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The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Recently superconductivity was observed in La₃Ni₂O₇ ultrathin film grown on the SrLaAlO₄ substrate with T_c ≈ 40 K at ambient pressure. Here, the authors propose that an imposed strong perpendicular electric field can strongly enhance the T_c in the single-bilayer film of La₃Ni₂O₇ at ambient pressure.

YTHDC2 is a promising therapeutic target, but lacks potent inhibitors. Yang et al. develop a deep learning-based molecule generator EPMolGen. Using this model, they discover a potent, selective, and cell-active small molecule inhibitor of YTHDC2.

N-Cyano amides are pivotal in agrochemicals, biologically active compounds, and nitrogen-containing heterocycles synthesis. Here, the authors report nucleophilic cyanation reactions using O-tosyl hydroxamates as nitrogen electrophiles for the synthesis of N-cyano amides.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

The success of photocatalytic coupling of CH₄ has been limited by the low solar absorption of wide-bandgap semiconductors and the uncontrolled oxidation caused by radical oxygen species. Here a Pd/Co₃O₄ heterojunction derived from a metal–organic framework demonstrates the selective conversion of CH₄ to C₂H₆ by less reactive oxygen species under full-solar-spectrum irradiation.

Periodic marine oxygen oscillations occurred throughout the middle Ediacaran Gaskiers Glaciation, probably stemming from increased organic carbon burial destabilizing ocean redox systems, according to geochemical constraints and modelling.

Analysis of a placebo-controlled trial of a BCMA-targeting CAR-T cell therapy in patients with myasthenia gravis shows that CAR-T cell infusion selectively remodels the systemic immune environment, with elimination of BCMA-high plasma cells and activated plasmacytoid dendritic cells and changes in the autoreactive B cell repertoire.

This work demonstrates superadiabatic topological pumping on photonic chips, achieving a 20-fold device miniaturization and high-efficiency operation across a 650–920 nm bandwidth, paving the way for ultracompact integrated photonic transports.

Quantum light sources are promising for quantum circuits, yet facing an inherent trade-off between multifunction and brightness. By leveraging a strategy based on parity-time symmetry, we demonstrate an on-chip quantum light source with programmable lifetime, achieving a 20-fold tuning range of lifetime and balanced photon-pairs generation rate.

The Taiwan Precision Medicine Initiative (TPMI) has built a cohort of more than half a million individuals with Han Chinese ancestry, providing a rich resource of genetic and medical data for this group.

Paired electrolysis converts industrial SO₂ directly into valuable cyclic sulfite esters, turning a common pollutant into useful chemicals. Mechanistic studies reveal key intermediates, offering a sustainable and versatile platform for green organosulfur synthesis and pollutant valorization.

Coherence is widely seen as essential for quantum source quality. Here, authors demonstrate on-chip photon states with increased brightness and purity using incoherent light. It reveals the mechanism of pump coherence and lowers the barrier for the generation of high-quality quantum states.

SARS-CoV-2 variants with mutations in spike have emerged during the pandemic. Magaret et al. show that in Latin America, efficacy of the Ad26.COV2.S vaccine against moderate to severe–critical COVID-19 varied by sequence features, antibody escape scores, and neutralization impacting features of the SARS-CoV-2 variant.

Machine learning expands quantum chemistry’s reach, but it struggles to generalize to unseen chemistry. Here, the authors develop a real-space learning strategy based on energy densities to build highly transferable quantum-chemical models.

An intratumoural vaccination chimera reprograms tumour cells into an antigen-presenting state with restored anti-tumour immunity.

This work describes FX-Cell and its derivatives to achieve single-cell RNA sequencing from challenging and cryopreserved plant tissues, expanding the scope of single-cell genomics across field-grown samples.

The oxygen evolution reaction enables many clean energy technologies, but most acid-unstable catalysts still block deployment. Here the authors report a temperature dependent mechanistic evolution in RhRu3Ox that links reaction pathways to stability, enabling durable acidic water electrolysis.

Authors in this study discover a CCKBR agonist MF-8 with β-arrestin bias. This biased agonist can reduce other CCKBR signaling pathways, including Gαs-induced cAMP and Gαq/11-induced calcium signaling, thereby inhibiting the CCKBR-LTP. This discovery provides us with new ideas for developing drugs targeting CCKBR.

In this phase 1 trial, treatment of patients with fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the fusion kinase DNAJB1–PRKACA, which is the driver of the disease, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses, and translational analysis showed activation of immune responses.

METTL3 promotes healthy placenta function by regulating m⁶A methylation and histone epigenetics. Deficiency in METTL3 leads to premature senescence, inflammation activation of trophoblasts, contributing to pregnancy complications like preeclampsia.

Installing algal pyrenoids or cyanobacterial carboxysomes into plants to enhance photosynthetic efficiency remains a formidable challenge. Here, the authors report the construction of CO₂-fixing nanocompartments by encapsulating Rubisco using encapsulin from Quasibacillus thermotolerans.

Nanomechanical resonators behave as resonant filters for driving forces. Here, the authors employ a few-layer graphene nanomechanical resonator as a filter for multifrequency forces modulated by a video signal. They demonstrate that the modulated vibrations encode an accurate copy of the video.

