Clinical Sciences articles

Time frame: 1 May 2025 - 30 April 2026

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Count: 6142

Article ‘Count’ for Clinical Sciences.

Journal Count
93
Chemotherapeutic Agent-Loaded Nanoparticles Synergizing with X-ray Irradiation to Regulate Fibroblast-like Synoviocytes for Rheumatoid Arthritis Treatment
Nanotrap–AI Integration Enables Ultra-Sensitive Point-of-Care HIV Testing
Exosome-Mitochondrial Hybrid Membrane with Targeted Delivery of CO Prevents Mitochondrial Dysfunction and Pyroptosis against Myocardial Ischemia-Reperfusion Injury
A Bispecific Nanovehicle Disarms a Biofilm Amyloid Shield for Implant-Related Osteomyelitis Therapy
A Self-Alarming Nanoantidote for Early Urinary Diagnosis and Antioxidative Therapy of Drug-Induced Acute Kidney Injury
Mosaic Inverted Hemagglutinin Extracellular Vesicle Vaccines Elicit Protective Systemic and Mucosal Immunity against Heterosubtypic Influenza Infection
DNA Repair Enzyme Regulation Strategy for Enhanced Pancreatic Neuroendocrine Tumor Therapy via Targeting siRNA-Lipid Nanoparticles
Combination mRNA Vaccine Adjuvanted with CpG Oligodeoxynucleotides Enhances Protection against Respiratory Virus Infection
Simultaneous Monitoring of Cytochrome c and Caspase-3 Dynamics Using a Dual-Channel Nanoprobe for Deciphering Single-Cell Apoptosis
An Engineered Triple-Functional Nanoplatform for Effective Sepsis Therapy via Macrophage-Targeted Polo-like Kinase 1 Inhibition
Development of Intervertebral Disc Organoids through Directed Differentiation of Mesenchymal Stem Cells and Hierarchical 3D Printing
An Acidosis-Activatable Nanocomposite for Synergistic Microenvironment Remodeling and Reprogramming of Innate–Adaptive Immune Crosstalk in Rheumatoid Arthritis
Predicting Plaque Vulnerability Using Machine Learning-Enabled Nanoagents Sensitized Molecular High-Resolution Magnetic Resonance Imaging Data
Engineering Bacteriophage Cocktail with Mutually Promoted Chemodynamic–Photodynamic Activity for Targeted and Synergistic Biofilm Eradication
Ultrasmall Platinum Nanoclusters Modulating Dysregulated Reactive Oxide Species and Immunity for Psoriasis Therapy and Prevention
Dynamic Simulation Assists Insights into the Deafness Prevention of a Self-Assembly Pd Nanozyme with Intrinsic Targeting
HA/CD44–SS31 Mitochondrial Targeting of Manganese Oxide Nanozymes for Ischemia-Reperfusion-Induced Acute Kidney Injury Therapy
Diagnostic-Mediated Interactive Superlattices Engineering for Threshold-Saltatory Visual Assessment of Tuberculous Meningitis
Disrupting the Senescence-Associated Secretory Phenotype–M1Macrophage Feedback Loop in Synovitis Using Dual Nano-Switches To Restore Joint Homeostasis
A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy
Heterogeneous Magnetic Resonance Nanoprobe for Assisting Liver Fibrosis Three-Dimensional Reconstruction and Cascaded Therapy
A Sonopiezoelectric Z-Scheme Nanoplatform Synergizing Trace Ag+ for Eradicating Methicillin-Resistant Staphylococcus aureus-Induced Pneumonia
Ultrasmall Surface-Charge-Modified Tantalum Oxide Nanoparticles for the Assessment of Articular Cartilage Using Contrast-Enhanced Computed Tomography
Smart Nanoplatform with Self-Stimulation Strategy for Dynamic Regulation and In Situ Visual Imaging of Histamine Activities in Allergic Rhinitis
TA-Zr/Ce Nanozyme-Mediated Lipopolysaccharide Dephosphorylation: A Targeted Strategy for Sepsis Treatment with Hemoperfusion Applications
Chemical Gambit in Bone Microenvironment: pH-Responsive Cu–Mn Nanoplatform Breaks the Inflammation-Osteoclast Vicious Cycle in Prosthesis-Associated Osteolysis
Bone-Targeted Platinum Nanoframework Prevents Postmenopausal Osteoporosis via Transmembrane Protein 16A Channel Blockade and Reactive Oxygen Species Scavenging
Effective Osteoporosis Treatment by Polypeptosome-Mediated Neutralization of Acid Bone Microenvironment
An Ultralong-Circulating Tantalum-Based Computed Tomography Contrast Agent for Vascular Imaging in Large Animals
Membrane-Targeting Poly(Amino Acids) with a Phage-Like Action Process for Antifungal Therapy
Sequential Mitochondrial Transplantation for Myocardial Ischemia-Reperfusion Injury Treatment
Mitochondria-Targeting Polymeric Micelles for Intervertebral Disc Degeneration Alleviation via Coordinated Cascade Energetic Intervention
A Diselenide-Linkage Self-Assembled Nanoprodrug for Enhanced Osteoarthritis Treatment
In Situ Supply and Anchoring of Glycosaminoglycan by Dual-Modified Hydrogel Loaded with Glycoengineered Stem Cells for Attenuating Disc Degeneration
Oral PTP1B siRNA Delivery Using Milk-Derived Extracellular Vesicles for Alleviation of Acute Kidney Injury
Single-Molecule and Super-Resolution Diffusion Quantification Unveils Reversible Enhancement of Lipid-Membrane Diffusivity by General Anesthetics
A Multifunctional MOF Heterojunction for Combating Antibiotic Resistance and Promoting Regenerative Immunity
Oral Bacterial Predator with “Catch-and-Kill” Functionality for Bacterial Enteritis via Selective Pathogen Capture and Sonodynamic Elimination
Neutrophil Granule-Mimetic Emulsion Inducing Gastrointestinal Immunity against Helicobacter pylori via Subcutaneous Vaccination
On-Demand Collaborative Delivery for Remodeling the Senescent Microenvironment in Intervertebral Disc Degeneration
Self-Reinforcing Nanosonosensitizer Boosts Cascade Immune Activation for Refractory Osteomyelitis Treatment and Recurrence Prevention
Oral Multi-Enzymatic Manganese–Carbon Dots Alleviate Sepsis-Associated Lung Injury via the Gut–Lung Axis
Aggregation-Induced Emission-Based Nanoparticles for Synergistic Photothermal Antibacterial Therapy and Anti-Inflammatory Regulation in Periodontal Infections
Artificial Intelligence-Assisted Low-Dose High Atomic Number Contrast Agent for Ultrahigh-Resolution Computed Tomography Angiography
N-Acetylcysteine-Capped TLQP21-Containing Au Nanocages Alleviate Depression in Mice
Dendritic Cell-Inspired Triple-Functional Biocatalysts with Atomic Iron Sites To Eradicate Drug-Resistant Bacteria and Biofilms
A Therapeutic System Regulating Iron Metabolism in CD63+ Macrophage Subsets Activates Anti-tumor Immunity for Bone Metastasis Therapy
Evaluation of Malaria Parasite Transmission Competency Using a Nanozyme-Based Immunodiagnostic Targeting Female Gamete Antigen Release
Cell Wall-Binding Proteins-Armed Controlled-Release Nanodelivery System Enhances Nisin’s Efficacy against Streptococcus pneumoniae Infections
Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys
A Near-Infrared-II Molecular Probe for Early Diagnosis of Acute Kidney Injury Induced by Diverse Etiologies
Autoinducing Peptide-Mediated Bacterial Keratitis Therapy by Camouflaged Staphylococcus aureus
Injectable Plant Phosphate Coordination Compound-Based Adhesive Hydrogel Accelerates Osteoporotic Fracture Healing by Restoring Osteoclast/Osteoblast Imbalance
Cobalt-Doped Carbon Quantum Dots Work Synergistically with Weak Acetic Acid to Eliminate Antimicrobial-Resistant Bacterial Infections
Light-Driven Double-Layer Polydopamine-Coated Flexible Metal–Organic Frameworks: Balancing Antibacterial and Regenerative Functions
Metal–Organic Framework-Integrated Nanoplatform Orchestrates Osteochondral-Synovial Homeostasis for Osteoarthritis Therapy
Hybrid Spike-Facilitated Capture and Biofilm Destruction Co-Enhances Ultrasound-Mediated Bactericidal Therapy
An Activated Gasdermin Mimicking Polymer for Antitumor Immunity
Biofilm-Responsive Nano-Antibiotics for Degradation of Extracellular Polymeric Substance Matrix and Reduction of Pathogenicity against Drug-Resistant Bacterial Infections
Metal–Organic Framework-Remodeled Gut Microbiota Alleviates Colonic Inflammation via Selective Modulation of Roseburia intestinalis
Conformational versus Configurational Entropy: Deciphering the Alkyl Chain-Dependent Membrane Attack Mechanism of Ionic Liquid Derivatives
Multiplexed Ultrafast Photothermal Digital Polymerase Chain Reaction Based on Oligo(Phenylene-Ethynylene)
Hydrogen Therapy and Lipopolysaccharide Trapping with MgB2@Inulin Gel for Reversing Colitis and Its Associated Psychiatric Complications via the Gut–Brain Axis
Hierarchical Micro–Nano Porous Structure of Diatom Biosilica Induces Selective Absorption and Protease Inhibition for Bleeding Control
Dual-Pronged Attack: Biomimetic Multi-Functional MOFs for Rheumatoid Arthritis Therapy via Inhibiting Synovial Hyperplasia and Improving Immune Microenvironment
A Droplet Microfluidic-Derived Pathological Microenvironment-Activated Spore Nanozyme Device for the Precise Regulation and Treatment of Colitis
Selenium Nanoplatform Engages Tranexamic Acid to Alleviate Ultraviolet B-Induced Skin Pigmentation via Inflammatory Response
Lysosome-Targeting Nanochimeras Attenuating Liver Fibrosis by Interconnected Transforming Growth Factor-β Reduction and Activin Receptor-Like Kinase 5 Degradation
Oral Nanoarmored Live Bacterial Biotherapeutics Bearing Polyphenol-Based Supraparticles Enhance Chemotherapy via Reestablishing Immuno-Oncology-Microbiome Axis
Nanoparticle–Protein Corona Boosted Cancer Diagnosis with Proteomic Transfer Learning
Defective RuO2 Nanospheres Attenuate Osteoarthritis Progression via Suppressing the ROS/NLRP3/Caspase-1 Signaling Pathway
Photoactivatable Exosenolytics Activate Natural Killer Cells for Delaying Osteoarthritis
Microenvironment-Activatable Long-Wavelength NIR-II Visualization and Synergistic Treatment of Pulmonary Embolism
Simultaneous Visualization of Anatomical Structure and Molecular Pathology Variation in Vascular Inflammation with Informationized Serum Albumin
Biosynthesis of Melanin with Engineered Probiotics for Oral Treatment of Ulcerative Colitis
An Intein-Spliced Nipah G Protein Ferritin Nanoparticle Vaccine Provides Complete Protection against Lethal Nipah Virus Challenge
Cell-Free Expression of Nipah Virus Transmembrane Proteins for Proteoliposome Vaccine Design
Valence Electron Fluctuation in a High-Entropy Oxide Heterojunction Enables Collaborative Photodynamic and Mild-Thermal Therapy for Cutaneous Biofilm Infections
Defect-Boosted Piezoelectric and Nanozymatic Synergetic Catalysis for Deep Bacterial Abscess Therapy
Monitoring Abundance and Activity of Electrochemically Inactive Protein in a Single Cell by an Atomically Precise Metal Cluster-Based Electrochemical Sensor
MXene-Based Cartilage-Adhesive Microspheres for Photothermal-Controlled Hydrophobic Drug Release and Mesenchymal Stem Cell Delivery in Osteoarthritis
Functional Amyloid Phenol-Soluble Modulin α1-Targeting Photothermal Nanoplatform for Effective Elimination of Biofilm-Associated Infections
Capillary Force-Driven Capture of Magnetic Nanoparticles in Calcium Phosphate Hollow-Tube Whisker Scaffolds for Osteonecrosis of the Femoral Head
Epitope-Optimized Influenza Hemagglutinin Nanoparticle Vaccine Provides Broad Cross-Reactive Immunity against H9N2 Influenza Virus
High-Sensitivity Cell-Based Plasmonic Biolayer Interferometry with a Two-Tiered Enhancement for Clinical Autoimmunity Surveillance of Pemphigus Vulgaris
A Precision-Guided “Trojan Horse” for Tissue-Cell-Bacteria Targeted Therapy of iSalmonella/i Intestinal Infections
In Situ Generation of Pyroptosis Inducer Mediated by Intracellular Labile Copper Pool for Safe and Robust Antitumor Immunotherapy
Antibacterial Peptides-Produced Cell Hydrogel Eliminates Intracellular Pathogens and Remodels Immune Microenvironment for Osteomyelitis Therapy
Oxygen-Independent Sulfate Radical and Fe2+-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects
Selenium-Doped Carbon Dots as a Multipronged Nanoplatform to Alleviate Oxidative Stress and Ferroptosis for the Reversal of Acute Kidney Injury
Acid-Triggered Charge-Switchable Antibacterial Hydrogel for Accelerated Healing of Gastric Mucosal Wounds
Nicotinamide Adenine Dinucleotide-Loaded Lubricated Hydrogel Microspheres with a Three-Pronged Approach Alleviate Age-Related Osteoarthritis
Dual Treatment of Chronic Chagasic Cardiomyopathy and Parasitic Burden via Combination Nanotherapy
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Nano-enabled enzyme-assisted layer-by-layer coating prevents biofilm formation on urinary catheters
Biomaterial-mediated scavenging of extracellular thrombospondin-1 in peripheral vessels mitigates intestinal ischemia-reperfusion injury
Hyaluronic Acid–Phosphatidylcholine Complexes as Reductionist Mimics of Extracellular Vesicle–Mediated Boundary Lubrication in Synovial Joints
Topical hydrosulphide ion gels: A Paradigm shift in onychomycosis treatment
Age and Region Dependent Biomechanical and Ultrastructural Differences in Porcine White Matter
THE EFFECT OF PERFUSION WITH AND WITHOUT MECHANICAL LOADING ON AN IN VITRO MODEL OF THE OUTER ANNULUS FIBROSUS-CARTILAGE ENDPLATE INTERFACE
Development of a Nanocement Platform for Site-Specific Antibiotic Delivery in Skeletal Tuberculosis
Polypyrrole nanozymes with cell-free DNA scavenging and ferroptosis inhibition capabilities for the treatment of acetaminophen-induced acute liver injury
Phagocyte-Inspired Supramolecular Self-Assembly Design of Abiotic Cell-Mimics for Pathogen Recognition and Eradication
Thermosensitive hydrogel delivers nanoparticles for the modulation of immune homeostasis for salpingitis therapy
Bio-lubrication in insect joints: A lesson for designing a low-friction micro-bearing
Bioinspired and Absorbable Self-Gelling Powder with Anti-Polyelectrolyte Effect for Effective Hemostasis and Tissue Adhesion Prevention of Non-Compressible Wounds
An amyloid-based hydrogel with remineralizing and antibacterial properties for interrupting dental caries
Synergistic therapy with cerium-based nanozymes and mitochondrial RNA polymerase inhibition combats mitochondrial double-stranded RNA-mediated inflammation in osteoarthritis
Multilayer Lipid Vesicles Loaded with Deoxyribonuclease 1 for the Degradation of Neutrophil Extracellular Traps in Rheumatoid Arthritis
Biodegradable sodium citrate-treated hyaluronic acid microspheres for genicular artery embolization
Osteoarthritic chondrocytes exert higher contractile forces and exhibit enhanced protrusive activity when cultured in 3D degradable hydrogels
M2 macrophage-derived exosome nanoplatform for targeted H2S delivery to alleviate hepatic ischemia–reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects
Self-Assembled Polymeric Nanoparticles for Redox- and Gene-Regulated Osteoarthritis Therapy
A Physiological Oxygen Gradient Liver-Zonation-on-a-Chip Reveals HIF-2α Intervention in Hepatic Lipotoxicity
Oxygen-Self-Supplying Biomimetic Nanozymes Synergize with Methotrexate to Reprogram Macrophage Polarization for Rheumatoid Arthritis Therapy
Presentation of hemagglutinin on adjuvant-bearing self-assembling peptide nanofibers increases heterologous responses against influenza
Harnessing Albumin as a Carrier for the Delivery of Anti-HIV Drugs to the Lymphatic System
Advanced polyelectrolyte complexes for ultrafast hemostasis and blood superabsorption
Metal Ion-Protein-Based Liquid Hemostatic Foam for Prehospital Emergency Treatment of Incompressible Hemorrhage
Breast Implant microbiome profile correlates with foreign body response severity
Angiogenesis-Driven Hybrid Hydrogel with pH/ROS-Activated Anti-infection and Enhanced Cellular Metabolism for Efficient MRSA-Impaired Wound Repair
A multifunctional self-gelling hemostatic powder based on synergistic non-covalent interactions for rapid hemostasis and infected wound healing
Post-yield Behavior and Failure Mechanisms of Murine Cortical Bone at the Microscale across Different Ages Depend on Alterations in Mineralized Collagen Fibrils’ Arrangement
A multiscale finite element model of fluid-microstructure interactions in human intervertebral disc compression
Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae
Broad-spectrum Antibacterial Peptidopolysaccharides for Targeted Therapy of a Drug-resistant Bacterial Liver Abscess
An engineering-reinforced hypoxia-preconditioned exosome-integrated hydrogel delays intervertebral disc degeneration via the PPARγ-autophagy axis
Ultrasound-activated directional and controllable nitric oxide therapy for vascular calcification repair through the modulation of eNOS/iNOS homeostasis
Macrophage membrane-camouflaged dual drug-based biomimetic pH-responsive nanomedicine for synergistic antifungal-antioxidant therapy in oral candidiasis
Mechanical and Structural Changes to the Annulus Fibrosus in Response to Sub-Failure Cyclic Loading
Chlorocatechol-Functionalized Gelatin Nanoparticles as a Hemostatic Agent with Antimicrobial Properties
Tear growth mechanisms in high-grade bursal-sided partial thickness tears in the rotator cuff measured with full volume magnetic resonance imaging methods
Biofilm-triggered interfacial assembly of dual-porphyrin heterojunctions for chemo-/sonodynamic treatment of pyomyositis
Equine Influenza Antigen-Based Particle Vaccine Protects Mice Against Homologous and Heterosubtypic Viral Challenges
A hydrogel-based drug delivery system reduces inflammation and oxidative stress to alleviate intervertebral disc degeneration
A Supramolecular Photopyroptosis Nanoinducer with Acidity-Activatable Immunomodulation for Potentiating Cancer immunotherapy
Carboxybetaine zwitterionic coatings on kidney dialyzer components: Surface characterization and blood interactions
Additively manufactured shape-morphing implants for the treatment of acetabular defects
An image-based approach for advanced statistical quantification of architectural parameters and permeability in porous biological media
Biofilm penetrating and disrupting polymers to effectively treat endotracheal-tube-associated biofilm infections
In vitro and in vivo delivery of mRNA to joint cells using polymeric nanoparticles
Impact of transient versus continuous IL−1β-driven inflammatory 3D models on annulus fibrosus cells
Tailored “Three-stage booster” nano-extinguisher for synergistic treatment of severe acute pancreatitis by rectifying mitochondrial dysfunction and inhibiting pancreatic autodigestion
Multiscale characterization of ultrasmall fluorescent core-shell silica nanoparticles in cartilage and synovial joints reveals rapid cartilage penetration and sustained joint residence
A noninvasive method for determining elastic parameters of valve tissue using physics-informed neural networks
Development and mechanical characterisation of an animal model of acute compartment syndrome
Sonosensitizer-doped framework theranostic nanoprobe for enhanced spatiotemporal eradication of helicobacter pylori with photoacoustic imaging guidance
Synergistic reversal of inflammation-mediated degeneration in intervertebral discs: Phenylboric acid-grafted hyaluronic acid hydrogel as an anti-oxidative vehicle for Timp-3 delivery and promotion of extracellular matrix synthesis
Collagen glycation-mediated mechanical stress aggravates ischemia-reperfusion injury
Large animal model of controlled peripheral artery calcification
Extracellular matrix repair and organization of chronic infected diabetic wounds treated with methacrylated chitosan-based hydrogels
A smart capsule with a bacteria- and pH-triggered enteric polymer coating for targeted colonic microbiome sampling
CD4+ T cell membrane-based nanocomposites for enhanced dual epigenetic therapy in psoriasis
Drug-loaded microneedle patches containing regulatory T cell-derived exosomes for psoriasis treatment
Liposomic lubricants suppress acute inflammatory gene regulation in the joint in vivo
Esterase-responsive kartogenin composite hydrogel microspheres boost nucleus pulposus regeneration in intervertebral disc degeneration
Role of mechanical representativity in multiaxial and transverse mechanics of human annulus fibrosus: A microstructure-based biphasic finite element study
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Near‑Infrared Driven Renal Nanomotors for Oxidative‑Stress Relief and Stone Prevention
Gene‐Engineered Nucleus Pulposus‐Mimetic Microspheres Reshaping the Hydration Microenvironment to Delay Intervertebral Disc Degeneration
Ternary Synergy in an Atomically Precise Alloy Nanocluster: Precision Engineering of a ROS-Scavenging Nanozyme for Effective Psoriasis Therapy
Sequential Physical Disruption and Metabolic Interference via a Photothermal Nanozyme Integrated Platform for Eradicating Biofilm Associated Infections and Promoting Tissue Regeneration
Microenvironment-Adaptive, Size-Transformable Self-Assembling Peptide Nanoassemblies for Targeted Delivery and Synergistic Combat Biofilm and Deep Tissue Associated Infections
A Sonosensitizer-Cationic Polypeptide Conjugate Potentiates Sonodynamic Therapy for Mature Biofilm Eradication and Periodontitis Treatment
Polydopamine‐Mediated Thermotherapy Hydrogel for Disc Degeneration Inhibition via Modulating Inflammation and Extracellular Matrix Metabolism
Rational Design of Pentamethine Cyanine With Enhanced NIR-II Fluorescence and Photothermal Conversion Efficiency for Gram-Selective Antibacterial Applications
LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models
Reversing Pro‐adhesive Niche Through Manipulating Aggregative Behaviors of Immune Cell Subsets With a Lubricous Janus Spray Gel for Enhancing Colorectal Cancer Postoperative Adjuvant Immunotherapy
Zwitterionic Polymer-Functionalized Carbon Quantum Dots as High-Performance Nanolubricants for Potential Osteoarthritis Treatment
Closed-Loop Control of Cerebral ATP Transients by an Optogenetic Nanosensor for Alleviation of Depressive-Like Symptoms
NIR‐II‐Triggered Cascade Nanoplatform Combats Biofilms Through CO Release and Macrophage Reprogramming
Lesion-Localized Lubricating Microspheres Loaded with Highly Permeable Spermidine-Derived Carbon Quantum Dots Attenuate Post-Traumatic Ankle Osteoarthritis
Eradicating Helicobacter Pylori with a Multifunctional Trojan Horse Nanoplatform Armored with β-Cyclodextrin
Kidney-Targeted Nanoparticles with ROS Scavenging and STING Inhibition for the Treatment of Acute Kidney Injury
Spatiotemporally Controllable In Situ Hydrogels Enabled by Nanobottle‐Mediated Encapsulation Technology for Stage‐Specific Synergistic Therapy of Osteoarthritis
Domain Confined Fluid-Solid-Piezoelectricity Interaction Triggered Thrombogenesis by Directional Scalariform Meta-Aerogel for Rapid Hemostasis
Interface-Engineered C3N4/TiN Heterostructures for Synergistic Photocatalytic-Nanozyme ROS Generation and Anti-Infective Therapy
NIR‐Triggered Hydrogen‐Thermotherapy Regulates Inflammatory Circuits Between Macrophages and Synovial Fibroblasts in Rheumatoid Arthritis
A Novel NIR‐II Organic Fluorescent Small Molecule for the Early Diagnosis of Fat Embolism Syndrome
Ultrasound‐Triggered Diselenide Bonds Scission for On‐Demand Drug Release in Osteoarthritis Therapy
Iterative‐Designed Multifunctional Carbon Dots Nanodrug for Celastrol Loading, Targeting Delivery, and Combination Therapy of Kidney Stones
Discovery of a Novel Nephroprotective Drug Leveraging a Customized Photoacoustic Imaging Nanoprobe
Preferential Drug Loading into Platelet α Granules Boosts Inflammation‐Targeted Delivery in Rheumatoid Arthritis
Inhalable Microenvironment‐Responsive and Self‐Adaptive AuCu Bimetallic Clusterzyme‐Based Microgel for Spatiotemporally Precise Therapy of Bacterial Pneumonia
Biochemically Responsive Bacterial Codes Enabled by Photodynamic AIE Nanoparticles for Advanced Information Encryption
Charge-Guided Deep Cartilage Targeting Carriers for Nav1.7-Mediated Osteoarthritis Treatment via Simultaneous Pain Management and Cartilage Protection
Self-Propelled Janus Micromotors with Cascade Microenvironments-Responsiveness for Hydrogen-Actuated Whole-Stage Symptomatic Therapy of Helicobacter Pylori-Associated Gastritis
Cascade‐Amplified Light‐Free Singlet Oxygen Generation: A Biomimetic‐Targeted Nanogenerator for Precision Rheumatoid Arthritis Therapy
Breaking the ΔEST Barrier: Triazole-AIE Nanoplatforms with Near-Degenerate Excited States for Combating Drug-Resistant Bacteria
Mechanically Robust Super-Lubrication Polycarbonate-Polyurethane (PCU) Enabled by Design of Dynamic Mechanics Network and Manufacture of Constrained Hydrogel Coating
ROS-Scavenging Hydrogel Microneedles Reverse Intervertebral Disc Degeneration via Combined Mild Photothermal and NO Gas Therapy
An AB-Type Hydrogel CT Contrast Agent for Precise Localization of Intra-Abdominal Hemorrhage
Engineered NK Exosomes for Tumor Immunotherapy via a Positive Feedback Loop-Mediated Efficient Pyroptosis
Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System
Barnacle‐Inspired Nanocomposite Paste with Enhanced Toughness and Crack Blunting for Rapid Hemostasis
ROS‐Responsive Nanoplatforms for Atherosclerosis Photoacoustic Diagnosis and Endothelial Cell‐Macrophage Crosstalk Regulation
An Ionic Gelation Powder for Ultrafast Hemostasis and Accelerated Wound Healing
Robust Superlubricity in Artificial Cartilage Hydrogels via Gradient Stress Dissipation and Comb-Like Polymer Structures
TMEM16A Channel Blockade and Strontium/ROS Regulation by Carrier‐Free Nanoprodrug to Reconstruct Bone Homeostasis for Enhanced Osteoporosis Prevention and Treatment
Rapid Shape Recovery Sponge with Reinforced Skeletons Prepared by Centrifugation‐Assisted Mechanochemical Crosslinking Strategy for Noncompressible Hemostasis
AIE-Powered Nanosoldiers for Precision Disruption of Biofilm's Extracellular Defense in Infection Treatment
Wide-Gamut and Reversible Phosphorescence Tuning From Green to NIR in Carbon Dots via Acid-Responsive Protonation-Assembly Strategy
Lubrication on Demand: A Stress‐Adaptive and Self‐Repairing Material
Bioinspired Wavy Self‐Secretion Surface for Anti‐Encrustation
Flexible Wireless Electrical Stimulator Based on Liquid Metal High‐Density Coils for Chronic Pain Therapy
X‐Ray‐Activated ROS Storm: A Multimechanistic SAO25‐AO@Gel Platform for Deep‐Tissue Bacterial Eradication
Engineered Nanosponge Platform Corrects TLR7-Related Efferocytosis and Platelet-Activation for Treatment of Different Systemic Lupus Erythematosus Stages
Highly Efficient Photocatalytic Elimination of Bacteria and Antibiotic Resistance Genes via a Strong Oxidation Surface in Donor-Acceptor SA-PDI@C60
LipoGels: Robust Self-Lubricating Physically Cross-Linked Alginate Hydrogels Embedded with Liposomes
Extracellular Vesicle–Based Biohybrid Enabling Synergistic Anti‐Oxidative Stress and Anti‐Inflammation for Targeted Therapy of Acute Kidney Injury
An MSR1‐Targeting Glycolipid Platform for Imaging the Changes of Phagocytic Macrophages in the Progression of Atherosclerotic Plaque
Rapid Self‐Gelling Powder Forms Dual‐Crosslinked Hydrogel for Robust Tissue Adhesion and Non‐Compressible Hemorrhage Control
Mild Hyperthermia‐Assisted Coaxial Electrospun Nanofiber Patches for Epicutaneous Allergen‐Specific Immunotherapy
Design and Development of Fiber Patch to Prevent Reperfusion Injury and Provide Thermal Stimulation for Treating Severe Frostbite
MnO2–Pd/PAAS Hydrogels With OXD-Like and SOD-Like Dual Enzymatic Activities Accelerate Infected Wound Healing by Inhibiting Bacterial Growth and Mitigating Oxidative Stress
Orchestration of Pathological Osteoclast‐Chondrocyte Communication via Acid‐Responsive Nanotherapeutics for Articular Cartilage Regeneration
Phage-Inspired Nanomotor Synergized with Sono-Sensitive Antibiotics for Treating Multidrug-Resistant Klebsiella pneumoniae Lung Infection
Lubrication Barriers Hydrogel Microspheres Improve Dynamic Tissue Repair via the Blockade of Inflammatory Communication
Hydration-Lubricated, Cartilage-Targeted, and Anti-Inflammatory Triple-Functional Nanospheres for the Treatment of Osteoarthritis
Spatiotemporal Regulation of Oxidative Stress by Redox Relays for Ischemia‐Reperfusion Injury Rescue
Au-Modified SrTiO3 Nanoarray Featuring Enhanced Ultrasound-Responsive Mott–Schottky Heterojunction Speeds Bone Regeneration Through Sonodynamic Antibacterial and Inflammatory Management
A Vascularized Microphysiological System Reproducing Endochondral Ossification in Vitro to Study Ewing Sarcoma Proliferation and Migration
Polymeric Skin Booster with Moderate Collagen Regeneration
Bio‐Responsive Hydrogel for Targeted on‐Demand Release of a Phage Cocktail for Treatment of iPseudomonas aeruginosa/i Infection
An In Situ Transformable Orally Administrated System for Targeted Intestinal Barrier Protection and Inflammatory Microenvironment Modulation in Sepsis Therapy
Self‐Propelled Lung‐Targeting Nanovaccine Modulates Iron Homeostasis‐Immune Crosstalk for Therapeutic‐Prophylactic Intervention in Bacterial Pneumonia
Oxygen‐Immunomodulated Nanocatalysts Enhance Anti‐Infection by Trained Immunity
“Precision-Guided Killer” Engineered Phage for Combating Carbapenem-Resistant Klebsiella Pneumoniae Induced Inflammatory Bowel Disease
Polyphenol‐Driven Modular Self‐Assembled Nano‐Antibiotic for Inflammation Control via Bacterial Infection Clearance and Pyroptosis Inhibition
Biomimetic Hydrogen‐Generating Piezoelectric Hydrogel for Dual Glucose Regulation and Mitophagy Activation in Diabetes‐Induced IVDD
Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism
Pollen‐Inspired Aptamer Delivery System for Multi‐Target Therapy in Rheumatoid Arthritis
Enhanced Sonodynamic Bacterial Elimination and Wound Healing Therapy Based on Lanthanide Ion Doped Bisub2/subWOsub6/sub Nanosheets and Hydrogel Platform
Ferroelectric Heterojunction Membrane with Rapid Disinfection Through Coupling Piezoelectric and Pyroelectric Catalysis for Wound Regeneration
Toxin‐Responsive Antigen Reservoir Nanovaccines for In Situ Vaccination Against Bacterial Infection Recurrence
Surface-Bound Gene-Functionalized Injectable Short Fibers via Reversing Collagen Aging for Inhibiting Intervertebral Disc Degeneration
Precise Synthesis of Tri‐Pyrroles for Combating Drug‐Resistant Bacteria
Montmorillonite Modulates Manganese d-Band Center to Enhance Cascade Reaction Activity Against Inflammatory Bowel Disease
Cellular Capsule Delivery Bioink with Punicalagin-Loaded Chondrocyte Membrane Vesicles for Tissue Engineering Therapy
A Printed Polarization-Sensitive Biochip for Rapid and Accurate Detection of Respiratory Infections
Activatable Near-Infrared IIb Rare-Earth Nanoprobe for Early Monitoring Chemotherapy-Induced Liver Injury
Dual-Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing
Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection
Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation
Joule‐Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures
Peptide-Decorated Liposomes Enhance Fungal Targeting and Antifungal Drug Delivery
Self-Assembled Poly(sarcosine) Functionalized Host Defense Peptide-Mimicking Poly-β-Peptides for Combating Drug-Resistant Fungal Infection
Advanced Injectable Microgels: Porous, Small-Sized, and Lubricated Systems for Targeted Synergistic Therapy in Osteoarthritis
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Dual Single-Atom Engineered NADH Oxidase-Mimic Boosts In Situ NAD+ Biotransformation for Targeted Myocardial Ischemia/Reperfusion Protection
Circularly Polarized Metamaterial Cage for Homogeneous Signal‐to‐Noise Ratio Enhancement in Magnetic Resonance Imaging
Selective Induction of Cancer Cell Pyroptosis by Erbium Nanotuner Enhances Potent Anti‐Cancer Immunity
Immune and Stem Cell-Mediated Bactericidal Amplification and Bone Remodeling for Infection Clearance and Osteointegration
Coagulation-Independent Hemostasis Through Architecturally Programmed Chitosan Aerogels with Dual-Crosslinked Networks
A Nanochiral Biosensor Enables Clinical Anesthesia Monitoring
Multifunctional Self-Assembling Peptide System for Preventing Noise-Induced Hearing Loss
High-Efficiency Targeted Mitochondrial Transfer and AUTAC4-Enhanced Dual Renewal Strategy for Rheumatoid Arthritis
Intercellular Communication‐Driven Mitochondrial Transfer via CXCR4‐Engineered Macrophages Reprograms Bone Marrow Metabolism for Osteoporosis Therapy
Sheath‐Inspired Durable Semi‐Convertible Hydrogel Enabled Controllable Lubrication and Contractibility
Metamaterial Antennas Enhance MRI of the Eye and Occipital Brain
Polysaccharide Engineered Nanozymes Target Inflammation for Alleviating Colitis‐Associated Mental Disorders via Microbiome‐Gut–Brain Axis
Bubble Evolution-Guided Interconnected Hierarchical Macroporous Sponges for Non-Compressible Hemostasis in Preclinical Models
Novel Antimicrobial Nano Bacteriocin: Lactic Acid Bacteria-Derived, Self-Assembled, and Enhanced for Superior Antimicrobial Activity
Enhanced Biofilm Infiltration by Drug-laden Coacervate for Treating Refractory Infections
Magnetic Mesoporous Nanoparticles Loaded with Lycium barbarum Glycopeptide for Targeted Therapy of Noise-Triggered Auditory Dysfunction
Poly(Ionic Liquid) Nanofibers Suppress S. aureus Membrane Vesicle-Induced NETosis to Mitigate Wound and Lung Damage
Fluoropolymer-Mediated Delivery of a Dual TSHR/IGF1R-Targeting CRISPR-Cas9 System for Localized Therapy in Thyroid-Associated Ophthalmopathy
Chiral Single-Atom Nanozymes-Enabled ROS Catalysis and Metal Transport Regulation Cooperatively Induce Ferroptosis to Treat Bacterial Infections
Selectively Breaking Bicontinuous Microphase Confinement for Sustainable and Unprecedented Superlubricating Hydrogels
Integrating Vibrio natriegens for Photon Manipulation in Living Lighting Devices
Lattice‐Reconstructed Ru‐Clusters on FeOOH‐Based Self‐Adaptive Artificial Peroxisome with Programmed ROS Regulation for Infectious and Inflammatory Chronic Wounds
Enzymatically Switchable Pyroptosis-Inducing Polymer Conjugate to Coordinate Host Immune Responses in Cancer Immunotherapy
Disrupting Complement‐Inflammation Positive Feedback Circuit via Oligonucleotide Hydrogel Microspheres for Reversing Joint Inflammation
LPS-Binding Hydrogel for TLR4-Mediated Microbiota-Immune Modulation
Bio‐Orthogonally Labeled Orbitals‐Hybridizing Nanozymes Induce Tissue‐Resident NK Cells for Enhanced Photo‐Immunologic Therapy of Biofilms and Preventing Secondary Infection
Mitochondria Rewiring by Polyphenol-Copper Nanodots to Truncate Mitochondrial-Endoplasmic Reticulum Crosstalk for Acute Kidney Injury Therapy
A Single-Cell-Inspired Self-Enrichment Therapeutic Strategy Delays Intervertebral Disc Degeneration by Inhibiting Pyroptosis
Fully Biocompatible Tantalum-Based Antioxidant Nanoshields for Proximal Tubule Epithelial Cells-Targeted Mitochondrial Holistic Protection in Acute Kidney Injury
Janus Graphene Oxide Nanoplatform with Oppositely Functionalized Adhesion and Lubrication Enables Local Sustained Fenofibrate Release to Synergistically Halt Osteoarthritis
Virus Enhanced Microrobots for Biofilm Eradication
Engineered Apoptotic Extracellular Vesicles for Programmable Regulation of Neutrophil-Macrophage-ROS Pathogenic Axis to Reconstruct Rheumatoid Arthritis Microenvironment
In Vivo Reprogramming Dysfunctional Retinal Ganglion Cells and Visual‐phototransduction via Wireless Charging Nanogold for Leber's Hereditary Optic Neuropathy
Flexible Photovoltaic Neurostimulator for Analgesia
Oral Covalent Organic Frameworks as Dysbiosis‐Mitigating Oxalate Sequestrants for Crystalline Nephropathy
Push–Pull Electronic Effect and D‐Band Center Bi‐Modulated Bio‐Heterojunction Enzyme Enables All‐Stage Infected Wound Healing
3D Acoustic Imaging Hitting the Diffraction Limit via Fully Parameter‐Optimized Meta‐Lens and Frequency‐Domain Reconstruction
Photosensitive Biomimetic Nanomedicine‐Mediated Recombination of Adipose Microenvironments for Antiobesity Therapy
Biomimetic Engineering of Robust Gradient Antibacterial Coatings using Hollow Nanoframes of Prussian Blue Analogues
Dendritic Cell‐Based Biohybrid Immunomodulator Alleviates Intestinal Inflammatory Disease
Spatiotemporal Charging Single‐Atom Nanozymes Activated Pyroptosis for Antitumor Immunotherapy via Bioorthogonal Disruption of Succination and Reinvigorating T Lymphocytes
Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding
DNA‐Engineered Modular Nanovaccines Featuring Precise Topology for Enhanced Immunogenicity
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Presidential Address: Investing in Children to Address the Child Mental Health Crisis
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Differential associations between menstrual blood loss scores and iron status in Northern European and East Asian individuals: findings from a cross-sectional analysis of the iron genes in East Asians and Northern European adults (FeGenes) cohort
Ingestion of diverse protein-rich whole-foods result in similar post exercise whole body and myofibrillar protein synthesis rates compared with a more isolated protein source in young adults
Fiber Intake and Laxation in People With Normal Bowel Function: A Systematic Review
Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial
Ultra-processed food consumption and incident autoimmune-related hypothyroidism: A sex-stratified prospective analysis from the UK Biobank
Is light-to-moderate alcohol drinking associated with the onset of metabolic dysfunction-associated steatotic liver disease in a Chinese cohort?
