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The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.

Fibre integrated circuits created by first preparing circuitry on extremely thin and flexible substrates and then mechanically rolling them up demonstrate microdevice density reaching 100,000 transistors per centimetre and excellent stability under harsh service conditions.

Interrupting the copper-catalysed azide–alkyne cycloaddition has emerged as a strategy to broaden the scope of these transformations. Here, the autuors intercepts a copper triazolide intermediate with a cyclic diaryliodonium reagent, enabling a three-component coupling of the cyclic diaryliodonium species, an alkyne, and an azide under atroposelective control.

YTHDC2 is a promising therapeutic target, but lacks potent inhibitors. Yang et al. develop a deep learning-based molecule generator EPMolGen. Using this model, they discover a potent, selective, and cell-active small molecule inhibitor of YTHDC2.

A model trained to generate spatial proteomics profiles and predict the expression of 40 biomarkers directly from histopathology slides is shown to improve survival and treatment response prediction in patients with lung cancer.

In this work, authors show that micro- and nanoplastics at environmentally relevant levels promote conjugative transfer of antibiotic resistance genes between bacteria by altering oxidative stress, membrane permeability and energy metabolism.

Structural, genetic, functional and biochemical analyses of the complex flagellar motor of Campylobacter jejuni reveal structural adaptations with an ancient origin also found more widely across bacterial species, including elements exapted from the type IV pilus machinery.

In this longitudinal cohort study, Wang et al. examine how depression and recall of adverse childhood experiences interact over time among Chinese university students.

Liu, Liu, Wu and Yao et al. developed a peptide inhibitor that selectively blocks the Ada-two-A-containing histone complex by targeting the YEATS2 YEATS domain and suppresses tumor growth in non-small cell lung cancer.

The intrinsic light reflection of organic conjugated films significantly influences the optical performance of devices through Fabry–Pérot micro-cavity effect. Here, authors modulate cell micro cavity via tuning materials’ refractive index to improve photovoltaic performance of organic solar cells.

Enantioselective recognition and chiral separation of amino acids hold significant importance in chemistry, materials science, and life science. Here, the authors report a water-soluble chiral fluorescent probe that enables visual chiral recognition and separation by incorporating a morpholinium quaternary cation into BINOL frameworks.

ROSE-3D is a single-molecule localization microscopy approach that achieves high isotropic resolution via interferometric localization. The approach is capable of whole-cell and multicolor imaging.

Wang et al. identify the intragrain impurity nanoclusters of a metastable (FA,Cs)PbI₄ phase, arising from intragrain cation segregation, to be the performance-limiting defect structure in FA–Cs mixed-cation perovskites. An inner salt is introduced to mitigate these intragrain defects, enabling n-i-p perovskite solar cells with efficiency of 26.03%.

This study reveals how the bat coronavirus HKU5 recognizes ACE2 receptors across mammals and birds, uncovering a cross-class receptor usage in coronaviruses and highlighting its potential for interspecies and zoonotic transmission.

Using ancient DNA, isotopes and proteomics, this work reveals social inequality and mobility in Eastern Zhou China, showing female sacrifices, dietary disparities across classes, kinship networks among elites, and rare evidence of social mobility.

Forest management primarily drives the carbon sink enhancement in China from 2001 to 2021, achieving carbon gains at a rate over 4 times higher than afforestation, according to an integrated framework combining remote sensing-driven and climate-driven process models.

Metabolic syndrome (MS) is associated with enhanced risk to develop endometrial cancer (EC). Here, the authors show that oleic acid, increased in MS, promotes endometrial cancer by supporting the stability of the rate-limiting enzyme in polyamine metabolism ODC1 and polyamine accumulation.

In this work, authors show that a small molecule inhibitor, C607-0736, blocks the virulence of pandemic Vibrio cholerae by targeting the outer membrane protein OmpV, reducing bacterial adhesion and toxin delivery.

The relationship between innate immunity and cellular senescence is unclear. Here the authors show that NRF1 promotes inflammatory signaling and suggest that NRF1 inhibition may improve age-related health outcomes.

The authors leverage a super-bunching light to develop a spectrally encoded parallel LiDAR that achieves crosstalk-free optical channel division and supports effective long-range detection beyond conventional pulse-period limitations without requiring additional encoding or decoding.

