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Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Yu et al. report a self-assembled heterogeneous microstructure consisting of chiral-deficit grains and chiral-rich grain boundaries in chiral perovskite with the former as in-plane spin valves for spin selection. Retinomorphic sensor arrays based on the chiral perovskite film enable binocular artificial visual systems.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

Here the authors present a photoinduced Mn(II)-bipyridine catalyzed cross-coupling reaction between aryl halides, particularly less-reactive aryl chlorides, and nucleophiles containing nitrogen, oxygen, and sulfur.

A single-breath-hold 3D abdominal MRI technique (SSE-CEST) enables label-free mapping of glucose, glycogen and mobile protein in human liver, offering motion-robust, high-resolution imaging for cancer detection and metabolic monitoring.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Microcavity exciton polaritons are a promising platform for optical parametric processes. Here, authors achieve efficient parametric emission with strong phase coherence in quantum confined microcavities, demonstrating a polariton supersolid phase at room temperature.

Osteoarthritis is driven by epigenetic dysregulation, yet targeted therapies remain elusive. Here, the authors develop a cartilage-targeting hydrogel delivering BRD4-degrading PROTACs to suppress the BRD4- Nav1.7 axis and alleviate osteoarthritis.

Making phenols from lignocellulose without added hydrogen is attractive but typically requires high metal loadings and yields mostly saturated products. A single-atom Pt1Ni alloy converts birch sawdust to phenolic monomers with high yield and propenyl selectivity while leaving cellulose intact.

Spatial principles of regulatory elements in primate cortex are poorly understood. Here, authors show a chromatin accessibility atlas identifying primate-specific cis-elements associated with psychiatric disease risks in specific cell types.

The COMPASSION16 trial showed survival benefits of cadonilimab plus standard therapy in advanced cervical cancer. Here, subgroup analysis confirms consistent progression-free and overall survival improvements across diverse patient profiles.

The mid-infrared (MIR) range of the electromagnetic spectrum can be indirectly accessed by frequency upconversion. Here, authors propose a phase-matching-free scheme for broadband and efficient upconversion, covering wavelengths from MIR to ultraviolet with high-order harmonics generated from a NbOI₂ crystal. MIR imaging is demonstrated with a standard silicon camera.

Conventional neuromorphic vision systems based on pixels-to-one-memristor architecture face efficiency challenge. Here, Sun et al. report an architecture employing one-pixel-to-multiple-memristor structure, mapping weight updates to voltage vectors to enhance both processing speed and energy efficiency.

Multi-trait genetic analysis in East Asians identifies a novel gastric cancer risk locus shared with cardiovascular traits and shows that this variant modulates regulation of nearby genes, including VEZT, with functional effects on gastric cancer cell behaviour.

Liu, Tao, et al. share a Phase 4 randomized in which nearly 500 women undergoing hysteroscopic surgery received either oliceridine or a standard opioid in combination with propofol sedation, with continuous monitoring of respiratory and recovery parameters. Patients receiving oliceridine experienced fewer episodes of intraoperative hypoxia, required less propofol, and reported higher satisfaction, as did surgeons.

Aqueous iron-ion batteries represent a compelling energy storage solution due to the cost-effectiveness, suitable redox potential, and high capacity of Fe negative electrodes. This study activates phosphorus redox activity in a carboxyl small molecule positive electrode for iron-ion batteries.

Traditional recycling of polyoxymethylene plastic often leads to significant material loss and toxic emissions. Here, the authors introduce an acidic electrochemical process that efficiently converts plastic waste into valuable chemicals with conversion efficiency approaching 90%.

The PD-1/PD-L1 pathway is central to immunotherapy, but PD-L1 recycling limits durable responses. This study identifies TM9SF2 as a key regulator of PD-L1 trafficking and shows that disrupting its PGK1-dependent complex depletes PD-L1 and enhances antitumor immunity.

By engineering single residue of protein with a light-switchable molecule, this study reveals that local hydrophobicity propagates through hydrogen bond network to reshape protein structure and function, shifting the paradigm to structure–hydration– function.

Nanozymes are promising for controlling plant bacterial diseases, but conventional nanozymes suffer from low bacterial affinity, inefficient enzyme-like activity, and thus poor antibacterial efficacy. Here, the authors report a copper single-atom nanozyme that outperforms commercial thiodiazole copper in controlling plant bacterial diseases via intelligent capture and photo-enhanced activity.

The development of high-performance electrochemical biosensors is limited by the lack of robust methods for creating well-controlled biointerfaces. Here, the authors present i-eY-Click, a rapid (<3 min), tyrosine-selective electrochemical method for covalently immobilizing native proteins under mild conditions. Applied to carbon microelectrode arrays, it forms well-controlled antibody layers and enhances cytokine sensing, improving sensitivity, detection limits, and reproducibility.

This study identifies extensive lateral interdigitations in the kidney’s ascending thin limb and demonstrates that Claudin-10b regulates both epithelial architecture and urine-concentrating function in this distinct nephron segment.