Post-malnutrition weight gain is associated with changes to muscle and energy metabolism in adolescence: a cohort analysis
Association between hemoglobin levels and mild cognitive impairment in generally healthy European community-dwelling older adults: a three-year prospective analysis of the DO-HEALTH trial
STRENGTHS AND LIMITATIONS OF URINARY SUGAR TESTING; AN OBSERVATIONAL STUDY OF INTESTINAL PERMEABILITY AND ABSORPTION IN ADULTS AND CHILDREN IN ZAMBIA AND TANZANIA WITH REFERENCE TO MUCOSAL BIOPSIES
Prenatal and preschool micronutrient supplementation and behavioral outcomes in school aged children in Nepal – a cohort study.
Preoperative plasma short- and branched-chain fatty acids in relation to risk of complications after colorectal cancer surgery: a prospective cohort study
Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: A randomized, double-blind placebo-controlled study
Lanthanum carbonate lowers serum phosphorus without altering body phosphorus burden in maintenance peritoneal dialysis patients: a randomized crossover trial
Arm circumference as a marker of muscle mass: cutoff values from NHANES 1999-2006
Relationship between skeletal muscle indicators and clinical outcomes in cystic fibrosis is modified by adiposity and CFTR modulator use: A cross-sectional analysis
Novel protein targets for type 2 diabetes prevention and their mediating role in the diet–disease relationship: evidence from 2 population-based cohorts and a Mendelian randomization analysis
Weight-adjusted-waist index, estimated glucose disposal rate, C-reactive protein, and mortality risks among individuals with type 2 diabetes: two prospective cohort studies in China and the UK
Magnesium Treatment Increases Gut Microbiome Synthesizing Vitamin D and Inhibiting Colorectal Cancer: Results from a Double-Blind Precision-based Randomized Placebo-Controlled Trial
Vitamin C Status across the Spectrum of Chronic Kidney Disease and Healthy Controls: a Cross-sectional Study
The effect of muscle quality index on the risk of adverse health outcomes: a prospective cohort study of 355,209 adults
Associations of body mass index, waist circumference, and weight-adjusted waist index with body composition and biomarkers: A multinational pooled analysis
Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study
The Interplay of Nutritional Status and Physical Function on Health Outcomes in Older Adults: A Longitudinal Study in Singapore
Empirical Dietary Index for Lower Urate Levels and Risk of Gout: Evidence From Cohort Studies
Efficacy of rice bran extract for alleviating depressive symptoms in adults: A randomized, double-blind, placebo-controlled trial
3
Lack of Relationship between Posttraumatic Stress Disorder and Coronary Atherosclerotic Burden among Twin Veterans from the Vietnam Era
A three-part model for the self-controlled case series design to estimate and characterize adverse event risk in an overlapping risk period after multiple vaccines: application to ischemic stroke following Pfizer-BioNTech bivalent COVID-19 vaccine and influenza vaccine
Mixture effects of prenatal exposure to polybrominated diphenyl ethers on urinary oxidative stress biomarkers in the Chemicals in Our Bodies cohort
27
Benchmarking genetic birth prevalence estimates against newborn screening data
Performance of LFSPRO prediction in TP53 mutation status for prospectively collected probands
Measuring disease likelihood in genomic ascertainment
Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B
Identification of de novo variants from parent-proband duos via long-read sequencing
Newborn screening for type 1 diabetes using genome-based risk scores in the Early Check program
Rare-variant aggregation highlights disease-linked genes associated with brain volume variation
Variant interpretation training for the genomics era: Learning outcomes to inform professional competencies and education
Low population penetrance of variants associated with inherited retinal degenerations
Residual allelic activity likely underlies the low rates of disease expression for predicted loss-of-function variants in population-scale biobanks
A scalable approach for genomic-first rare disorder detection in a healthcare-based population
Transcriptome-wide outlier approach identifies individuals with minor spliceopathies
Specifications of the ACMG/AMP variant curation guidelines for the analysis of germline PALB2 sequence variants
Availability of benign missense variant “truthsets” for validation of functional assays: Current status and a systematic approach
Single-cell analysis of human fibrous dysplasia bone reveals a fibrotic transcriptome and GNAS variants in endothelial, perivascular, and stromal cells
Phenome-wide association study of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank
When two plus four does not equal six: Combining computational and functional evidence to classify BRCA1 key domain missense substitutions
Genetic predisposition for immunoglobulin E production explains atopic risk in children: Tohoku Medical Megabank cohort study
Extracting and calibrating evidence of variant pathogenicity from population biobank data
Exclusion-based exome sequencing in critically ill adults 18–40 years old has a 24% diagnostic rate and finds racial disparities in access to genetic testing
Exploring depression treatment response by using polygenic risk scoring across diverse populations
Genomic rare variant mechanisms for congenital cardiac laterality defect: A digenic model approach
Bi-allelic mutations in FASTKD5 are associated with cytochrome c oxidase deficiency and early- to late-onset Leigh syndrome
Consultation informs strategies for improving the use of functional evidence in variant classification
Insights on improving accessibility and usability of functional data to unlock their potential for variant interpretation
Public preferences for the value and implementation of genomic newborn screening: Insights from two discrete choice experiments in Australia
Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder
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Associations Between Psychological and Trauma-Related Factors and Urinary Incontinence Severity and Treatment Response Among Women Veterans
Multi-dose Ibuprofen Prior to IUD insertion (MIPI): A Triple Blinded Randomized Controlled Trial
Does Contained Manual Morcellation in Minimally Invasive Hysterectomy Prevent Myometrial Cell Spillage? Evidence From Sequential Pelvic Washings.
Trachelectomy in decline: national trends, outcomes, and academic output across 3 major databases
Laparoscopic transabdominal cerclage: preconception versus postconception placement
Artificial cycle frozen embryo transfer improves uterine perfusion during later pregnancy but is associated with higher preeclampsia incidence
Altered microbial colonization of the urogenital tract in female overactive bladder syndrome
Survival outcomes after inadvertent surgery in low-risk early-stage cervical cancer
Treatment of unfavorable bleeding patterns in contraceptive implant users with tranexamic acid: randomized clinical trial
The prognostic and clinical significance of cervical stromal invasion in endometrial cancer: a multicenter retrospective study
Topical Therapy and Vulvar Malignancy Risk in Lichen Sclerosus: A Large Propensity-Matched Study
Sexual function after the Manchester procedure versus sacrospinous hysteropexy in women treated for uterine prolapse: a planned analysis of a randomized clinical trial
PGT-A Mosaicism Reporting Lacks Clinical Predictive Value For Live Birth in a Multisite, Double-Blinded Study with Independent Validation
Outcomes by Frailty and Mobility In Older Patients Undergoing Major Urogynecologic Surgery: A Planned Supplementary Study of the ASPIRe Trial
Vaginal hysterectomy versus laparoscopic hysterectomy for benign indications: complications and length of stay in a national analysis of contemporary data
Limits On Vaginal Intercourse after Mid-urEthral Sling (LOVE): A randomized trial
Semi-supervised deep learning for uterus and bladder segmentation on female pelvic floor MRI with limited labeled data
Long-term lymphedema and quality of life following lymph node staging in early cervical cancer: 3 years follow-up in the prospective multicenter SENTIREC CERVIX study
Recovery after Low-Impact Laparoscopic Hysterectomy: A Randomized Controlled Clinical Trial
Whole-Genome Sequencing for the Prenatal Evaluation of Fetal Structural Anomalies: A prospective multicenter study
Differences in pessary support between successful and unsuccessful fit: an analysis in upright position
Association of frailty with healthcare utilization and days alive at home in patients with gynecologic cancers: a population-based study
Impact of Social Determinants of Health on Fecal Incontinence Treatment In Older Women
Increased Frequency of Autism by Previous Diagnosis and Screening in Children with Fetal-Neonatal Alloimmune Thrombocytopenia (FNAIT) with and without an Intracranial Hemorrhage (ICH)
Expanded Non-Invasive Prenatal Screening for Dominant Single-Gene Disorders: Proof-of-concept, Performance, and Challenges
Recommended Standardized Terminology Related to the Clitoris and Vestibular Bulbs Based on a Structured Medical Literature Review.
Optimizing use of a uterine manipulator for laparoscopic hysterectomy: a cadaveric study of distances to the pelvic ureter
Association between urinary incontinence and device-measured physical activity: A cross-sectional study
Genetic diseases underlying a spectrum of fetal effusions
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Dual Immune Lineage Activation Underlies Systemic Immunopathology in ACLF
Cuproptosis Is Induced in Drug-Induced Liver Injury by Oxidative Stress–Mediated Copper Overload
Notch1-Gli1 Axis Reprograms Macrophage Polarization and Promotes Hepatic Inflammation and Fibrosis in Metabolic Dysfunction–Associated Steatohepatitis
Semaphorin 3C/Plexin D1 Interaction Regulates Collagen Metabolism in Keloid Fibroblasts via the Transforming Growth Factor-β1 Signaling Pathway
Spatial Transcriptomics Profiling of Small Intestine Adenocarcinoma and Adenoma in Humans and a Murine Model with KRASG12D and Loss of CDKN2a-p16
Pseudogene-derived long non-coding RNAs GSM3P1/Gstm2-ps1 exacerbate sepsis-associated acute kidney injury by suppressing their parent gene translation
Quantitative 3D Imaging of Mouse and Human Intrahepatic Bile Ducts in Homeostasis and Liver Injury
Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in Mice
Deletion of megalin in kidney tubular epithelium upregulates TGFβ1 signaling, aggravates ischemia/reperfusion kidney injury and accelerates the progression to CKD
Matrix Gla Protein Expression in Pericytes and Myofibroblasts Contributes to Renal Fibrosis
Systemic Disease Progression and Neurodegeneration in the Gbe1 ys/ys Mouse Model of Glycogen Storage Disease IV
Iron and bile acids synergize to exacerbate congenital cholestatic liver injury via ferroptosis
Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages
Necroptosis Inhibition Preserves Diaphragm Function in Experimental Sepsis
Selective Depletion of Gut Gram-Negative Bacteria Attenuates Alcohol-Binge-Induced Cardiovascular Dysfunction by Lowering Cardiac Anandamide Levels
Microglia promote neurodegeneration and hyperkatifeia during withdrawal and abstinence from binge alcohol.
Liver macrophage changes during early adaptation to alcohol exposure
Intra-host genomic variation of Haemophilus influenzae isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions
Hepatocyte-specific MET deletion exacerbates acetaminophen-induced hepatotoxicity in mice
Low-potassium triggers tubular epithelial NLRP3/ASC-driven kidney inflammation independently of inflammasomes
Growth differentiation factor 11 attenuates photoaging through ferroptosis pathway in SZ95 sebocytes
Stromal SRD5A2 promotes prostate growth through WNT5A-LEF1-IGF1 signaling in benign prostatic hyperplasia
Aldehyde dehydrogenase 2 deficiency impairs liver progenitor cell proliferation in alcohol-fed mice
Novel Perineural Pathways and The Dynamics of Simian Immunodeficiency Virus-Infected Macrophage Trafficking Out of the Central Nervous System
The Long Noncoding RNA TUG1 Is Down-Regulated in Osteonecrosis of the Femoral Head and Enhances the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Stimulating the Wnt/β-Catenin Pathway
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus
Peroxisome Proliferator-activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis
Chronic alcohol consumption enhances the differentiation capacity of hematopoietic stem and progenitor cells into osteoclast precursors.
Interleukin-6 Trans Signaling Regulates Neutrophilic Inflammation in Alcohol-Associated Hepatitis
Identification of pre-clinical biomarkers of MASLD vs MetALD and the impact of diet
The PNPLA3 148M variant exacerbates alcohol-induced liver injury and tumorigenesis in mice
PI3K Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation
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Cost-Effectiveness of Community Tuberculosis Screening in South Africa
Early Changes of Lung Mechanics After PEEP Reduction in ARDS: A 4D-CT Study
A large-scale single-cell atlas reveals the pulmonary immune panorama in adult patients with influenza
Lung stress mapping: an innovative technology to visualize the hidden risk of ventilator-induced lung injury
Lower Airway Dysbiosis in NTM+ Bronchiectasis is Associated with NET-Predominant Severe Phenotypes
Early mechanical reperfusion in high-risk pulmonary embolism supported by V-A ECMO: a multicenter international cohort study
Plasma exchange for severe alveolar hemorrhage in ANCA-associated vasculitis: emulation of a target trial
Electrical impedance tomography-guided PEEP and mortality of patients with the acute respiratory distress syndrome: The EITVent randomized clinical trial
Study of Risk Assessment Scores as Surrogate Endpoints in Pulmonary Arterial Hypertension Trials
Human Sputum Microbiome Composition and Sputum Inflammatory Cell Profiles Are Altered with Controlled Wood Smoke Exposure as a Model for Wildfire Smoke
Transcriptomic Profiling in Mycobacterium avium Complex Pulmonary Disease Identifies Clusters Linked to Disease Severity and Neutrophil Activation.
Role of Spontaneous Effort During Mechanical Ventilation on Lung Injury in Preterm Lambs.
Assessment of Respiratory Mechanics and Inspiratory Effort During Spontaneous Breathing Trials to Predict Extubation Failure in High-Risk Patients.
Transmission of Bedaquiline-resistant Mycobacterium tuberculosis in KwaZulu-Natal, South Africa.
The Effectiveness of Isoniazid Preventive Treatment among Contacts of Multidrug-Resistant Tuberculosis: A Systematic Review and Individual-Participant Meta-Analysis.
Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure.
Host-Microbe Multiomic Profiling Predicts Mortality in Sepsis.
Continuous On-Demand Diaphragm Neurostimulation to Prevent Diaphragm Inactivity During Mechanical Ventilation: A Phase 1 Clinical Trial (STIMULUS)
Improving the Reporting of Trials Evaluating Organ Support Therapies Using Multistate Modeling
Telacebec, a Potent Agent in the Fight against Tuberculosis: Findings from a Randomized, Phase 2 Clinical Trial and Beyond
Anti-Anaerobic Antibiotics, Gut Microbiota, and Sepsis-associated Acute Kidney Injury.
Physiological Consequences of Breathing Effort According to the Mode of Ventilation During Acute Hypoxemic Respiratory Failure.
Impact of Visitation Restrictions in ICU on Psychological Symptoms in Family Members: Experience of the COVID-19 Pandemic.
Dynamic 11C–Para–Aminobenzoic Acid Positron Emission Tomography/Computed Tomography for Visualizing Pulmonary Mycobacteroides abscessus Infections
Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.
Robotic versus Electromagnetic Bronchoscopy for Peripheral Pulmonary Lesions: A Randomized Trial (RELIANT).
Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation (RESCUE-3).
Differences in Arterial Blood Gas Testing by Race and Sex across 161 U.S. Hospitals in Four Electronic Health Record Databases
Elastance May Determine the Neuromuscular Blockade Effect on Mortality in Acute Respiratory Distress Syndrome
83
Elucidation of the Relationship between Hydrogen Peroxide and Pyroptosis by a Superior near-Infrared Fluorescent Probe
Engineering an Activatable Near-Infrared Fluorogenic Probe for Hypochlorous Acid in Keloid Diagnosis and Therapeutic Evaluation
High-Throughput Quantification of Spike Protein Expression by LC–MS for mRNA-LNP Evaluation and Immune Response Profiling
Unlocking Spatiotemporal Dynamics: Precise Dual-Modal Bioimaging of Endogenous c-MYC mRNA in Tumors via a CHA-Activated Ratiometric Nanoplatform
Tandem Mass Spectrometry Fingerprint Tags (TMSFT) Applied for Early Gestation Noninvasive Prenatal Detection of Single-Gene Disorders
Hypoxia-Responsive Artificial Urinary Biomarker Probe for Early Detection of Drug-Induced Acute Kidney Injury
Construction of a Renal-Clearable NIR Fluorescent Probe with Sequential Response to Peroxynitrite/Hypochlorous Acid for Visualizing Autophagy Progression in Cisplatin-Induced Acute Kidney Injury
Probing the Dynamic Pore Formation of Antimicrobial Peptide in Nanoscale Lipid Membranes
Application of Proteomic Workflows for the Identification of Biomarkers for the Retrospective Verification of Sulfur Mustard Intoxication
Rapid Antifungal Susceptibility Testing by Stimulated Raman Photothermal Imaging of D2O Metabolism
Rapid Identification of Yeasts in Foods Based on Thermal-Scanning Fluorescence Spectroscopy
A Portable Surface-Free Electrochemical Aptamer-Based Biosensor for Multiplex Detection of Arboviruses
Rapid and Accurate Quantification of Viable Bacteria in Reproducibly Generated Bioaerosols with a Certified Microbial Reference Material
The Noninvasive Diagnosis of Central Nervous System Leukemia by Specifically Enhanced Magnetic Resonance Imaging
Rapid Diagnosis of Bacteremia in Febrile Pediatric Oncology Patients via Host-Response Infrared Spectroscopy of Blood and Machine Learning
Mass Spectrometric Analysis of Exercise-Induced Breath Metabolites, Lipids, and Proteins Using Wearable Cold-Mask Sampling
An LC-Immuno-MRM-MS Winterplex Method Development Framework for Respiratory Viral Screening
Prolonging Sample Stability with Machine Learning Expands the Catalog of Tests Available for Mail-In Capillary Blood Collected At-Home
A Membrane-Impermeable Near-Infrared Probe Enables High-Fidelity Tracking of Foam Cell Progression
A Visible/NIR-II Dual-Channel Fluorescent Probe for Investigating the Roles of NLRP3 Inflammasome and Ferroptosis during Hepatic Ischemia-Reperfusion Injury
Lipidomics in Children: Noninvasive Sebum Sampling in Children and Adults Allows for Assessment of Lipidomic Differences According to Age, Sex, and Biological Relatedness
Single-Molecule Analysis of Glycopeptide Antibiotic–Target Interactions Using Nanopore-Based Biomimetic Probes
Preclinical Evaluation of Rationally Designed Peptide-NIRF Probe for c-Met Positive Liver Cancer Imaging-Guided Surgery
From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood
A Deep Multimodal Fusion Framework Integrating SERS, Clinical Data, and Metabolomics for Noninvasive MASH Diagnosis
Antimicrobial Peptide Activity in Lipid Bilayers with Smooth-Type Lipopolysaccharides
Label-Free SERS Strategy for Simultaneous Detection of Triplex Renal Biomarkers in Serum toward Precise Renal Function Evaluation
Application of Analytical Measurement Uncertainty and Considerations toward Pharmaceutical Material Quality Control Strategies
Integrating AI-assisted SERS Biosensing and Photoactivated Antibacterial Therapy in Au@Cu2–xSe for Combating Multidrug-Resistant Bacteria
Enhanced Integrative Diagnosis and Therapeutic Strategy for Hepatic Ischemia-Reperfusion Injury through HOCl-Sensitive Cysteine Delivery System for Targeted Antioxidant Modulation
HematoCARD: A Volumetric Duplicate Dried Blood Spot Collection Cartridge Validated for Therapeutic Drug Monitoring
ZNGEA: ZINB-NMF Integrated Graph Embedding Autoencoder for Metabolite-Disease Association Identification
Rapid Selective Detection of Phosphatidylethanols by Neutral Loss Scans in Tandem Mass Spectrometry to Evaluate Alcohol Consumption
A Novel Lithium Ion-Assisted TPP Approach for Enhanced Target Discovery
Dipeptidyl Peptidase IV Activated Near-Infrared Fluorescent Probe for Visually Evaluating Diabetes Models under Microplastic Exposure
Highly Specific Targeting of Tumor Extracellular Matrix by a Sharply pH-Activated Single-Chain Collagen Mimetic Peptide Probe
ATR-FTIR Spectroscopy of Saliva and Machine Learning as a Screening Test for Sjögren Disease
Dual Targeting and Cascaded Aggregation of Luminogen for Washing-Free and Enhanced Fluorescence Imaging of Intracellular Bacteria
Simultaneous Elemental and Molecular Mass Spectrometry of Tattoo Inks and Tattooed Skin Biopsies: A Novel Laser Ablation-Based Technique for Tattoo Pigment Analysis
Development of a Novel Homogeneous Liposome-Based One-Step Assay for SARS-CoV-2 Antibody Detection in Human Serum Based on Fluorescent Liposomes and Complement Activity
Rambutan-Like Magnetic Nanozyme Modified with Wheat Germ Agglutinin Enhances Lateral Flow Immunoassay for Ultrasensitive and Broad-Spectrum Detection of Respiratory Microorganisms
The Burst Enhancement of MRI Using Magnetic Resonance Tuning Based Contrast Agents
A Target-Induced In Situ J-Aggregation Coupling Cascade Catalyzing Reactive Oxygen Species Clearance Strategy for 3D NIR-II Photoacoustic Imaging Diagnosis and Smart Therapy of Acute Kidney Injury
Tracking Mutual Interactions of Mitochondria/Lysosomes/Lipid Droplets in DILI and NAFLD with a Viscosity and Peroxynitrite-Sensitive Single Fluorescent Probe
Deep Learning-Assisted Lens-Free Holography Integrated Pd Nanozyme-Armed Phages for the Rapid and Extraction-Free Detection of Viable Bacteria
A Highly Efficient Pyroptosis Activator for Three-Photon Fluorescence Imaging-Guided Phototherapy and Hypoxia Tumor Immunotherapy
A Structure-Guided Bifunctional Aptamer Mitigates Pseudomonas aeruginosa Virulence and Biofilms by Disrupting las and rhl Quorum Sensing Systems
Rational Design of a Novel Dual-Functional Fluorescent Probe for Simultaneous Monitoring and Imaging of Mitochondrial CO and ATP Fluctuations during Drug-Induced Liver Injury without Spectral Crosstalk
Cholesterol-Anchored AND-Logic NIR-II Probe for Triple-Responsive Atherosclerosis Imaging
Apoptotic Body-Hitchhiked Manganese-Based Biomimetic Nanoprobe for Sensitive Magnetic Resonance Imaging of Bacteria Triggering Peritoneal Dialysis-Associated Peritonitis In Vivo
Multiomics Analysis of Dried Plasma Spots Using Stable Isotope Internal Standards for Biomarker Discovery
Multifunctional Co3O4@PDA Nanocomposite-Based Sensitive Dual-Mode Lateral Flow Immunoassay for the Simultaneous Detection of Two Antibodies against Respiratory Tract Pathogens
A Recyclable Affinity Chromatographic Device for Rapid Colorimetry of Bacteria Using Phage-Derived Cell Wall Binding Domains As Recognition Ligands
Investigating Interfacial Interactions between the Adjuvant and Antigens in Pneumococcal Conjugate Vaccine In Situ at the Molecular Level
Non-Invasive Preimplantation Genetic Testing: Cell-Free DNA Detection in Embryo Culture Media Using a Plasmonic Biosensor
Knitting Organic Cage into Hyper Cross-Linked Polymers for the Efficient Capture of Fluoroquinolones in Pork Samples
Development of SPQC Biosensor for iStreptococcus pneumoniae/i Detection Based on IscB Nuclease Recognition
Reversible NIR Ratiometric Probe for Monitoring Redox Homeostasis in Lipid Droplets during Ferroptosis-Driven Liver Injury
Aptamer-Functionalized Granzyme B-Responsive Nanoprobe for Immunotherapy Assessment: Real-Time Monitoring of Cytotoxic T Lymphocyte Activation Cleavage
Evaluation of Simultaneous Production Strategies for Adenoviral Vector-Based SARS-CoV-2 Multivalent Vaccines via an Expanded Allele-specific Competitive Blocker PCR Quantification Method
p-Cresol and C. difficile: A Love-Hate Story Revealed by Raman Spectroscopy
Tandem Bioluminescent Tests for Rapid Detection of Urinary Tract Infections and Antimicrobial Resistance Using a Portable Luminometer
Impact of Heat and Acidic Stress on the Biochemical Composition of Pseudomonas aeruginosa Bacteriophages─A Nanoscale AFM-IR Study
Efficient Compression of Mass Spectrometry Images via Contrastive Learning-Based Encoding
Discrimination of Dengue Diseases in Children Using Surface-Enhanced Raman Spectroscopy Coupled with Machine Learning Approaches
Seamless Tiling and Scalable Coherent Raman Spectroscopic Analysis Reveals Developmental Maturation of Lipids in the Mouse Brain
Phage Cell Wall Binding Domain for Gram-Negative Bacteria and Its Application in Detection of Acinetobacter baumannii
Development of a Protein-Free Nucleic Acid Lateral Flow Assay for Trichomonas vaginalis
Intratumoral Bacterial-Targeted Cascade-Responsive Sonoafterglow Nanoprobes for Immune Reprogramming and Visualization in Glioblastoma
Rational Design and Synthesis of Peptide-Based Probes for Fibroblast Activation Protein-Targeted Magnetic Resonance and NIR-I/II Fluorescence Imaging of Cancer-Associated Fibroblasts
A Bienzyme-Locked Activatable Photoacoustic Probe for Precise in Vivo Imaging of Drug-Induced Liver Injury
Construction of Flexible Electrochemical Sensing Interfaces Based on Paper/PEDOT:PSS for the Detection of Cystatin C
Interaction of Single E. coli Bacteria and Phage Revealed and Quantified by Electrochemical Collision Technique
Rapid Multi-Omics for Bacterial Identification Using Flow Injection–Ion Mobility–Mass Spectrometry
Augmentation of Infrared Microscopy of White Blood Cells and Medical Measures for Rapid and Accurate Diagnosis of Bacterial or Viral Infections in Febrile Pediatric Oncology Patients: An Expert System-Based Study
Bacteriophage-Gated Optical Sensor for Bacteria Detection
Toward “Receive-Only” Nuclear Magnetic Resonance Complementary Metal-Oxide-Semiconductor Microcoil Arrays for High-Throughput Analysis of Environmental Samples
Glycan-Induced Transchelation of Gadolinium from Magnetic Resonance Imaging Contrast Agent-Complexes
An NAG-Activatable Glow-Type Chemiluminescent Probe for Sensitive and Early Diagnosis of Acute Kidney Injury through Urinalysis
An Efficient Electrochemiluminescence Biosensor Based on Ru(bpy)32+@AuNPs@SWCNTs for miRNAs Detection Using a Dual Engine-Triggered DNA Walker
Synergistic Integration of Aggregation-Induced Emission and FRET Mechanisms in Conjugated Polymers via Molecular Engineering for Ultrasensitive, Rapid, and Discriminative Detection of Perfluoroalkyl Substances
A Facile Workflow for Sebum Fatty Acids and Squalene Identification via Advanced Lipidomic Methodologies
Determination of Thyroid Hormones and 11 Metabolites in the Human Serum Using a Simple Derivatization Strategy and Analysis by Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry
67
Recirculation quantified by Trans-ECMO thermodilution to predict mixed venous oxygenation during V-V ECMO: an in vivo porcine study.