Human Glucose-6- phosphate Transporter (G6PT1) is critical for systemic glucose homeostasis. By integrating multiple cryo-EM structures with functional validation, the study elucidates the molecular mechanism of G6PT1 and its dysregulation in glycogen storage disease.

Hirschsprung disease, characterized by the absence of ganglion cells leading to functional bowel obstruction, can be treated with surgery. Here, the authors report that preoperative nutritional support in children with Hirschsprung disease reduced the risk of postoperative enterocolitis by comparison to standard of care in a randomized controlled trial.

Solute carrier family 26 (SLC26) mediates transmembrane transport of negatively charged ions. Here, the authors report cryo-EM structures of human SLC26A7 in apo and iodide binding states, providing insight into the ion recognition mechanism of SLC26 family proteins.

Radical repositioning to activate remote bonds is underdeveloped in synthetic biocatalysis. Now a photobiocatalytic system couples light-driven single-electron transfer and the relocation of unpaired electrons to activate remote C–C and C–H bonds for enzymatically controlled enantioselective acylation.

Neonatal brain injury from intermittent hypoxemia increases fatty acid oxidation and causes long-term changes in hippocampal lipid profile. Here authors demonstrate oral treatment with glycerol-triacetate restores lipid fatty acid profile and promotes functional recovery.

Grassland productivity is shaped by water and nutrient availability, but belowground growth shows distinct patterns. Here, the authors show that root productivity is most nitrogen-limited under intermediate precipitation, unlike aboveground growth where nitrogen limitation rises with more rainfall.

Iron oxide nanoparticles (IONP) are approved to treat iron deficiency and have been reported to reduce leukaemia in preclinical models. Here, the authors show that carboxymethyl dextran-coated IONP, but not other types of surface coating, activate the complement alternative pathway, enhancing macrophage phagocytosis and adaptive immunity to reduce leukaemia burden in mouse models.

Vitamin K-dependent carboxylation is vital for human health. Here, authors present cryo-EM structures of the relevant γ-glutamyl carboxylase, uncovering substrate recognition, processive modification, and a bicarbonate-mediated CO₂ fixation mechanism.

Despite the global spread of the mpox virus, the long-term durability and breadth of infection-induced immunity are not fully understood. Here, the authors analyze MPXV-specific immune responses up to 18 months post-infection, revealing robust cellular immunity and cross-neutralization among orthopoxviruses, which inform reinfection risks and vaccine development strategies.

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

The clinical activity of neoadjuvant immunochemotherapy for treating locally advanced oral squamous cell carcinoma (LA-OSCC) remains uncertain. In this single-arm, phase II trial, the authors show that neoadjuvant camrelizumab plus nab-paclitaxel and cisplatin provides a favourable pathological response and manageable safety in patients with LA-OSCC while baseline CD4_Tfh_CXCL13 cells may serve as a predictive biomarker of efficacy.

Minimally invasive oral vaccine delivery is a desired approach. Here, the authors report on an engineered probiotic-based oral vaccine system that enables controlled mucosal delivery of ferritin-displayed dual antigens, eliciting robust mucosal and systemic antitumor immune responses.

BCNE, an unsupervised deep-learning method, reveals clear trajectories of brain activity and effectively distinguishes cognitive events, learning stages and active versus passive movement, outperforming traditional data visualization methods.

Wildfire observations reveal that 21% of black carbon aerosols contain multiple cores, and accounting for this morphology increases global absorption by 19%, highlighting a missing source of radiative forcing in current models.

Central thalamic patterns index recovery in patients with disorders of consciousness (DoC) across different severities, etiologies and ages, revealing a shared mechanism underlying consciousness recovery in DoC and informing treatment strategies.

DNA damage response inhibitors are a promising cancer therapy. Here, the authors show that combined PARP and ATR inhibition triggers ZBP1-dependent PANoptosis in cancer and normal cells, revealing a mechanism to balance efficacy and toxicity in DDR inhibitor therapies.

Confocal Airy beam integrated with single-photon oblique light-sheet tomography (CAB-OLST) is a high-throughput imaging approach for brain-wide mapping of neurons, as demonstrated in cleared mouse brains.

A diethyl ether-triggered luminescence strategy is designed to spot the critical point distinguishing atomic sites from heterointerfaces in In₂O₃/ZrO₂. It is validated for other metal oxide catalysts and serves as an alternative to HRTEM detection.