The adhesion of meningococci to endothelial cells relies on type IV pili, which induce the formation of long tubular structures on the host cell membrane. Here, the authors show that the tubular structures accumulate and trap host membrane-associated proteins, which facilitates their interaction with bacterial ligands and the activation of adhesion and signaling receptors.

Allogenic mesenchymal stem cells are engineered with three mRNAs to bind to multiple myeloma B cells while activating T cells for cancer therapy.

Bao and colleagues introduce a deep learning method that infers developmental time at 1 min resolution from fixed Drosophila embryo images, enabling high-resolution decoding of dynamic gene regulation without requiring live imaging.

Here, the authors investigate the Raman spectra of few-layered WS₂ when the excitation energy is in resonance with the dark exciton, and observe a Fano resonance between dark excitonsand zone-edge acoustic phonons.

Difunctionalization of readily available alkenes is a powerful method to quickly build molecular complexity. Here the authors report a three-component, oxidative carboamination between alkenes, alkyl nitriles and amines, producingγ-amino alkyl nitriles.

Using data from the CoVPN 3008 study, the authors show that the neutralizing antibody correlate of risk holds in people living with HIV. However, the nAb correlate was weaker and shorter-lived in a vaccine-immunity versus hybrid-immunity population.

Mechanically locked molecules provide interesting topological structures and can present challenging synthetic targets. Here the authors report the synthesis of mechanically self-locked molecules, including chiral endo-spirobicyclics containing multiply interlocked rings within a single molecule.

All-solid-state batteries require external high pressure for good contact between the solid electrolyte and electrodes. Here the authors introduce iodine anions into electrolytes to form interphases that adapt to morphology at the interface, lifting the dependence on high pressure.

Optimizing the crystallization of the active materials in organic solar cells is challenging. Fu et al. use an acenaphthene additive to induce a two-step crystallization of the non-fullerene acceptor, achieving a certified 20.5% power conversion efficiency.

Maturation of functional eggs in mammalian follicles is crucial for ovarian physiology. Here, Biswas et al. report that compressive stress by contractile theca cells or extrinsic perturbations can impact overall follicle mechanics, somatic cell signalling and functional growth of follicles, revealing insights into follicle mechanosensing and biophysical control of ovarian biology.

Stability and flexibility are important, if antagonistic, features of memory. Here the authors show that a class of inhibitory neurons regulate plasticity and therefore the stability of memory representations in novel contexts requiring flexibility.

Control of quantum interference in engineered atomic-scale systems could enable precise manipulation of quantum states, however it has remained challenging. Here the authors demonstrate electrically tunable quantum interference in a system of Ti atoms on MgO surface, using a scanning probe microscope setup.

The photochemical transformations of aryl thiols to other functional groups have been scarcely explored. Here the authors present a carboxylation of aryl thiols using 1 atmosphere of CO₂ under photoirradiative conditions, a methodology which can be extended to the degradation of polyphenylene sulfide.

Chiral vicinal amino alcohols are found in many bioactive compounds and may serve as chiral ligands. Here, the authors report a photocatalytic enantioselective cross-coupling of nitrones with aromatic aldehydes with a chiral ligand-coordinated rare earth ion synergistically producing enantiopure vicinal amino alcohols.

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Understanding ultrafast dynamics of excited states of nitrogen-vacancy helps its manipulation for technological applications. Here the authors use polarization anisotropy spectroscopy and molecular dynamics to investigate sub-picosecond dephasing dynamics, identifying the origin of orbital averaging effects.

Most optical tools for cortex-wide imaging are focused on either neuronal physiology or hemodynamics. Here, the authors present a cortex-wide multimodal imaging approach that facilitates simultaneous observation of neural activity and hemodynamics in awake mice.

Miniature of electronic devices is attractive yet challenging due to structural variation at nanoscale. Here, Gao et al. report atomic imaging of reconstruction and unusual domain walls on Pb(Zr_0.2Ti_0.8)O₃surfaces, providing possibilities to engineer nanoscale structural change.

The authors observed multiple time crystals in the continuously driven-dissipative and strongly interacting Rydberg thermal gases. This discovery may benefit the field of quantum metrology, such as continuous sensing, potentially surpassing the standard quantum limit, and time crystalline order as a frequency standard.

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Despite the importance of polycyclic carboxylic acids and derivatives in various fields, general methods for the arylcarboxylation of alkenes with CO₂ remain elusive. Here, the authors transform unactivated alkenes into high value-added polycyclic carboxylic acids and derivatives via visible-light photoredox-catalysis, using CO₂ as the one-carbon feedstock.

Quantum phase transitions are generally associated with many-body quantum systems undergoing changes between different phases. This study examines the connection between such phase transitions and quantum information processing, and finds that different quantum phases can have different computational power.

Molecular recognition is an important biological process where guest and host molecules interact through non-covalent bonding. Yeet al. show that this can be sensed by the dielectric and ferroelectric signals of the final complexes in a series of metal-coordination compounds with different diol molecules.

Tergaonkar and colleagues identify a noncanonical interaction between the NF-κB transcription factor family member p52 and the ETS family member ETS1. They find that the p52–ETS1 complex is required for splenic germinal center B cell formation and T cell-dependent antibody responses.