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Aging is characterised by visceral adipose tissue (VAT) inflammation but the molecular mechanisms driving or inhibiting the VAT-driven processes are not fully known. Here the authors identify BAFF as a soluble mediator in VAT to promote the expansion of regulatory B cells that produce IL-10 to inhibit aging-related inflammation.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Lipid Nanoparticles (LNPs) effectively deliver mRNA to cells but suffer have low levels of endosomal release. Here the authors report on core-shell LNPs with ionizable lipid–coated gold nanoparticle cores with enhanced pH-responsive membrane disruption, endosomal escape, and cytosolic mRNA delivery improving therapeutic efficiency.

The exogenous excitation requirement and electron-hole pair recombination are the key factors limiting the application of catalytic therapies. Here, the authors address these limitations by designing a tumor microenvironment-specific self-triggered thermoelectric nanoheterojunction with a self-built-in electric field that facilitates charge separation for cancer treatment.

This study reveals that during a series of learning tasks, the macaque brain represents the shared (e.g. the decision strategy) and task-unique information (e.g., sensory inputs) in a near-orthogonal manner, thereby supporting reuse of the shared component to facilitate learning, while remain flexible to changes in specifics.

Liquid-based direct air capture relies on natural gas combustion to drive calcination. Here, the authors present a solar-driven hydrogen-fluidized solar calciner integrated with on-site CO₂ conversion to produce sustainable aviation fuel. The analysis shows its economic feasibility.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

The authors discover oldhamite (CaS) in Chang’E-6 lunar soils. Through thermodynamic calculations, the authors suggest a potentially large-scale, high-energy impact event with an S-rich asteroid or involving lunar S-rich mantle-core excavation to be responsible for the formation of oldhamite.

Endogenous triggered delivery of antibiotics over an external triggered delivery has distinct advantages. Here, the authors report on a nanoreactor triggered by bacterial toxin to trigger a drug release mechanism and capture the toxin for reduced toxicity of toxins and improved immune response.

Cryo-electron microscopy structures of two PSII intermediates from psbV-deletion and wild-type strains of cyanobacteria show substantial structural changes. These provide a structural basis for understanding the assembly process of native PSII.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

RegIIIα is an antibacterial protein that forms hexametric pores on Gram-positive bacterial membranes leading to cell lysis, however, hexamers can further assemble into filaments diminishing RegIIIα activity. Here, the authors use cryo-electron microscopy to reveal the 2.2 Å structure of RegIIIα filaments, uncovering a distinct subunit orientation and key interfaces for RegIIIα assembly, proposing the inhibitory mechanism of the pro-segment of RegIIIα.

Thymine DNA glycosylase (TDG) was identified as a synthetic-lethal target in p53-deficient cancers through alterations in double-stranded RNA accumulation. A covalent small-molecule inhibitor of TDG exhibited potent efficacy against p53-deficient tumors.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Exemplified by Bi_0.4Sb_1.6Te₃, the authors reveal the reason for low thermal conductivity induced by compositional inhomogeneity lies in randomly aligned edge dislocations induced by random composition distribution.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Han et.al. report the isolation and characterization of two neutralizing antibodies, C34 and C37, from a convalescent CHIKV patient. These antibodies demonstrate in vitro and in vivo efficacy against Chikungunya virus by targeting an epitope on the E2 protein and blocking the Mxra8 receptor.

Sequencing of 144 ancient genomes from Shimao city and its satellites presents pedigrees among tomb owners spanning up to four generations showing predominantly patrilineal descent structure across Shimao communities, and possibly sex-specific sacrificial rituals.

MATTERIX, a multiscale graphics processing unit-accelerated framework for high-fidelity digital twins and workflows of chemistry laboratories, is presented, simulating robot and device operation, fluids and powders, and processes such as heat transfer and chemical kinetics.

IRF3 initiates type I IFN transcription, and this is required for host defense. Here, Chen and colleagues show that RAD18 terminates the transcriptional activity of IRF3 and subsequently promotes the autophagic degradation of IRF3.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

Organic solvent nanofiltration is a promising alternative to existing energy-intensive industrial separation processes but it requires suitable membranes. Here a chemically and mechanically robust conjugated polymer framework membrane is designed for efficient molecular-sieving separations.

Ancient DNA can reveal evolutionary and demographic history of a region. Here, the authors analyze ancient human DNA from ShanDong, China to reveal two waves of gene flow from Yellow River populations in the DaWenKou (6-4 kBP) and early dynastic (3.5-1.5 kBP) periods.

SpatialZ generates virtual single-cell spatial transcriptomics slices between experimentally measured sections, enabling accurate and efficient building of 3D cell atlases of different tissues.

Developing photocatalysts from earth-abundant materials is crucial for sustainable solar hydrogen production, yet challenges in efficiency and stability persist. Here, the authors report that the topological semimetal cobalt triarsenide functions as an active and durable platform for this reaction.

The monolayer transition-metal dichalcogenide molybdenum disulphide has recently attracted attention owing to its distinctive electronic properties. Cao and co-workers present numerical evidence suggesting that circularly polarized light can preferentially excite a single valley in the band structure of this system.

The key regulators driving intrinsic immune responses and neuropathic pain remain elusive. Here, the authors elucidate that ZFP612-mediated epigenetic disinhibition of Il1rl1 within the 3D genome in dorsal root ganglion neurons causes neuropathic pain.

Activating ground-state molecular oxygen without added oxidants or external energy remains a major challenge in aerobic catalysis. Here, the authors present a high-rate, energy-neutral O₂ activation platform that directly generates singlet oxygen from ambient air under room-temperature, bias-free conditions.

An analogue memory built from a two-dimensional material with antimony contacts enables very high, energy-efficient in-memory searches and k-nearest-neighbour classification, offering a scalable, low-power hardware platform for real-time edge artificial intelligence applications.