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Oral leukoplakia is a precancerous lesion that can transform into oral squamous cell carcinoma (OSCC). Here, the authors discover that OSCC migrasome-derived PTGES promotes oral leukoplakia carcinogenesis through macrophages reprogramming.

Autophagy has been reported to have an important role in glioblastoma temozolomide resistance but the underlying mechanisms are unclear. Here, the authors identify RFC4-STK38-BECN1 complex as a driver of autophagy activation and subsequent temozolomide resistance in preclinical models of glioblastoma.

RNA polymerase II (RNAPII) is typically considered as an essential enzyme. Here the authors show that natural degradation of RNAPII drives chromatin reorganization in growing oocytes, preparing the chromatin for genome activation after fertilization.

The crystal structure of the CHS-CHIL complex reveals a gating mechanism that enhances CHS activity and specificity. This conserved regulatory paradigm, validated by engineering a CHIL variant, offers strategies to improve flavonoid production in plants.

Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease in which macrophage-driven inflammation plays a central role. Here the authors show that macrophage Gsα promotes AAA by stabilizing NLRP3 inflammasome activity, while Gsα silencing via lipid nanoparticles suppresses inflammation and disease progression.

Available genomic prediction models lack scalability and interpretability. The authors introduce a deep learning framework that incorporates GWAS derived SNP weights into a hybrid CNN Transformer architecture, improving prediction accuracy and interpretability in soybean, maize, rice, and wheat.

Mutations in the follicle-stimulating hormone receptor (FSHR) cause spontaneous ovarian hyperstimulation syndrome (OHSS). Here, the authors report that estrildid finches naturally carry an analogous pathogenic mutation found in patients but avoid the syndrome by lowering a related receptor’s activity. Blocking this receptor successfully treats OHSS in mice.

Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

This study reveals how the Vip1-Vip2 binary toxin assembles and enables protein translocation into target cells, providing structural insights into binary toxin action and suggesting strategies for developing next-generation bioinsecticides.

The thermoelectric performance of rhombohedral GeTe-based material is boosted by the TiB₂ nanoparticle-induced interfacial constraint effect that results in reduced equivalent deformation potential and substantial interfacial thermal resistance.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

Chronic diabetic wounds heal poorly due to impaired tissue repair and persistent inflammation. Here, authors demonstrate that a Smad7-based topical biologic accelerates diabetic wound healing by improving epithelial regeneration and reducing inflammatory neutrophil activity.

In vanadium flow batteries, crossovers are critical challenges for membrane design. Here, authors propose a balanced state electrolyte strategy that overcomes crossovers, thereby circumventing existing membrane-related constraints and establishing a new framework for advanced electrolyte design.

Wearable energy-harvesting devices suffer from low electrical output and poor wear comfort. Here, authors develop a self-powered fabric with good wear comfort that pumps sweat directionally, achieving 6.3 °C skin cooling and a 0.40 mA·cm⁻² DC current output for practical wearable power supply.

Researchers report a metal-organic framework with “gate-channel-cavity” for the energy-efficient separation of propylene. By combining sieving gates with a large diffusion channel, the material achieves record-fast diffusion and high capacity for industrial use.

Leveraging multi-element symbiosis, protective interfacial nanolayers are engineered in an intermetallic alloy. This results in a high fatigue limit of ~1,100 MPa, far exceeding that of conventional intermetallic alloys.

Managing hazardous industrial wastewater remains a critical hurdle for sustainable manufacturing and environmental protection. This study converts metal-rich integrated circuit waste into high-performance catalysts that efficiently upcycle plastic pollution.

In this study, the authors identify an Aurka–Bhlhe41 axis, which prevents microglia from aging-like dysfunction by limiting CD22 upregulation, preserving myelin debris clearance and remyelination, and highlighting a potential therapy target for neurodegeneration.

Taurine transporter TauT is a key drug target for multiple diseases. Here, authors reveal structure of human TauT in four states, showing how inhibitors mimic taurine and guiding future TauT-targeted drug design.

Authors designed BaTiO₃-based multilayer ceramic capacitors through synergistic polymorphic nanodomain and defect optimization, achieving 18.7 J cm^-3 and 92.1% efficiency with excellent stability, offering a paradigm for synergistic domain and defect engineering.

Women with diminished ovarian reserve face persistently low success rates during in vitro fertilization. Here, the authors show that a modified letrozole protocol yields cumulative clinical pregnancy rates and cumulative live birth rates comparable to those of the GnRH antagonist protocol.

How the brain learns to suppress self-generated sensory input remains unclear. Here, the authors show that global modulation guiding local plasticity provides a circuit mechanism for error computation in motor-sensory mismatch responses underlying corollary discharge/efference copy.

Topological interfacial coupling enhances PMA in 2D Fe₄GeTe₂, yielding coexisting IMA/PMA components enabling field-free SOT switching at low current density with polarity control, demonstrating reconfigurable logic for low-power spintronics.

Mechanical forces from the extracellular matrix (ECM) impacts breast cancer invasion and metastasis. Here the authors find that low ECM rigidity suppresses basal-subtype breast cancer metastasis via the JAK family kinase TYK2-mediated suppression of Epithelial-Mesenchymal Transition.

Accurately mapping diverse cell types in complex tissues remains a challenge for spatial transcriptomics. Here, the authors present UCASpatial, an entropy-weighted algorithm that enables ultra-precision deconvolution to resolve fine-grained immune landscapes and explore intercellular mechanisms.