Cryoneurolysis Thermal Graphs: In Vivo Descriptive Data from Ultrasound-Guided Percutaneous Thermocouples.
Efficacy and Safety of Remimazolam Tosylate versus Propofol for Sedation of Postoperative Mechanically Ventilated Patients in Intensive Care Units: a Multicenter, Randomized, Single-blind, Non-inferiority, Phase 3 trial.
Multi-Planar Ultrasonographic Assessment of Gastric Volume: A Prospective Observational Study.
Intranasal naloxone reversal of opioid-induced respiratory depression in opioid-naïve individuals and self-reported daily opioid users.
Feasibility of a Multicomponent Protocol to Promote Dreaming during Surgical Anesthesia.
Ropivacaine-Based Regional Anesthesia Exerts Muscle-Protective Effects Despite Elevated Compartment Pressure In A Porcine Model Of Acute Compartment Syndrome.
Perspectives of children, parents and health care providers on outcomes following anesthesia for surgery:: An international mixed methods stakeholder engagement study from the Pediatric Perioperative Outcomes Group.
Frontal Electroencephalogram Phase-Amplitude Coupling Reflects Nociception and the Analgesic Effect of Transversus Abdominis Plane Block in Laparoscopic Surgery.
Severe post-operative bleeding after heart transplantation.
Association of Peripheral Nerve Block with Postoperative Myocardial Injury in High-Risk Cardiac Older Adults Undergoing Hip Fracture Surgery: A Two-Center Retrospective Cohort Study.
Evaluating the Acute Effects of the Cannabinoid Dronabinol and the Opioid Hydromorphone Alone and in Combination: A Double-Blind, Randomized, Placebo-Controlled Trial in Knee Osteoarthritis.
Individualised Perioperative Blood Pressure and Fluid Therapy in Oesophagectomy a prospective, single-blind randomised controlled trial.
Mechanical power and the association with postoperative impaired oxygenation and pulmonary complications in orthopedic patients: post hoc analysis of a cluster factorial randomized trial.
The role of the dorsomedial periaqueductal gray glutamatergic neurons in promoting arousal under multiple general anesthetics in mice.
Evaluating The Statistical Robustness Of Randomized Controlled Trials Of Spinal Cord Stimulation For Pain Through The Use Of Fragility Index.
Saccade tasks: A non-invasive approach for predicting postoperative delirium in elderly arthroplasty patients.
Single Muscle Fibre Calcium Wave Frequency Assay for Malignant Hyperthermia Diagnosis: an Exploratory Validation Study.
Critical Closing and Tissue Perfusion Pressures in Sepsis-Implications for Risk Stratification: A Retrospective Cohort Study.
Changes in intraoperative rocuronium dosing following the introduction of sugammadex and association with postoperative respiratory complications: A retrospective cohort study.
Liposomal Bupivacaine, Plain Bupivacaine, and Saline for Transversus Abdominis Plane Blocks: The CLEVELAND Randomized Trial.
Nitric Oxide to Reduce Acute Kidney Injury in Patients with Pre-existing Endothelial Dysfunction Requiring Prolonged Cardiopulmonary Bypass: A Randomized Clinical Trial.
Discordances Between Preoperative Creatinine- and Cystatin C-Based Estimated Glomerular Filtration Rate and Outcomes After Noncardiac Surgery: An Observational Study.
Inpatient Cost of Complications After Total Hip and Knee Arthroplasty.
Individualized Flow-Controlled versus Pressure-Controlled Ventilation in Cardiac Surgery: A Randomized Controlled Trial.
Ultrasound-guided external oblique intercostal plane block with ropivacaine for analgesia after open hepatectomy- a randomized controlled study.
Paravertebral or serratus anterior plane block combined with PECS I (interpectoral) blocks versus paravertebral block for mastectomy: A cluster-randomized trial of 1507 patients.
Preoperative Hypnosis versus Mindfulness for Reducing Postoperative symptoms in Breast Surgery: A Randomized Clinical Trial.
Association of liver fibrosis FIB-4 score with perioperative complications and mortality: a retrospective multicenter analysis.
Sex-specific effects of acute stress on emergence from isoflurane anesthesia via brainstem circuitry in mice.
Pain as a driver of myocardial injury in hip fracture patients: a HIP fracture Accelerated surgical TreaTment And Care track (HIP ATTACK) Trial secondary analysis.
Relationship Between V̇A/Q̇ Mismatch and Capnogram Phase III Slope in Acute Bronchoconstriction and Its Modulation by Salbutamol Assessed by Synchrotron Imaging in Rabbit Lung.
Effect of S-Ketamine on Postoperative Delirium in Elderly Patients Undergoing Arthroplasty: A Randomized Controlled Trial.
Minimal clinically important changes of patient-reported outcome measures for acute post-surgical pain.
Mixed-Methods Analysis of Preoperative Distress and Postoperative Outcomes in a Prospective, Observational Cohort of Older Adults.
Revisiting infusion rate limitations for continuous lumbar plexus blocks in children and adolescents with 0.2% ropivacaine: a pharmacokinetic analysis.
Bispectral Index-Guided Anesthesia for Older Patients Having Non-Cardiac Surgery: A Randomized Multicenter Trial.
Trends in Use of Medications for Opioid Use Disorder among Commercially Insured U.S. Surgical Patients, 2016-2022.
Using Quantity of Service Data in Medicaid Claims to Estimate Anesthesia Time.
Effects of Dexmedetomidine–Remifentanil on Neurodevelopment of Children after Inhalation Anesthesia: A Randomized Clinical Trial
The GABAergic Parafacial Zone: Integrating Consciousness and Respiratory Control in Sevoflurane Anesthesia.
Cognitive decline and dementia in chronic widespread pain: A longitudinal population-based study.
Heat Loss in Humans Warmed with Various Full-Body Forced-air Heating Systems.
Effect of urine-guided intraoperative hydration on incidence of acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei: a randomized trial.
Fentanyl-induced ventilatory depression: population pharmacokinetic/ pharmacodynamic framework for evaluation of opioid-induced ventilatory depression.
Effect of Intravenous, Inhalational, or Combined Anesthesia Maintenance on Postoperative Respiratory Adverse Events in Children Undergoing Adenotonsillectomy (AmPRAEC): A Multicenter Randomized Clinical Trial.
Sedation-Related Electroencephalographic Patterns in Acute Hypoxemic Respiratory Failure.
Early use of norepinephrine in high-risk patients undergoing major abdominal surgery: a randomized controlled trial.
Evaluation of the potential for lung recruitment with the Recruitment-to-Inflation ratio during general anesthesia.
Gabapentin for pain management following major surgery: a placebo controlled, double blind, randomized clinical trial (The GAP Study).
A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery: The Moderating Effect of Baseline Temporal Summation of Pain.
Head Strikes Among Perioperative Personnel in the United States: A Mixed Methods Study.
Recovery of the acute hypoxic ventilatory response after reversal of a minimal neuromuscular block. A randomized, controlled trial in healthy, non-obese volunteers.
Adverse events associated with airway management in pediatric anesthesia: A prospective, multicenter, observational Japan Pediatric Difficult Airway in Anesthesia (J-PEDIA) study.
Effects of increased cardiopulmonary bypass pump flow on renal filtration, perfusion, oxygenation and tubular injury in cardiac surgical patients - a randomized controlled trial.
Synergistic effects of commonly used ICU drugs and high temperature on skeletal muscle at the cellular and tissue levels.
Erector spinae plane block versus intercostal nerve blocks in uniportal videoscopic assisted thoracic surgery: a multicenter, double-blind, prospective randomized placebo controlled trial.
The association between preoperative depression and length of stay after major surgery: a systematic review and meta-analysis.
Associations between SNAP-25 gene polymorphism, autonomic nervous system activity and recovery of consciousness from propofol anesthesia.
Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-Center Retrospective Cohort and Genome-Wide Association Study.
Analgesic benefits of motor-sparing fascial plane blocks in comparison to periarticular local infiltration analgesia for total hip arthroplasty: A network meta-analysis.
Psychological Effects of Explicit Recall under Sedation and after Surgery (PEERS): a Prospective Cohort Study on 2500 Patients.
Increased Plasma Fibroblast Growth Factor 23 Significantly Associates with In-Hospital Acute Kidney Injury after Cardiac Surgery.
Ketamine-induced sustained modulation of GABAA receptor function in mouse hippocampal neurons following anesthesia.
A pharmacist-partnered opioid tapering service before total hip or knee arthroplasty: Qualitative analysis of patient counselling sessions.
The role of the supramammillary nucleus-medial septum glutamatergic pathway in mediating the effects of isoflurane anesthesia.
Association of Intraoperative Hypotension with Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery: A Secondary Analysis of a Randomized Trial
38
Bio-Propelled Stomatocyte Nanomotors with Glutathione-Responsiveness for Osteoarthritis Treatment
Self‐Assembling Nano‐Antimicrobial Oligopeptides With Dual Offense–Defense Functions for Synchronously Achieving High Activity and Biosafety
Varying Carbene Persistence in Membrane as a Mechanism for Modulating Antibacterial Carbon Acid Oligomer Killing Efficacy
Aggregation‐State Dynamics Drive Double Cooperativity Between Antimicrobial Peptides LL‐37 and HNP1
Enhancing Superlubricity and Wear Resistance in Mechanically Robust Hydrogel via Microliter‐Scale Subsurface‐Initiated Polymer Brush Grafting
Positron Emission Tomography Imaging of Bacterial Infections With an Enterobactin Analog to Monitor Treatment Efficacy With a Catechol Antibiotic
Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease
Protein‐Driven Copper Redox Regulation: Uncovering the Role of Disulphide Bonds and Allosteric Modulation
Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology
Rapid RASER MRI
Dual-Proximity Labeling Strategy Identifies TrxR1 as a Cuproprotein that Regulates Apoptosis via Caspase-3 S-Nitrosylation
Real‐Time Super‐Resolution Tracking of mtDNA Remodeling and Inflammatory Release with a Selective Fluorescent Probe
Dual-Channel Fluorescence Assays with Supramolecular Host-Dye Reporter Pairs for Membrane Activity Mapping of Peptides
Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance-Associated Vacuolar Sequestration in Candida Species
Semi-Synthesis of Immunogenic Mycobacterial Lipoproteins via Aryl Selenoester-Mediated Expressed Protein Ligation
A Smart Self‐Immobilization Magnetic Resonance Contrast Agent for Delayed Tumor Imaging In Vivo
C─H Amination of Polypropylene with Sodium N-Chloro-Amides
Discovery of Antivirulence ClpP Inhibitors by Self‐Resistance Gene‐Guided Mining Coupled with Dual Functional Screening
Single Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes
Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms
Molecular Rotor‐Based NIR‐II TICTgens for Mitochondria‐Targeted Pyroptosis Induction and Multi‐Model Monitoring of Cancer Immunotherapy
Molecular-Level Design of Polymeric Semiconductor Nanomotors with Multichannel Sensitive 3D Motion for Microorganism Inactivation
Exercise Modulates Exocytosis: Chemical Insights from the Intracellular Vesicle Perspective
Precision Screening and Surgical Resection of Pan‐Cancer Using a Tandem‐Locked NIR‐II Fluorescent Probe with Optimized Activation Efficiency
A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection
A “Cocktail” Fluorescent Probe for Multi‐ROS Imaging Unveils Ferroptosis‐Driven Liver Fibrosis Development
Covalent Organic Framework Nanohydrogel‐Based Oxidase‐Mimicking Nanozyme for Photocatalytic Antibacterial Therapy
Non‐Amphiphilic Antimicrobial Polymers
Dynamic Photoacoustic Imaging of Mobile Cu(II) in Vivo via Catalytic Radical Cation Formation
Host–Guest Antimicrobial Based on Conjugated Oligoelectrolyte and Cyclodextrin
Heavy‐Atom‐Free Supramolecular Photosensitizers Derived from Conventional Fluorophores
pH‐Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity
Blood Retention and Kidney Clearance of Renal‐Clearable Gold Nanoparticles Strongly Correlate with Renal Injury Biomarkers
Antimicrobial Peptide‐Peptoid Macrocycles from the Polymyxin B2 Chemical Space
Modular Synthesis of Dendritic Oligo‐Glycerol Cationic Surfactants for Enhanced Antibacterial Efficacy
Amphipathic Antimicrobial Peptides Illuminate a Reciprocal Relationship Between Self‐assembly and Cytolytic Activity
Self‐Assembly of Short Peptides Activates Specific ER‐Phagy and Induces Pyroptosis for Enhanced Tumor Immunotherapy
36
Emergency Department Observation and Computed Tomography Use in Children With Blunt Abdominal Trauma
Sex Differences in Clinical Outcomes and Resource Utilization Among Emergency Department Patients With Unexplained Syncope or Presyncope: A Prospective, Observational, Cohort Study
Patterns of Intramuscular Chemical Sedation Use for Patients Receiving a Mental Health Consultation While in the Emergency Department
Early Clinical Deterioration Among Emergency Department Boarders: A Retrospective Analysis
The National Pediatric Prehospital Readiness Project: First Comprehensive Assessment of United States Emergency Medical Services Agencies
Association Between Emergency Department Undertriage or Overtriage With Timeliness of Care and Patient Outcomes
Characterizing Emergency Department Visits to Pediatric Hospitals After Local Disaster Declarations
Capabilities Among Emergency Departments Participating in a Nationwide Quality Improvement Learning Collaborative to Care for Patients With Opioid Use Disorder: 2020 to 2024
Risk Factors for Pediatric Deep Neck Infection Revisit After Emergency Department Discharge for Pharyngitis or Localized Neck Symptoms
Individual Survey Items in Emergency Department Patient Experience Surveys Have Limited Ability to Distinguish Unique Aspects of Care
Cumulative Incidence of Stroke Disability and Mortality Following Emergency Department Discharge for Dizziness: A Cohort Study
Time to Vasopressor Initiation Is Not Associated With Increased Mortality in Patients With Septic Shock
Arterial Doppler Ultrasound Blood Flow Waveforms During Chest Compressions to Detect Arterial Line Pulsatility
Efficacy of Adding Intravenous Saline Solution to Nonsteroidal Anti-Inflammatory Drug-Based Treatment of Acute Migraine in the Emergency Department
Treatment of Opioid Use Disorder Across a National Emergency Department Practice Improvement Network
Serious Cardiac Outcomes and Physician Estimation of Risk in Emergency Department Patients With Presyncope Versus Syncope
Cool Running Water as a First Aid Treatment for Burn Injuries
Accuracy of Published Screening Tools for Large Vessel Occlusion in Patients With Suspected Acute Ischemic Stroke: A Prospective Cohort Study
Development of a Unified Geriatric Emergency Department Database, 2022
Clinical Pathway Revision Increases Amoxicillin Monotherapy and 5-Day Durations of Therapy for Pediatric Community-Acquired Pneumonia in the Emergency Department and Urgent Care: A Quality Improvement Initiative
Feasibility of Pediatric Diagnostic Quality Measurement in All United States Hospitals
Association Between Operator Experience and Procedural Outcomes of Tracheal Intubation in the Emergency Department and ICU
Outcomes Associated With an Age-Friendly Emergency Department Intervention
Not All Temperature Control Is Equal: High-Quality Temperature Control Is Associated With Improved Outcomes Following Out-of-Hospital Cardiac Arrest
Derivation and Validation of a Clinical Rule to Detect Bacteremia Versus Contaminants in Positive Pediatric Blood Cultures: A Retrospective Cohort Study
Treatment Initiation and Outcomes Associated With Receipt of Emergency Department-Based Peer Support Following Opioid Overdose
Tranexamic Acid Timing and Mortality Impact After Trauma
Association of Two Preoxygenation Approaches With Hypoxemia During Tracheal Intubation: A Secondary Analysis
Usual Care for Low Back Pain at United States Emergency Departments, 2016-2022
Adoption of Boarding in Inpatient Hallways During Emergency Department Crowding
Psychedelic Trips: Travel Within the United States to Use Psychedelic Drugs After Legalization
Diagnostic Accuracy of Point-of-Care Ultrasound for Hip Effusion: A Multicenter Diagnostic Study
Emergency Department Ketamine Sedation: Frequency and Predictors of Critical and High-Risk Adverse Events
The Association Between Out-of-Hospital Drug-Assisted Airway Management Approach and Intubation First-Pass Success
Effect of Routine Opt-Out HIV Screening on Emergency Department Operational Metrics: Results From the Pragmatic Randomized HIV TESTED Trial
Stroke Sensitivity Calculation in Medical Emergency Calls and Factors Associated With Stroke Suspicion: A Retrospective Registry-Based Study
6
Budget Impact Analysis of the Balanced Opioid Initiative: A Cluster Randomized Trial Aimed at Deprescribing Opioids for Chronic Pain in Primary Care Settings.
Why Are Family Physicians Leaving Comprehensive Care? A Qualitative Study on Retention in Ontario.
Family Physician Workforce Trends: The Toll on Rural Communities
Measurement of Practice-Level Antibiotic Utilization in a Medicaid Patient-Centered Medical Home Program
The Geographic Distribution of Family Physicians Providing Maternity Care and Opportunities for Expanding Access to Care in Rural Areas
Primary Care Patients With Opioid Use Disorder Symptoms: Initiation and Engagement in Treatment With Medicine
31
Multisite External Validation of a Clinical Screening Tool for Interpersonal Firearm Violence Risk.
The Effect of Fluvoxamine and Metformin for Fatigue in Patients With Long COVID : An Adaptive Randomized Trial.
Firearm Acquisition and New Exposure to Household Firearms After the Initial Pandemic Purchasing Surge: Results From the 2024 National Firearms Survey.
Sodium Correction Rates and Associated Outcomes Among Patients With Severe Hyponatremia : A Retrospective Cohort Study.
Effects of a Hospital-Based Violence Intervention Program on Community Violence in Boston, Massachusetts : A Target Trial Emulation.
Effect of Social Vulnerability on Efficacy of Bariatric Surgery Versus Medical and Lifestyle Intervention for Type 2 Diabetes: Analysis of the ARMMS-T2D Consortium of Randomized Trials.
Long-Term Mpox Sequelae 11 to 18 Months After Acute Illness : A Cohort Study in Two U.S. Cities.
Once-Weekly Oral Islatravir Plus Lenacapavir Versus Daily Oral Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Persons With HIV-1 : A Phase 2 Randomized Study.
Integrating Methadone Services Into Primary Care in Ukraine: Two-Year Outcomes From a Randomized Trial.
Effect of Nonmedical Cannabis Legalization and Exposure to Retail Stores on Cannabis Harms : A Quasi-experimental Study.
Risk for Scrotal Surgery After Laparoscopic Donor Nephrectomy : A Population-Based Cohort Study.
Proteinuria or Albuminuria as Markers of Kidney and Cardiovascular Disease Risk : An Individual Patient-Level Meta-analysis.
The Mediterranean Diet for Irritable Bowel Syndrome : A Randomized Clinical Trial.
Step Accumulation Patterns and Risk for Cardiovascular Events and Mortality Among Suboptimally Active Adults.
Effectiveness of Recombinant Herpes Zoster Vaccine in the U.S. Medicare Population, 2018 to 2019, by Immunocompetence and Prior Receipt of Live Zoster Vaccine.
Association Between Body Composition and Cardiometabolic Outcomes : A Prospective Cohort Study.
Firearm-Related Hospitalization and Death in Aotearoa New Zealand, 2000 to 2023 : A Cohort Study.
The Potential Impact of Ending the Ryan White HIV/AIDS Program on HIV Incidence: A Simulation Study in 31 U.S. Cities.
Long-Term Routine Laboratory Toxicity Monitoring of Immunomodulatory Drugs in Rheumatoid Arthritis : A Retrospective Cohort Study.
Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain : A Randomized Controlled Trial.
Treatment With Canagliflozin Versus Placebo in Children and Adolescents With Type 2 Diabetes : A Randomized Clinical Trial.
Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis : A Randomized Controlled Trial.
High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.
Evaluation of a Region-Wide Hospital-Based Violence Intervention Program : A Pilot Cohort Study.
Medications and Risk for Microscopic Colitis: A Nationwide Study of Older Adults in Sweden.
Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial.
Birth Cohort Effects in Appendiceal Adenocarcinoma Incidence Across the United States.
Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery.
Confirmatory Testing for Primary Aldosteronism : A Study of Diagnostic Test Accuracy.
Thyroid Function Reference Intervals by Age, Sex, and Race : A Cross-Sectional Study.
Diet and Risk for Incident Diverticulitis in Women : A Prospective Cohort Study.
23
Use of Machine Learning to Identify Markers of Risk for Fragile X‐Associated Tremor/Ataxia Syndrome: A Preliminary Analysis
Longitudinal Phenotypic Trajectories in GNAO1-Related Disorders: Defining Disease Progression and Clinical Profiles
Homozygous RFC1 AAGGG Repeat Expansions Are Common in Idiopathic Peripheral Neuropathy
High Prevalence of SOD1 Pathogenic Variants in the UK Biobank: Implications for Early Intervention in Amyotrophic Lateral Sclerosis
Safety and Efficacy of Fecal Microbiota Transplantation in Alleviating Symptoms of Parkinson's Disease: A Randomized, Placebo‐Controlled, Double‐Blinded Study
Sex-Specific Genetic Architecture of ALS: Evidence of a Female Protective Effect?
Fibroblast Transcriptomics in Molecular Diagnostics of a Comprehensive Dystonia Cohort
Enhanced Sensitivity of a Modified Quaking‐Induced Conversion Diagnostic Test for the Broad Detection of Sporadic and Inherited Prion Diseases: A Retrospective Study
Topographical Variation of Iron‐Rimmed Lesions in the Multiple Sclerosis Brain and Spinal Cord: A Neuropathological Study
Intranasal Seletracetam in a Patient with Reading Epilepsy: First‐in‐Human Use to Prevent Reflex Seizures
The Phenotypic Spectrum of Sporadic Creutzfeldt‐Jakob Disease Cortical Subtype
Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease
Incidence and Prevalence of Congenital Myopathies ‐ A Population‐Based Study From Western Sweden
A Digital Measure of Eye Movements During Reading Sensitively Captures Oculomotor and Speech Dysfunction, Early Changes, and Disease Progression in Ataxias
Identification of New scpKCNT1/scp‐Epilepsy Drugs by iIn Silico/i, Cell, and iDrosophila/i Modeling
Midlife Steroid‐Binding Globulin Levels and iIn Vivo/i Neuroimaging Measures of Tau in Older Men and Women
The Spectrum of Neurologic Phenotypes Associated With scpiNUS1/i/scp Pathogenic Variants: A Comprehensive Case Series
Longitudinal Analysis of Neuroradiological Biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome and Implications for Clinical Trials
Biallelic Variants in the scpiDARS2/i/scp Gene as a Novel Cause of Axonal Charcot–Marie–Tooth Disease
Proteomics and the Risk of Incident Embolic and Thrombotic Stroke
Volumetric scpMRI/scp Comparing Longitudinal Change in scpMOGAD/scp to scpNMOSD/scp, scpMS/scp and Healthy Controls, and Disability Associations
Clinical, Prognostic, and Longitudinal Functional and Neuropsychological Features of West Nile Virus Neuroinvasive Disease in the United States: A Systematic Review and Meta‐Analysis
Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy
58
A Multicenter Randomized Controlled Trial on the Surgery of Fractured Ribs: The SOFRIB Trial.
Prognostic Impact of Postoperative Complications After Neoadjuvant Therapy Followed by Esophagectomy for Esophageal Cancer: An Exploratory Analysis of Phase III Trial JCOG1109.
Preoperative GLP-1 Receptor Agonist Use and Weight Loss Outcomes Following Bariatric Surgery.
Long-term Outcomes of Biologic versus Synthetic Mesh for Parastomal Hernia Repair: Post-Hoc Analysis of a Multicenter Randomized Clinical Trial.
Long Term and Oncologic Outcomes for Patients Receiving Piperacillin-Tazobactam or Cefoxitin as Antibiotic Prophylaxis for Pancreatoduodenectomy.
Cancer in the Excluded Stomach After Gastric Bypass Surgery for Obesity.
Practice, Policy, and Research Recommendations to Improve Decision-Making about Surgery for People Living with Dementia: A Delphi Panel Consensus.
Impact of Normothermic Regional Perfusion on Clinical Outcomes in Kidney Transplantation from Donors After Circulatory Death: A US Nationwide Analysis of 38,048 Cases.
Incidence and Indications for Revisional Metabolic Bariatric Surgery: A 10-Year Analysis from the Australian and New Zealand Registry.
Sensitivity of Insurance Claims Codes in Identifying Robotic Assisted Surgery.
A Phase III Randomized Controlled Trial of Pyloroplasty versus No Pyloroplasty in Patients Undergoing Minimally Invasive Esophagectomy or Robot-Assisted Minimally Invasive Esophagectomy.
Rare and Tricky: The Relationship Between Hospital Trauma Volume and Delay in Surgical Intervention in Blunt Intestinal Injury.
Postoperative Pancreatic Fistula After Pancreatoduodenectomy: Can Radiomics Improve Clinical Risk Scores?
Impact of Dexamethasone-Enriched Tumescent Anesthesia for Radiofrequency Ablation of GSV insufficiency: A Double-Blind Randomized Clinical Trial.
Hepatectomies under Hypothermic Perfusion of the Liver: Analysis of 110 Cases from a Single Center.
A Randomized, Single-Center, Superiority Trial of Radioactive Seed Localization Versus Wire Localization for Malignant Breast Disease
Cryoanalgesia Increases Neuropathic Pain in Adults Undergoing Minimally Invasive Surgery: A 1-Year Follow-up of a Randomized Study.
A Multicenter Double-blind Randomized Sham-controlled Trial Assessing the EndoBarrier Duodenal-jejunal Bypass Liner for the Treatment of Poorly Controlled type 2 Diabetes Mellitus with Concomitant Obesity: The ENDO Trial.
Comparative Safety of Robotic Versus Laparoscopic Bariatric Surgery.
Prescription Default Nudges for Opioid Reduction after Major Surgery (NORMS): A Randomized Controlled Trial.
Is Standardized Right Hemicolectomy with D2 Lymphadenectomy Enough to Limit Local Recurrence in Adenocarcinoma of the Right Colon?
Long-term Follow-up After Hypothermic Oxygenated Machine Perfusion in DCD Liver Transplantation
Long-Term Survival on Extent of Lymphadenectomy for Right-Sided Colon Cancer: Five-Year Follow-up Results of a Randomized Controlled Trial (RELARC Trial).
In vivo Hypothermic Perfusion Intestinal Auto-transplantation for Patients With Tumors Invading the Mesenteric Root Vascular System: An Unusual Consecutive 19-case Series (with video).
Upfront Colectomy vs. Initial Appendectomy followed by Completion Colectomy for Appendiceal Cancer: A Comparison of Outcomes.
Association of Prophylactic Antibiotic Guideline Non-Adherence with Surgical Site Infections in Patients Receiving Perioperative Vancomycin: Results from a Multi-Institutional Combined NSQIP and MPOG Registry.
International Consensus on Global Surgery Learning Objectives and Competencies.
U.S. Surgical Practice: 23-Year Trends in Medicare Procedures and Reimbursement.
Mesh-related Outcomes of Biologic versus Synthetic Mesh for Single-stage Repair of Contaminated Ventral Hernias: A Five to Ten Year Analysis of a Randomized Controlled Trial.
Two-stage Hepatectomy Versus Liver Transplantation for Patients with Marginally Resectable Extensive Bilobar Colorectal Liver Metastases.
Postoperative Opioid Prescribing Among Adults with Disabilities After a Medicare Opioid Limit Policy.
Liver Transplantation Versus Alpps for Colorectal Liver Metastases: An Entropy Balanced Retrospective Analysis.
Clinical Validation of NerveTrend vs. NerveAssure Mode of Intraoperative Neuromonitoring in Prevention of Recurrent Laryngeal Nerve Injury During Thyroid Surgery: A Randomized Controlled Trial.
Long-Term Outcomes of Patients Undergoing Two-Stage Hepatectomy For Extensive Colorectal Liver Metastasis Treated With Perioperative Hepatic Artery and Systemic Chemotherapy.
Defining Global Benchmarks for Robotic Liver Resections: An International Multicenter Study.
Treatment Trends and Outcomes of Endovascular versus Open Thoracoabdominal Aortic Aneurysm Repair - A Single-center Comparative Cohort Study.
Comparative outcomes of Single and Dual Proglide Strategies in Endovascular Aortic Repair: A Multi-center Cohort Study.
Perioperative Outcomes in Open Versus Minimally Invasive Gastrectomy For Gastric Cancer: A European Multicenter Study Based on the GASTRODATA Registry.
Ex-situ Split Transplants into Adult Recipients can Provide Long-term Outcomes Equivalent to the Gold Standard Splits from Living Donors
Stratifying Endoscopic Submucosal Dissection Risks: A Validated Perforation Preoperative Risk Scoring Tool.
Mosaic Loss of Y Chromosome Defines a Proximal Tubular Cell State Associated with Recovery from DGF and of Allograft Quality and Functional Reserve Post DCD Kidney Transplantation.
MiR-7-5p as a Diagnostic and Monitoring Biomarker for Neuroendocrine Tumors: Insights from the SKY-NET Multicenter Study.
Timing of Antibiotic Prophylaxis Prior to Abdominal Surgery Has No Impact on Infectious Complications: A Retrospective Matched Cohort Study.
Preoperative Electrodiagnosis of Brachial Plexopathy is Associated With Diminished Functional Outcomes After Surgery for Neurogenic Thoracic Outlet Syndrome.
Prophylactic Antibiotic use and Outcomes in Infants Undergoing Pyloromyotomy: A Multicenter Propensity Matched Cohort Analysis.
Improved Short-Term Outcomes With Fully Robotic Recipient Adult Living Donor Liver Transplantation: A Comparative Study.
The Death of Laparoscopy - Volume 2: A Revised Prognosis. A retrospective study.
Female Patients Have a Reduced Risk of Reoperation for Recurrence After Laparoscopic Groin Hernia Repair: A Case-control Matched Nationwide Register-based Study.
Implementation of a Contrast Challenge Algorithm for Adhesive Small Bowel Obstructions in Children: A Prospective, Multi-Institutional Study.
Enabling Long Term Follow up After Ventral Hernia Repair Through Clinical Registry and Medicare Claims Linkage.
Multistate Model of Chronic Wounds, Amputations, and Mortality: Cohort Study of a State-wide Registry.
Novel Benchmark for Robotic Liver Resection - Bridging Tradition with Innovation.
Supply, Distribution, and Aging of the General Surgeon Workforce by Rurality and Over Time: A National Observational Study.
ACS NSQIP Risk Calculator Performance Across Multiple Domains of Operative Risk and Risk-associated Features.
GLP-1RA in the Real World: 1-year Compliance and Outcomes of Semaglutide use in Patients With or Without Previous History of Bariatric Surgery.
Combined Clinical and Histopathological Risk Stratification for Prediction of (severe) Endoscopic Postoperative Recurrence in Patients with Crohn's Disease after Ileocolic Resection: Results from A Prospective Multicenter Cohort Study.
Patient-Reported Symptom Burden Associated with Treatment Modality for Malignant Bowel Obstruction.
Abnormal Milan Score and Compromised Esophageal Mucosal Integrity Stratify Gastroesophageal Reflux Disease Severity.
