Search

A quasi-melting transfer technique enables clean, sequential transfer of graphene and hexagonal boron nitride monolayers from germanium substrates under vacuum conditions. Controlled lattice alignment yields atomically precise, wrinkle-free superlattices with tunable stacking and twist angles, enabling scalable fabrication of high-quality 2D heterostructures for advanced electronics.

Authors reconstruct the molecular evolution of severe fever with thrombocytopenia syndrome virus (SFTSV) in East Asia. SFTSV splits into two lineages with diversity driven by segment-specific reassortment; transmission occurs via distinct networks.

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.

Aqueous zinc batteries suffer from poor reversibility due to interfacial instability. Here, the authors propose an electric field-responsive electrolyte design that modulates zinc-ion solvation and interfacial chemistry, leading to uniform deposition and extended cycling stability.

Cultivated banana is threatened by Fusarium oxysporum f. sp. cubense tropical race 4 (TR4). In this study, the authors assemble the genome of Musa cheesmanii, a wild banana species that is highly resistant to TR4, and use it in crossbreeding with two cultivars to enhance disease resistance.

Emulating biological vision with dual functions of photoreceptors and photosynapses through light-modulated ion transport presents a significant challenge. Here, the authors present a light-regulated nanofluidic iontronic device that can mimic the dual visual functionalities with adjustable polarity-switching behaviour.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

In a prospective multi-centre cohort in China, people living in areas of high soil selenium had a 35% increased risk of incident diabetes over a 3-year study period, with a stronger effect seen for men.

You, Hu et al. discover a population of COTL1^high NK cells regulated by GITRL⁺ macrophages and demonstrate their functional importance in mediating anti-tumour immunity in cancer with impaired tumour-specific MHC-I expression.

The incorporation of alkali metals in kesterite solar cells enables high efficiency but is challenging to control. Xu et al. show that combining Na and Li ions yields optimal phase formation, enabling efficient solar cells and modules.

Traditional iterative catalysis in RiPP biosynthesis typically modifies linear peptides. Here the authors discover GNAT enzymes that iteratively modify fully folded lasso peptides and engineer them to create lipolasso peptides with expanded chemical diversity.

A generative modeling framework enables large-scale designed DNA synthesis, yielding candidate cell therapies.

Analysis of FeTe films grown using molecular-beam epitaxy and annealed under a Te flux post-growth shows that stoichiometric FeTe is inherently a superconductor, contradicting the long-held view that it is an antiferromagnetic metal.

It is currently challenging to identify the Blood-brain barrier (BBB) status using non-contrast MR images due to lack of gadolinium-based contrast agents (GBCA)-induced features. Here the authors find that the contrast-free BBB status identification model (CBSI) overcomes such limitations due to its ability to perform comparably to the gadolinium-enhanced T1-weighted (T1Gd) magnetic resonance (MR) model as well as its generalizability potential.

Li, Turaga and colleagues reveal intrinsic cardiomyocyte senescence and a hypoxic, mechanically stressed microvascular niche in hypoplastic left heart syndrome right ventricles and demonstrate that ventricular assist device therapy can alleviate these senescent states.

Bacterial phosphate transporter PstSCAB is essential for survival and virulence. Here, authors reveal cryo-EM structures of PstSCAB in multiple states, uncovering how conformational changes drive phosphate import and providing insights for antibiotic development.

The origins of non-periodic growth features observed in irregular eutectics have been a source of controversy. Here authors use time-resolved X-ray microtomography during eutectic growth of an alloy to show how competing models can be extended and reconciled.

Using diffusion MRI data from over 10,000 youth, the authors develop 30 tract-specific brain age models and show that developmental deviations in association and limbic tracts are linked to concurrent and future cognition and psychiatric risks.

Selenization is a key step in kesterite solar cell fabrication, but controlling ion migration during this process is challenging. Cui et al. address this issue by introducing a Li₂SnS₃ interphase, achieving a certified power conversion efficiency of 15.0%.

Liquid-like chalcogenide adhesive enables robust mid-IR fiber bonding, eliminating refractive index mismatch and organic absorption, achieving efficient 11.7 W laser power delivery at 4.7 µm with record performance.

Here, the authors determine the cryo-EM structures of chicken ROS1, the ROS1/NEL complex, and the ROS1/NEL/NICOL complex, providing structural insight into how vertebrate ROS1 is activated by the NEL/NICOL ligand–co-ligand complex.