The thermoelectric performance of rhombohedral GeTe-based material is boosted by the TiB₂ nanoparticle-induced interfacial constraint effect that results in reduced equivalent deformation potential and substantial interfacial thermal resistance.

High-performance battery materials often degrade during standard cleaning processes. Here, the authors identify why water washing causes structural collapse in sodium-based oxides and demonstrate that ethylene glycol can safely remove impurities while maintaining the material’s integrity.

Mitochondrial genomes of bilateral animals exhibit high variability in architectural rearrangement rates, but the reason for this disparity remains unknown. This study provides evidence that purifying selection mediated by locomotory capacity and species ecology is a major driver of mitogenomic architectural evolution.

This study presents azo-Q2a, a quinidine-derived photo-switchable molecule that enables optical control of Na_V1.5. It exhibits selectivity, and its binding mode is revealed by cryo-EM, offering a potential strategy for managing heart arrhythmia.

In the nonpivotal stage 1 of the randomized phase 3 PRESERVE-003 trial, patients with immunochemotherapy-resistant metastatic squamous non-small cell lung cancer without actionable genomic alterations treated with the next-generation, pH-sensitive anti-CTLA-4 agent gotistobart had encouraging overall survival outcomes compared to docetaxel.

Here, the authors report a bacterial anti-phage defense system that targets the phage DNA entry phase. This system is termed HXS and consists of four proteins that function together to inhibit phage DNA entry providing broad-spectrum activity.

AI is transforming protein engineering, but the immobilization of enzymes often impairs their activity. Here, the authors present a machine-learning-based workflow that can be used to identify optimal nanohybrids with high activity recovery across diverse enzymes.

The iNKT cell-targeted microparticle recruitment and activation system (iMRAS) is a biomimetic platform that serves to locally recruit, activate and expand CAR-iNKT cells in vivo to enhance CAR-iNKT functionality for improved cancer immunotherapy.

How do avian eyes fulfill the intense metabolic activity of thick, high-acuity retinas in the absence of direct vascular support? The study finds that birds’ rapid, oscillating saccadic eye movements pump glucose from the pecten to the avascular retina, sustaining nutrient supply and boosting visual responses in the brain; especially when driven by dynamic visual stimuli.

African swine fever virus (ASFV) virions mainly contain capsid protein p72. Here, the authors show that host cyclophilin A binds to and stabilizes p72, promoting viral factory formation and virion assembly, thus offering a promising anti-ASFV target.

Ammonium-ion batteries are booming for next-generation energy storage systems due to high safety, low cost, non-toxicity, and fast redox kinetics. Here, authors report a multi-electron nitrobenzothiadiazole sp-conjugated alkynyl covalent organic framework negative electrode for ammonium-ion batteries.

Liu et al. show that the C9orf72 GGGGCC-repeat RNA drives liquid-to-solid phase transition of poly(GR) in ALS/FTD through forming G-quadruplex and hairpin scaffolds, whereas targeting the RNA structures with small molecules reduces poly(GR) aggregation and cellular dysfunction.

Lithium-metal batteries promise high energy but dendrites limit life. Here, authors introduce a 90 wt.% lithium multicomponent solid solution alloy negative electrode that drives lithium into the bulk, enabling 3100 mAh g − 1 capacity and a 385 Wh kg−1 pouch cell that retains 82% capacity after 600 cycles.

Stable, ultra-low-noise integrated lasers are essential for scalable quantum computers and portable optical clocks. Here, authors demonstrate a chip-scale coil stabilized Brillion laser driving a room-temperature trapped-ion clock and qubit without a bulk reference cavity achieving 99.6% SPAM fidelity.

Tunnel oxide passivating contact solar cells face unresolved questions about the atomic scale nature of pinholes that limit performance. The authors use aberration corrected transmission electron microscopy to reveal two pinhole types and showing that oxygen-based passivation rather than pinholes geometry drives efficiency.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

A wearable sensor fuses biopotential and biomechanical signals into a single cross-modal biosignal through in-sensor fusion, enabling accurate haemodynamic monitoring and improved gesture decoding.

Rice indica varieties have higher nitrogen use efficiency (NUE) than that of japonica varieties. Here, the authors show that natural variation of OsWRKY23 and its interaction with DULL NITROGEN RESPONSE1 (DNR1)-mediated auxin accumulation play a role in NUE divergence between the two rice subspecies.

Parasitoid wasps are reared and released as biocontrol agents to manage aphids and protect crops. Here, the authors use genomes from 542 wasps to show that, in spite of wide scale release of low-diversity captive individuals, diversity in wild populations is maintained.

Five nuclear spins in silicon and the [[4, 2, 2]] code are used to demonstrate a universal logical gate set and to execute a variational quantum eigensolver computation of the ground-state energy of a water molecule.

Two distinct types of atomic insulator can be distinguished by the distribution of charges within the unit cell. Now, real-space imaging of WSe₂ shows that it is a so-called obstructed insulator.