113
Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progression
Response of ultrasound-assessed synovitis to baricitinib, in monotherapy and combined with methotrexate, compared with etanercept in rheumatoid arthritis: a randomised, international, multicentre trial
Musculoskeletal ultrasound findings in people with asymptomatic hyperuricemia: baseline analysis from the Transitions in Gout Research (TIGER) study using the OMERACT gout ultrasound semiquantitative scoring system
Human hypofunctional NCF1 variant aggravates salivary gland immunopathology in Sjögren’s disease by promoting switched memory B-cell recruitment and long-lived plasma cell differentiation
Transmembrane TNF-α signalling of macrophages drives pathological osteogenesis in radiographic axial spondyloarthritis
Topoisomerase 1-DNA complexes are preferentially recognised by a subset of anti-topoisomerase 1 autoantibodies and their corresponding B cell receptors in systemic sclerosis
Psoriatic arthritis monocyte DNA methylomes bridge joint and skin inflammatory pathways across rheumatoid arthritis and psoriasis
RA and PsA synovial tissue single-cell analysis demonstrates differential fibroblast populations with distinct phenotypes and functional capacities
Differentiation of physiological from pathological bone erosions in rheumatoid arthritis: an 8-year HR-pQCT study of the second metacarpal head
Frequency and characteristics of axial involvement in psoriatic arthritis: results from the International Multicentre AXIS Study
Human blood vessel organoids recapitulate key mechanisms of transition from vasculopathy to fibrosis in systemic sclerosis
Neutrophil transcriptomics in SLE reveals intrinsic disease signatures, shared ex vivo adaptation, and transcriptional reset after CAR T-cell therapy
Inhibition of the type I interferon receptor pathway protects against muscle weakness induced by dermatomyositis serum
Risk score for early mortality to stratify for intensive SSc therapy in the EUSTAR network: the RESIST score
An app-based nonpharmacological intervention improves patient-reported disease activity, functionality, and quality of life in patients with axial spondyloarthritis: a randomised controlled trial
Risk of first and second primary keratinocyte cancers in relation to treatment of rheumatoid arthritis with JAKi, TNFi, and non-TNFi bDMARDs—a Swedish nationwide study
A novel murine model of early calcium pyrophosphate deposition disease based on the TNFRSF11B mutation mimics features of the human disease
Quantitative MRI tenosynovitis volume explains the association between tendon involvement and future development of clinical arthritis in anti-cyclic citrullinated peptide-positive at-risk individuals
Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials
Prevalence and impact of suspected fibromyalgia on disease outcomes and treatment in axial spondyloarthritis: 10-year follow-up data from the DESIR cohort
Psoriatic dactylitis: the association with HLA genetic susceptibility markers
Progression from at-risk state to clinical and severe systemic lupus erythematosus involves molecular dysregulations potentially reversible by biologics: implications for early diagnosis and treatment
How long do people with rheumatic and musculoskeletal diseases stay healthy and in work across Europe? Analysis of data from SHARE and ELSA
Microbial signatures in psoriatic arthritis distinguish disease phenotypes and newly diagnosed inflammatory bowel disease independent of faecal calprotectin
Spacing of a TNF inhibitor or dose reduction of methotrexate vs continued treatment in patients with rheumatoid arthritis in remission or low disease activity: a randomised, controlled trial (SORAIRO trial)
The epigenomic landscape of primary tissues in osteoarthritis
Efficacy and safety of mufemilast in patients with Behçet’s syndrome: a phase 2 randomised clinical trial
A phase 2, randomised, placebo-controlled study of guselkumab in adults with new-onset or relapsing giant cell arteritis
Safety and immunogenicity of the recombinant zoster vaccine in patients with rheumatoid arthritis using abatacept: a pilot multicentre, double-blind, randomised controlled trial
The positive perspective paradigm: proposal of a model to mitigate the impact of chronic inflammatory arthritis through comprehensive and early intervention
Intra-articular injection of autologous tolerogenic dendritic cells modifies the synovial immune landscape in rheumatoid and inflammatory arthritis
The incidence of interstitial lung disease in patients with systemic sclerosis: rate, risk factors and prognostic implications in a EUSTAR cohort analysis (CP 133)
A genetic variant of BAFF is associated with the risk of lymphoma in Sjögren disease
Type I interferon endotypes drive divergent clinical trajectories in childhood-onset SLE uncovered through a novel systems immunology approach
A brain-driven neural circuit contributes to tissue regeneration in joint cartilage
Untargeted breathomics identifies metabolic signatures of immune activity, intestinal integrity, and fatigue in systemic lupus erythematosus
Identification of novel fibroblast subsets in diffuse cutaneous systemic sclerosis
Inflammation rather than anticitrullinated protein antibodies is associated with cardiovascular mortality in RA: insights from rheumatoid arthritis and coronary artery disease cohorts
Evaluation of the placebo and treatment effect overtime in randomised clinical trials evaluating the efficacy of biologics in axial spondyloarthritis: systematic review and meta-analysis
Shared and unique molecular signatures across different autoantibody groups in systemic sclerosis: a multiomics analysis
Development and validation of a model to predict the disease activity score: towards a remote treat-to-target approach for rheumatoid arthritis
Antimitochondrial antibodies in systemic lupus erythematosus are associated with and predict nephritis, arterial vascular events, and mortality
RUNX1 is expressed in a subpopulation of dermal fibroblasts and is associated with disease severity of systemic sclerosis
Ultrasound for assessing disease activity and structural damage in psoriatic arthritis: the UPsA scores from a multicentre study by the Italian Society of Rheumatology
Cigarette smoke-primed citrullinated HLA-DR4 T cell reactivity is modulated by γδ-T cells
Ultrasound-detected crystal depositions and clinical flares dissolve during successful urate-lowering therapy: 5-year follow-up results from the treat-to-target NOR-Gout study
A de novo dominant-negative PSMB8 mutation causes severe CANDLE/PRAAS due to arrested proteasome biogenesis
Final validation of the hierarchical framework for outcomes in axial spondyloarthritis: longitudinal determinants of health-related quality of life
Effects of clofutriben, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, on the efficacy and toxicity of prednisolone in patients with polymyalgia rheumatica: a single-blind controlled trial with sequential cohorts
CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study
Inadequate response to anti-TNFα therapy is associated with a gain-of-function TNFR2-R polymorphic variant in patients with psoriatic arthritis
Tirzepatide and change in uric acid and its association with weight reduction: post hoc analyses of the SURMOUNT-1 randomised placebo-controlled trial
Low-dose belimumab reduced risk of flares in patients with systemic lupus erythematosus: a multicentre, randomised, double-blind, placebo-controlled trial
Difficult-to-treat rheumatoid arthritis (part 1): systematic review and meta-analysis on global prevalence
Understanding the drivers of BASDAI and back pain scores in psoriatic arthritis
Association between socioeconomic status and patient delay in rheumatoid arthritis: linking self-reported and national registry data
Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response
Deconstruction of tophi and synovium defines SPP1+ macrophages involved in extracellular matrix remodelling in gout
Entheseal tissue signature in response to IL-17A inhibition in psoriatic arthritis: results from the EBIO entheseal biopsy study
Healthy human enthesis stromal cells mediate immunoregulation via the CD39/CD73 adenosine ectonucleotidase pathway
Innate immune cell subsets are enriched in synovial fluid of ACPA-negative rheumatoid arthritis and characterized by distinct type I IFN gene signatures
Short-chain fatty acids and their gut microbial pathways distinguish rheumatoid arthritis in discordant monozygotic twins
Augmentation of immunothrombosis as a key mechanism underlying JAK inhibition associated hypercoagulability in rheumatoid arthritis
The likelihood of joint inflammation recurrence in previously affected joints during psoriatic arthritis disease course
Development and validation of a Disease Activity index for PSoriatic Arthritis based on 44 joints (DAPSA44)
Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in lupus nephritis
Inhibition of structural damage progression with the selective interleukin-23 inhibitor guselkumab in participants with active PsA: results through week 24 of the phase 3b, randomised, double-blind, placebo-controlled APEX study
The impact of population ageing on musculoskeletal disorders in 204 countries and territories, 1990-2021: global burden and healthcare costs
Myositis-specific autoantibodies recognising Mi2 also target the AIRE protein at a shared PHD zinc finger
Multiomics analysis uncovers subtype-specific mechanisms and biomarkers in idiopathic inflammatory myopathies
Discovery of tissue-specific proteomic signatures in juvenile dermatomyositis highlights pathways reflecting persistent disease activity, clinical heterogeneity, and myositis-specific autoantibody subtype
Evolution of osteitis condensans ilii-like sclerosis in first-time mothers by serial sacroiliac joint MRI during pregnancy and in the postpartum period
Identification of a novel transcriptome signature for predicting the response to anti-TNF-α treatment in patients with rheumatoid arthritis
Transcriptome analysis of unmedicated heterozygous familial Mediterranean fever patients reveals a type I interferon signature driving increasing Pyrin expression
Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1+ macrophage network associated with response to therapy
Mycophenolate mofetil plus methotrexate versus cyclophosphamide with sequential azathioprine for treatment of Takayasu arteritis
Clinical application of synovial biopsy in noninflammatory and persistent inflammatory refractory rheumatoid arthritis
SLE classification criteria item relationships: implications on SLE as a disease entity
Transcriptomic profiling of Sjögren’s disease salivary glands identifies signatures associated with both follicular and extrafollicular responses linked to rheumatoid factor and anti-La/SSB seropositivity
Collagen-binding integrin α11β1 contributes to joint destruction in arthritic hTNFtg mice
Chondrocalcinosis and incident knee osteoarthritis: findings from 2 large prospective cohorts with 20 years of follow-up
HLA loci heterozygosity modulates genetic risk in idiopathic inflammatory myopathies
A glossary of signs and symptoms of giant cell arteritis
Development of bispecific antibodies that drive selective targeted local complement inhibition on rheumatoid arthritis-related antigens
Frontoparietal functional connectivity is related to active disease and processing speed in adolescents with childhood-onset lupus
AYLo study–elevated relapse risk and dysregulated proinflammatory signalling in giant cell arteritis patients with mosaic loss of the Y chromosome
Osteoarthritis risk associated with romosozumab compared with teriparatide in individuals with osteoporosis: a target trial emulation study
Autoantibody reactome analysis reveals diagnostic biomarkers and molecular classification for relapsing polychondritis
Development of an MHC imputation panel highlights independent contributions of HLA amino acid residues and C4 copy number variations to SLE risk
Highly selective tyrosine kinase 2 inhibition with zasocitinib (TAK-279) improves outcomes in patients with active psoriatic arthritis: a randomised phase 2b study
Antimitochondrial antibodies in systemic sclerosis target enteric neurons and are associated with GI dysmotility
Comparative risk of incident malignancies in rheumatoid arthritis patients treated with Janus kinase inhibitors or bDMARDs: observational data from the German RABBIT register
Efficacy and safety of treatments in familial Mediterranean fever and its complications: a systematic review informing the EULAR/PReS recommendations for familial Mediterranean fever
Influence of canstatin on fibroblast-driven hypervascularisation in rheumatoid arthritis
Spatiotemporal distributions and regional disparities of rheumatoid arthritis in 953 global to local locations, 1980-2040, with deep learning-empowered forecasts and evaluation of interventional policies’ benefits
Exploring the limit of image resolution for human expert classification of vascular ultrasound images in giant cell arteritis and healthy subjects: the GCA-US-AI project
Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland
Genome-wide association study in chondrocalcinosis reveals ENPP1 as a candidate therapeutic target in calcium pyrophosphate deposition disease
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
Remote monitoring or patient-initiated care in axial spondyloarthritis: a 3-armed randomised controlled noninferiority trial
Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis
Identification and validation of interferon-driven gene signature as a predictor of response to methotrexate in juvenile idiopathic arthritis
Disease-modifying antirheumatic drug–free remission in psoriatic arthritis: is it attainable and sustainable? A large longitudinal study
Radiographic structural damage in axial spondyloarthritis: is there a preferred way to quantify progression over time? Comparison of blinded versus unblinded mSASSS scoring
New IgG and IgA autoantibody specificities against DNA-binding and RNA-binding proteins discriminate systemic lupus erythematosus from health and non-lupus autoimmunity–could anti-LIN28A enhance precision in diagnostics?
Anti-TFAM antibodies link mitochondrial damage with antiphospholipid syndrome and thrombosis in SLE
Epitopes targeted by autoantibodies in presymptomatic individuals predict early rheumatoid arthritis
Time-independent disease state identification defines distinct trajectories determined by localised vs systemic inflammation in patients with early rheumatoid arthritis
Novel IgG and IgA autoantibodies validated in two independent cohorts are associated with disease activity and determine organ manifestations in systemic lupus erythematosus: implications for anti-LIN28A, anti-HMGN5, anti-IRF5, and anti-TGIF1
Enhanced B cell and complement cascade gene signatures in patients with neuropsychiatric systemic lupus erythematosus
Systematic review and independent validation of genetic factors of radiographic outcome in rheumatoid arthritis identifies a genome-wide association with CARD9
Adalimumab serum concentration to choose a subsequent biological DMARD in patients with rheumatoid arthritis (ADDORA-switch): results of a blinded randomised test-treatment trial
A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren’s disease
5
Printed organic electronic sensors for glucose detection in human saliva
Integrated ultraviolet photoacoustic and spectroscopic autofluorescence microscopy for label-free histological and molecular imaging
Noninvasive in vivo imaging of brain specific absorption rate using thermoacoustic tomography
Plasma-activated CNT nanofluid aerosols for spray-based surface bacterial inactivation
Spatial sound modulation through manual reconfiguration of phased plate
54
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis
What Is the Optimal Timing for Intradialytic Resistance Exercise? A Randomized Controlled Trial
Effect of Extracorporeal Shock Wave Therapy Combined With Kinesio Taping on Shoulder Function in Patients With Long-Head Biceps Tendinopathy: A Randomized Controlled Trial
Relationships of Substance Use Disorders With Discharge Outcomes After Inpatient Rehabilitation: A Retrospective Cohort Study
Plantar Pressure–Paraspinal Surface Electromyography Associations and Within-Participant Surface Electromyography Changes Under Orthotic Insoles in Idiopathic Scoliosis: A Pilot Study
Effects of a Bone-Strengthening Exercise Intervention on Bone Health in Pediatric Cancer Survivors: A Randomized Controlled Trial
Can Blood Flow Restriction Training Improve Mental Health and Quality of Life in Multiple Sclerosis?
Tailored Physical Activity Patterns Reduce Poststroke Cognitive Impairment Risk and Improve Long-Term Cognitive Trajectories: Evidence From the Decade-Long CHARLS Cohort
Integrated Structural Analysis of Trunk Function Assessment After Stroke—New Evaluation Model Based on Multiscale Factor Analysis and Rasch Analysis
The Impact of a Prior Traumatic Brain Injury & Injury Characteristics on Frailty in the Canadian Longitudinal Study on Aging
Association Between Mobility as a Time-Dependent Exposure Factor and Risk of Fall: A Retrospective Cohort Study of Older Patients with Orthopedic Conditions in a Sub-acute Rehabilitation Setting
Does the Minimal Detectable Change in the 10-Meter Walk Test and Timed Up and Go Test Differ by Parkinson’s Disease Severity?
Getting to Know Pain Effect Sizes – Guidelines for Effect Size and Sample Size in Global Pain Research
Association Between Sitting Time and Physical Activity with Survival Among Stroke Survivors: A National Cohort Study
Association between healthy lifestyle index trajectories and functional disability in middle-aged and older adults: a longitudinal cohort study
Cortical response and functional connectivity in subacute stroke patients during dual task: An fNIRS study
The dose-response relationship between gait training dose and gait independence in individuals with hemiparetic stroke
Association between weekly amount of home-visit rehabilitation and changes in activities of daily living: A retrospective cohort study using home-visit nursing station records
Shoulder rotators isokinetic profile according to instability and/or sport specificity: Implications for rehabilitation Shoulder rotators isokinetic profile
Trends in Opioids and Non-Pharmacologic Pain Management among U.S. Cancer Survivors, 2011–2020
Comparable Cardiovascular, Functional, and Lipid Profile Outcomes of High Intensity Telerehabilitation Versus Face to Face Rehabilitation in Chronic Stroke: A Randomized Controlled Trial
Practice Guideline for Methylphenidate Use in Persons with Traumatic Brain Injury: Report of the American Congress of Rehabilitation Medicine
Improved tracking of mobility across care settings: a crosswalk between AM-PAC mobility ‘6-clicks’ and GG Items
Effects of Progressive Resistance Training on Cardiovascular Risk Factors in People With Progressive Multiple Sclerosis
Health related quality of life and factors predicting impairment following intensive interdisciplinary pain treatment among children with chronic pain
Insights into the Complex Relationship Between Domain-Specific Physical Activity, Sedentary Behavior and Mortality in Adults with Chest Pain in the US
Perineuromal Botulinum Toxin Injection for War-Related Postamputation Pain: A Pragmatic, Multicenter, Comparative Effectiveness Study
Discriminatory characteristics of responders and non-responders septic patients to neuromuscular electrical stimulation - A subanalysis of a randomized controlled double-blinded trial
Validity of Scores from the 12-Item Multiple Sclerosis Walking Scale Among Young, Middle-Aged, and Older Adults with Multiple Sclerosis
Fear-Avoidant Adults Have Worse Clinical Outcomes and Recovery Time Following Concussion
The relationship between physical activity domains by level and illness intrusiveness in people with multiple sclerosis
Microdialysis Evaluation of Blood Flow, Lactate, and Glucose in Active Trigger Points of Tension-Type Headache Patients and Latent Trigger Points in Healthy Muscle
The Effect of Dextrose Injection Therapy on Chronic Anterior Talofibular Ligament Sprain: A Randomized Controlled Trial.
Post-Acute COVID-19 Syndrome: Brain Fog Phenotype, Patient Centric Understanding and Biopsychosocial Oriented Treatment
Acoustic Measures of Voice Perturbation Offer Limited Value as Standalone Indicators of Laryngeal Penetration or Aspiration
Quantifying Exercise Intensity to Predict Changes in Walking Capacity in People with Chronic Stroke
Effect of a Digitally Monitored Walking Program on Functional and Psychological Outcomes in Individuals with Mild Traumatic Brain Injury: A Randomized Controlled Trial
Temporal Association Between Reported Use of Psychoactive Substances and Cognitive Function in People with Multiple Sclerosis
“From Impairment to Disability: Unveiling Predictors for Movement Control Impairment Subgroup of Non-Specific Low Back Pain”
Dual-Site Transcranial Direct Current Stimulation Combined With Exercising Improves Fatigue and Sleep Quality in People With Fibromyalgia: A Randomized Sham-Controlled Clinical Trial
Pain Catastrophization and Fear of movement are Potential Moderators for Response to Treatment in Women with Fibromyalgia: Secondary Analyses of Randomized Controlled Trial
Prevalence and Characteristics of Prehabilitation Utilization among Older Medicare Beneficiaries Undergoing Elective Inpatient Lower Extremity Joint Replacement
Effectiveness of the ProACTIVE SCI intervention on physical activity and psychosocial outcomes during the transition from rehabilitation to community among adults with spinal cord injury: A Pre-Post Trial
Investigating the Effectiveness of Pelvic Floor Muscle Training, Including Sensor-Based Diaphragm Exercises in Women with Stress Urinary Incontinence: A Randomized Controlled Study
Comparing the Effect of Intermittent Blood Flow Restriction Training and High-Load Resistance Training in Patients with Patellofemoral Pain: A Randomized Controlled Trial
Effects of a Teleexercise Movement-to-Music Intervention on Health Outcomes in People with Mobility Disabilities: A Randomized Controlled Trial.
Does orthosis improve outcomes of conservative treatment in trigger fingers? A three-arm prospective randomized controlled trial
The Effects of Synchronous Versus Asynchronous Telerehabilitation Programs for Chronic Non-specific Low Back Pain: A 3-Arm randomized controlled trial
Psychometric properties of free-living step-based metrics (daily steps and peak cadence) in multiple sclerosis
The Validity, Test-Retest Reliability, and Learning Effect on the One-Minute Sit-To-Stand Test in Patients with Heart Failure
Opioid and benzodiazepine use among a population-based cohort of adults with chronic spinal cord injury: Correspondence between self-report and state prescription monitoring data
Clinical Characterization of Hip Subgroups in Geriatric Chronic Low Back Pain
Minimal Important Changes of Common Outcome Measures of Physical Function in Individuals with Knee Osteoarthritis: A Prospective Clinical Study
Prevalence of Chronic Health Conditions Among People With Disabilities in the United States
139
Determinants of Difficult‐to‐Manage and Treatment‐Refractory Axial Spondyloarthritis: A Cross‐Sectional Analysis within a Longitudinal Cohort
Differences in SARS‐CoV‐2 antigen persistence in individuals with systemic autoimmune rheumatic diseases compared to the general population: A RECOVER‐Adult Cohort Study
Association of Epigenetic Trajectory With Development of Clinical Rheumatoid Arthritis in Individuals With Anti–Citrullinated Protein Antibody Positivity: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)
autoscoRA: Deep Learning to Automate Sharp/van der Heijde Scoring of Radiographic Damage in Rheumatoid Arthritis
High‐resolution deep learning DIXON MRI of the sacroiliac joints is non‐inferior to standard MRI in patients with suspected axial Spondyloarthritis
Integrative Multi‐omics Approaches Identify Biomarkers Associated with Progression from Arthralgia to Rheumatoid Arthritis
Autoantibodies to Joint‐Related Peptides Are Associated with Onset of Rheumatoid Arthritis in Presymptomatic Seronegative Individuals
Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts
Landscape of Somatic Mutations in a Large Cohort of Chinese Patients With Immune Dysregulations
PEPITEM Regulates the Synovial Microenvironment During Immune-Mediated Inflammatory Arthritis to Limit Disease
Inferring rheumatoid arthritis disease activity status from the electronic health records across health systems
Toll‐like receptor 8 is a therapeutic target in rheumatoid arthritis
CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post-traumatic Osteoarthritis
TWIST1-Mediated Induction of AEBP1 in Fibroblast-Like Synoviocytes Activates Transforming Growth Factor β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis
Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in Pediatric Patients: An ARChiVe Study
Subsets of Patients With Lupus Identified by Gene Expression Profiles Exhibit Differential Clinical Responsiveness to Baricitinib
Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice
18F‐Fluorodeoxyglucose Positron Emission Tomography Imaging Assessment within a Randomized Controlled Trial in Giant Cell Arteritis
Nerve growth factor is sufficient to cause multiple osteoarthritis‐relevant pathological features in naïve murine knee joints
Machine Learning to Predict Remission Between Six and 24 Months in Rheumatoid Arthritis: Insights from the JAK‐pot Collaboration
Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis
Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA-Reporter Assay
The Effect of Intranasal Niclosamide on Nasal Symptoms in Patients with Antineutrophil Cytoplasmic Antibody–Associated Vasculitis
ANK1 and EPB41 Variants and the Risk of Steroid-Induced Osteonecrosis
Improved Detection of Myositis‐Specific Autoantibodies Using Luciferase Immunoprecipitation Systems Assay: Comparison With Line Blot and Conventional Immunoprecipitation
Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial
Identifying systemic lupus erythematosus from serum proteomic profiles using machine learning and genetic risk stratification
Combination Therapy in Participants With Active Psoriatic Arthritis Using Subcutaneous Guselkumab and Golimumab: Week 24 Results From a Phase 2a, Multicenter, Randomized, Double-Blind, Proof-of-Concept Study
Prognosis and Long‐Term Outcome of Stenotic Large Vessel Involvement in Giant Cell Arteritis
Validation of International Classification of Diseases Code–Based Case Definitions of Immune Checkpoint Inhibitor–Associated Inflammatory Arthritis From Administrative Health Data
A Rare RIPK3 Variant Enhances Necroptosis and Promotes Inflammation in a Still Disease–Like Autoinflammatory Syndrome
Functional Impact of Structural Damage in Psoriatic Arthritis: Insights from a Prospective Cohort Study
Dysregulation of U12-Type Splicing in Lupus Neutrophils
Association of Clonal Hematopoiesis With Incident, Late‐Onset, Seropositive Rheumatoid Arthritis
Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population‐Based Cohort
Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models
Coverage Generosity of Novel Antirheumatic Drugs in Medicare Advantage and Stand‐Alone Part D Plans
Telocyte Deletion is Associated with Loss of Lymphatic Drainage and Exacerbation of Inflammatory‐Erosive Arthritis in Mice
Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results From the Phase 2 Randomized Trial
Prediction of Relapse and Glucocorticoid Dependence in Eosinophilic Granulomatosis With Polyangiitis: Findings From a Large European Cohort
A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis
OGFRL1 Deficiency Causes Chronic Recurrent Multifocal Osteomyelitis Via Pathologic Osteoclastogenesis, With Therapeutic Response to Tumor Necrosis Factor Inhibitor
Multimodal Integration of Protein Interactomes With Genomic and Molecular Data Discovers Distinct Rheumatoid Arthritis Endotypes
Unveiling Endotypes in Systemic Lupus Erythematosus Through Multiomic Analysis: Insights Into Cardiovascular and Renal Complications
Biologic and Targeted Synthetic Disease‐Modifying Antirheumatic Drugs Do Not Arrest Bone Loss in Patients With Rheumatoid Arthritis: A Long‐Term Multicenter Observational Study
TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays
Baseline Interleukin‐10 Levels as a Predictive Biomarker for Achieving Clinical Response With Abatacept in Patients Who Were Disease‐Modifying Antirheumatic Drug Naive and Anti–Citrullinated Protein Antibody Positive With Early Rheumatoid Arthritis
Multi‐Omic Profiling Reveals Immune Cell Priming Signature Linked to Lupus Prognosis
Serum Proteomic Signatures of Rheumatoid Arthritis Risk and Response: Analysis of a Rheumatoid Arthritis Interception Trial
Efficacy and Safety of Guselkumab in Participants With Active Psoriatic Arthritis After Inadequate Response to One Prior Tumor Necrosis Factor Inhibitor: Week‐24 Results of a Phase 3, Randomized, Placebo‐Controlled Study
XCR1+ Conventional Type 1 Dendritic Cells Exacerbate the Inflammation in Osteogenic Arthritis Through IL-17A+CD8+ T Cells
<atl>First‐Year scpIgG/scp Dynamics in scpIgG4/scp ‐Related Disease: A Critical Window for Predicting Long‐Term Outcomes</atl>
In synergy with interferon‐gamma, interleukin‐17 activates vascular stromal cells towards a pro‐inflammatory profile in giant cell arteritis
Integrative single cell RNA-sequencing and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis
Glucagon‐Like Peptide‐1 Receptor Agonists, Sodium‐Glucose Cotransporter‐2 Inhibitors, and Risk of Autoimmune Rheumatic Diseases
Dual Action of Dipyridamole in Experimental Rheumatoid Arthritis: Suppression of Joint Inflammation and Upregulation of Muscle Anabolism via Adenosine and AMPK pathways
Measuring the Impact: MRI Response of Sacroiliac Joints to TNF Inhibitors in Youth with Axial Disease
DNA methylation profiling reveals distinct epigenetic clusters and suggests epigenetic patterns associated with sex and disease activity in childhood‐onset lupus
Single‐Cell Profiling Reveals Divergent Mechanisms of Fibrosis in Localized Scleroderma and Systemic Sclerosis
Deficiency of AP1M2 causes a new autoinflammatory disease with colitis
Tumor Necrosis Factor–Induced Neuropilin-2 in Fibroblast-Like Synoviocytes Exacerbates Rheumatoid Arthritis
Antineutrophil Cytoplasmic Antibody–Associated Vasculitides in Systemic Sclerosis: A Unique Clinical Overlap With Significant Implications for Treatment and Outcomes
Plasma Proteomics Identifies TAOK3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target
Decision tree analysis as a preliminary evidence‐based tool for identifying the syndrome of undifferentiated recurrent fever in children compared with hereditary recurrent fevers and periodic fever, aphthosis, pharyngitis and adenitis syndrome
Risk factors for relapse in ANCA-associated vasculitis among patients with relapse after induction of remission with rituximab
Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis
Low‐Grade Proteinuria Does Not Predict Favorable Outcomes in Lupus Nephritis: A Longitudinal Cohort Study
Autoantigen peptide-8-arm PEG-Dyes (APP-Dyes) specifically recognize antigen-specific B cells and improve the diagnosis of rheumatoid arthritis
The impact of non‐steroidal anti‐inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: 10‐year results from an inception cohort
The relation of colchicine to total joint arthroplasty among people with gout in a population‐based cohort study
Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus
Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis
Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation
Toward a treat‐to‐target strategy in juvenile dermatomyositis: what are the suitable targets and optimal timing of their achievement?
Relapse Rate After Glucocorticoid‐free Remission in patients with Idiopathic Inflammatory Myopathies and Validation of the International Myositis Assessment and Clinical Studies Group (IMACS) Criteria for Complete Clinical Response and Worsening
Tofacitinib for the Treatment of Juvenile Idiopathic Arthritis: Patient‐Reported Outcomes in a Phase III, Randomized, Double‐Blind, Placebo‐Controlled Withdrawal Trial
Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?
HLA‐DQA1*01:02 is associated with antibody multi‐reactivity with citrulline‐containing type II collagen epitopes while HLA‐DRB1*04:01 is associated with more private antibody reactivity with citrulline‐containing IgG epitopes in rheumatoid arthritis
The efficacy of Telitacicept in Childhood-onset Systemic Lupus Erythematosus: a prospective multi-center cohort study with IPTW-adjusted comparison to a historical control group treated with Belimumab
Identification of risk factors for incident left ventricular systolic dysfunction and predictors of cardiac recovery in patients with systemic sclerosis
Longitudinal Changes in Serum Urate Levels from Pre‐menopause through Post‐menopause: Interrupted Time‐Series Analyses
Effect of time to start of biologic therapy on treatment response in childhood arthritis: Results from the UCAN CAN‐DU study
Telomere Length of Peripheral Blood Leukocytes Predicts Disease Severity and Worse Survival in Systemic Sclerosis
Transition from psoriasis to psoriatic arthritis is characterized by distinct alterations in peripheral blood Tc17, Th17 and CD4+ TEM cells
A randomized, placebo‐controlled trial of hydroxychloroquine in incomplete lupus
Interleukin‐23 receptor deficiency in podocytes averts the development of lupus nephritis.
ZBTB20 Regulating Postnatal Articular Cartilage Development and Homeostasis: Implications for Early‐Onset Osteoarthritis
Where we Live matters: Varied Disease Burden and Treatment Patterns in Psoriatic Arthritis in the United States
ROS‐induced modifications of fibrin clots connect immune responses to atherothrombosis in systemic lupus erythematosus
Skin biopsies enhance prediction of clinical trajectory in diffuse cutaneous systemic sclerosis
Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the scpHLA/scp Class scpII/scp Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis
Clinical Factors Associated With Pneumocystis Pneumonia Despite Its Primary Prophylaxis: When to Stop Prophylaxis?
Incidence of Major Adverse Cardiovascular Events in Patients With Rheumatoid Arthritis Treated With scpJAK/scp Inhibitors Compared With Biologic Disease‐Modifying Antirheumatic Drugs: Data From an International Collaboration of Registries
Efficacy and Safety of ABBV-154 for the Treatment of Active Rheumatoid Arthritis: A Phase 2b, Randomized, Placebo-Controlled Trial
Spermidine reproduces the anti‐inflammatory effects of intermittent fasting and prevents urate and calcium pyrophosphate crystal‐induced inflammation
Genome‐wide DNA methylation study reveals specific signatures in the affected arterial tissue of giant cell arteritis patients
Clinical Significance of Gut Microbiota Community Types for Long‐term Response to Fecal Microbiota Transplantation in Patients with Psoriatic Arthritis
Longitudinal Autoantibody and Proteomic Profiles Uncover Biomarkers and Mechanisms of Disease Progression in Systemic Sclerosis
Chitinase 3‐Like 1 Promotes Endothelial‐to‐Mesenchymal Transition in Systemic Sclerosis via scpmTORC1/scp Signaling Pathway
Clinical Impact of Multiparametric Contrast‐Enhanced Dual‐Energy Computed Tomography in Arthritis Imaging: A Prospective Single‐Center Study
Epidermal Interferon kappa drives cutaneous lupus‐like lesions, photosensitivity and systemic autoimmunity iin vivo/i
Efficacy and Safety of Ivarmacitinib, a Selective JAK1 Inhibitor, in Patients With Active Ankylosing Spondylitis: Results From an Adaptive Seamless Phase 2/3 Trial
Peripheral Biomarker Signatures in Rheumatoid Arthritis–Associated Interstitial Lung Disease
Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT2BR) in murine models and ex vivo models of scleroderma skin
Risk of serious infection in patients with rheumatoid arthritis‐associated interstitial lung disease or bronchiectasis: A comparative cohort study
Distinct Cancer Risk Profiles in Patients with Systemic Sclerosis with Autoantibody Stratification
Serum urate levels alter the spatial distribution of urate crystals in synovium and correlate with synovitis and pain in non‐gout female patients with anteromedial knee osteoarthritis
Differences in IgG Sialylation Distinguish Asymptomatic from Symptomatic Anti‐Nuclear Antibody Positive Individuals
Precision Medicine in Pediatric Autoimmunity: Leniolisib Treatment of Childhood‐Onset Lupus Nephritis Due to Activated Phosphoinositide 3‐Kinase δ Syndrome
Hand Swelling and Other Non–Raynaud Phenomenon Symptoms as the Initial Presentation of Systemic Sclerosis: Prevalence and Clinical Associations in Two scpUS/scp Cohorts
Late‐Onset Spondylarthritis Presenting as Glucocorticoid‐Resistant Polymyalgia Rheumatica: A hitherto underappreciated entity where scpTNF/scp or scpIL/scp‐17 Blockade may have a Therapeutic Role
Association of Abatacept with Lower Mortality Risk Compared to Rituximab in Rheumatoid Arthritis‐Associated Interstitial Lung Disease: An Emulated Target Trial
ADAM9 promotes glycolysis in Th17 cells and autoimmunity through activation of IGF‐1 signaling
Autoantibody response towards chromatin in patients with juvenile idiopathic arthritis
Effect of Long‐Term Voclosporin Treatment on Renal Histology in Patients With Active Lupus Nephritis With Repeat Renal Biopsies
Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients with and without a Family History of Psoriatic Disease
C3a‐C3aR1‐mediated interactions between fibroblast‐like synoviocytes and macrophages promote the progression of rheumatoid arthritis
Deficiency of cartilage‐specific Y‐box binding protein 1 represses NF‐κB signaling and alleviates osteoarthritis progression
Monocyte‐derived macrophages‐synovial fibroblasts crosstalk unravels oncostatin signaling network as a driver of synovitis in osteoarthritis
Three‐Year Outcomes and Latent Class Trajectory Analysis of the Childhood Arthritis and Rheumatology Research Alliance Polyarticular scpJIA/scp Consensus Treatment Plans Study
Complex Regulatory Interactions at scpiGDF5/i/scp Shape Joint Morphology and Osteoarthritis Disease Risk
Paradoxical Activation of Entheseal Myeloid Cells by scpJAK1/scp and Tyk2 Inhibitors via Interleukin‐10 Antagonism
Differences in Dynamics of Specific Antinuclear Antibodies and Their Susceptibility to B Cell–Targeting Treatment in Patients With Systemic Lupus Erythematosus
Three‐Year Results of Tapering Tumor Necrosis Factor Inhibitor to Withdrawal Compared to Stable Tumor Necrosis Factor Inhibitor Among Patients With Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial
Comparative Effectiveness of Abatacept versus Adalimumab in Shared Epitope positive and negative Rheumatoid Arthritis patients
A tolerogenic plasmid inhibits autoantibody production triggered by immunization with human peptidyl arginine deiminase 4.
scpEAT/scp‐lancet Diet Modifies the Risk of Rheumatoid Arthritis through Metabolomic Signature
Clonal sharing of CD8+ T‐cells links skin and joint inflammation in psoriatic arthritis
Efficacy of Golimumab in Early Axial Spondyloarthritis in Relation to Gut Inflammation (GO-GUT), an Early Remission Induction Study
A randomized, double‐blind, placebo‐controlled trial of abatacept for the treatment of relapsing, non‐severe, granulomatosis with polyangiitis
Changes in Pain Sensitization after DMARD therapy are Associated with Changes in Disease Activity in Established Rheumatoid Arthritis
Peripheral blood gene expression profiling shows prognostic significance for the course of interstitial lung disease in systemic sclerosis
Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China
Machine Learning Analysis of Whole‐Blood Transcriptomics Data in Rheumatoid Arthritis Patients Treated with Adalimumab Identifies Predictive Biomarkers of Response
Efficacy and Safety of Zimlovisertib, Ritlecitinib, and Tofacitinib, Alone and in Combination, in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate
Trio whole exome sequencing in Chinese childhood‐onset lupus reveals novel candidate genes
HLA class I‐downregulated senescent epidermal basal cells orchestrate skin pathology in cutaneous lupus erythematosus
Maintenance of remission after tocilizumab withdrawal in patients with glucocorticoid‐dependent polymyalgia rheumatica
Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement
7
Plasmodium knowlesi can adapt to infect Duffy-negative erythrocytes
Single-cell profiling of ANKRD26 thrombocytopenia reveals progenitor expansion and polyploid apoptosis via JUNB-p21
Heat stress activates the coagulation cascade through Z-DNA-binding protein 1–dependent necroptosis
BRAFV600E-positive mononuclear cells in blood at diagnosis portend treatment failure and neurodegeneration in pediatric LCH
Endothelial mTORC2-Foxo1 axis serves as an iron-responsive sensor governing systemic iron homeostasis
Single-cell and clonal analysis of AL amyloidosis plasma cells and their bone marrow microenvironment.