Current antiviral treatment approaches target specific Ebola virus species. Here, the authors develop bispecific antibodies with pan-ebolavirus neutralization capacity, structurally resolve the epitope and neutralization mode and show potent protection in a rodent model.

PIF4 is a central regulator of plant growth responses to warm ambient temperatures. Here the authors show that PIF4’s ability to oligomerize is key, while DNA binding and transcriptional activation can be supplied by partner proteins.

Single-cell transcriptome profiling has been reported for human thymi, but high-resolution spatial information is still lacking. Here the authors use Stereo-seq to report spatial transcriptomic and proteomic information from human fetal and pediatric thymi to provide a useful resource, and to define transcription factor networks regulating rare thymic cell types.

FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and remodels the tumor microenvironment characterized by immunosuppressive myeloid cell accumulation and T-cell dysfunction.

Noninvasive hippocampal modulation is key for addressing hippocampal dysfunction. Using multimodal brain recordings, the authors show that personalized connectivity-guided transcranial magnetic stimulation can causally alter hippocampal activity.

Electrochemical direct air CO₂ capture (eDAC) provides a sustainable approach for decarbonization but suffers efficiency losses from O₂-induced side reactions. Here, the authors integrate redox-active carriers with gas selective channels, enabling stable CO₂ capture under ambient conditions.

Balancing activity and selectivity limits the performance of many catalysts in fine chemical hydrogenation. This study shows that paired platinum atoms work together to fully convert a nitroarene into its diamine with enhanced catalytic activity, high selectivity and good recyclability.

Standard of care CD19-targeting CAR-T therapy for Relapsed-Refractory Diffuse Large B Cell Lymphoma (r/r DLBCL) faces frequent resistance often driven by regulatory T cell (Treg) activation. This study identifies Timosaponin AIII (TAIII) as A2AR inhibitor for enhanced CAR-T activity while depleting CAR-Treg formation.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Endometriosis causes pelvic pain and infertility, but how uterine development and disease are linked is unclear. Here, the authors show that TCF21 shapes uterine development and drives endometriosis by promoting epithelial–mesenchymal transition and reorganization of the cell skeleton.

The template-free synthesis of colloidal assemblies with molecule-like architectures from colloidal quantum dots holds promise for optical applications but remains challenging. Here we report a one-pot synthesis of geometries resembling sp-, sp²-, and sp³-hybridized orbitals.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

This study explores the role of protein hyperacetylation in heart failure with preserved ejection fraction (HFpEF). It identifies Dlat as a key regulator of mitochondrial fatty acid oxidation, offering insights for clinical HFpEF interventions.

Neutrophils are known to be important in COPD pathogenesis and calcium signaling is involved in this process. Here the authors examine the function of Na⁺Ca²⁺ exchanger 1 (NCX1) in neutrophil function in mouse models of chronic cigarette smoke exposure and show that inhibition of NCX1 reduces neutrophil accumulation in the lungs and formation of neutrophil extracellular traps (NETs).

Excavated bamboo slips from East Asia hold crucial archeological information, but many are fragmented, making their restoration challenging. To facilitate this process, Zhu et al. introduce a physics-driven deep learning framework named WisePanda, to rejoin fragmented pieces with improved accuracy.

Near-infrared-II carbon dots offer exceptional deep-tissue penetration for biomedical imaging, but challenges remain in their synthesis and photoluminescence mechanisms. In this work, the authors designed and synthesized a series of carbon dots (CDs-1 to CDs-3) through extension of aniline-based frameworks, achieving tunable emission extending into the NIR-II region, and applied these CDs in deeptissue NIR-II imaging of the hepatobiliary system.

Excessive inflammation contributes to mortality in sepsis. Here, the authors propose a protective function for DPEP2 in monocytes, with sepsis-induced repression of DPEP2 causing a metabolic shift toward inflammatory cytokine production, while LNP-mediated Dpep2 expression restoration shows therapeutic potential.

Copper nanoclusters are promising photothermal heaters, but their conversion efficiency is limited efficiency. Here, the authors present a rotor-stator ligand architecture that enables enhanced photothermal conversion efficiency of copper nanoclusters.

Metal–organic frameworks with dynamic metal–ligand bonds form reversible gates that admit enzymes larger than the pores, enabling stable encapsulation and efficient multi-enzyme cascade catalysis for glycan precursor synthesis.

Hybrid sites of single atoms and clusters promise to overcome scaling relations but are limited by spatial decoupling. Here, the authors report an electrocatalyst (Zn₁Fe_1+x/f-NC) with Fe_x clusters and Fe/Zn-N₄ sites within nano-fingerprint carbon layers, enhancing ORR and Zn-air battery performance.

Determining the optimal start of the growing season presents a fundamental dilemma for plants. This meta-analysis suggests that plants exhibit high freezing resistance (to -12 °C) and low lethal frost risk (safety margin of 17 °C) during spring emergence, indicating strong long-term evolutionary pressure.

Achieving both high strength and toughness in single-covalent-network hydrogels is a challenge. Here, the authors report a transient entanglement strategy which enables energy dissipation and stress redistribution to achieve strong, tough polyacrylamide hydrogels.

Frameworks of β-branched aromatic D-amino acids are crucial for the efficacy of pharmaceuticals, but the synthesis of such scaffolds remained undeveloped. Here, authors present the first asymmetric synthesis of β-branched aromatic D-amino acid analogues via the transaminase BsDAAT catalyzed dynamic kinetic resolution (DKR) process.