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Recent studies have shown the potential of higher-order exceptional points originating from the Liouvillian dynamics as opposed to their Hamiltonian counterparts. Here, the authors explore different classes of third-order Liouvillian exceptional points in a two-level system realised in a single trapped ion.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Genome evolutionary history of wild Arachis species remains unclear. Here, the authors report the origin of small chromosome A08 and genome evolution of Arachis species via comparative oligopainting and genomic analysis of A. hoehnei.

Cryogenic transport measurements of CsV₃Sb₅ nanobeams show a zero-field Josephson diode effect and radio-frequency rectification with power-dependent quantized voltage output.

A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Wastewater treatment plants harbour extensive but poorly characterized microbial genetic diversity. Using 828 metagenomes from wastewater treatement plants globally, this study reconstructs >24,000 metagenome-assembled genomes, including >12,000 new species, providing a genome-resolved framework for understanding and engineering activated sludge functions.

Wild relatives of wheat provide a valuable source of genes and allelic variants for wheat improvement. Here, the authors identify a type-B response regulator (RR) AcRR1 from Agropyron cristatum and show its potential of boosting wheat yield by increasing the grain number per spike and promoting early heading.

Induction of CD11b-positive regulatory B cells and low expression of CD40 in melanoma cells have been associated with resistance to agonist CD40 (aCD40) and immune checkpoint blockade (ICB). Here the authors show that the addition of RAS/MEK/PI3K inhibitors to aCD40 abrogates these effects and reverses ICB resistance in preclinical melanoma models.

Antibiotic resistance is a growing global threat, yet the role of extracellular defence mechanisms remains underexplored. This study reveals that evolved extracellular polymeric substances act as a frontline shield, substantially boosting Escherichia coli antibiotic resistance, demonstrating their key but overlooked role in antibiotic resistance.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

This analysis performs comprehensive comparisons of 27 single-cell perturbation response prediction methods using 29 datasets under different test scenarios and against multiple evaluation metrics.

There is an unmet medical need for endometrial cancer patients with mismatch-repair proficient disease. Here, the authors report the primary analysis of the FRUSICA-1 phase Ib/II trial evaluating fruquintinib plus sintilimab in this population, showing an ORR of 32.7%, a median PFS of 8.6 months, and manageable toxicity.

Researchers identified a unique “latch bulge” in yeast mitofusin Fzo1. This fungi-specific structure allows Fzo1 to dimerize and remain locked after catalyzing GTP hydrolysis, enabling efficient mitochondrial fusion with minimal energy consumption.

The study finds that seasonal marsquake patterns may indicate active near-surface brines on Mars today. By connecting seismicity changes to ice-to-brine melting, it infers that shallow liquid water continues to operate beneath the surface and influence Martian fault activity.

Nanometer-wide lateral heterostructures between 2D semiconductors are still rare. Here the authors report the valley-selective hole state transmission between ferroelectric SnTe monolayers separated by a PbTe barrier with the width of merely 2 nm.

The primary entry route of vanilloid ligands to the vanilloid-binding site in transient receptor potential vanilloid 1 (TRPV1) is found to be a distinct and targetable hydrophobic pathway at the TRPV1–cell membrane interface rather than through direct membrane penetration.

The study identifies PLUM, a uORF-encoded microprotein from Lin28b, as a key regulator that drives deterministic induction of naïve pluripotency through coordinated RNA regulation and metabolic remodeling.

SARS-CoV-2 variants with immune escape capability highlight the need for the development of cross-neutralising vaccines and regimens. Here, the authors assess the immunogenicity and safety of NVSI-06-08, that integrates antigens from multiple SARS-CoV-2 strains into a single immunogen, as a heterologous booster in adults previously vaccinated with the inactivated vaccine.