Novel regulators of GVHD revealed through microbiome and metabolome patterns across distinct intestinal regions
29
Biosignatures of cognitive basic symptoms mark a distinct neurodevelopmental pathway to schizophrenia
Exploring the association between antidepressants, progression and mortality in Huntington’s disease
Angiogenic switching in cerebral cavernous malformations driven by MAP3K3–PIK3CA synergy
Biological classification of memory clinic patients
Predictive models for ataxia progression and conversion in spinocerebellar ataxia type 1 and 3
Memory deficits of MDMA users are linked to cortical thinning related to 5-HT receptor densities
Staging Alzheimer’s disease through amyloid and tau PET
Distinct cerebellar networks underpin clinical improvement in adolescent Tourette disorder
A large cohort study of prenatal exome sequencing redefines diagnosis in fetal corpus callosum anomalies
Aβ low threshold mechanoreceptors contribute to sensory abnormalities in fibromyalgia
Biallelic variants in iCOX18/i cause a mitochondrial disorder primarily manifesting as peripheral neuropathy
Connectivity as a universal predictor of tau progression in atypical Alzheimer’s disease
Cognitive loss after brain trauma results from sex-specific activation of synaptic pruning processes
Treatment resistant recurrent unipolar and bipolar depression: associative learning abnormalities
Brain health concerns in former rugby players: clinical and cognitive phenotypes
Interferon-γ causes myogenic cell dysfunction and senescence in immune myopathies
Genome-wide association study of neuropathological features in Lewy body disease
Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial
Combined genomics and proteomics unveils elusive variants and vast aetiologic heterogeneity in dystonia
Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer’s disease
Loss of the neuronal kinase DCLK3 leads to anxiety-like behaviour and memory deficits
Transthyretin variants impact blood–nerve barrier and neuroinflammation in amyloidotic neuropathy
Stimulation of the human ventral tegmental area increases strategic betting
Impaired reward sensitivity in Parkinson's depression is unresponsive to dopamine treatment
Modelling fragile X-associated neuropsychiatric disorders in young inducible 90CGG premutation mice
Oligoadenylate synthetase 1a suppresses prion infection through binding to cellular prion protein
Are brain arteriovenous malformations congenital or developmental? Evidence from paediatric age data
Ventriculitis characteristics and outcomes (VELCRO): an international retrospective cohort study
At-home wearables and machine learning capture motor impairment and progression in adult ataxias
42
Diagnosis of inflammatory bowel disease following symptomatic faecal immunochemical testing – A population based cohort study
Nationwide outcomes of endovascular thoracoabdominal aortic aneurysm repair
Preoperative low-energy diets for patients with body mass index amp;gt;30kg/m2 undergoing non-bariatric surgery: A pilot feasibility randomized clinical trial and a systematic review and meta-analysis of efficacy data
Emergency hospital admissions while on an elective waiting list in England: an observational study using administrative data
Day case and inpatient elective thyroid lobectomy across England: observational study of variation in practice and safety
Open excisional haemorrhoidectomy versus transanal haemorrhoidal dearterialization for grade III haemorrhoids: open-label randomized clinical trial
Outcomes of endovascular aortic arch repair with an off-the-shelf modular inner branched stent-graft: an IDEAL 2a prospective multicentre trial
Effect of standard versus long alimentary limb distal Roux-en-Y gastric bypass on weight loss and nutritional outcomes at 10 years in patients with BMI 50–60 kg/m2—a secondary analysis of a randomized clinical trial
Robotic versus laparoscopic minimally invasive inguinal hernia repair: randomized clinical trial (the ROGER trial)
Performance indicators for organ donation and transplantation programmes in Europe: modified Delphi consensus study
Laparoscopic-assisted transversus abdominis plane block versus port-site infiltration in appendicectomy: multicentre randomized clinical trial
Parallel Endografting And Chimney Endovascular (PEACE) registry outcomes in emergency repair of complex abdominal aortic aneurysms
Qualitative perspectives (on incoming medical teams during conflict) from surgeons in the Middle East and North Africa
Training needs analysis of surgical teams in Somaliland
Outcomes after elective inguinal hernia repair with mesh performed by associate clinicians versus medical doctors in Sierra Leone: 5-year follow-up of a randomized clinical trial
Effect of standard wound dressing versus prophylactic closed incision negative-pressure therapy on surgical-site infection after open incisional hernia repair: multicentre randomized clinical trial
Treatment strategies for Boerhaave syndrome: multinational retrospective cohort study
Magnetic seed versus guidewire-based breast cancer localization with magnetic lymph node detection: cost-minimization analysis
Major systemic infection following breast cancer surgery and oncological outcomes
Rectus diastasis repair with and without mesh at 1 year: randomized clinical trial
Anatomical basis for sensory preservation in robotic mastectomy
Randomized clinical trial of intradermal suture and metallic stapling for incisional groin closure after vascular surgery (VASC-INF trial)
Endovascular aortic arch repair with a triple branch arch device
Alcohol use disorder and alcohol-related mortality after metabolic bariatric surgery: prospective controlled cohort study
Variation in outcomes after metabolic bariatric surgery: multilevel analysis to assess the contribution of patient, surgeon, and hospital factors
Recurrence rate and mesh bulging are reduced with primary fascial closure in ventral hernia repair: the PROSECO randomized clinical trial
Endoscopic and surgical treatment options for gastroparesis: systematic review and network meta-analysis
Oncological safety of portal vein embolization without prior tumour clearance in the future liver remnant followed by one-stage hepatectomy for bilateral colorectal liver metastases
Perioperative changes in the microbiome during rectal cancer surgery: exploratory analysis of the National Institute for Health and Care Research (NIHR) IntAct trial
Quilt technique after mastectomy: stepped-wedge randomized cluster trial showing superior textbook outcome and reduced healthcare utilization
Comparison of outcomes after living and deceased donor kidney transplantation: UK national cohort study
The effect of weight change on death and cardiovascular events after Roux-en-Y gastric bypass
Impact of bariatric surgery on patients with chronic kidney disease and severe obesity: multiple-linked population-based cohort study
Prevalence and severity of pain, anxiety, stress, and sleep disturbances among surgical patients: a nationwide single-day multicentre flash mob study
Prognostic factors associated with primary non-responsiveness to antibiotics and appendicitis recurrence for CT-diagnosed uncomplicated acute appendicitis: secondary analysis of two randomized clinical trials
Nutritional deficiencies after sleeve gastrectomy and Roux-en-Y gastric bypass at 10 years: secondary analysis of the SLEEVEPASS randomized clinical trial
Global funding for surgical research between 2016 and 2020: content analysis of public and philanthropic investments
Effect of virtual reality on pain and stress in children during Kirschner-wire removal after fracture treatment: a randomized clinical trial
Validation of the Swiss-Finnish Bariatric Metabolic Outcome Score within a large prospective registry cohort
Magnetic resonance-derived hepatic uptake index improves the identification of patients at risk of severe post-hepatectomy liver failure
Comparison of revision surgery after implant-based breast reconstruction between smooth, textured, and polyurethane-covered implants: results from the Dutch Breast Implant Registry
Empty pelvis syndrome as a cause of major morbidity after pelvic exenteration: validation of a core data set
4
Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct patterns and potential markers of progression
Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors
Immunosequencing identifies signatures of T cell responses for early detection of nasopharyngeal carcinoma
7
Intratumoral Lactobacillus johnsonii Enhances Sensitivity to PD-1 Blockade by Inducing CD8+ T-cell Expansion in Hepatocellular Carcinoma
Spermine Oxidase Serves as a Key Functional Node in Microbial Dysbiosis–Induced Breast Carcinogenesis
Cis-Regulatory Alterations in iFOXP4/i Modulate Esophageal Cancer Susceptibility Induced by Chronic Alcohol Exposure
Multitask Deep Learning Based on Longitudinal CT Images Facilitates Prediction of Lymph Node Metastasis and Survival in Chemotherapy-Treated Gastric Cancer
Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
Mathematical Modeling and Association Analysis Deciphers the Impact of the Gut Microbiome on Cancer Immunotherapy.
Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer.
36
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets
B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism
Gut microbiome is associated with recurrence-free survival in patients with resected high-risk melanoma receiving adjuvant immune checkpoint blockade
The spatiotemporal dynamics of postnatal vascularization in the mouse brain
Arbitrium phages can manipulate each other’s lysis/lysogeny decisions
Phages communicate across species to shape microbial ecosystems
Microbiome-produced nicotinic acid controls colon regional identity and injury susceptibility
Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature
Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi
Establishing the relationship between brain cellular senescence and brain structure
Autoantibody-triggered podocyte membrane budding drives autoimmune kidney disease
Structure of pancreatic hIAPP fibrils derived from patients with type 2 diabetes
Stimulant medications affect arousal and reward, not attention networks
In vivo transcriptomic, functional, circuit-based, and translational analyses of enteric neurons
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
Properties and functions of transcriptionally distinct enteric neurons
Single-cell susceptibility to viral infection is driven by variable cell states
Genetic modifiers and ascertainment drive variable expressivity of complex disorders
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization
A generative deep learning approach to de novo antibiotic design
Bronze Age Yersinia pestis genome from sheep sheds light on hosts and evolution of a prehistoric plague lineage
Microbiota-derived inosine programs protective CD8+ T cell responses against influenza in newborns
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Personalized molecular signatures of insulin resistance and type 2 diabetes
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment
Procr+ chondroprogenitors sense mechanical stimuli to govern articular cartilage maintenance and regeneration
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1
Combination antiretroviral therapy and MCL-1 inhibition mitigate HTLV-1 infection in vivo
Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition
Systematic profiling reveals betaine as an exercise mimetic for geroprotection
Neuroendocrine circuit for sleep-dependent growth hormone release
Trichophyton concentricum fungal infections and skin microbiomes of Indigenous Peninsular Malaysians
Dopamine encodes deep network teaching signals for individual learning trajectories
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects
Cyclic-dinucleotide-induced filamentous assembly of phospholipases governs broad CBASS immunity
39
Gut microbiota-derived ergothioneine alleviates antipsychotic-induced synaptic and cognitive impairments
Bacteroides acidifaciens exacerbates cardiac ischemia/reperfusion injury via the microbial-host isozyme DPP4
The DanRI regulatory system in uropathogenic Escherichia coli subverts neutrophil responses
The skin microbiota drives cutaneous immune checkpoint inhibitor toxicity in genetically susceptible mice
Discovery of human gut phage-encoded anti-CRISPR proteins unveils diverse mechanisms for phages to evade type II CRISPR immunity
Leveraging intratumoral probiotics for pancreatic cancer immunotherapy via xenophagy
Commensal enteric virome regulates intestinal carbohydrate digestion and absorption
Meta-analysis of the uncultured gut microbiome across 11,115 global metagenomes reveals a candidate signature of health
A DNA recognition-mimicry switch governs induction in arbitrium phages
A widespread extended arbitrium system controls lysis/lysogeny through antirepression
Molecular basis of 60 years of antigenic evolution of human influenza A(H3N2) virus neuraminidase
Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosis
A gut-secreted histidine methyltransferase enforces cross-kingdom catalytic antifungal defense
Transitions in lung microbiota landscape associate with distinct patterns of pneumonia progression
Diet modulates Vibrio cholerae colonization and competitive outcomes with the gut microbiota
A commensal bacterium secretes effector proteins to establish population heterogeneity in the gut
A Bacteroides fragilis protease activates host PAR2 to induce intestinal pain and inflammation
The microbiota extends the reproductive lifespan of mice by safeguarding the ovarian reserve
Gut microbiota and metabolites drive chronic sickle cell disease pain in mice
A prophage intercepts pathogenic activity of infecting phage for defense
Macrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ
Cryptosporidium parvum multidrug resistance protein confers resistance to toxic gut microbial metabolite
Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system
Metabolic cross-feeding of a dietary antioxidant enhances anaerobic energy metabolism by human gut bacteria
Amino acid competition shapes Acinetobacter baumannii gut carriage
Metagenomic selections reveal diverse antiphage defenses in human and environmental microbiomes
The prototypic crAssphage is a linear phage-plasmid
Restoration of the human skin microbiome following immune recovery after hematopoietic stem cell transplantation
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma
Bacteriophage genomes encode both broad and specific counter-defense repertoires to overcome bacterial defense systems
Immune profiling in subclinical secondary dengue-infected cases reveals adaptive immune signatures correlated to protection from severe dengue
Phage arabinosyl-hydroxy-cytosine DNA modifications result in distinct evasion and sensitivity responses to phage defense systems
Microbial contribution to metabolic niche formation varies across the respiratory tract
Epithelial cells provide immunocompetence to the early embryo for bacterial clearance
E. coli prophages encode an arsenal of defense systems to protect against temperate phages
Microbiota-derived urocanic acid triggered by tyrosine kinase inhibitors potentiates cancer immunotherapy efficacy
Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease
Cohabitation facilitates microbiome shifts that promote isoflavone transformation to ameliorate liver injury
16
Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia
The gut microbiota alleviates depression by remodeling gut-brain energy metabolism
Maltol induces diabetic fragility fractures by disrupting the balance of bone remodeling
Plasma proteomic signature of frailty in 50,506 adults
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism
Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes
Macrophage PD-1 regulates energy expenditure and metabolic dysfunction under immune checkpoint blockade
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender
Gut microbiome-adipose crosstalk modulates soluble IL-6 receptor influencing exercise responsiveness in glycemic control and insulin sensitivity
Therapeutic remodeling of the ceramide backbone prevents kidney injury
Liver-breast communication of adipocyte-oriented exosomes drives primary mammary cancer progression
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
Localized GLP1 receptor pre-internalization directs pancreatic alpha cell to beta cell communication
Sphingomyelins in mosquito saliva reconfigure skin lipidome to promote viral protein levels and enhance transmission of flaviviruses
FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
FGF21 reverses MASH through coordinated actions on the CNS and liver
9
Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis
Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system
VIPR1 acts as an enteric neural checkpoint that suppresses intestinal stem cell-driven epithelial regeneration and exacerbates colitis
Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition
Niche-preserving transplantation promotes functional engraftment of intestinal organoids in rat short bowel syndrome
A phenotypic brain organoid atlas and biobank for neurodevelopmental disorders
Human adult hippocampal neurogenesis is shaped by neuropsychiatric disorders, demographics, and lifestyle-related factors
Reconstruction of endocrine subtype-complete human pluripotent stem cell-derived islets with capacity for hypoglycemia protection in vivo
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic kidney disease
10
The anion–π+ interaction strategy enhances the PDT antibacterial performance of AIE-active photosensitizers
Cationic donor–π–acceptor AIEgen enabling dual-mode reactive oxygen species generation for antibacterial photodynamic therapy
Mechanistic principles of antimicrobial peptides uncovered by charge density-based machine learning
A light-activated nickel(ii)–antibiotic conjugate for synergistic antibacterial therapy
Novel Ru(ii)-photo-antibiotics for the development of infection-resistant mask coatings
An AIE photosensitizer with type I/II ROS generation for photodynamic therapy of toxoplasmosis
Core–shell covalent organic framework-copper nickel disulfide nanoreactors for the synergistic treatment of wound infections
Chain-engineered tetraphenylethylene derivatives for potent antimicrobial activity against pathogens
A sensitive 2D Cu-TCPP-based respiratory ammonia sensor for non-invasive and more accessible detection of Helicobacter pylori infection
Triphenyl phosphonium functionalized amphiphilic peptides as promising antibacterial and anticancer agents
19
An extrinsic enzyme-activatable fluorescent probe for high-contrast tumor imaging
Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer
Lanthanide complexes with acetophenone-based push-pull antennas as efficient MRI and two-photon microscopy imaging probes
Photoactivated antifungal polymers prepared by PET-RAFT polymerization
Development of a glutamine-responsive MRI contrast agent
Macrocycle formation-mediated augmentation in reactive oxygen species production
Regulating the photoelectric properties of porphyrin-based COF nanozymes by pillararene with polyphenol structure for efficient photo-enhanced antibacterial effect
A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress
Tri-specific molecularly imprinted lysosomal nanodegrader enables synergistic therapy of cytokine storm
β-Lactamase cleavable antimicrobial peptide–drug conjugates
Photothermal therapy for bacteria-infected wound healing via a cation–anion inverted antiperovskite with full-spectrum solar absorption
Bismuth drug eradicates multi-drug resistant Burkholderia cepacia complex via aerobic respiration
Cefiderocol “under siege”? Understanding the rise of NDM-mediated resistance to novel agents
Ultra-high resolution magnetic resonance microscopy of iin situ/i gadolinium gold nanoparticle-labeled cells in the rat brain
Targeted recognition, fluorescent tracking and augmented killing of multi-bacterial infections via synergizing a magnetic bead-armored phage cocktail with enzyme-activated AIE probes
β-Lactamase-activated antimicrobial dendron ivia/i the amine uncaging strategy
Promotion or suppression of hydrogen evolution activity? The competition between sodium cations and quaternary ammonium ions at the metal/water interface
Binding assays enable discovery of Tet(X) inhibitors that combat tetracycline destructase resistance
Fluorescent molecular probe for in vivo and in vitro targeting and imaging of an intracellular bacterial infection
32
Cone Beam CT Imaging-Guided Bronchoscopy vs CT Imaging-Guided Transthoracic Needle Biopsy for Peripheral Pulmonary Lesion Diagnosis
Diaphragm Thickening Fraction Fails to Predict Esophageal Pressure or Ventilator Weaning in Children
Evaluation of Lung Disease in Adults With Osteogenesis Imperfecta
Timely Antibiotics and Fluid Resuscitation Are Associated With Increased Discharge to Home After Sepsis
Diagnostic Yield of CT Imaging and Point-of-Care Ultrasound After In-Hospital Cardiac Arrest
Prophylactic Hemostatic Treatment to Control Iatrogenic Bleeding During Endobronchial Biopsy (PROTECT Study)
Antimicrobial Treatment of Mild Mycobacterium avium Complex Pulmonary Disease Predicted to Increase Survival and Quality-Adjusted Life Years
The Impact of Weight Loss on the Physiological Endotypes Associated With OSA
Daily Physical Activity in Pulmonary Arterial Hypertension
Associations between Prior Lung Diseases and Risk of Lung Cancer in Populations With No Smoking History: A Systematic Review and Meta-Analysis
“Lateral Decubitus Strategy (LADS) is Superior to Ventilatory Strategy (VESPA) in Preventing Atelectasis from Obscuring Targets during Robotic Bronchoscopy, Leading to Improved Procedural Outcomes” (LADS vs VESPA Trial)
Adjunctive Corticosteroid Use and Clinical Outcomes in Non-HIV Pneumocystis jirovecii Pneumonia
A National Evaluation of Intercostal Chest Drain Removal Strategies
Post-ICU Care Trajectories and Outcomes Among Veterans: Comparing VA and Community Hospital Discharges
Inspiratory effort and dynamic transpulmonary driving pressure in extremely preterm infants
Post Intensive Care Syndrome Awareness and Communication: Surveys of ICU Providers and Patients
Pleural Manometry in Pneumothorax: Evaluating Tension Physiology and Predicting Outcomes
Poor olfaction is associated with lower pulmonary function in older adults
Effect of Continuous High-Frequency Oscillation Therapy on Lung Aeration in Mechanically Ventilated Patients with Impaired Consciousness: A Multicenter Randomized Controlled Trial
Comparative Effectiveness of Tocilizumab Versus Rituximab in RA-ILD: A Emulated Target Trial
Contribution of Key Comorbidities to Unfavorable Treatment Outcomes among Adults with Drug-sensitive Pulmonary Tuberculosis in India: a Prospective Cohort Analysis
Mass medical evacuations to decrease the intensive care burden: results from the TRANSCOV cohort study.
Impact of Treatment Outcome on Mortality in Mycobacterium abscessus Complex Pulmonary Disease
The Consistency of Hypercapnic Respiratory Failure Case Definitions in Electronic Health Record Data
Contemporary Trends in Pediatric Extubation Failure and Non-Invasive Respiratory Support Use
Medical Thoracoscopy with versus without Prior Artificial Pneumothorax for Patients with Minimal or Absent Pleural Effusion
Low tidal volume ventilation and mortality in patients with acute brain injury: a secondary analysis of an international observational study*
Covert triage during the COVID-19 pandemic: A qualitative analysis of rationing in intensive care
Anomalous differences between the Global Lung Function Initiative 2023 and 2012 spirometry reference values
Ultrathin bronchoscopy with radial endobronchial ultrasound and rapid on-site evaluation for the diagnosis of peripheral pulmonary lesions: a multicentre randomized controlled factorial trial
Pulmonary Rehabilitation Referral Practice Patterns across Lung Transplant Centers in the US: A Multi-Center Survey-Based Study
Oxygen Saturation Targets and Neurologic Outcomes after Cardiac Arrest: A Secondary Analysis of the PILOT Trial
20
Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity.
Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery Disease.
The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis.
TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn2+ Homeostasis.
Cell-Specific Inducible Human APOL1 Risk Variant Expression in Mice Causes Hypertension and Renal Damage.
N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness.
Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: a Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial.
High-Dose vs. Standard-Dose Influenza Vaccine and Cardiovascular Outcomes in Older Adults: The FLUNITY-HD Prespecified Pooled Analysis.
Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial.
Impact of Cerebral Embolic Protection On Cognitive Function Following Transcatheter Aortic Valve Implantation: Data From the BHF PROTECT-TAVI Randomized Trial.
Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling.
Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry.
Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial.
PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations.
Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study.
Partnership Model of Regionalized Care for Congenital Heart Disease in Resource-Limited Settings: Results From the ASSIST Project
Nonculprit Vulnerable Plaques and Prognosis in Myocardial Infarction With Versus Without ST-Segment Elevation: A PROSPECT II Substudy
High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation Through Central Fibroblast Growth Factor Receptor Signaling.
Intracellular L-PGDS-Derived 15d-PGJ2 Inhibits CaMKII Through Lipoxidation to Alleviate Cardiac Ischemia/Reperfusion Injury.
Dusp14-Mediated Dephosphorylation of MLKL Protects Against Cardiomyocyte Necroptosis in Hypothyroidism-Induced Heart Failure.
3
Mapping environmental determinants of aging in place through network analysis: insights from Taipei
Housing for “ageing in place”: Urban densification projects and the provision of age-appropriate housing in Switzerland
Demographic influences on urban commercial spaces: Spatial characteristics and purchase patterns across age groups in Incheon, Korea
140
Diagnostic Yield of Tongue Swab- Compared to Sputum-Based Molecular Testing for Tuberculosis in Four High-Burden Countries
Challenges in malaria diagnosis and treatment in Kinshasa Province, Democratic Republic of the Congo
Renal and Cardiovascular Complications Following Type 2 Diabetes Mellitus in People With and Without HIV: Data from Cohort Study on Morbidity and HIV in Sweden (COSMOHS) between 2010-2024
Comparing the Antimicrobial Resistance Crisis to the Coronavirus Disease 2019 Pandemic: A Randomized Public Health Messaging Experiment
Mapping Hospitals That Treat Severe Malaria Cases in the United States: Evidence to Inform Health Systems Strategies for Intravenous Artesunate Supply
Age-Specific Risk of Herpes Zoster in Adults Aged ≥18 Years With Comorbid Conditions—A Retrospective Cohort Study in the United States
Frequent Plasmodium ovale Recurrence in Coastal Tanzania
Role of Low-Dose Infliximab for Inflammatory Complications of Central Nervous System Tuberculosis: A Retrospective Cohort Study
Prevalence and Predictors of Tuberculosis in Adults and Adolescents With Sputum Trace Ultra Results in 2 High-Burden Clinical Settings
A 48-Week, Randomized Controlled Trial of Doravirine for Individuals With HIV and Obesity on Integrase Inhibitors and Tenofovir Alafenamide: The Do IT Study (ACTG A5391)
Limited durability of improvements in infection prevention and control practices following reactive interventions leaves healthcare facilities vulnerable to Ebola virus transmission
Antiretroviral Activity, Pharmacokinetics, and Safety of MK-8527, an Oral Nucleoside Reverse Transcriptase Translocation Inhibitor, in Adults Living With HIV-1 Who Had Not Previously Taken Antiretroviral Agents: Results From Two Open-Label, Phase 1 Studies
Cephalosporins Versus Non-Cephalosporin Antibiotics for Perioperative Prophylaxis in Primary Arthroplasty: A Systematic Review and Meta-Analysis
Using Probability of Community-Acquired Pneumonia to Tailor Antimicrobials Among Inpatients: A Pragmatic, Randomized Trial
Patterns of HIV-1 Viral Load Suppression and Drug Resistance During the Dolutegravir Transition: A Population-based Longitudinal Study
Virological Failure on Long-Acting Injectable Cabotegravir and Rilpivirine: An Analysis of Subtypes, Drug Levels, Resistance, and Therapeutic Implications
Shorter Antitubercular Regimens Versus 9 Months of Isoniazid for Latent Tuberculosis in Children: A Systematic Review and Meta-Analysis
Dolutegravir Reduces HTLV-1 Proviral Load and Improves Neurological Outcomes in a Phase II Controlled Trial
Progression risk in cancer patients with HIV compared to cancer patients without HIV
Escherichia coli ST131 Drives Carbapenem Use for E. coli Bloodstream Infections
Risk of Major Adverse Cardiovascular Events With Dolutegravir Versus Efavirenz-Based Antiretroviral Therapy: Emulated Target Trials Using Routine, De-Identified Data From South Africa
Duration of Therapy for Pseudomonas aeruginosa Bacteremia—A Post Hoc Subgroup Analysis From the BALANCE Randomized Controlled Trial
<atl>Diagnostic Performance of New Commercial IGRAs for iMycobacterium tuberculosis/i Infection: An updated Systematic Review and Meta-analysis</atl>
Intrathecal Isoniazid and Dexamethasone Therapy May Improve Outcomes in Patients with Tuberculous Meningitis: A Two-Center Retrospective Cohort Study
A Public Health Approach to Antimicrobial Stewardship in Long-Term Care Facilities: A Multifaceted Program in Massachusetts
Fatal Overdose, Acute Viral Hepatitis, and Human Immunodeficiency Virus Attributed to Injection Drug Use, Appalachian Region of the United States, 2000–2023
Impact of Proviral-DNA M184V/I on 96-Week Outcomes of DTG/3TC Maintenance Therapy: Results From the VOLVER Clinical Trial
Point-of-Care Urine Tenofovir Drug-Level Feedback Counseling Improves Long-term PrEP Adherence for U.S. MSM in Pilot RCT
Melioidosis Complicated by Native Valve Endocarditis in a Traveler Returning From Thailand to the United States
Treatment adherence with an oral nine-month regimen for rifampicin-resistant tuberculosis in South Africa
Clinical Manifestations, Long-Term Trends, and Risk Factors for Treatment Failure in Native Vertebral Osteomyelitis: A 26-Year Mayo Clinic Experience
Implementing a Program of Comprehensive Tuberculosis Preventive Treatment: Safety, Effectiveness, and Acceptability of Moxifloxacin or Bedaquiline Use for Contacts Exposed to Drug-Resistant Strains
Symptomatic and asymptomatic norovirus infections in early life; The PREVAIL Cohort, 2017-2020
Pregnant women with MDR/RR-TB and the all-oral 6-month regimen: experiences from a patient series in South Africa
Short-Course Tuberculosis Preventive Therapy in a High Migration Setting: Early Experience With 1HP in Cook County, Illinois
Effect of Direct-from-blood Bacterial Testing on Antibiotics Administration in Adults Presenting With Acute Infection: A Randomized Trial
<atl>Documenting environmentally acquired iMycobacterium intracellulare/i subsp. ichimaera/i pulmonary disease soon after bronchiectasis onset</atl>
Overlapping Clinical Presentation of Long COVID and Postacute COVID-19 Vaccination Syndrome: Phenotypes, Severity, and Biomarkers
Switch to BIC/TAF/FTC or DTG + TDF/FTC in virologically suppressed PWH: outcomes in real-world setting with and without tenofovir resistance
Evaluation of a Remote Therapeutic Monitoring (RTM) Device and Integrated Care Platform in Outpatient Parenteral Antimicrobial Therapy (OPAT)
Integrating HIV and Stimulant Use Disorder Treatment: A Pilot Implementation Effectiveness Trial of Contingency Management in HIV Care
Early symptom response in patients with uncomplicated urinary tract infection treated with gepotidacin or nitrofurantoin: pooled analysis from two pivotal Phase 3 studies
Association of Mycobacterium Avium paratuberculosis with Crohn’s Disease: A large multicentre study from TB endemic region
Regional variations of rates and determinants of drug resistance mutations in people failing first-line therapy for HIV-1: a substudy from the D2EFT phase 3b/4 clinical trial
Using the Comparing Oral versus Parenteral Antimicrobial Therapy (COPAT) Clinical Trial to Influence Institutional Practice Transformation Towards Earlier Transition to Oral Antibiotics
“Bone biopsy not superior to ulcer bed biopsy guided antibacterial therapy on remission of diabetic foot osteomyelitis: A randomized controlled trial”
Disease Trends and Mortality from Invasive Pneumococcal Disease: A Long-Term Population-Based Study
Reproducible Identification of Staphylococcus aureus Bacteremia Clinical Subphenotypes
The Bounce-Back Effect: What Happens After Cessation of Low-Dose Semaglutide in People with HIV
Aspergillosis-Attributable Mortality in the United States: Analysis of Death Certificate Data
Using generative artificial intelligence to identify central line-associated bloodstream infections
Rethinking the routine: Are repeat blood cultures necessary after completion of infective endocarditis treatment?
