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Balancing structural miniaturization with reliable shape-morphing performance is challenging in microrobot design. Here, the authors design an acoustic shape-morphing micromachine that can rapidly switch between multiple modes with precise control.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Natural variation in the promoter of OsTPS8 contributes to differences in grain chalkiness and seed vigor between indica and japonica rice subspecies by altering trehalose-6-phosphate biosynthesis and α-amylase levels.

SARS-CoV-2 variants often exhibit immune evasion, necessitating antiviral strategies beyond vaccination. This study presents a papain-like protease (PLpro) inhibitor called YL1004, which exhibits potent, broad-spectrum antiviral activity against wild-type, Delta, and Omicron variants in vitro and in vivo.

The lack of high-energy positive materials hinders the development of magnesium metal batteries. Here, authors design an anion receptor-mediated electrolyte that enables the electrochemical cooperation between fluoride and magnesium, and develop a high-performance Mg | |FeO0.7F1.3 battery prototype.

The complexity of the evolved metabolic networks of flavonoids complicates pathway elucidation and design. Here, the authors identify enzymes that modify isoflavan scaffolds from the genome and transcriptome data of Glycyrrhiza glabra, and reconstruct de novo glabridin biosynthesis in yeast.

Improving the elongation of stretchable organic electronics typically increases flexibility at the expense of ductility. Here, authors construct a covalent network, reinforced by silica filler, for improving crack-onset strain and modulus, achieving efficiency of 16.5% for stretchable solar cells.

The authors identify AMsh glia, expressing both cold and heat receptors, function as a dual-mode thermosensory hub, bidirectionally modulating neural circuits to regulate various thermal behaviors in C. elegans.

This study presents a scalable and sustainable electro-membrane crystallization-assisted general recycling technology that efficiently recovers high-purity lithium, manganese, nickel, and cobalt from spent lithium-ion batteries.

Sclerostin impairs whole-body lipidandglucosemetabolism. Here, the authors further demonstrate that adipocytic sclerostin loop3-LRP4 interactionparticipatesin the impairment effect of sclerostin on whole-body lipid and glucose metabolism.

Multifunctional underwater sensors with integrated self-powered signal transmission, effective thermal-moisture regulation, and multi-signal decoupling are desirable of underwater tasks. Here, the authors report a three-dimensional thermoelectric device composed of porous polyurethane foam coated with a waterproof conductive layer for human-machine interaction in aquatic settings.

Environmental Li pollution and health problems have been becoming an important concern worldwide. Here, the authors show that Li exposure causes trophoblast cell ferroptosis and thus induces unexplained miscarriage through a non-canonical MBOAT1 pathway.

Using single-cell transcriptomics and functional analyses, the authors identify a specialized neural network in the male schistosome gynecophoric canal and show that lsamp maintains its integrity, enabling intersex communication and female reproductive maturation.

STING–type-I interferon pathway regulates the immunogenicity of several cancer types, including head and neck squamous cell carcinoma. Here the authors describe that glutamine metabolism in the tumour microenvironment dampens the STING–type-I interferon pathway by epigenetically silencing the expression of BATF2, which functions as a tumour suppressor.

All-solid-state batteries face significant performance challenges with conventional anodes under high currents. Here, the authors design an In₀.₃₈Sn₀.₃₃Bi₀.₂₉ alloy anode that forms a robust mixed ionic–electronic network, enabling high-rate capability and durable solid-state cells.

Gravitationally induced stratification during self-assembly often leads to density driven vertical segregation limiting the synthesis of metastable nanofilms. Here, the authors address this limitation with an antigravity confined interfacial self-assembly synthesis where capillary forces dominate and enable precise molecular organization resulting in ordered and stable nanofilms.

This study shows that excessive atmospheric nitrogen deposition can enhance methane production and emissions by impacting microbial phosphorus acquisition due to the change of N/P ratios in oxygenated surface oceans.

The study used snMultiome-seq to map gene expression and chromatin accessibility in human central amygdala cells from people with and without AUD. Here, the authors show that inhibitory neurons are most affected, with KLF16-driven regulatory changes and AUD-risk variants disrupting gene activity.

Macrocyclic polymer membranes are well suited for wastewater treatment, though it is challenging to fabricate porous networks using macrocycles. Here the authors report a membrane containing tetraaldehyde appended calixarene using a unidirectional diffusion assisted interfacial polymerization method for a wastewater treatment membrane.