Zhang, Han, Tan, Lu, Ma et al. report that kynurenine derived from peritumoural adipose tissue is hijacked by cancer cells to mediate ferroptosis resistance, a process that could potentially be targeted with immunotherapy to inhibit tumour growth.

Using data involving 24,984 clinicians and 5,210 trials, an AI model integrates information from medical claims, unstructured trial documents and historical enrolment relationships to suggest optimal trial-site configurations, to enhance cost-effectiveness and ethnicity representation.

Newly emerging SARS-CoV-2 variants underscore the need for broad-spectrum antiviral solutions. This study shows a macrocyclic peptide inhibitor that locks the SARS-CoV-2 spike trimer into a “closed” conformation by engaging a conserved region, and demonstrates that intranasal administration of the peptide inhibitor protects against Omicron variants.

The authors propose a targeted doping strategy that enables copper atoms to occupy specific positions within the material’s crystal structure, avoiding the unwanted defects typically introduced by conventional methods.

An integrated photonics scheme is presented for the manufacture of communication systems supporting the use of fibre and wireless infrastructures simultaneously, addressing the long-standing bandwidth mismatch between the two domains and demonstrating ultrahigh data rates.

The authors synthesize cubic GeSe through the alloying of the metavalent compound Sb₂Te₃ and vacancy engineering, achieving a record ZT of 1.38 at 723 K and an energy conversion efficiency of 6.13% in a single-leg thermoelectric device.

Measurement-based quantum computing implements quantum algorithms by performing sequences of measurements on special classes of entangled states, such as cluster states. This approach has now been demonstrated on a superconducting quantum processor.

Chen et al. show that redox signals activate ADAR1 to fix faulty RNA pieces during DNA copying, ensuring smooth replication and protecting genome stability.

A histone ubiquitin-dependent regulatory hub governs stimulus-dependent heterochromatin propagation, with important implications for understanding mechanisms governing rapid changes in the epigenetic landscape in physiology and disease.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

Replacing the toxic lead in the state-of-the-art halide perovskite solar cells is highly desired but the device performance and stability are usually compromised. Here Chen et al. develop inorganic cesium tin and germanium mixed-cation perovskites that show high operational stability and efficiency over 7%.

The PCRCR complex of Plasmodium spp. binds basigin on the erythrocyte surface. While Rh5 of the complex is restricted to P. falciparum, PTRAMP, CSS and Ripr orthologs are present across the genus, for which the authors report common features.

Precise control of individual neuron firing is key for neuroscience. Here, the authors show a novel opsin-free photostimulation method that activates single neurons in vivo by femtosecond laser scanning-induced Ca2+ influx and action potential firing.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

This study reports on a hydrogen-molecule-mediated proton-exchange membrane. The design leverages hydrogen evolution and oxidation reactions on gas diffusion electrodes to overcome the typical trade-off between selectivity and conductivity, with demonstrations in a pH-decoupled rechargeable battery and an electrochemical stack for efficient acid and base generation.

Exemplified by Bi_0.4Sb_1.6Te₃, the authors reveal the reason for low thermal conductivity induced by compositional inhomogeneity lies in randomly aligned edge dislocations induced by random composition distribution.

Nuclear Factor IA is important for development and metabolism. Here, the authors present high-resolution molecular structures of Nuclear Factor IA, and detail how it recognizes the TGGCA DNA motif.

Wang, Zheng, Qian, Pan, Tian et al. characterize the crosstalk between peritumoural visceral adipose tissue and colorectal tumour microenvironment and report an immune escape mechanism, which may be potentially targeted for improved immunotherapy.

A van der Waals heterostructure made from atomic layers of ferroelectric CuCrP₂S₆ and ferromagnetic Fe₃GeTe₂ can offer reversible, non-volatile ferroelectric control of two-dimensional magnetism.

Gene redundancy in prokaryotes remains understudied. This analysis shows redundant genes are widespread, with pathogens accumulating more than non-pathogens, and are linked to virulence of Acinetobacter baumannii.

Stable adipocytes resist lipolysis in healthy states but are highly susceptible to a catecholamine-independent, neurosystemic pathway-driven catabolic state.

Here they show that G9a-mediated H3K9me2 regulates intestinal homeostasis and injury repair through repression of cell cycle arrest genes in both mouse and human.

The development of novel two-dimensional antiferromagnets is crucial for enhancing the performance of spintronic devices. Here, authors realize the synthesis of CrOCl monolayer films and nanosheets that exhibit excellent performance.

The number of metal complexes featuring gold-germanium bonds is limited. Here the authors report the preparation of germylene-bridged digold complexes complexes and study their structure, bonding, and reactivity.