Estimating the Accuracy and Additionality of TB-LAM to Diagnose TB in Children Without HIV (AccuLAM)
Effects of a Water, Sanitation, and Hygiene Program on Diarrhea, Cholera, and Child Growth in the Democratic Republic of the Congo: A Cluster-Randomized Controlled Trial of the Preventative Intervention for Cholera for 7 Days (PICHA7 WASHmobile) Mobile Health Program
Epidemiology of Vibrio cholerae Infections in the Households of Cholera Patients in the Democratic Republic of the Congo: PICHA7 WASHmobile Prospective Cohort Study
Combined use of ibalizumab and lenacapavir for the treatment of multidrug-resistant HIV-1: A case series
Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)
Integrase Strand Transfer Inhibitors for Treatment-experienced Young Adults With Perinatal HIV in the US: Immunologic, Virologic, and Anthropometric Outcomes
Mortality Among Patients With Invasive Group A Streptococcal Infections Caused by the M1UK Lineage: A Retrospective Cohort Study in England and Wales
Trends in Persons Prescribed HIV Postexposure Prophylaxis in the United States, 2015–2023
Long-term clinical, immunologic, and viral reservoir outcomes in children treated with VRC01LS and 10-1074 monoclonal antibodies in the Tatelo Study
Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults with HIV (INSTINCT/GESIDA10918 Study)
Prophylactic Efficacy of CD388, a Novel Drug–Fc Conjugate, in a Human Influenza A/H3N2 Virus Challenge Model: A Randomized, Controlled Phase 2a Study
Prognostic Value of Blood Epigenetic Biomarkers of Aging in Persons With Well-Controlled Human Immunodeficiency Virus (HIV-1) Infection
Effectiveness of COVID-19 Vaccination and Prior Infections to Reduce Long COVID Risk During the Pre-Omicron and Omicron Periods
Severity of Clinical Presentation and Outcomes in Hospitalized Adult Patients with Influenza by Type and Subtype, United States—2017–2020
Cluster-Randomized Controlled Trial of Enhanced Carbapenem-Resistant Enterobacterales Prevention Program in General Medicine Wards, Siriraj Hospital
Randomized Pragmatic Trial of the Comparative Effectiveness of Chicken Egg-Based Inactivated, Mammalian Cell Culture-Based Inactivated, and Recombinant Protein Quadrivalent Seasonal Influenza Vaccines in United States Military Health System Beneficiaries
Antibody Response in Healthcare Workers During the SARS-CoV-2 Gamma Variant Outbreak in Manaus, Brazil
Empirical Antifungal Treatment of Critically Ⅲ Patients With Influenza-Associated Acute Respiratory Distress Syndrome: A Propensity Score Weighted Observational Study
Transient Increased Risk of Shingles Post–Shingrix Vaccination: Self-Controlled Case-Series Analysis
HIV Resistance to Dolutegravir Varies With Coadministered Agents
Increasing HIV Testing During Gonorrhea and Chlamydia Evaluations in Urgent Care and Emergency Departments: A Large Health System Initiative
Efficacy and Safety of Dual Therapy With Dolutegravir/Lamivudine in Treatment-naive Persons With CD4 Counts amp;lt;200/mm3: 48-Week Results of the DOLCE Study
Characterizing Treatment Adherence Trajectories in the endTB Multisite Cohort of Drug-Resistant Tuberculosis Patients: An Application of Group-Based Trajectory Modeling
Nontuberculous Mycobacterium Skin Infections Associated With One Tattoo Studio—Oregon, January–April 2023
The three-gene Xpert Host Response signature for pediatric tuberculosis screening: A prospective diagnostic accuracy study
Impact of different INSTIs on BMI among people living with HIV who newly started ART in Shenzhen, China: a real-world data analysis
Evaluation of COVID-19 and Influenza-like Illness Surveillance Case Definitions in a Prospective Cohort of Healthcare Personnel in Peru
Design and evaluation of next-generation HIV genotyping for detection of resistance mutations to 28 antiretroviral drugs across five major classes including lenacapavir
Therapeutic Drug Monitoring of Long-Acting Cabotegravir and Rilpivirine in a National Cohort of People With Human Immunodeficiency Virus Type 1: First Results From the ANRS-MIE CARLAPOP Study
Should We Extend the Use of Oral Antibiotics in Infective Endocarditis? The ENDO-ORAL Study
Background HIV Incidence in PURPOSE 1 and 2 PrEP Trials
Continuation Versus Temporary Interruption of Immunomodulatory Agents During Infections in Patients With Inflammatory Rheumatic Diseases: A Randomized Controlled Trial
Comparing clinical, microbiological and genetic definitions of relapse in patients with subsequent episodes of MRSA bone and joint infection
Adjuvanted recombinant zoster vaccine is effective against herpes zoster ophthalmicus, and is associated with lower risk of acute myocardial infarction and stroke in adults aged ≥50 years
Long-term Immunogenicity and Boostability of the 13-valent Pneumococcal Conjugate Vaccine Followed by the 23-valent Pneumococcal Polysaccharide Vaccine in Adults Receiving Immunosuppressive Therapy and Adults Living With HIV—3-year Follow-up of a Prospective Cohort Study
Clinical consequences of delaying implementation of long-acting antiretroviral therapy for people with HIV and persistent viremia in the US
Kinetics of Non-nucleoside Reverse Transcriptase Inhibitor Resistance-associated Mutations in HIV-1 Proviral Cellular Reservoirs in NNRTI-experienced Persons
Long-acting cabotegravir/rilpivirine, lenacapavir, and ibalizumab use among persons with HIV-1 viremia at a Ryan White-funded clinic in the urban U.S. South
All-Cause Mortality in People With Four-Class Drug-Resistant Human Immunodeficiency Virus: A Matched Cohort Analysis With Data From the PRESTIGIO Registry
Weekly Screening of Circulating iMucorales/i DNA and early treatment in Severely Burned Patients Improves Survival: Real-Life Bi-center Experience in France
Consequences of stopping antiretroviral treatment in a persistently seronegative individual infected with HIV-1
Incidence of and Risk Factors for SARS-CoV-2 Infection Among Vaccinated Healthcare Workers During Emergence of SARS-CoV-2 Gamma Variant in the Amazon Region, Brazil, 2021
Implementation of Diagnostic Stewardship to Improve Urinary Tract Infection Antibiotic Use Across Three Medical Centers
Sputum and tongue swab molecular testing for the in-home diagnosis of tuberculosis in unselected household contacts: a cost and cost-effectiveness analysis
Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence, Illness Recall, and Work Absenteeism Among Healthcare Workers: A Facility-Based Cross-Sectional Study in the Philippines, 2021
Safety, feasibility and rifapentine plasma concentration in Chinese children with 1 month of daily rifapentine plus isoniazid for tuberculosis infection
The Impact of Synergistic Therapy Between Colistin and Meropenem on Outcomes of Patients With Pneumonia or Bloodstream Infection Due to Carbapenem-Resistant Gram-Negative Pathogens
Oral washes and tongue swabs for Xpert MTB/RIF Ultra-based tuberculosis diagnosis in people with and without the ability to make sputum
Impact of Sonication Fluid Cultures on Prosthetic Joint Infection Diagnosis and Management: A Microbiology-Driven Evaluation Using IDSA and EBJIS Criteria
Projecting the Impact and Costs of Near Point-of-Care Tuberculosis Screening Assays in Community-based Active Case Finding
Low Trauma Fractures in People With HIV: Longitudinal Time Trends in the Swiss HIV Cohort Study, 2009–2022
Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic andiral Characteristics and Response to Dual and Extended Antiviral Therapy
Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital
Phase 2 Trial of Long-Acting Cabotegravir and VRC07-523LS for Viral Suppression in Adults with HIV-1: ACTG A5357
Improved consistency of iCandida auris/i colonization screening with an anterior nares and hands composite sample
Long-term outcomes among people with multi-drug resistant tuberculosis in Vietnam: a prospective cohort study
The hepatitis C cascade of care for opioid agonist therapy recipients in Australia
A Short, All-Oral Regimen for Pre-Extensively Drug-Resistant Tuberculosis: A Multicenter Open-label Single-arm Study
A point-of-care prediction tool for recurrent tuberculosis
Outcomes of critical illness in peoples with Advanced HIV Disease: 30 years of binational data
Bone Changes With Long-Acting Cabotegravir or Tenofovir Disoproxil Fumarate/Emtricitabine for HIV Prevention in Cisgender Men and Transgender Women: HPTN 083
A randomised trial to compare dolutegravir plus boosted darunavir versus recommended standard of care antiretroviral regimens in people with HIV-1, whose first-line non-nucleoside reverse transcriptase inhibitor therapy has failed: Final 96-week results of the D2EFT study
SARS-CoV-2 infection increases long-term risk of pneumonia in an urban population: an observational cohort study up to 46 months post-infection
Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study
Effectiveness of the Adjuvanted Recombinant Zoster Vaccine in Adults ≥50 Years in the United States
A real-time urine tenofovir assay improves drug adherence among people with HIV with prior virologic failure in a randomized controlled trial
What is the impact of anti-enterococcal empirical therapy on survival of patients with enterococcal bloodstream infections?
Patient perspectives regarding different contact precaution policies for MRSA across two hospitals: patients are in favor of contact precautions
Effect of Pitavastatin on Epigenetic Aging Biomarkers in People With HIV: Pilot Substudy of the REPRIEVE Trial
Cumulative antibiotic exposure is associated with ceftriaxone resistance among patients with urinary source Gram-negative bloodstream infection: A retrospective cohort study
Long-term protection from TB preventive treatment among people with HIV in a high-burden tuberculosis setting: an observational cohort study from India
Characteristics Associated with Disseminated Gonococcal Infections vs Uncomplicated Gonorrhea: A California Case-Control Study, 2021-2022
Incidence of AIDS-defining Conditions among Adults with Perinatally Acquired HIV after Transition to Adult HIV Care in the United States and Canada, 2000-2022
Stool processing methods for Xpert Ultra testing in childhood tuberculosis: A prospective, multi-country accuracy study
Risk of Tuberculosis Infection in Young Children Exposed to Multidrug-resistant Tuberculosis in the TB-CHAMP Multi-site Randomized Controlled Trial
Drug Resistance in People With Viremia on Dolutegravir-based Antiretroviral Therapy in Sub-Saharan Africa: The DTG RESIST Study
Carbapenem-Resistant Gram-Negative Bacilli Bacteremia in Argentina (EMBARCAR): Findings From a Prospective, Multicenter Cohort Study
Screening and Vaccination Rates for Tetanus, Hepatitis A, and Hepatitis B Among Individuals With Substance Use Disorders Hospitalized in an Integrated US Health System
Contamination of Blood Cultures Drawn From Arterial Catheters Versus Venipuncture or Venous Catheters in Critically Ill Patients: A Systematic Review and Meta-analysis
iHistoplasma/i Antigenuria Prevalence in Patients With Advanced HIV Disease in Côte d’Ivoire: A Prospective Trial Ancillary Study
Effectiveness of a Home-based Approach to Child Contact Investigation and TPT Management by Community Health Workers in Ethiopia: A Pragmatic Cluster-randomized Trial
Risk of Cancer in People With Human Immunodeficiency Virus Experiencing Varying Degrees of Immune Recovery With Sustained Virological Suppression on Antiretroviral Treatment for More Than 2 Years: An International, Multicenter, Observational Cohort
“I Didn’t Know Him Before the Pandemic… Now He's on My Speed Dial”: Strengthening Collaboration Between Infectious Diseases Physicians and State and Local Public Health for Future Public Health Emergencies
Epidemiology of Healthcare Facility-Associated Nontuberculous Mycobacteria From 2012 Through 2020 in a 10-Hospital Network in the United States
Human Immunodeficiency Virus Infection and Long COVID: A RECOVER Program, Electronic Health Record–Based Cohort Study
Modeling the Impact and Cost of a Culture-Dependent Molecular Test for Antimicrobial Resistance in Resource-Limited Settings
Treatment Outcomes With an Oral Short Course Regimen for Rifampicin-resistant Tuberculosis in a High HIV Prevalence, Programmatic Setting in South Africa
Limited Utility of HIV RNA Testing to Monitor Oral Preexposure Prophylaxis Use: A Real-World Cohort Study—United States, 2019–2023
2
Paradoxical Positivity and Community Engagement in Online Suicide Discourse
Temporal dynamics in the content of wishes after the expression of suicidal ideation on Twitter: Focusing on changes in retweet content
95
Effects of Early Versus Delayed Mechanical Thrombectomy on Outcomes in Intermediate-Risk Acute Pulmonary Embolism.
Disparities in Finding Delirium in Critically Ill Latinos.
The Influence of Older Age on RBC Transfusion Decisions in ICU Patients.
Power, Duration, and Compliance: Reframing Risk of Ventilatory-Induced Lung Injury With the Risk-Adjusted Mechanical-Power Score.
Defining the Resolution of Acute Respiratory Distress Syndrome: A Delphi Consensus Study.
An Examination of Organ Donor Hemodynamic Variation and Warm Ischemic Times Stratified by Functional Thresholds.
Effect of a Lower Vs. Higher Positive End-Expiratory Pressure Strategy on Clinically Relevant Outcomes in ICU Patients Without Acute Respiratory Distress Syndrome: Bayesian Re-analysis of the REstricted Vs. Liberal Positive End-Expiratory Pressure in Patients Without Acute Respiratory Distress Syndrome (RELAx) Randomized Clinical Trial.
Diastolic Blood Pressure During Pediatric In-Hospital Cardiac Arrest: Trends and Associations With Outcomes.
Sex-Specific Differences in Tidal Volumes and Mortality of Mechanically Ventilated Patients.
External Validation, Molecular Signatures, and Therapeutic Relevance of Pediatric Sepsis-Associated Acute Kidney Injury Subphenotypes
A Modified Delphi Consensus-Based Comprehensive Checklist and Angoff Standard for Assessment of Competency in Brain Death/Death by Neurologic Criteria Determination
Factors Associated With R01 Submission Among Pediatric Critical Care Medicine Career Development Award Recipients.
Economic and Regional Disparities in Critical Care Ultrasound Training, Equipment Access, and Implementation Barriers in China: A Nationwide Cross-Sectional Survey.
Sepsis and Subsequent Psychiatric Morbidity: A Nationwide Population-Based Matched Cohort Study, 2008-2019.
Temperature Control After In-Hospital Cardiac Arrest: Outcomes From the Discover In-Hospital Cardiac Arrest Cohort.
Temporal Trends in Outcomes After Out-of-Hospital Cardiac Arrest Transported to Critical Care Medical Centers in Japan, 2014-2022: A Nationwide Retrospective Observational Study.
Discrepancies Between Point of Care and Central Laboratory Sodium and Potassium Measurements in ICU: Analytical Biases and Physician Awareness.
Days Alive and at Home After Critical Illness Hospitalization Among Older Adults and Its Association With Delivery of In-Hospital Rehabilitation.
Exposure to Antipsychotic Medication Is Associated With Less Days Alive and Free From Catatonia in Critically Ill Patients.
Association of Hypercapnic and Nonrespiratory Acidemia With Hospital Mortality in Mechanically Ventilated Patients With Sepsis: A Retrospective Multicenter Cohort Study.
Fiberoptic Bronchoscopy Monitoring During Percutaneous Dilatational Tracheostomy: A Multicenter, Randomized, Controlled Trial. The FIBERTRACH Randomized Clinical Trial.
Association Between Systemic Anticoagulation and Outcomes in Patients With Acute Respiratory Distress Syndrome Receiving Venovenous Extracorporeal Membrane Oxygenation: Insights From a Multicenter Propensity-Weighted Study.
Location of In-Hospital Cardiac Arrest: An Updated Analysis of Epidemiology, Emergency Response, and Outcomes.
Association Between Hospital-Level Volume of Extracorporeal Membrane Oxygenation and Complications: A Clustered, Mixed-Effect Analysis of the Extracorporeal Life Support Organization Registry.
Utilization of Intensive Care Interventions in Critically Ill Patients With Candidemia Versus Bacteremia: A Multicenter Retrospective Cohort Study
Machine Learning-Based Return of Spontaneous Circulation Prediction During Cardiopulmonary Resuscitation in a Swine Model of Cardiac Arrest: Effect of Data Resolution and Multimodal Physiological Waveforms
Conversion From Venovenous to Venoarterial or Hybrid Extracorporeal Membrane Oxygenation: Analysis From the Extracorporeal Life Support Organization Registry.
Predictive and Prognostic Performance of the Phoenix Sepsis Criteria and Phoenix Sepsis Score in PICU Patients With Suspected Infection: A Multicenter Prospective Study.
Agreement Between Patient and Surrogate Assessments of Pre-Critical Illness Physical Function.
Gender Disparity in Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest.
Identifying Research Priorities in Canadian Adult and Pediatric Critical Care: Results From a James Lind Alliance Priority Setting Partnership.
Remimazolam Besylate Versus Dexmedetomidine As a Sedative in ICU Patients Undergoing Mechanical Ventilation: A Multicenter, Single-blinded, Randomized, Noninferiority Trial.
Association of Prolonged Emergency Department Length of Stay With Process of Care Measures for Critically Ill Patients.
Minimal Gain in Prognostic Certainty for Patients With Hematologic Malignancies Over 2 Weeks of Intensive Care: An Analysis to Inform Time-Limited Trials.
Recombinant Human Soluble Thrombomodulin and In-Hospital Mortality in Acute Pancreatitis With Disseminated Intravascular Coagulation: A Japanese Nationwide Study.
An Electronic Health Record-Based Classifier for Moderate-to-Severe Acute Respiratory Distress Syndrome With Persistent Hypoxemia.
Risk of Developing Lower Limb Ischemia in Patients With Extracorporeal Cardiopulmonary Resuscitation: A Secondary Analysis of the Study of Advanced Cardiac Life Support for Ventricular Fibrillation With Extracorporeal Circulation in Japan II (SAVE-J II) Study.
Platelet Transfusion Thresholds for Children Supported by Extracorporeal Membrane Oxygenation: The Extracorporeal Membrane Oxygenation Hemostatic Transfusions in Children (ECSTATIC) Feasibility Clinical Trial.
The Role of Perceived Urgency and Barriers in Using Emergency Medical Care for Sepsis: A German-Wide, Representative Survey Using Case Vignettes.
Association of Sepsis Survivor Subtypes With Long-Term Mortality and Disability After Discharge: A Retrospective Cohort Study.
Acute Kidney Injury After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest.
Acute Respiratory Distress Syndrome in Trauma 2007-2019: Comprehensive Patient and Center-Level Retrospective Cohort Analysis.
Neurological Complications During Venoarterial Extracorporeal Membrane Oxygenation and Their Implications for 6-Month Patient-Centered Outcomes.
Analysis of Mortality and Length of Stay Associated With Implementation of a Large Telecritical Care Program in an Integrated Healthcare System.
Acute Brain Injury in COVID-19 Versus Influenza A Patients on Venovenous Extracorporeal Membrane Oxygenation: A Propensity Score Matching Analysis of the Extracorporeal Life Support Organization Registry.
The Association Between Frailty, Pao2/Fio2 Ratio, and Hospital Mortality: A Retrospective Registry-Based Cohort Study.
Phenylephrine Vs. Norepinephrine on the Renin-Angiotensin-Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial.
Extracorporeal Membrane Oxygenation Complications Are Not Causal for Mortality in Patients With Infarct-Related Cardiogenic Shock: A Mediation Analysis of the Extracorporeal Life Support in Infarct-Related Cardiogenic Shock (ECLS-SHOCK) Trial.
Impact of Left Ventricular Venting on Acute Brain Injury in Patients With Cardiogenic Shock: An Extracorporeal Life Support Organization Registry Analysis.
Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial-The TARTARE-2S Trial.
RBC Transfusion Practices in Critically Ill Patients With Sepsis.
Variability in Venovenous Extracorporeal Membrane Oxygenation Candidacy Decision-Making: An International Survey.
Five Years After Extracorporeal Membrane Oxygenation: A Prospective Cohort Study of Health-Related Quality of Life and Patient Outcomes.
Hyperosmolar Dehydration in Sepsis: Implications for Initial Fluid Management.
Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study.
Digital Twins to Evaluate the Risk of Ventilator-Induced Lung Injury During Airway Pressure Release Ventilation Compared With Pressure-Controlled Ventilation.
Institutional Risk Factors Associated With Healthcare-Associated Infections in Brazilian ICUs: A Nested Cohort Within the IMPACTO-MR Platform.
Impact of Conservative Vs. Liberal Extracorporeal Oxygen Target During Venoarterial Extracorporeal Membrane Oxygenation Support for Cardiogenic Shock: A Pilot Randomized Control Trial.
Optimizing Agreement Between Bedside Nurse-Documented and Trained Researcher Delirium Assessments in the ICU.
Association Between Activation of a Rapid Response Team and Outcomes of Sepsis in General Wards: A Nationwide Observational Study Using the Japanese Intensive Care Patient Database.
Venovenous Extracorporeal Membrane Oxygenation Cannulation by Intensivists and Surgeons: A Single-Center Retrospective Noninferiority Analysis of Complications and Outcomes From 2018 to 2023.
Functional Status After Delirium in the ICU: A 1-Year Follow-Up of the Agents Intervening Against Delirium in the ICU (AID-ICU) Trial.
Enhancing Quality of Care Assessments: Managing Atypical Patients in ICU Benchmarking in The Netherlands.
Differentiating Lung From Chest Wall Mechanics Is Difficult Without Esophageal Manometry in Children With Acute Respiratory Distress Syndrome.
Effects of Preoxygenation With Intratracheal Suctioning During Extubation: An Alternating Cluster-Controlled Trial (INtratracheal suctioning and oxygenation AT Extubation [INNOVATE]).
Hyperoxia and End-Organ Complications Among Cardiogenic Shock Patients Supported by Veno-Arterial Extracorporeal Membrane Oxygenation.
An IV Sodium Bicarbonate Shortage in the Critically Ill: An Interrupted Time-Series Analysis.
Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome.
Association Between Mechanical Power During Prone Positioning and Mortality in Patients With Acute Respiratory Distress Syndrome.
Epidemiology of Substance-Related Admissions to ICUs in the United States.
Epinephrine Before Defibrillation in Children With Initially Shockable In-Hospital Cardiac Arrest.
Association Between Patients' Admission to the ICU and Psychological Disorders in Their Families: A Retrospective Matched-Pair Cohort Study.
Early Vasopressor Utilization in Critically Ill Patients With Acute Traumatic Spinal Cord Injury: A Retrospective Cohort Study.
Association of Medical Burden and Capacity Changes With Clinical Outcomes Among Patients Without COVID-19 During the Pandemic: A Multicenter Retrospective Cohort Study.
Prolonged Mechanical Ventilation Before Venovenous Extracorporeal Membrane Oxygenation and In-Hospital Mortality in Patients With Acute Respiratory Distress Syndrome
The Impact of Hospital-Level Median Door-to-Extracorporeal Cardiopulmonary Resuscitation Time on the Prognosis of Patients With Refractory Out-of-Hospital Cardiac Arrest.
Comparison of the Incidence of Arterial Pressure Line Insufficiency Between Polyethylene and Polyurethane Catheters in the ICU: A Randomized Study.
Cardiac Rhythm Conversions and the Outcome in Refractory Out-of-Hospital Cardiac Arrest: Extracorporeal Versus Conventional Resuscitation.
P0.1 is an Unreliable Measure of Effort in Support Mechanical Ventilation in Comparison With Esophageal-Derived Measures of Effort: A Comparison Study.
The Varying Impact of Frailty With Increasing Body Mass Index on Survival Up To 3 Years After ICU Admission: A Retrospective Registry-Based Study.
Association Between Driving Pressure and Subsequent Development of Acute Kidney Injury in Acute Respiratory Distress Syndrome.
Delirium Severity Trajectories in Critically Ill Adults Using the Intensive Care Delirium Screening Checklist: A Population-Based Cohort.
Effects of Sevoflurane Inhalation on Pulmonary Hemodynamics in Moderate to Severe Acute Respiratory Distress Syndrome Patients With Septic Shock: A Prospective Cohort Study.
Persistent Critical Illness Among Intensive Care Patients in India: A Registry-Embedded Cohort Study.
Pulse Oximetry and Arterial Blood Gas Oxygen Saturation Discrepancies and Mortality in Extracorporeal Cardiopulmonary Resuscitation Patients: An Extracorporeal Life Support Organization Registry Analysis.
Epidemiology of Septic Shock Associated Acute Kidney Injury: A National Retrospective Cohort Study.
Fifth Centile Versus 50th Centile Mean Blood Pressure Targets in Pediatric Septic Shock: A Randomized Controlled Trial.
Habitual Glucosamine Use and Risk of Sepsis: A 16-Year Follow-Up Study.
Lactate Values and Mortality in Patients With Cardiogenic Shock: Insights From the Altshock-2 Registry.
Early Use of a Risk-Adjusted Mechanical Ventilation Digital Quality Measure Bundle in a Large Health System.
Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy
Association Between Rewarming Rate and Survival and Neurologic Outcome of Accidental Hypothermia.
Methylprednisolone for Infant Heart Surgery: Subpopulation Analyses of a Randomized Controlled Trial.
Multicomponent Communication Intervention to Support Family Members of the Critically Ill: A Controlled Pre-Post Study.
Potassium Levels and In-Hospital Cardiac Arrest: A Matched Case-Control Study.
35
Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans
Cocaine pollution alters the movement and space use of Atlantic salmon (Salmo salar) in a large natural lake
A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice
The evidence for constrained total energy expenditure in humans and other animals
Motivation under aversive conditions is regulated by a striatopallidal pathway in primates
Oscillatory control of cortical space as a computational dimension
Re-exposure to reward re-evaluates related memories
Poly-immunity arrays associated with Rhs toxins confer wide protection against competitors
Longitudinal assessment of total daily energy expenditure in professional cyclists supports a maximal sustainable metabolic ceiling
Psilocybin induces sex- and context-specific recruitment of the stress axis
Modulation of relative aversive and safety learning by D2-expressing neurons of the anterior paraventricular nucleus of the thalamus
A small Candida glabrata protein promotes hyphal growth in C. albicans during mixed-species invasive candidiasis
Asymmetric lateral habenula function and peripheral neural mechanisms in regulating itch-evoked scratching
A common serial structure causes offline excitability changes linked to generalization between different memory types
Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior
Nonlinear integration of sensory inputs and behavioral state by a single neuron in C. elegans
Motivational control is implemented by a cingulo-prefrontal network
Paratyphoid fever and relapsing fever in 1812 Napoleon's devastated army
Ultra-endurance athletes and the metabolic ceiling
Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants
Filamentous cheater phages drive bacterial and phage populations to lower fitness
Spatiotemporal dissociation of physical salience and stimulus evaluation in the human midbrain
Neurogenesis-dependent transformation of hippocampal memory traces during systems consolidation
Monkeys adjust goals and strategies in a foraging task based on time constraints
The Arp2/3 complex maintains gut epithelial integrity under mechanical challenge
Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning
Conscious awareness determines whether a second learning session disrupts or facilitates earlier learning
Programmed seasonal brain shrinkage in the common shrew via water loss without cell death
A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior
Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates
Flexible updating of reward and punishment contingencies by VTA GABA neurons
Disentangling prediction error and value in a formal test of dopamine’s role in reinforcement learning
A history of injury enhances affective and sensory responses to predator threat by sensitizing corticosterone release through TRPA1 receptor signaling
Endogenous and exogenous attentional interplay through mixed prefrontal cortex resources
Humans have nasal respiratory fingerprints
12
BAF60C links nucleolar stress to β cell dysfunction in type 2 diabetes through controlling Reg3b mRNA decay
Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID
Reconstructing human pancreatic gene networks enhances stem cell-derived β cell induction
A non-canonical immunometabolic function of BRD3 during sepsis
Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche
Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis
Single-cell transcriptomics identifies chondrocyte differentiation dynamics in vivo and in vitro
Telocytes deliver essential Wnts directly to murine intestinal stem cells via synapse-like contacts
Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics analysis of progression from Barrett’s Esophagus to adenocarcinoma
Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila
Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma through an innate immune process
NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation
46
Ultrarapid Lispro (Lyumjev) Has an Improved Pharmacokinetic Profile for Exercise Compared With Humalog, Resulting in Less Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes on Open-Loop Continuous Subcutaneous Insulin Infusion.
Comparative Effectiveness of Tirzepatide Versus Dulaglutide or Semaglutide on Major Cardiovascular Events in Type 2 Diabetes and Cardiovascular Disease: Insights From Two Target-Trial Emulations.
Everyone or Just Some? Cost-Effectiveness of General Population Versus Targeted Screening Strategies for Type 1 Diabetes in Canada.
Investigating the Spectrum of Normoglycemia: Time in Glycemic Ranges and Their Association With Metabolic Outcomes in Individuals Without Diabetes.
Impact of Metabolic Bariatric Surgery on Weight Loss and Glycemic Control in Adults With Type 1 Diabetes: A Multicenter Retrospective Cohort Study.
Pathophysiological Risk Factors Preceding Incidence of Type 2 Diabetes Subtypes: A Pooled Cohort Study in the United States.
Gout-Related Medication Use After Initiating Sodium-Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies.
GLP-1 Receptor Agonists Are Associated With Reduced Mortality Following Diabetic Foot Ulcers: A Nationwide Observational Study.
Global, Regional, and National Estimates of Undiagnosed Diabetes in Adults: Findings From the 2025 IDF Diabetes Atlas.
Sex Hormones and Cardiovascular Risk in Type 2 Diabetes: Cohort Study of the LookAHEAD Trial.
Interlaboratory Evaluation of Multiplex Autoantibody Assay Performance in the Islet Autoantibody Standardization Program 2024 Workshop.
Medication Adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
Soluble Urokinase Plasminogen Activator Receptor (suPAR) Mediates the Impact of Diabetes on Adverse Outcomes in Coronary Artery Disease.
Empagliflozin in HNF1A-MODY (MODY3)-a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Effect of Semaglutide on Insulin Dose Reduction in Adults With Type 1 Diabetes and Obesity Using Automated Insulin Delivery Systems: ADJUST-T1D Post Hoc Analysis.
Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial.
Effect of Semaglutide on Insulin Sensitivity and Cardiometabolic Risk Factors in Adolescents With Obesity: The STEP TEENS Study.
Tirzepatide in Adults With Type 1 Diabetes: A Phase 2 Randomized Placebo-Controlled Clinical Trial.
Young-Onset Hypertension Confers Higher Risk of Cardiovascular Disease, Kidney Disease, and All-Cause Mortality in Individuals With Type 2 Diabetes: A Propensity Score-Matched Cohort Analysis.
Novel Phenotypic Clusters of Youth-Onset Type 2 Diabetes Offer No Added Prognostic Value to Simple Clinical Measures.
Inflammatory and Insulinemic Dietary Patterns and Risk of Type 2 Diabetes Among Women With a History of Gestational Diabetes Mellitus: A Prospective Study of 84,174 Person-Years of Follow-up.
Sodium-Glucose Cotransporter-2 Inhibitors, Glucagon-Like Peptide-1 Receptor Agonists, and Frailty Progression in Older Adults With Type 2 Diabetes.
Association of the Age at Type 2 Diabetes Onset With Diabetes Progression.
White Matter Hyperintensities Moderate the Association Between Diabetes and Non-AD Brain Atrophy.
Relationship Between Metabolic and Histological Responses in People With Metabolic Dysfunction-Associated Steatohepatitis With and Without Type 2 Diabetes: Participant-Level Exploratory Analysis of the SYNERGY-NASH Trial With Tirzepatide.
Effectiveness of an Incentives-Enhanced Stepped Care Intervention Program in Diabetes Prevention in a Multiethnic Asian Prediabetes Cohort: Results From the Pre-DICTED Randomized Controlled Trial.
Dementia Risk in People With Type 1 Diabetes and Associated Risk Factors: A Nationwide, Register-Based Cohort Study.
Impact of Baseline GLP-1 Receptor Agonist Use on Albuminuria Reduction and Safety With Simultaneous Initiation of Finerenone and Empagliflozin in Type 2 Diabetes and Chronic Kidney Disease (CONFIDENCE Trial).
Reimagining Acute Diabetes Care: Insights From the Victorian Virtual Emergency Department.
Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks.
Prediction of Sarcopenia Onset in Type 2 Diabetes Using Urinary Titin Levels: A Japanese Prospective Cohort Study.
Effect of Diactive-1 mHealth-Supported Progressive Resistance Training on Insulin Requirements, Glycemic Stability, and Muscular Strength in Children and Adolescents With Type 1 Diabetes: A Parallel-Group Randomized Controlled Trial.
Plasma Metabolome, Long-term Body Weight Change, and Type 2 Diabetes in U.S. Individuals.
Risk of Phimosis Associated With SGLT2i Versus GLP-1RA: A Danish Cohort Study.
Clinical and Demographic Characteristics Associated With Diabetes Remission in Six Integrated Health Care Systems: A Retrospective Cohort Study.
Effects of Semaglutide With or Without Concomitant Mineralocorticoid Receptor Antagonist Use in Participants With Type 2 Diabetes and Chronic Kidney Disease: A FLOW Trial Prespecified Secondary Analysis.
Use of the Omnipod 5 Automated Insulin Delivery System Activity Feature Reduces Insulin Delivery and Attenuates the Drop in Glycemia Associated With Exercise in a Randomized Controlled Trial.
Gradual Titration of Semaglutide Results in Better Treatment Adherence and Fewer Adverse Events: A Randomized Controlled Open-Label Pilot Study Examining a 16-Week Flexible Titration Regimen Versus Label-Recommended 8-Week Semaglutide Titration Regimen.
Effect of SGLT2 Inhibition on Glucosuria During a Hyperglycemic Clamp in HNF1A-MODY (MODY3) and Type 2 Diabetes.
