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This work describes a Pd−B diatomic catalyst that can selectively catalyze the photosynthesis of glycine via C−N coupling reaction between PET-derived ethylene glycol and nitrate, achieving a yield of 2.9 mmol g_cat⁻¹ h⁻¹ and selectivity of 92%.

Hierarchical immobilization of multicomponent biomacromolecules is promising for constructing advanced biopharmaceuticals, but remains challenging. Here, the authors report a multicomponent synergistic approach integrating in-situ and dynamic exchange methods to construct hierarchical biopharmaceutical formulations.

Electrochemical C–N coupling of 5-hydroxymethylfurfural with methylamine offers a sustainable route to produce value-added amines. Here, the authors present a facet-controlled Ag catalyst that tunes the substrate adsorption geometry and hydrogenation propensity for promoted selectivity.

Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen where therapeutic antibiotic treatment can release toxins and disrupt gut microbiota. Here the authors demonstrate a therapeutic strategy where an engineered Escherichia coli Nissle 1917 limits the glucuronic acid utilization by EHEC.

Hepatectomy is an important part of hepatocellular carcinoma (HCC) treatment but postoperative recurrence limits long-term survival. Here, the authors report a phase II clinical trial investigating perioperative tislelizumab (anti-PD-1) and lenvatinib (multi tyrosine kinase inhibitor) in patients with resectable HCC with a high-risk of recurrence.

Cardiovascular risk is driven by genes, proteins, and metabolites, yet their combined predictive value is unclear. Here, the authors develop CardiOmicScore to integrate genomics, proteomics and metabolomics and predict six cardiovascular diseases up to 15 years prior to disease onset.

In the phase III NAPOLI-3 trial, first-line treatment with NALIRIFOX was associated with improved overall survival compared to gemcitabine plus nab-paclitaxel in patients with metastatic pancreatic adenocarcinoma. Here the authors report the results of a randomized phase II trial comparing the two regimens, NALIRIFOX versus Gemcitabine plus Nab-Paclitaxel, in Chinese patients.

Composite-letter DNA data storage promises higher density but suffers from readout challenges. Here, the authors present a decomposable diamond constellation and an entropy-guided two-stage detection strategy, enabling reliable recovery at low sequencing coverage for high-density DNA data storage.

Precise surface engineering of nanoparticles is essential for advancing bioimaging technologies, yet achieving atomically controlled ligand functionalization remains a challenge. Here, the authors develop an interphase-assisted ligand exchange method, which leverages mass transfer resistance between immiscible phases to precisely control the concentration of foreign ligands interacting with gold nanoclusters.

The peripheral nervous system plays a role in the development of head and neck squamous cell carcinoma (HNSCC). Here the authors show that HNSCC cancer cells promote the expression of caveolin-2 (Cav2) on neural cells, while Cav2-expressing neurons or glial cells induce a mitochondrial oxidative phosphorylation phenotype in cancer cells to maintain cancer stemness.

All-in-one computing, which merges sensing, linear computing, and nonlinear activation, is a critical goal for next-generation AI hardware. Here, Zhang et al. introduce a high-speed, reconfigurable split-floating-gate memory, enabling multi-function integration within a unified platform and hardware native neuromorphic processing.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Current anion exchange membrane water electrolysers are hindered by poor performance in pure water. Here, the authors report a strategy that creates built-in alkaline microenvironments, enabling high performance and long-term stability using only pure water.

Taxanes, including paclitaxel (PTX) and Nab-PTX (comprising PTX bound to albumin nanoparticles), are first-line chemotherapeutic agents in breast cancer therapies. Here, the authors report that PTX, but not Nab-PTX, induces the expansion of tumor-promoting TREM2+ macrophages as a mechanism underlying the inferior antitumor efficacy of PTX compared with Nab-PTX in patients with breast cancer.