Surface reconstruction during reactions often generates unique active sites that boost catalytic performance. Here, the authors show that supported Ni₃InC₀.₅ nanoparticles undergo CO₂-induced surface oxidation, forming defective In₂O₃₋ₓ layers and inverse In₂O₃₋ₓ/Ni interfaces during CO₂ hydrogenation.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Here they show that gasdermin-E (GSDME) acts as a key driver of abdominal aortic aneurysm (AAA) by triggering senescence in vascular smooth muscle cells, a process reversible with senolytic drugs, highlighting a promising therapeutic target of AAA.

A DNA matrix material potentiates humoral response through multiple administration routes, generating neutralizing antibodies and conferring robust protection against infection.

A dipolar-passivation strategy enables all-perovskite tandem solar cells with a power conversion efficiency of over 30%.

A tension-modulated DNA origami-based nanosensor, compatible with bulk biochemical analysis in cell lysates, is used to assess the force-induced interaction of proteins involved in cellular mechanotransduction.

Insect genomics is entering a telomere-to-telomere (T2T) era. This study presents a 596-Mb T2T genome of an individual male Bactrocera dorsalis—a species with atypical telomeres, centromeres, and sex-chromosome architecture—advancing genetics, chromosome biology, and pest management.

Transfer RNA-derived small RNAs (tsRNAs) emerge as crucial players in biological processes but their disease relevance is unknow. Here, the authors show that tsRNA-Glu-CTC is the most abundant hepatic tsRNA that plays a key role in regulating cholesterol homeostasis and atherosclerosis development.

In mitochondria transplantation, the limited activity and yield of mitochondria constrain their clinical application for mitochondrial diseases. Here, authors develop a method for producing mitochondria-enriched extracellular vesicles, which offer high-quality, abundant mitochondrial material for transplantation.

Here, in a study of over 6,000 women across China, the authors show that Mycoplasma hominis infection strongly influences vaginal microbiota and is linked to higher risk of cervical lesions, highlighting its importance in women’s reproductive health.

Mammal and reptile chromosomes have diverged extensively in sequence and 3D organization, but the principles shaping these differences remain unclear. This study shows that ancestral microchromosomes retain conserved nuclear architecture despite lineage-specific rearrangements, revealing deep constraints on chromosome evolution.

The authors achieve piezoelectric coefficient d₃₃ ∼ 807 pC·N⁻¹, along with high k₃₃ ∼ 88 % and T_c ∼ 245 °C in (K,Na)(Nb_1-xSb_x)O₃-Bi_0.5Na_0.5ZrO₃-BiFeO₃ system through structural flexibility and grain orientation strategies.

The mitochondrial membranes present a formidable barrier to the delivery of exogenous genes. Here, the authors report on the development of fluorinated lipid nanoparticles to efficiently introduce therapeutic genes into mitochondria, for the correction of mitochondrial genomic defects.

Achieving wide-gamut structural colours with brightness control is challenging. Here, the authors demonstrate colours beyond Rec.2020 and continuous, polarizer-free brightness tuning in dielectric metasurfaces via mode interference and diffraction control.

Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.

Tian et al. reveal that rich temporal dynamics within individual brain regions form stable individual-specific ‘barcodes’, advancing generalizable brain-wide association studies beyond traditional connectivity measures.

The prevalence of mutations that can predispose to pancreatic adenocarcinoma (PDAC) remains unclear, especially in underrepresented populations. Here, the authors create a germline mutation map of 1,123 Chinese PDAC patients and compare them to cohorts from other populations, finding CFTR as a potential driver.

Infection with SARS-CoV-2 causes interstitial pneumonia and viral replication in the lungs of transgenic mice that express a human version of ACE2, confirming the pathogenicity of the virus in this model.

An Ohmic contact interface engineering strategy was proposed by loading copper nano islands on indium hydroxide nanocubes, which could trigger and stabilize the polarized Cu0 -Cuδ+ active sites. Such catalyst enabled effective ammonia electrosynthesis with nitrate under ambient conditions

The authors demonstrate that with appropriate control, a typical stick-slip nanopositioner can simultaneously deliver nanometer precision, macroscale range, and hundreds-of-hertz resonance frequency, enabling cross-scale, high-bandwidth atomic force microscopy.