A Multimodal Predictive Model for Chronic Kidney Disease and Its Association With Vascular Complications in Patients With Type 2 Diabetes: Model Development and Validation Study in South Korea and the U.K.
Impaired Rest-Activity Rhythm Characteristics Predict Higher Risk of Incident Type 2 Diabetes in UK Biobank Participants.
Glucagon-Like Peptide 1 Receptor Agonists and the Risk of Emergency Department Visits and Hospitalization in Patients With Chronic Kidney Disease.
Benefit of Semaglutide in Symptomatic Peripheral Artery Disease by Baseline Type 2 Diabetes Characteristics: Insights From STRIDE, a Randomized, Placebo-Controlled, Double-Blind Trial.
Detecting Hyperglycemia Using Biomarkers Versus Continuous Glucose Monitoring.
The Association Between Hemoglobin A1c and Complications Among Individuals With Diabetes and Severe Chronic Kidney Disease.
Capillary Ketone Level and Future Ketoacidosis Risk in Patients With Type 1 Diabetes Using Sodium-Glucose Cotransporter Inhibitors.
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An innovative ventilation system hygienizing the air in continuous mode
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Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα
Mobilization of the Environmental Toxicant Chlorpyrifos during Weight Loss and Its Impact on Liver and Adipose Tissue Metabolism in Mice
Mobilization of the environmental toxicant chlorpyrifos during weight loss and its impact on liver and adipose tissue metabolism in mice.
Associations of gestational and childhood urinary triclosan concentrations with atopic and allergic symptoms in Health Outcomes and Measures of the Environment (HOME) Study participants ages 1-12 years.
Beyond the Surface: Mapping DDE's Metabolic Footprint on Adolescent Obesity.
Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics.
Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: a Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos.
Estimation of Dermal Exposure to Volatile Organic Compounds (VOCs) from Feminine Hygiene Products: Integrating Measurement Data and Physiologically Based Toxicokinetic (PBTK) Model.
A Machine Learning-Based Clustering Analysis to Explore Bisphenol A and Phthalate Exposure from Medical Devices in Infants with Congenital Heart Defects.
Effect modification of serum omega-3 fatty acids on the associations between urinary phthalate biomarkers mixture and pregnancy outcomes among women seeking fertility care.
Perinatal exposure to lead or diethylhexyl phthalate in mice: Sex-specific effects on cardiac DNA methylation and gene expression across time.
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Prenatal Exposure to Gas Stoves, Mold, and Water Damage: Associations With Gestational Duration and Fetal Growth in the ECHO Cohort
Transcriptomics and single cell sequencing revealed the important role of PPAR signaling pathway in zebrafish liver fibrosis induced by thioacetamide
Profiling Hydrophobic Organic Pollutants in Serum from Vulnerable Populations in Dalian, China
Oxidative stress-mediated cardio- and neurotoxicity of 2-ethylhexanol in Daphnia magna
Associations of urinary and follicular fluid phthalate exposure with salpingitis in women seeking fertility treatment
Nanoplastics Exacerbated Renal Injury amid Hypertension: Rethinking Health Hazards in Disease and Implication of Renal Senescence and EMT Associated with Sirt1 Downregulation
Toxic effects of bisphenol M, a bisphenol A substitute, on early developmental stages of marine medaka (Oryzias melastigma)
Parental DEHP exposure induces sex-specific reproductive toxicity in zebrafish and behavioral deficits in unexposed offspring
Associations between classroom ventilation rates and school characteristics with indoor air in classrooms during wildfire smoke events
Dibutyl phthalate exposure-induced AhR activation drives ferroptosis and HMGB1/TLR4-mediated inflammatory liver injury via NRF2–HO-1 signaling
Occurrence and Transplacental Transfer of Benzotriazole Ultraviolet Stabilizers in Maternal-Cord Serum and Association with Birth Outcomes
Liver steatosis induced by per- and polyfluoroalkyl substances exerts a limited influence on heterocyclic aromatic amine–mediated DNA damage at population-relevant exposure levels
Bisphenol analogs affected hepatic development and disrupted lipid homeostasis in zebrafish larvae
Associations of residential environmental factors with kidney function in older adults in the Netherlands: A cross-sectional and longitudinal study
Associations of Environmental Phenols Exposure with Cognitive Function in Middle-Aged and Older Adults: A Nested Case-Control Study
Molecular and toxicological study of the plasticizers exposure-induced metabolic disorders
Urinary metabolomics reveals associations between benzophenone exposure and thyroid function in Children: A repeated-measures study
Binding Activities of Bisphenol Analogues toward TTR and TBG and Their Potential to Disrupt Thyroid Hormone Homeostasis
The Effects of Polystyrene Nanoplastic and Bisphenol A Exposure on the Thyroid Gland in Mice
Occupational exposure to phthalate esters and systemic clinical changes in municipal sanitation workers: Human Biomonitoring and Network Analysis approach
Paternal BPA and BPS exposure induce testicular dysfunction in pubertal male offspring: roles of OCTN2 carnitine transporter disruption and exacerbated oxidative stress/apoptosis
Chlorpyrifos-induced autism and depression-like behaviors are ameliorated by trehalose: Integrating network pharmacology and toxicology analyses and animal experiments
Phthalates, bisphenols, and childhood allergic Phenotypes: Findings from two birth cohort studies
Developmental and metabolic toxicity of diphenyl phosphate: insights from an integrative mechanistic framework in zebrafish embryos
Network toxicology and multi-omics analyses identify diagnostic genes and elucidate underlying mechanisms of 6PPDQ-induced hepatocellular carcinoma
Integrative Analysis of DEHP Exposure and Prostate Cancer: Mechanistic Insights and Predictive Modeling
Exposure to a persistent organic pollutant mixture resulted in sex-specific steatotic liver disease: Role of the liver-endocrine axis
Impairment of zebrafish (Danio rerio) oogenesis and F1 embryonic development by maternal methylparaben exposure: Insights from transcriptomic analysis
Nonylphenol Exposure and Cardiovascular Toxicity: Mechanistic Insights and Integrated Risk Assessment from Experimental Models
Inhibition of human organic anion transporter 4 (OAT4) activity by bisphenol analogues
Endocrine disrupting phenolic plasticizers in the Bay of Bengal coastal waters, India: Occurrence, Distribution and Environmental Risk Assessment
6-PPD quinone inhibits ammonia excretion to cause multiple aspects of toxicity in Caenorhabditis elegans by activating dual oxidase complex-SKN-1 axis
Is Reproductive Toxicity of Bisphenols an Adverse Outcome from Insulin Homeostasis Disruption in Fish?
Bisphenol exposure during pregnancy and serum total bile acid levels across trimesters: single and combined effects in pregnant women from Guangxi Zhuang, China
Investigating the role and mechanism of methionine in different types of skeletal fluorosis based on Siglec-15 methylation
Determination of phthalic acid esters and di(2-ethylhexyl) adipate in tissues from stranded dolphins in the Canary Islands
Association between prenatal phthalate exposure and preschoolers’ blood pressure: Mediating role of DNA methylation in hypertension-related genes
Psychosocial Stressors as Modifiers of the Associations Between Well-Studied and Understudied Chemicals and Birth Outcomes in the ECHO Cohort
Lipid metabolism disruption as a conserved early response to Benzophenone-1: Pathway sensitivity profiling via dose-dependent yeast functional genomics platform
Neurotoxic Effects of 4-Hydroxy-4'-Isopropoxydiphenylsulfone Exposure on Zebrafish Embryos
The Effects of Prenatal GenX (HFPO-DA) Exposure on Gut Microbiota and Metabolic Function in Pregnant Rats and Their Offspring
Unraveling the reproductive toxicity mechanisms of emerging environmental contaminants 6:2 and 8:2 diPAPs in male mice: an integrated transcriptome-metabolome investigation
Chronic DBP exposure may cause reduced fertility in female mice by interfering with the HPO axis
School backpacks and commuter bags: A non-negligible source of human exposure to phthalate monoesters
Synergistic Exposure to Endocrine-Disrupting Chemicals in Pediatric Lungs: Epidemiological Drivers and Disease-Associated Variations
Exploring the toxicological impact of 6PPDQ exposure on psoriasis through network toxicology, machine learning, and multidimensional bioinformatics analysis
The sanitation in restrooms to respiratory health: modelling concentration distribution changes of bioaerosols across buildings with/without semi-open settings
Associations of urinary biomarkers of exposure to drinking-water disinfection by-products with haematological parameters and systemic inflammation indices among women undergoing assisted reproductive technology treatment
Novel Bacteroides bacteriophage-like quantitative real-time PCR assays for human sewage pollution measurement
Responses of zebrafish to phthalate exposure and recovery: Insights into transcriptome-based molecular mechanisms
Multi-omics analysis reveals fluorinated liquid crystal monomers BDPrB/EDPrB exposure disrupts the steroid biosynthesis function via inhibition of CYP17A1
Phthalate exposure to adult mice alters non-coding RNAs in cauda epididymosomes
Mycotoxin Alternariol exposure promotes endoplasmic reticulum stress-induced hepatotoxicity to exacerbate chronic liver injury
Insights into the occurrence of ten bisphenol analogues in tidal flat and deepwater sediments in the Pearl River Basin
Integrated culture-based and metagenomic profiling of airborne and surface-deposited bacterial communities in residential environments
Micro-bioplastic impact on gut microbiome, cephalic transcription and cognitive function in the aquatic invertebrate Daphnia magna
Integrative Genetic, Single-Cell and Mechanistic Dissection Identifies Bisphenol A as a Causal Driver of Preeclampsia via Fibroblast-Derived IL-6/STAT3 Signaling
Investigating the biphasic impacts of dodecamethylcyclohexasiloxane on Caenorhabditis elegans: From reproductive and mitochondrial dysfunctions to biochemical and molecular responses
Exploring the toxicity of bisphenol A and its analogue bisphenol S-MPE to Escherichia coli K12 from integrated AutoQSAR and transcriptomics analysis
Integrated physiological, transcriptomics, and metabolite analysis reveal photosynthetic toxicity related to the bisphenol A stress response mechanism in pepper (Capsicum annuum L.)
Diversity and functional roles of viral communities in gene transfer and antibiotic resistance in aquaculture waters and microplastic biofilms
Elucidating the mechanisms of environmental pollutant BPA inducing neurotoxicity through metabolomics and network toxicology strategy
Perfluorooctane sulfonate exposure disrupts steroid hormone synthesis in rats via the gut-metabolism-testis axis
Exposome-wide association study of sex-steroid hormones in the U.S. general population: evaluation of complex mixture effects
Hyperbaric oxygen therapy attenuates carbon monoxide-induced lung injury by restoring mitochondrial dynamics and suppressing Pink1/Parkin-mediated mitophagy
Environmental levels of bis(2-ethylhexyl)-tetrabromophthalate (TBPH) cause thyroid toxicity and early carcinogenic signals in juvenile fish
Environmental exposure to endocrine disruptors induces insulin resistance and hepatic inflammation in adult male rats, with partial transmission across subsequent generations
Co-exposure to bisphenol a and arsenic enhance hepatotoxicity in zebrafish by targeting the hypothalamic–pituitary–thyroid axis and PPAR pathway
Ferroptosis-driven neurobehavioral impairment in zebrafish embryos: Mechanistic links to developmental dibutyl phthalate exposure
Effects of BPAF exposure on endometrial remodeling: A focus on the homeostasis of the extracellular matrix and the immune status
Phenol exposure, polygenic risk score, and dyslexia in Chinese children: Gene-environment interaction
Long-term exposure to environmentally relevant concentrations of hexafluoropropylene oxide dimer acid (GenX) induces trans-generational motor deficits through H3K27 demethylase jmjd-1.2 /PHF8 in Caenorhabditis elegans
LCCPs exposure induces pulmonary inflammatory injury via AIM2 mediated pulmonary macrophage PANoptosis and M1 polarization
Benzotriazole UV-stabilizer exposure in ring-billed gulls from an urban, freshwater harbour in Lake Ontario, Canada: evaluating contaminant bioaccumulation and potential health impacts
Phenanthrene Exposure Disrupts Puberty Onset in SD rats by Influencing Hypothalamic Neural Networks
Transfer of antibiotic residues from digestate-amended soil to edible crops in a circular food production system
Nano polystyrene accelerated the reproductive toxicity induced by the Tris(1,3-dichloro-2-propyl) phosphate via Nhr-69-PISD-Drp-1-mediated mitochondrial fragmentation in Caenorhabditis elegans
Prioritization of Legacy and Emerging Halogenated Organic Contaminants in Humpback Dolphins from Northern South China Sea
Detrimental impacts of chronic bisphenol A (BPA) exposure on follicular signalling modulation and ovulatory competence in zebrafish (Danio rerio)
Postnatal exposure to various benzophenones at environmentally relevant levels enhances the susceptibility of mammalian testes to cyclophosphamide-induced spermatogenic stress in adulthood
Maternal exposure to tris (2-chloroethyl) phosphate during pregnancy and suckling period alters gut microbiota and SCFAs metabolism in offspring of rats
Environmental tobacco smoke exposure in pregnant women and thyroid hormone levels in newborn cord blood: A birth cohort in China
The association between maternal exposure to ten neonicotinoid insecticides and preterm birth in Guangxi, China
Association of Urinary Pesticide Metabolites and Iodine with Thyroid Volume in School-Aged Children
Bisphenol analogues in soils and lettuce (Lactuca sativa L.) around typical factories in eastern China: Occurrence, contamination characteristics, and health risks
Associations between urinary polycyclic aromatic hydrocarbon biomarker concentrations and birth outcomes in the LIFECODES cohort
Bisphenol A drives nuclear factor-kappa B signaling activation and enhanced motility in non-transformed breast cells
Assessment of the effects of estetrol and 17α-ethinylestradiol on zebrafish (Danio rerio) metamorphosis: a morphological and transcriptomic approach
Novel insights into DBP-induced zebrafish liver inflammatory damage: Ferroptosis activating the HMGB1-TLR4-NF-κB signaling pathway
Promoting effects of lipophilic pollutants on the reproductive toxicity of proteinophilic pollutants to Daphnia magna under chronic exposure
Pentachlorophenol exposure, plasma metabolomic markers, and gestational diabetes mellitus: Association and potential mediation analyses
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Life-time levonorgestrel exposure causes intergenerational alterations of the thyroid-catecholaminergic–GABAergic functional network in zebrafish (Danio rerio)
Prenatal exposure to 33 endocrine-disrupting chemicals and pubertal development at age 9 in Spain
Prenatal exposure to persistent organic pollutants and childhood adiposity: Findings from the MIREC cohort
Exposure to organophosphate esters and trajectories of gestational weight gain: A large prospective cohort study
Climate Change and Chronic Kidney Disease: A Global Analysis Integrating the Global Burden of Disease study 2021 with TerraClimate Data
Joint effects of prenatal endocrine disrupting chemicals and heavy metal mixture on birth size and maternal complication in the Korea Children's Environmental Health Cohort Study
Bisphenol S-induced cardiac remodeling is associated with an imbalance in the renin-angiotensin system
Associations between Repeated Measures of Exposure to Phthalates, Phenols, Parabens, and their Mixtures and Metabolic Syndrome in Midlife Women in Mexico City
Di-tert-Butylphenol (2,4-DTBP) and its analogs disrupt thyroid hormone signaling via activation of retinoid X receptor α
Fetal exposure to bisphenols and phthalates and risk of respiratory conditions in infancy. The Generation R Next Study
Disposable plastic-alcohol leachates as emerging Neurotoxicants: Evidence for the mir-330-3p/Acsl1 pathway in cognitive performance
Prenatal Exposure to Tire-Derived Chemical Mixtures and Childhood Neurodevelopment at 2 years: Integrating Mixture and Single-Pollutant Models
PFOS exposure at environmentally relevant concentrations promote papillary thyroid carcinoma progression through PI3K/AKT/mTOR-mediated epithelial-mesenchymal transition
Histone H3K27 acetylation of slc25a4 mediates triclocarban-induced transgenerational developmental toxicity in zebrafish (Danio rerio) at subthreshold exposure
Placental DNA Methylation at Thyroid Hormone-related Genes Mediates the Association between Prenatal Exposure to Bisphenol Analogues and Increased Offspring Obesity Risk
Associations of prenatal exposure to organophosphate pesticides with eczema and allergic rhinoconjunctivitis in 4-year-old children: The Japan Environment and Children's Study
Prenatal PFHxS exposure alters ovarian development in female adolescent mice: Transcriptomic, hormonal, and structural evidence of disrupted steroidogenesis
Prenatal arsenic speciation and thyroid hormone levels during pregnancy and adolescence
Physical exercise mitigates the adverse effects of PM2.5 constituents on lung function: New evidence for inflammatory pathways from a crossover study
Associations of maternal exposure to nonylphenol and bisphenols with precocious puberty in girls: A nested case-control study
Association between flood exposure and chronic kidney disease: A nationwide cross-sectional study in China
Prenatal exposure to persistent organic pollutants and sex-specific neonatal outcomes in the ENVIRONAGE birth cohort
Association of nitrogen dioxide with non-alcoholic fatty liver disease in Chinese rural older adults: The mediating role of fasting plasma glucose
Hormonal changes in professional printers exposed to phthalates suggesting potential disturbances of the hypothalamic–pituitary–gonadal axis
Enhancing butyrate production from food waste fermentation: an overlooked role of fungal yeast
Association of phthalate and substitute exposure with gestational liver function: A longitudinal cohort study
Prenatal organophosphate esters exposure impacts placental structure and inflammatory markers in a trimester-specific manner
Bisphenol A triggers adipocyte dysfunction, thereby fostering triple-negative breast cancer aggressiveness
Seasonal testicular morphometry of European brown bears in relation to pollutants
High-throughput screening of estrogen receptor activity for personalized mixtures of persistent organic pollutants detected in blood of Swedish adults.
Acute effects of temperature fluctuations on skin health: A randomized, crossover trial
A comprehensive assessment of contaminant exposure in an endangered tern population
Breast milk bisphenol concentrations in Canada and South Africa and associations with body size among South African infants
Associations of Urinary Environmental phenols with Obesity and Lipid Metabolism in Children and Adolescents: The Expanded Chinese National Human Biomonitoring (CNHBM) Project
Chemical exposure in childhood: A study on organophosphate flame retardants and plasticizers in a Flemish birth cohort
Developmental PBDE exposure persistently impairs mast cell function in vivo and drives sex-specific morphological and transcriptional changes in bone marrow–derived mast cells
Associations between emerging endocrine-disrupting chemicals and thyroid hormone homeostasis in pregnant women
Exposure to triclosan and triclocarban are associated with estrogen metabolism in Chinese pregnant women
Adipose tissue deposition and placental transfer of persistent organic pollutants in ewes
Compact and cost-effective autofluorescence sensor for real-time environmental biofilm monitoring
Responses of marine pathogen Vibrio parahaemolyticus to 6:2 and 8:2 polyfluoroalkyl phosphate diesters at environmentally relevant concentrations: Concentration-dependent but not fluorocarbon chain length-dependent
Elucidation of Xenobiotics in Textiles for Infants Using Non-Targeted Approaches: The Role of Fabrics as a Source of Early-life Exposure to Potentially Harmful Chemicals.
Using eye tracking to evaluate cognitive and visual outcomes of early life phenol exposure
Parabens, bisphenols, and other environmental phenols exposure from cosmetics use in Korean adolescent girls: Findings from a 2-day intervention study
Unraveling the environmental links to feline hyperthyroidism: Insights from silicone passive samplers
Occupational and environmental livestock exposures are associated with alterations in the upper respiratory tract microbiome
Acute exposure to environmental doses of di-n-butyl phthalate but not di-2-ethylhexyl phthalate induces mortality in isolated and cold-stressed workers of Bombus terrestris L. (Hymenoptera: Apidae)
Organophosphate Flame Retardants Disrupt Neurodevelopmental Gene Networks with Autism-Relevant Features: A Multi-Omics Study in Rats
Impact of summer heat on male children's physiological responses during football training
Adolescent exposure to benzophenone ultraviolet filters: cross-sectional associations with obesity, cardiometabolic biomarkers, and asthma/allergy in six European biomonitoring studies
Occurrence, Maternal Transfer, and Risk Implications of Parabens in Humpback Dolphins from the South China Sea
Influence of urinary creatinine concentration and specific gravity correction in exposure assessment: Comparison between chronic kidney disease patients and general population
Associations Between Chronic Exposure to Bisphenols and Parabens and Gut Microbiota in Children
Association of urinary phthalate metabolite concentrations with inflammatory biomarker levels among pregnant women
Dysregulation of gut barrier and microbiota in Asiatic hard clams (Meretrix petechialis) exposed to environmentally relevant bisphenol A
Impact of human lifestyle on the pathogenic potential of urban wastewater
AO168=O at environmentally relevant concentrations induces reproductive toxicity by causing germline apoptosis and cell cycle arrest in Caenorhabditis elegans
2,4,6-Tri-tert-butylphenol Promoted Adipogenesis in 3T3-L1 Cells through a Retinoid X Receptor α-Dependent Mechanism
Longitudinal associations and interactions of heat and metal(loid) exposure with kidney outcomes in Mexican agricultural workers
Elevated exposure to phthalates and non-phthalate plasticizers among urban and rural Egyptian children: Biomonitoring and health risk assessment
Assessment of human parabens exposure and health risk based on global biomonitoring data
Changes of urinary bisphenol A and alternatives in Korea 2015–2020 and environmental disparities by socioeconomic status
Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study
Impact of the environmental endocrine disruptor 4-octylphenol on reproductive function in pubertal male mice
Exposure to Bisphenol S promotes renal damage via aryl hydrocarbon receptor and NF-κB pathways in a mice model of obesity
Urinary parabens, advanced glycation end products and blood pressure in children: a longitudinal cohort study
Response of life-history traits, population dynamics, offspring size of Brachionus plicatilis exposure to BTBPE
Joint effects of environmental and neighborhood socioeconomic factors on cognitive function in the Heinz Nixdorf Recall Study
Early life phthalate exposure impacts gray matter and white matter volume in infants and young children
Effects of phthalate exposure on human ovarian extracellular matrix composition: insights from a 3D spheroid model
17β-Trenbolone modulates anxiety-related synaptic plasticity by affecting the interaction between hippocampal TACR3 and systemic testosterone in male mice
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Systematic Revelation of the Metabolic Fate of Typical Quaternary Ammonium Compounds in Wheat Seedlings
miR-184/hamp-Mediated Cardiotoxicity and Hepatotoxicity in Offspring Zebrafish Following Paternal Exposure to Environmentally Relevant Concentrations of Tris(1,3-dichloro-2-propyl) Phosphate
Phage-Encoded Metabolic Bypass Drives Herbicide Resistance in Soil Microbiomes
Maternal Exposure to Bisphenol A Bis(diphenyl Phosphate) Induces Offspring Colitis through Disrupting the Gut Microbiome-Metabolite Axis
Gut Microbiota Mediates HFPO–DA-Induced Hepatotoxicity via Arginine Reprogramming in Lean NAFLD Mice
From Field Metagenomes to Mutant Genomes: Coevolution of Cyanophages and Synechococcus in Estuarine Ecosystems
Synthetic Fiber Sanitary Napkins: Nonnegligible Exposure Source of Organophosphate Esters in Women
Insights into the Arms Race between Prokaryotic Hosts and Their Viruses in Mangrove Ecosystem
Gestational Exposure to Tri-n-butyl Phosphate Induces Maternal Insulin Resistance and Glucose Intolerance by Antagonizing Estrogen Receptor Alpha
Prenatal Exposure to Mixtures of Nonpersistent Endocrine-Disrupting Chemicals and Angiogenic Biomarkers, Placental Function, and Fetal Growth
Is There an Optimal Wavelength for Germicidal Ultraviolet Air Disinfection?
Methylparaben Induces Gut Microbiota–Dependent Neurotoxicity in Zebrafish
AIE Gemini Surfactant-Enabled Janus Membrane for All-In-One “Sampling–Detection–Elimination” of Airborne Pathogens
Temporal (2012–2021), Age, and Sex Trends in Exposure to Bisphenols, Antimicrobials, and Parabens in the Australian General Population
Integrated Network Toxicology and Multiomics Analyses Reveal the Potential Hepatocarcinogenic Effect of BDE 47 and Its Underlying Mechanism
Prenatal Exposure to Primary Aromatic Amines: Structure-Dependent Transplacental Transfer Mechanism and Toxicity
Beyond Nephrotoxicity: Maternal–Fetal Transfer of Melamine and Potential Disruption of Placental Steroid Hormones
Exposure Profile and Combined Effects of Human PPARγ Agonists in Residential Indoor Dust from China
Exposure to Quaternary Ammonium Compounds (QACs) in Assisted Living Facilities: Implications for Older Adults
Chemical-Class Submixture Screening Reveals Drivers of Endocrine Disruption in Personalized Human Blood POP Mixtures
Approaching a 0% False Positive Rate for PFAS Determination Leveraging Only MS1 Data
6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate (6:2 Cl-PFAES), a PFOS Alternative, Impairs Testosterone Synthesis in Leydig Cells by Targeting Lipophagy via the SIRT1–FOXO1–RAB7 Axis: An In Vitro and In Vivo Study
Deglycosylation Enhances the Toxicity of Plant-Derived Glycosyl Bisphenol A during Gastrointestinal Digestion
Kidney Urate Underexcretion Mediates the Relationship between Per- and Polyfluoroalkyl Substances and their Alternatives and Uric Acid Levels: Evidence from a Case–Control Study and an Animal Study
Elemental Exposure and Attention-Deficit Hyperactivity Disorder Risk in Population Aged 6–16 Years: Associations and Potential Mediation by Oxylipins
Far-UVC (222 nm) Suppresses Bacterial UV Resistance and Repair through Inhibition of DNA Repair Pathways
Elevated Exposure to Pharmaceutical and Personal Care Products Increases Hyperlipidemia Risk: The Mediating Effect of Thyroid Hormones
Combining Suspect Screening with Large Language Model-Based Text Mining to Comprehensively Characterize Organic Compounds in Human Milk Associated with Pregnancy Complications
Transport and Survival of Marine Tracer Phages in Topsoil at Field Conditions
In-Depth Investigation into the Neurotoxic and Neuroglioma Risks of 6PPD Exposure in Zebrafish Larvae: Benchmark Dose Analysis, Molecular Mechanisms, and Adult Pathological Effects
Disruption of the Reproductive–Metabolic–Aging Signaling Cascade by Organophosphate Esters: Comparative Toxicity of Tris(1,3-dichloro-2-propyl) phosphate and Bis(1,3-dichloro-2-propyl) phosphate in Caenorhabditis elegans
Unraveling the Mechanisms of Osteoporosis Triggered by Methylparaben and Monomethyl Phthalate through Integrated Mendelian Randomization, In Silico Simulations, and Experimental Validation
Experimental Tracing and Modeling of Exogenous Microbe Dynamics in Home Environments
Phthalates and Alternative Plasticizers in Duplicated Diet Samples from Korea
Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Maternal Thyroid Function during Pregnancy in a Cohort with High Familial Likelihood of Autism Spectrum Disorder
Tetrabromobisphenol S (TBBPS) Causes Non-Negligible and Multigenerational Reproductive Toxicity in Zebrafish
Food-Associated Phthalate Exposure and Health Risk: Insights from Urinary Biomonitoring and Dose–Response Modeling
Exposure to a GenX Homologue Results in Sexually Dimorphic Bile Acid Metabolism Disorders Mediated by Hepatic PPARα in Mice
Interfacial Stabilization of Cu(I) in Ultralow-Dose Cu2O/ZIF-8 Heterojunctions Enabling Rapid and Energy-Efficient Genomic Disruption of Pathogens
Bisphenol A Disrupts Spermatogenesis via Excessive Mitophagy-Driven Ferroptosis
Assessment of Population Relevance of Endocrine-sensitive Apical Endpoints in Fish Chronic Studies Using Individual-Based Models
Revealing Ferroptosis Induction by Bisphenol A and Bisphenol S through Distinct Protein Targets
Translocation and Tissue Distribution of Bisphenol AF and Its Transformation Products in Pumpkin Seedlings
Human Internal Exposures of Bisphenol A and Six Data-Poor Analogs Predicted by Physiologically Based Kinetic Models with Multimodal Parametrization
Chain Length-Dependent Inhibition of Human and Rat Placental Aromatase by Benzalkonium Disinfectants: Experimental, Quantitative Structure–Activity Relationship, and In Silico Docking Insights
Toxic Switch and Key Effectors of Cu in Zebrafish Gills: Coupling Single-Cell RNA Sequencing and Redox Imaging
The Susceptibility of Airborne SARS-CoV-2 to Far-UVC Irradiation
Placentation Disruption by Perfluorooctanoic Acid and Perfluorooctanesulfonate in Human Trophoblast Organoids
Hepatotoxicity of 8:2 Polyfluoroalkyl Phosphate Diesters Exposure via JAK2/STAT3 Pathway Activation and M1 Macrophage Polarization in Mice
PBDE Flame Retardant Exposure Causes Neurobehavioral and Transcriptional Effects in First-Generation but Not Second-Generation Offspring Fish
Phthalate and Nonphthalate Plasticizer Exposure among Children of Korea, Thailand, Indonesia, and Bangladesh: Occurrences and Risk Comparison
Early Life PBDE Flame Retardant Exposures Cause Neurobehavioral Alterations in Fish That Persist into Adulthood and Vary by Sex and Route of Exposure
Quantitative Toxicokinetic Investigation of Emerging Aryl Organophosphate Esters in Rats
An iIn Vivo/i Fluorescence Image Analysis Tool for Esterase Activity Quantification in iDaphnia/i: Using Calcein AM in Ecotoxicological Studies
Identifying Metabolic Signatures of Bisphenol Analog Exposure: Implication for Rapid Toxicity Screening of New Alternatives
Reactivity of Viral Proteins with Free Chlorine: Structural Insights and Implications for Virus Inactivation
Beyond Estrogenicity: A Comparative Assessment of Bisphenol A and Its Alternatives in In Vitro Assays Questions Safety of Replacements
The Impact of UVC Light on Indoor Air Chemistry: A Modeling Study
Risk of Neurodevelopmental Disorders in Preschool Children Associated with the Longitudinal Trajectory of Phthalates during Pregnancy: Potential Mechanisms Based on Metabonomics of Cord Blood
Wavelength-Specific Biofilm Control from Internally UV-Emitting Glass Surfaces
Tetrabromobisphenol A Induces Neurotoxicity in Adult Zebrafish: Insights from the Gut Microbiota-Bile Acid-Brain Axis
Disrupted Cholesterol Homeostasis as a Mechanism of Pharmaceutical-Induced Neurodevelopmental Toxicity: A Transgenic Zebrafish Screening Model for abcg1
Neonatal Exposure to Phthalate and Alternative Plasticizers via Enteral Nutrition
Unraveling the Link between Air Pollution and Psoriasis Subtypes: Genetic Architecture of Epigenetic Insights and Mediating Cytokines
High-Throughput Screening Identifies Bisphenol P as a Potent Cardiotoxin, Inducing Cardiotoxicity through Apoptosis and the NF-κB Pathway
Machine Learning-Based Screening of Cosmetic Ingredients Identifies Vat Blue 6 as a Thyroid Hormone Receptor β Disruptor
Molecular Mechanisms of Premature Hippocampal and Hypothalamic Senescence Induced by Maternal Exposure to DBP in Male Offspring Mice
Life-Cycle Benzo[a]pyrene Exposure Induces Sex-Specific Reproductive Impairment, Feminization, and Transgenerational Disruption in Marine Medaka (Oryzias melastigma)
Benzotriazoles and Benzothiazoles, Maternal and Neonatal Thyroid Hormones, and Childhood Growth: A Longitudinal Cohort Study
Exposures to Contemporary and Emerging Chemicals among Children Aged 2 to 4 Years in the United States Environmental Influences on the Child Health Outcome (ECHO) Cohort
Multiphase OH Oxidation of Bisphenols: Chemical Transformation and Persistence in the Environment
Typical Thermochromic Dye Crystal Violet Lactone Acts as an Endocrine Disruptor: Nontargeted Screening, Prioritization, and In Vivo Experimental Verification
Unveiling Hidden Health Risks: Machine Learning Enhanced Modeling of Plastic Additive Release Kinetics in Fresh Produce Packaging
Similar Prophage Induction but Divergent Antibiotic Resistance Gene Occurrence: Leachates and Free Radicals Drive Differential Activation Mechanisms in Aged Tire Crumb Rubber
Occurrence and Emission Evaluation of Oxypurinol and Metformin from Effluent in WWTPs across Australia
Gestation Exposure to Organophosphate Esters: Structure-Dependent Transplacental Transfer Patterns, Mechanisms, and Toxicity
Microbial Dysbiosis in the Lung and Gut in Response to Inhalable Particulate Matters in Pneumoconiosis Patients and Animals
Renal Dysfunction Induced by Sodium p-Perfluorous Nonenoxybenzenesulfonate in Mice: Insights from the Intrinsic Mechanisms of Proteinuria
Screening and Evaluation of Male Reproductive Effects of Isothiazolinones at Human-Relevant Levels in Mammals: Direct Impairments and Increased Susceptibility to Subsequent Spermatogenic Stress
Aryl Organophosphate Esters and Hemostatic Disruption: Identifying Risk through Machine Learning and Experimental Validation
Enhanced Phytopathogen Biofilm Control in the Soybean Phyllosphere by the Phoresy of Bacteriophages Hitchhiking on Biocontrol Bacteria
Combined Analysis of Network Toxicology and Multiomics Revealed the Potential Mechanism of 6PPDQ-Induced Hepatotoxicity in Mice
Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A
6PPD and 6PPD Quinone Induce Endometrial Cell Dysfunction via Activating ERα and GPER at Human-Relevant Levels
Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights
Trends of Organophosphate Ester Flame Retardant Metabolites in Age- and Sex-Stratified Pooled Australian Urine Samples from the Past Decade (2012–2023)
Nontargeted Urinary Profiling Strategy for Endocrine-Disrupting Chemicals in Women with Ovarian Malignancies
25
Volume vs intensity of physical activity and risk of cardiovascular and non-cardiovascular chronic diseases
Silent plaque ruptures in non-obstructive lesions of non–infarct-related arteries: a multimodality, serial intracoronary imaging study
Exercise blood pressure relative to fitness and cardiovascular outcomes: the EXERTION study
Cardiovascular adaptation to training load in endurance athletes: a longitudinal study
C-reactive protein and cardiovascular risk in the general population
Frailty and long-term outcomes in younger patients with acute myocardial infarction
Optical coherence tomography-guided stent optimization for complex coronary lesions: the OCCUPI trial
LDL-cholesterol in newborns and children with genetically verified familial hypercholesterolaemia: implications for cholesterol-based screening
Urinary tract infection and continuation of sodium-glucose cotransporter-2 inhibitors in diabetic patients
Fractional flow reserve-guided renal artery stenting in atherosclerotic renovascular hypertension: the FAIR randomized trial
Artificial intelligence-enabled electrocardiography and echocardiography to track preclinical progression of transthyretin amyloid cardiomyopathy
Transient anticholinergic burden and out-of-hospital cardiac arrest: a case-crossover study
Artificial intelligence-based identification of thin-cap fibroatheromas and clinical outcomes: the PECTUS-AI study
Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study
Mitral valve replacement or repair and long-term risk of infective endocarditis: a Danish nationwide study
Infected native aortic aneurysms: epidemiology, management, and outcomes based on a nationwide population-based study
Transthyretin amyloid cardiomyopathy: natural history and treatment response assessed by cardiovascular magnetic resonance
Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool
Ischaemic conditioning: a renaissance with wider perspectives?