Although heat is a major stroke risk factor, targeted intervention tools are lacking, so we developed and evaluated a Stroke Heat Risk Model for personalized prevention. Here, the authors show that it yields three times the preventable heat-attributable stroke deaths of current heat warning systems.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Cystine levels in pancreatic ductal adenocarcinoma (PDAC) tumour microenvironment are deficient, despite its crucial role for cancer cell maintenance. Here, the authors show that adaptation to cystine limitation stress promotes PDAC growth through induces metabolic reprogramming to promote PDAC tumor growth, while conferring a vulnerability in lipid metabolism targetable by lomitapide.

Limiting dietary methionine protects against kidney fibrosis by blocking the TGF-β– Smad3–Hoxc8/P-TEFb pathway, identifying Hoxc8 as a central driver of fibrosis and a potential therapeutic target for chronic kidney disease.

A protocol to isolate small intracellular vesicles from human cells is reported; these are molecularly distinct from small extracellular vesicles and show superior therapeutic potential in retinal degeneration and drug delivery.

Accurately locating underground contaminations is a major hurdle for cleaning up groundwater. Here, the authors address this issue by designing a smart nano reporter that travels with groundwater and releases signals upon contact with even trace-level contamination, allowing precise mapping of the residual organic contaminants.

The preparation of thin covalent organic framework membranes on porous substrates using conventional in situ and secondary-growth methods is challenging. Here, the authors applied a non-solvent induced phase separation-triggered in situ interfacial polymerization strategy to produce covalent organic framework-mixed matrix membranes applied to gas separation.

Aortic aneurysm and dissection are lethal vascular diseases lacking effective medical therapy. Here the authors show that calcium channel blocker use increases AAD risk, worsens disease progression in models and patients, and may impair post-repair outcomes, warranting caution in at-risk hypertension.

Hashimoto’s thyroiditis (HT) is the main cause of hypothyroidism. Here the authors develop a deep learning model for diagnosis of HT on a large multi-site dataset including image and video data.

Retrons are bacterial genetic retroelements implicated in anti-phage defense. Here, the authors characterize the quaternary retron system Ec78 and elucidate the biochemical mechanisms underlying Ec78-mediated prokaryotic immunity.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

Cardiometabolic disease and depression often co-occur, but their multi-organ basis was unclear. Here, the authors analyse UK Biobank imaging and genetics, identifying abdomen-heart-brain networks and 43 shared loci, improving multimorbidity prediction

Electrocatalytic CO₂-to-acetate remains challenging for metal catalysts due to the linear scaling relationship. Here, the authors report a deposition-etching strategy to modulate sp²/sp³ carbon hybridization in diamond, regulating adsorption equilibrium of key intermediates for acetate formation.

PMAK integrates pre-trained enzyme and reaction representations with residue-aware attention to improve kcat prediction, demonstrating robust generalization under warm- and cold-start settings and highlighting the value of full reaction context for unseen enzymes.

A nanoimprint technique exploiting capillary forces in nanohole arrays enables patterning CdSe-based quantum-dot LEDs with a resolution of nearly 170,000 pixels per inch while maintaining high average external quantum efficiencies of 17.0%, 10.5% and 5.7% for red-, green- and blue-emitting pixels, respectively.

Reverse iontophoresis offers non-invasive extraction of interstitial fluid but it has proven hard to be used for glucose monitoring. Here, the authors establish the mechanism by which skin surface pH modulates RI through zeta potential changes of keratin, supported by theoretical analysis and numerical simulations

Worldwide, the number of only-child families is increasing. This research examines how growing up without siblings affects adult brain structure, function and connectivity, cognition, personality and mental health.

Nucleophilic oxidation in electrosynthesis is hindered by slow dehydrogenation and the competing oxygen evolution reaction (OER). Here an oxyanion-stabilized low-coordinated Ni catalyst suppresses OER and Ni over-oxidation, enabling co-production of H₂ and valuable organic compounds.

Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Recent research has indicated that cancer patients infected with respiratory viruses exhibit a positive antitumor response. This group develops a bioorthogonal optimized nonpathogenic-recombinant virus for targeted therapy of solid tumors.