Formamidinium lead iodide perovskite holds promise for high-efficiency solar cells, but the kinetic instability of its α-phase crystallization remains an issue. He et al. report a strategy for directing the crystallization process in a n-i-p architecture and champion power conversion efficiency of 26.18%.

The scaffold protein AXIN can promote the formation of two opposing complexes: the Wnt signalosome and a degradation complex that inhibits Wnt. Here, the authors show that mechanical compression and the presence/absence of Wnt ligand are inputs in a circuit that acts as a logic gate to control which complex is formed.

This study elucidates nanoscopic strain evolution in single-crystal Ni-rich positive electrodes, demonstrating that mechanical failure results from lattice distortions, and redefines the roles of cobalt and manganese in battery cycling stability.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

A martensitic alloy with a tensile strength exceeding 3 GPa and a fracture elongation of 5.13% is developed. These mechanical properties arise from interface complexes interacting with dense dislocation networks, which is a mechanism shown to be applicable to other compositions.

Researchers report a spontaneous method that produces chlorine directly from chloride-containing brines by harnessing their inherent osmotic energy and chloride ions, without any external energy input.

Understanding the impact of the solid electrolyte interphase (SEI) on lithium deposition is crucial for developing high-energy lithium metal batteries. Here, authors elucidate the multi-scale effects of the SEI on lithium deposition behavior based on the established SEI-omics framework.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Strong paramagnetism is generated in hydrogels rich in carbon–oxygen double bonds simply by coupling with diamagnetic Ca cations. These paramagnetic hydrogels are applied as magnetic resonance imaging contrast agents and magnetic drug carriers.

A pathogenic subset of NK cells is identified that promotes type 1 diabetes and is generated via T cell-derived IL-21.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

An extreme barocaloric effect in NH₄SCN aqueous solutions is enabled by pressure-induced dissolution and precipitation, but without using a separate heat-transfer liquid.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Antibody-conjugated Mesenchymal stromal cells (Ac-MSC) carrying internalized therapeutic agents represent a promising therapeutic approach for the treatment of autoimmune disease. Here, an ac-MSC-based drug delivery system, consisting of anti-CD4 antibody-conjugated MSCs loaded with a RORγt inverse agonist, is engineered to achieve selective targeting of pathogenic CD4 T cells and to deliver therapeutic benefits in mouse models of psoriasis and arthritis.

Limited genomic resources constrain our understanding of fern evolution and conservation. Here, the authors present the genome of Brainea insignis, a monotypic endangered fern, and identify evolutionary signatures to guide conservation strategies from comparative and population genomic analyses.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Efficient voltage-controlled regulation of water and ion transport was achieved in stable Zr₄-Ti₃C₂T_x membranes. Under negative voltage, water diffusion was enhanced while ion transport was suppressed. This provides a promising strategy to overcome the intrinsic permeability– selectivity trade-off.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Personalized nanovaccines derived from autologous tumour cells and engineered to display dendritic cell-like features enhance immune activation and prevent postoperative metastatic cancer in preclinical models.

Escalating phosphorus pollution and depleting reserves necessitate sustainable control and recovery strategies. Here the authors develop a microbially enhanced La–Zr-loaded basalt system that achieves over 90% phosphorus removal and recovery, promoting a circular economy and reducing ecological impacts, offering an economically superior alternative to traditional chemical methods.

Xu et al. report that CDK10 drives immune evasion by reducing nucleic acid sensors-mediated innate immune response in tumor cells and that its inhibition improves response to immune-checkpoint blockade in preclinical cancer models.

Li-rich oxides suffer from severe degradation in lithium-ion batteries. To investigate this, authors employ operando methodologies to follow microstructural changes and demonstrate that interlayer twinning structures and intralayer frustrations formed during cycling drive performance degradation.

In a trial involving 2,069 patients and 111 clinicians across 24 disciplines, patients performing a preconsultation session with an LLM-powered chatbot had a significantly lower consultation time and both patients and clinicians reported improved communication and satisfaction.

Membranes which extract lithium are critical to developing sustainable technologies. Here, the authors report a covalent organic framework featuring randomly oriented channels, separating lithium from a mixture of cations.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

A multimedia e-learning chatbot codesigned with community stakeholders increased health awareness in a randomized trial of 2,113 participants in urban and rural areas across 11 Chinese provinces.