative epistatic effects for grain yield heterosis.

MultiSuSiE is an extension of the Sum of Single Effects fine-mapping model that allows causal effect sizes to vary across ancestries. Applying MultiSuSiE to quantitative traits in All of Us identifies fine-mapped variants not implicated by other methods.

This study introduces glassy adhesion dynamics within a motor–clutch framework, revealing the mechanism by which cellular and extracellular timescales interplay and govern anomalous cancer cell migration.

Bacterial flagellar motors switch rotation direction with high sensitivity to environmental inputs. A theoretical model explains how torque-dependent non-equilibrium switching contributes to ultrasensitivity.

How neuron-level interactions produce complex cognitive behavior remains unclear. Here, the authors develop a brain circuit mechanistic model based on physiological computation, that uncovers an unexpected neural code, subsequently validated by empirical data.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Extrachromosomal circular DNAs (ecDNAs) are prevalent in human cancers and are thought to drive tumor evolution and drug resistance by amplifying oncogenes. Here, authors develop ec3D to reconstruct three-dimensional ecDNA structures, revealing how their spatial organization rewires regulatory circuits.

Reported detections of gases in exoplanet atmospheres, including claims of biosignatures on K2-18 b, disappear when broader models are tested, revealing that such detections often reflect modelling limits rather than real signals.

Time-resolved serial femtosecond crystallography at X-ray free-electron lasers is a powerful approach for studying macromolecular dynamics, but its widespread use is limited by high sample consumption. Here, the authors introduce a segmented-droplet mix-and-inject strategy at the European XFEL that reduces sample consumption by up to 97% while preserving the data quality required for time-resolved structural studies of the enzyme NQO1.

u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, including cells with complex morphologies.

piggyBat is the only known DNA transposon active in mammals. Here the authors used cellular assays and 3D structure to show that sequences within the transposon ends restrict activity, and also how transposition activity can be substantially increased.

Here, the authors explore spatially indirect excitons in van der Waals heterostructures and observe long-distance spin transport. The mechanism of protection against the spin relaxation is based on the suppression of scattering.

Small-scale vorticity dynamics are central to turbulence, but their transient and chaotic nature makes direct measurement and control extremely challenging. By using magnetically driven particles, authors uncover stochastic resonance and a symmetry-breaking mechanism that may enable both control of particle dynamics and a magnetic resonance- based method for probing turbulence at its smallest scales.

Topologically protected vortex knots are shown to undergo fusion and fission, with electric pulses acting as a switch between the two processes. This might enable applications in electro-optics and photonics.

Dermatoscopy is a common method to aid in diagnosis of melanoma, however, its utility in predicting metastasis is not fully known. Here, the authors leverage a cohort of 30 dermatologists to develop models to predict prognosis from dermatoscopic images.

A hidden Markov model that uses probabilistic retrospective inference allows for up to one month of unsupervised recalibration in an online cursor-based intracortical brain–machine interface.

Adding tunable photon-photon nonlinearities to programmable photonic circuits would greatly extend their capabilities. Here, the authors demonstrate this by embedding a photonic-crystal waveguide nanostructure hosting an InAs quantum dot within a programmable linear optical circuit, and using it to realise a proof-of-concept quantum simulation of anharmonic molecular vibrational dynamics.

Ultra-fast charging for electric vehicles poses challenges to power grid stability. Here, the authors show that under time-of-use pricing in China, they create sharp demand peaks, and on-site energy storage can worsen the risk.

Rajshekar et al. show that a hierarchy of affinities layers pericentromeric heterochromatin around nucleoli, with the RNA helicase Pitchoune (DDX18) acting as a key dual-affinity linker in Drosophila melanogaster.

Multi-ancestry genome-wide and transcriptome-wide association studies of aortic stenosis identify more than 200 independent risk loci and provide insights into its genetic architecture.

Mirusviruses were detected in metagenomic datasets, but little is known about how they infect their hosts. Here, the authors characterize mirusviruses in the marine protist Aurantiochytrium, detecting virions, viral genes and proteins, and establishing this as a valuable model system.

Wearable data from 7,013 participants in the All of Us Research Program show that park accessibility across 53 US cities is positively associated with daily step counts, providing a mechanism for how urban green space can improve health.

Although CAR T therapy has greatly improved the therapeutic prospects for haematological malignancies, it is not yet widely used for solid tumors, such as prostate cancer. Here, using prostate cancer patient-derived xenografts, the authors demonstrate the efficacy of CAR T cells specific for Lewis Y antigen when combined with low-dose carboplatin.