Optical coherence tomography- vs angiography-guided coronary stent implantation in calcified lesions: the ILUMIEN IV trial
Predicting imminent ventricular arrhythmias from ambulatory ECG signals: far-reaching or too far to reach?
Acute pulmonary embolism: a multimarker calculator to predict short-term outcomes
Coronary artery bypass grafting with or without preoperative physiological stenosis assessment: a SWEDEHEART study
Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study
Live zoster vaccination and cardiovascular outcomes: a nationwide, South Korean study
5
RESECT: A Randomised Controlled Trial of Audit and Feedback in Non–muscle-invasive Bladder Cancer Surgery
Association of Polygenic Risk Scores for Depression, Anxiety, and Neuroticism with Lower Urinary Tract Symptoms Among Women
Irreversible Electroporation for Prostate Tissue Ablation in Patients with Intermediate-risk Prostate Cancer: Results from the PRESERVE Trial
Duration of Androgen Suppression with Postoperative Radiotherapy (DADSPORT) for Nonmetastatic Prostate Cancer: A Collaborative Systematic Review and Meta-analysis of Aggregate Data
Flexible Ureteroscopy with a Flexible and Navigable Suction Ureteral Access Sheath Versus Mini-Percutaneous Nephrolithotomy for Treatment of 2–3 cm Renal Stones: An International, Multicenter, Randomized, Noninferiority Trial
30
A Prospective Study of Gluten Transfer Through Kissing in Celiac-Discordant Couples
Genetic Risk of Inflammatory Bowel Disease Is Associated With Disease Course Severity
ENPP1-Regulated Extracellular Purine Metabolism Drives Pancreatitis-Mediated Pancreatic Cancer
A Randomized Double-Blind, Placebo-Controlled Dose–Response Study to Assess the Gluten Threshold Dose in Celiac Disease
Intestinal Ultrasound Scan in Acute Severe Ulcerative Colitis in Children: A Multicenter Prospective Study on Behalf of the Porto Inflammatory Bowel Disease Working Group of European Society for Paediatric Gastroenterology Hepatology and Nutrition
Ganglioside-Mediated Neural-Acinar Crosstalk Facilitates Pancreatic Carcinogenesis via Metaplastic Niche Remodeling
Darvadstrocel in Patients With Crohn’s Disease With Complex Perianal Fistulas: The ADMIRE CD II Phase 3 Randomized Trial
Revealing the Antagonistic Interactions of Faecalibacterium prausnitzii and Bacteroides fragilis in Colorectal Cancer
Targeting APE1-Redox Function Reverses SOX9-mediated Chemoresistance in Esophageal Adenocarcinoma
From Gut Feeling to Gray Matter: Mapping Defecation Urgency in Irritable Bowel Syndrome
The MetALD-ALD Prediction Index: A Phosphatidylethanol-Driven Biomarker Panel for Identifying Individuals With Steatotic Liver Disease and Excessive Alcohol Use
The Gut Microbiome at the Onset of Inflammatory Bowel Disease: A Systematic Review and Unified Bioinformatic Synthesis
Prognostic Performance of Phosphatidylethanol With Noninvasive Liver Fibrosis Tests in Alcohol-Related Liver Disease
Clusterin Drives Fiber Endocytosis by Mesothelial Cells to Resolve Liver Fibrosis
Postoperative Ileum Transcriptomics Implicate Sex-Biased Mechanisms in Crohn’s Disease Recurrence
The ANTICIPATE-NASH Models Stratify Better the Risk of Clinical Events Than Histology in Metabolic Dysfunction-Associated Steatotic Liver Disease Patients With Advanced Chronic Liver Disease
Intestinal LKB1 Loss Drives a Premalignant Program Along the Serrated Cancer Pathway
The Prevalence and Burden of Avoidant/Restrictive Food Intake Disorder (ARFID) Symptoms in Adults with Disorders of Gut-Brain Interaction: A Population-Based Study
Implications of shame for patient reported outcomes in Bowel Disorders of Gut-Brain Interaction
Histologic response is associated with improved esophageal distensibility and symptom burden in pediatric eosinophilic esophagitis
Low FODMAP diet improves colonic barrier function and mast cell activation in patients with IBS-D: A mechanistic trial
Enhancement of Inpatient Mortality Prognostication with Machine Learning in a Prospective Global Cohort of Patients with Cirrhosis with External Validation
Early infliximab levels and clearance predict outcomes after infliximab rescue in acute severe ulcerative colitis: Results from PREDICT-UC
The natural history of gastroesophageal varices in children with portal hypertension
Peyer’s patch B cells sample transglutaminase-gluten complexes and drive celiac disease autoimmunity
Total Pancreatectomy and Islet Auto Transplant for Chronic Pancreatitis
Blood-based T Cell Diagnosis of Celiac Disease
Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition.
Associations of alcohol consumption and genetic predisposition to hepatic steatosis with liver-related events: results from large population-based cohort studies
Inadequate Propulsion and Pelvic Floor Relaxation in Dyssynergic Defecation: Insights from Synchronous Proctomanometry
1
PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons in C. elegans
5
The oligogenic inheritance test GCOD detects risk genes and their interactions in congenital heart defects
Analyzing the large and complex SFARI autism cohort data using the Genotypes and Phenotypes in Families (GPF) platform
Lambdoid phages with abundant Chi recombination hotspots reflect diverse viral strategies for recombination-dependent growth
Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise
An iPSC-based model of 47,XYY Jacobs syndrome reveals a DNA methylation-independent transcriptional dysregulation shared with male X aneuploid cells
65
Metagenomic identification of gut microbiome signatures for accurate diagnosis and prognostic prediction of Epstein-Barr virus-associated nasopharyngeal carcinoma
Targeting PKM2-dependent glycolysis reprogrammes monocytes into Cadm1+ macrophages to promote mucosal repair and attenuate colitis progression
Tryptophan depletion generates hyper-reactive portal neutrophils in alcoholic liver disease
ifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8+ T cells
Commonly prescribed drugs as risk factors for Clostridioides difficile infections: a Swedish population-based case–control study
Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study
Token-guided multimodal prognosis in hepatocellular carcinoma: a framework steered by tumour–stroma ratio
Novel insights into autoimmune gastritis: clinical profile and gastric neoplastic risk from an international multicentre study
Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers
Endothelial RAP1A attenuates sinusoidal capillarisation and liver fibrosis by inhibiting RAF1-mediated Notch activation
Low-frequency repetitive transcranial magnetic stimulation attenuates visceral pain in IBS with diarrhoea via inhibition of the medial prefrontal cortex
Post-infection disorders of gut-brain interaction: results of the Rome Foundation Global Epidemiology Study
Two-step clinical care pathway to predict MASLD-related advanced fibrosis and long-term outcomes in type 2 diabetes
Steatosis grade and cardiometabolic burden as determinants of hepatocellular carcinoma risk after hepatitis C cure in patients with metabolic dysfunction-associated steatotic liver disease
Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study
Targeting ADAR1-mediated RNA editing inhibits hepatic stellate cell activation and liver fibrosis by enhancing HSC-intrinsic innate immunity
Oncological impact of universal endoscopic submucosal dissection for large Barrett’s cancers
Zinc-dependent RNA-binding protein controls hepatocyte senescence and recovery from alcohol-related liver failure
<atl>Novel imyo/i -inositol to butyrate fermentation pathway in the prevalent human gut species iDysosmobacter welbionis,/i a bacterium associated with improved metabolic and liver health</atl>
Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility
Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity
<atl>Pueraria lobata-derived exosome-like nanovesicles alleviate rheumatoid arthritis via targeting iRuminococcus gnavus/i phenylethylamine production</atl>
TL1A-activated T cells remodel the rectal mucosa in patients with Crohn’s disease with perianal fistulising disease
Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis
Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women
Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials
Spatial transcriptomics defines the molecular progression, invasion and immune landscape of IPMN and IPMN-derived pancreatic cancer
Autophagy of Kupffer cells modulates CD8+ T cell activation in primary biliary cholangitis
Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection
Gut microbe alleviates stress-related cancer metastasis by oleic acid degradation
Gut microbiota predict development of postdischarge diabetes mellitus in acute pancreatitis
FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis
Acute upper gastrointestinal bleeding in the UK: 2022 audit update
Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis
A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis
Global prevalence of self-reported non-coeliac gluten and wheat sensitivity: a systematic review and meta-analysis
First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia
Long-term prognosis of lean MASLD: evidence from three population-based prospective cohorts
Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data
Single-cell analysis identifies RETNsup+/sup monocyte-derived Resistin as a therapeutic target in hepatitis B virus-related acute-on-chronic liver failure
Endoscopic or surgical gastroenterostomy for malignant gastric outlet obstruction: a randomised trial
Holdemanella biformis augments washed microbiota transplantation for the treatment of radiation enteritis
Outcome of a FODMAP restriction diet with subsequent blinded reintroduction in functional dyspepsia/postprandial distress syndrome
Single-cell multimodal analysis reveals the dynamic immunopathogenesis of HBV-ACLF progression
ISG15 deficiency in hepatic stellate cells promotes TGFβ2-induced liver fibrosis by counteracting CREB1 ISGylation
Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes
Global prevalence and gastrointestinal symptom burden of individuals with a history of cholecystectomy
Mucosal transcriptomic landscape along the small and large intestines in individuals with and without type 2 diabetes
Thrombospondin-2 is a performant biomarker of at-risk MASH and advanced MASH fibrosis in a large multicentre European cohort
Performance of the China-CLIF framework in acute-on-chronic liver failure: a multicohort study across all aetiologies
Mitochondrial dysfunction drives basal cell hyperplasia in eosinophilic oesophagitis
Insulin-like peptide 5 is released in response to bile acid in the rectum and is associated with diarrhoea severity in patients with bile acid diarrhoea
Crohn’s disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset
Lifestyle factors, genetic susceptibility and risk of incident diverticulitis: an integrated analysis of four prospective cohort studies and electronic health records-linked biobank
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor
Results of endoscopic intermuscular dissection for deep submucosal invasive rectal cancer: a three-year follow-up study
Rice-derived recombinant human serum albumin as an alternative to human plasma for patients with decompensated liver cirrhosis: a randomised, double-blind, positive-controlled and non-inferiority trial
Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease
CagA-dependent Hobit+ gastric tissue-resident memory T cells confer full protection from Helicobacter pylori reinfection
Toxic microbiome and progression of chronic kidney disease: insights from a longitudinal CKD-Microbiome Study
Prophylactic clip closure after endoscopic submucosal dissection of large flat and sessile colorectal polyps: a multicentre randomised controlled trial (EPOC trial)
Commensal Bacteroides T6SS alleviate GI-aGVHD via mediating gut microbiota composition and bile acids metabolism
Cold snare endoscopic resection for large colon polyps: a randomised trial
Prevention of rebleeding after primary haemostasis using haemostatic powder in non-variceal upper gastrointestinal bleeding: a multicentre randomised controlled trial
Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD
47
Toxic lipid-induced epigenetic activation of ICAM1 in liver sinusoidal endothelium regulates myeloid-driven fibro-inflammatory response in MASH.
OCE-205, a selective V1a receptor mixed agonist-antagonist, for the treatment of hepatorenal syndrome-acute kidney injury: A phase 2 randomized trial.
Therapeutic plasma exchange improves short-term survival in patients with acute-on-chronic liver failure: A randomized controlled trial.
Forkhead box protein M1 network induction and crosstalk drives the development of alcohol-associated liver disease.
Prospective head-to-head comparison of routine non-invasive scores for predicting severe cirrhosis-related morbidity in the general population.
ECM1 produced by hepatic stellate cells serves as a gatekeeper of liver homeostasis in hepatic fibrosis.
Liver transcriptome sequencing contributes to the molecular diagnosis of genetic liver diseases.
Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeostasis and membrane integrity in acetaminophen-induced liver injury.
Original research: Amplification of genetic and metabolic factors in alpha-1 antitrypsin deficiency.
Real-world impact of AUD pharmacotherapy on healthcare utilization, cost, and cost-effectiveness in the United States.
Understanding hepatopancreatobiliary cancer risks in a population-based primary sclerosing cholangitis-inflammatory bowel disease cohort.
Head-to-head comparison between vibration-controlled transient elastography and histology in predicting liver-related events due to metabolic dysfunction-associated steatotic liver disease.
Myeloid CD36 deficiency alleviates hepatic fibrosis by promoting adaptive immunity of macrophage.
CXCR6 defines a distinct resident state in γδ T cells for protecting from liver cirrhosis.
Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity.
HBV induces liver fibrosis through the generation of reactive oxygen species in a pyruvate-dependent manner.
Predictors of fibrosis, clinical events and mortality in MASLD: Data from the Global-MASLD study.
Development and validation of a non-invasive score for at-risk metabolic dysfunction-associated steatohepatitis in individuals with obesity undergoing bariatric surgery.
Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus Immunotherapy and targeted therapy in HCC.
Semaglutide therapy for metabolic dysfunction-associated steatohepatitis: November 2025 updates to AASLD Practice Guidance.
Epigenetic repression of hepatocyte FoxO1 disrupts local immune homeostasis and promotes liver inflammation.
KLF9 drives intermittent hypoxia-induced NAFLD by suppressing the NR4A1-p38 MAPK hepatic metabolic axis.
Endothelial-to-mesenchymal transition: A targetable mechanism that contributes to portal vein thrombosis in cirrhosis.
Serum bile acid levels predict the development of portal hypertension and high-risk esophageal varices following successful Kasai in biliary atresia.
Sex and body size disparities under MELD 3.0: Evaluation of persisting gaps in liver transplant access.
Global performance of non-invasive tests in MASLD: Insights from the G-MASLD study.
Hepatocyte-derived extracellular vesicles promote endothelial dedifferentiation in chronic liver disease through the miR-153-3p - pyroptosis axis.
Association between longitudinal weight change and clinical outcome in individuals with MASLD.
Point-of-care ultrasound (POCUS)-guided volume management and the effect of cirrhotic cardiomyopathy on acute kidney injury outcomes in cirrhosis.
Natural history and development of a novel composite endpoint in patients with alcohol-associated Hepatitis: Data from a prospective multicenter study.
Early on-treatment LSM reliably predicts liver-related events in CHB patients with significant fibrosis and cirrhosis.
Use of liver stiffness measurement for hepatocellular carcinoma risk stratification in metabolic dysfunction associated steatotic liver disease.
Pilot trials of oral betaine in participants with non-alcoholic fatty liver disease and elevated alanine aminotransferase.
Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study.
Salivary microbiome and serum metabolomics add to clinical biomarkers to predict 6-month hospitalizations in a multi-center cirrhosis outpatient cohort.
Biliary YB-1/GLI2 axis facilitates ductular reaction and promotes hepatic stellate cell activation via SPP1/Integrin αvβ1 signaling during liver fibrogenesis.
Prognostic significance of mild ascites in patients with cirrhosis.
Antibody response to microbiota antigens is associated with alcohol-related liver disease severity and predicts mortality.
Distinct gut microbiota but common metabolomic signatures between viral and MASLD HCC contribute to outcomes of combination immunotherapy.
Dissecting liver inflammation ecosystem identifies annexin A1 as a pro-resolving target for liver failure.
Multimodal transcriptomics identifies metallothionein as a novel pathway in primary sclerosing cholangitis.
ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis.
Head-to-head comparison of MASH resolution index versus FAST for non-invasive prediction of resolution of MASH on biopsy.
Hepatocyte-specific C-C motif chemokine ligand 9 signaling promotes liver fibrosis progression in mice.
Comparison of diagnostic accuracy and utility of non-invasive tests for clinically significant liver disease in a general population with metabolic dysfunction.
Altered blood-brain barrier permeability is associated with abnormal distant connectivity and regional homogeneity in covert hepatic encephalopathy - a cross sectional study.
Alcohol-induced disruption of hepatic m6A modification exacerbates alcohol-associated steatohepatitis by impairing liver immune microenvironment homeostasis.
11
A clinical protocol for the detection of comorbidities associated with monogenic causes of male infertility
Clinical and molecular features of ovarian stimulation in peripubertal girls with mosaic Turner’s syndrome
DNAH14 deficiency disrupts sperm annulus positioning and compromises offspring postnatal development
Fertility preservation and counselling in prepubertal and pubertal girls with Turner syndrome
Studies of post-partum placentas provide insights into the origin of structural chromosomal aberrations
Microdeletion and microduplication syndromes, including recurrent rearrangements at 16p11.2 and 22q11.21, are enriched in unexplained male infertility
Preimplantation genetic testing for neurofibromatosis type 1: molecular genetic aspects and impact on reproductive counseling
Universal preimplantation genetic testing for monogenic disease (Karyomapping): diagnosis of amp;gt;1000 unique disorders with no detected misdiagnoses
Randomized controlled study on the use of virtual reality for pain relief in oocyte retrieval under transvaginal ultrasound guidance using paracervical block and conscious sedation
Blastocyst segmental aneuploidy breakpoints are highly correlated with human genome fragile sites
Clinical presentation of congenital hypogonadotropic hypogonadism in males with delayed puberty according to genetic etiology: a systematic review and meta-analysis after reclassification of gene variants
9
Towards Autonomous Robotic Electrosurgery via Thermal Imaging
Deep Coarse-to-Fine Networks for Robust Segmentation and Pose Estimation of Surgical Suturing Threads
Learning to Perform Low-Contact Autonomous Nasotracheal Intubation by Recurrent Action-Confidence Chunking with Transformer
Label-supervised surgical instrument segmentation using temporal equivariance and semantic continuity
Visual Anomaly Detection for Reliable Robotic Implantation of Flexible Microelectrode Array
Three-Dimensional Anatomical Data Generation Based on Artificial Neural Networks*
Unsupervised Liver Deformation Correction Network Using Optimal Transport for Image-Guided Liver Surgery
Exploring the Virtual Pivot Point in Unilateral Transfemoral Amputee Locomotion: Implications for Prosthetic Development
RoboNurse-VLA: Robotic Scrub Nurse System based on Vision-Language-Action Model
15
Genetically diverse influenza antibodies highlight the role of IG germline gene variation and inform population-comprehensive vaccine strategies
Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development
A myeloid Tet2-IL-1β axis modulates intestinal inflammation by restricting catecholaminergic stimulation of enterochromaffin cell differentiation
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis
Multi-scaled transcriptomics of chronically inflamed nasal epithelium reveals immune-epithelial dynamics and tissue remodeling in nasal polyp formation
Gut microbe-derived metabolites drive psoriatic inflammation via modulation of skin Th17 cells
Naturalized immune responses are stable over years in a colony of laboratory mice with wild-derived microbiota
Gasdermin-D-mediated epithelial-immune circuit synchronizes nutrient absorption and host defense in the small intestine
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo
ILC3s sense gut microbiota through STING to initiate immune tolerance
Computationally designed proteins mimic antibody immune evasion in viral evolution
Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer
A hierarchy of intestinal antigens instructs the CD4+ T cell receptor repertoire
8
Human Transthyretin with a Tailored Gd(III) Complex as a High-Relaxivity MRI Contrast Agent
Chemical Control of Aggregation-Induced Enhancement via β-Galactose and Gadolinium Chelates
Dual Amino Acid Swap in MUC7-Derived Peptide Enhances Resistance and Modulates Zn(II) and Cu(II) Complex Stability, Secondary Structure and Antimicrobial Activity
Investigating Cu(II) Complexes for MRI: A Comprehensive Approach Using EPR, Relaxometry, and Computational Modeling
Controlling the Kinetic and Electrochemical Properties of EuII–Containing Complexes Using Peripheral Charges
Optimizing Intracellular Transport of Antimicrobial Metallohelices Delivers Selective Nanomolar Potency in E. coli
Concerted Reactive Adsorption and Photocatalytic Degradation of Bisphenol-S on Molybdenum Cluster-Modified Nanoceria
Exploring a Rigid Macrocyclic Ligand Bearing Malonate Pendants for Gd(III) Complexation: the Coordination Chemistry of [Gd(OPDMA)]−
20
Reductions in malaria cases after deployment of dual-active ingredient insecticide-treated nets in Ghana—a Bayesian interrupted time series analysis
Estimates of vaccine effectiveness against measles and mumps: 14 years follow-up of a large cohort in Wales, UK
Exploring genetic confounding of the associations between screen time and depressive symptoms in adolescence and early adulthood
Reproducibility and associated regression dilution bias of accelerometer-derived physical activity and sleep in UK Biobank
Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health
New-onset diabetes following SARS-CoV-2 infection in the Omicron era: a matched cohort study
Higher sun exposure is associated with a reduced risk of primary biliary cholangitis
Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine–pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomized trial in Uganda
A countrywide study on post-COVID-19 condition in Brazil: the Epicovid 2.0
Impacts of the COVID-19 pandemic on Brazilian families: a countrywide population-based survey
Mediating impact of sleep quality and duration on the relationship between socio-economic conditions and pain
Local progress towards achieving the End TB targets in Ethiopia: a geospatial analysis
Evaluating potential associations between prior maternal yellow fever vaccination and protection against infant adverse outcomes following Zika virus antenatal exposure
Malaria amidst the COVID-19 pandemic in Gabon: an application of autoregressive integrated moving average (ARIMA) models within an interrupted time series (ITS) framework to hospital-based data
Quantifying disruptions to tuberculosis case detection in Brazilian states during the COVID-19 pandemic
Relationship between shingles and coronavirus disease 2019: a self-controlled case series study
Post-acute non-specific symptoms following COVID-19 vaccination: a Danish population-based study
Age and gender profiles of HIV infection burden and viraemia: novel metrics for HIV epidemic control in African populations with high antiretroviral therapy coverage
School opening associated with lower test-adjusted COVID-19 case rates in children
Adverse childhood experiences and lower urinary tract symptoms in adolescence: the mediating effect of inflammation
56
Movement behaviors, psychosocial well-being and childhood obesity: the IDEFICS/I.Family cohort
The effect of weight-loss surgery in patients with obesity on adipose tissue mesenchymal stem cells versus circulating endothelial progenitor cells
Association between metabolic signatures of predicted VAT mass and risk of MASLD and other chronic liver diseases
Clinical characteristics and survival in sarcopenic obesity defined by the Japanese working group on sarcopenic obesity criteria versus existing definitions in older adults: findings from the Otassha study
Weight loss independent outcomes in type 2 diabetes mellitus and other metabolic comorbidities after Roux-en-Y gastric bypass and sleeve gastrectomy
Association of body mass index, waist circumference, (abdominal) overweight and obesity with sex- and age-specific cognitive function over time—the Doetinchem Cohort Study
Exploring the interaction of obesity and allergy and the potential roles of gut microbiota in the development of this comorbidity in male mice
The impact of slope-adjusted visit-to-visit body mass index variability on early dementia risk prediction
Inversed impaired osteogenic activity in children with severe obesity due to deficiency compared to and deficiency
Long-term outcomes of metabolic and bariatric surgery: a 10-year study of effectiveness and predictors
Associations between anthropometric and body composition indices with subclinical arterial damage in chronic inflammatory diseases
The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens
Investigating the trend of revisional bariatric surgery, the complications, and associated risk factors in France
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity
Estimating the effect of hypothetical dietary protein interventions on changes in body composition of postmenopausal women over 3 years using data from the Women’s Health Initiative (WHI) Study: an emulated target trial
Body composition references, sarcopenia cutoffs, and prevalence in youth using bioelectrical impedance analysis
Greater early postprandial GLP-1 increase after Roux-en-Y than one-anastomosis gastric bypass, with unchanged secretin: a randomized controlled trial
Sex-specific longitudinal associations between repeatedly measured movement behaviours and adiposity measures in school-aged children: a compositional data analysis approach
Distinct fasting and postprandial bile acid responses following Roux-en-Y and one-anastomosis gastric bypass
Capturing metabolic syndrome: new thresholds for insulin resistance and novel body composition indices
Is lower extremity joint replacement surgery associated with weight loss? An institutional retrospective study of 36,993 cases
Long-term change in body composition following intentional weight loss and its effect on physical function
Waist-to-height ratio as a non-invasive marker of renal sinus fat: a MRI-based cohort study
Long-term impact of newly-proposed clinical obesity on autoimmune disease incidence: insights from the UK Biobank
Serum S100β and neuron-specific enolase correlate with obesity parameters in Mexican children
Metabolic bariatric surgery pays off: a longitudinal analysis of weight loss and HbA1c changes in real-world patients data in the West of Scotland
Whole blood TNF-α expression and apoptotic endothelial microparticles reveal early vascular injury in pediatric obesity
Are reallocating time to moderate-to-vigorous physical activity associated with preschoolers’ body composition?
Dynapenic abdominal obesity is associated with long-term cognitive trajectories and mild cognitive impairment
Visceral-to-peripheral adiposity ratio in proneness to sarcopenic obesity: association with low muscle strength, but not low muscle mass, in young women of South Asian descent
Ototoxic impacts of adipose-derived extracts on a murine auditory cell line: molecular insights from proteomic analyses
Abdominal skeletal muscle quality and quantity are independently and jointly associated with cardiometabolic health in children
A U-shaped relationship between body mass index and the risk of elevated liver stiffness in older people: evidence from the 5‐year retrospective cohort study
Association of relative fat mass with the incidence of type 2 diabetes: over a decade follow-up from the TLGS
Real world efficacy of naltrexone/bupropion for weight management in obesity and after bariatric surgery
Differential associations of subcutaneous and visceral fat with bone turnover markers: A study on bariatric surgery patients with severe obesity and individuals without obesity
The relationship between plasma sphingosine-1-phosphate, plasma apolipoprotein M, obesity, and the risk of incident type 2 diabetes: a prospective cohort study
Diurnal timing and volume of physical activity in relation to metabolic syndrome in US adults: a population-based cohort study
Mortality risk associated with general and central obesity in inflammatory bowel disease patients: a long-term prospective cohort study
Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases
The long-term effect of metabolic bariatric surgery on innate immune cell phenotype and function
Glycemic variability and entero-pancreatic hormones signatures after different bariatric surgery procedures: a cross-sectional study
Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study
Characterizing the effect of bariatric surgery on circulating S100A9
Predictive markers of obesity and glucose metabolism dysfunction in adult common marmosets (Callithrix jacchus)
The influence of physical activity intensity on bone mineral density and trabecular bone score in young adults with overweight and obesity
Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals
High fat diet induces gastric production of fibroblast growth factor 23 (FGF23)
Association between plasma proteomic dynamic changes and metabolic outcomes in patients undergoing bariatric surgery
Association between adiposity distribution and high-sensitivity C-reactive protein, adipokines, interleukins and plasminogen activator inhibitor-1
Multi-modal neo-adjuvant anti-obesity medications may be more effective than medically supervised weight loss or GLP-1 therapy alone in preparing BMI≥70 patients for metabolic surgery
Causal effects of body composition on lifespan: Mendelian randomization analysis
Pre-post changes of integrated care needs in patients undergoing bariatric surgery
Evaluating the obesity paradox in patients with sepsis and cancer
Does weighted vest use during weight loss influence long-term weight loss maintenance? A pilot study in older adults living with obesity and osteoarthritis
The effect of preoperative body weight loss on 5-year bariatric surgery outcomes
25
Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease
Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks
Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest
Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum
Diacerein for Knee Osteoarthritis
Incidental Rotator Cuff Abnormalities on Magnetic Resonance Imaging
Automated Screening and Education for Women With Urinary Incontinence in Primary Care
Oral Semaglutide and Heart Failure Outcomes in Persons With Type 2 Diabetes
Treat-to-Target Urate-Lowering Treatment and Cardiovascular Outcomes in Patients With Gout
High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes
Collaborative Care for Opioid Use Disorder and Mental Illness
Antibiotic De-Escalation in Adults Hospitalized for Community-Onset Sepsis
Medical Cannabis and Opioid Receipt Among Adults With Chronic Pain
Sex Differences in Mortality and Receipt of Kidney Replacement Therapy Among Adults With Stage 5 Chronic Kidney Disease
Community Health Worker Support for Hispanic and Latino Individuals Receiving Hemodialysis
Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes
Remote Bone Health Service for Osteoporosis Screening in High-Risk Men
Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality
Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis
Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes
Germicidal UV Light and Incidence of Acute Respiratory Infection in Long-Term Care for Older Adults
Clinical Decision Support System for Primary Care of Opioid Use Disorder
Transfusion Strategy Effect on Quality of Life in Patients With Myocardial Infarction and Anemia
Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis
Glucose-Lowering Medications, Glycemia, and Cognitive Outcomes
26
Reducing Stress After Trauma in Physically Injured Children
Chronotherapeutic Approaches to Target Insufficient and Late Sleep in Adolescents
HIV Preexposure Prophylaxis Uptake Among US Youth in a National Claims Database
Parent-Reported Chronic Pain in Children With and Without Developmental Disabilities
Sleep Health Dimensions From Wearables and Transdiagnostic Mental Health in Young Adolescents
Long-Term Trends in Pediatric Self-Injury in High-Income Countries
EEG-Guided Anesthesia for the Prevention of Emergence Delirium in Children
Clinical Signs Associated With Mortality and Sepsis in Young Infants
Intranasal Treatments for Children With Sleep-Disordered Breathing
Social Media Use and Well-Being Across Adolescent Development
Artificial Intelligence Length-of-Stay Forecasting and Pediatric Surgical Capacity
Once-Weekly Navepegritide in Children With Achondroplasia
Development of an Atlas for US Pediatric Acute Care
Derivation and Validation of Predictive Models for Early Pediatric Sepsis
40-Hz Light Stimulation and Emergence Delirium Incidence After Sevoflurane Anesthesia in Children
Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis
Digital Health Interventions in Pediatric Perioperative Care
Gonorrhea and Chlamydia Screening for Adolescents and Young Adults in Emergency Departments
Cost-Effectiveness of Treatment for Opioid Use Disorder in Pregnancy and Its Impact on Birth Outcomes
Opioid Timeliness in the Emergency Department and Hospitalizations for Acute Sickle Cell Pain
Optimal Dose of Intranasal Midazolam for Procedural Sedation in Children
Diaphragm Position on Chest Radiograph to Estimate Lung Volume in Neonates
Firearm Laws and Pediatric Mortality in the US
Acceptance and Commitment Therapy–Based Parenting Program in Children With Co-Occurring Asthma and ADHD
Characterizing Long COVID Symptoms During Early Childhood
Tacrolimus or Mycophenolate Mofetil for Frequently Relapsing or Steroid-Dependent Nephrotic Syndrome
41
Dialectical Behavior Therapy vs Schema Therapy for Patients With Borderline Personality Disorder
Antipsychotic Efficacy and Safety of LB-102 in the Treatment of Adults With Acute Schizophrenia
Prior Trial Effects on Working Memory in Schizophrenia, Bipolar Disorder, and Healthy Control Individuals
Age at First Attention-Deficit/Hyperactivity Disorder Diagnosis and Educational Outcomes
Mirtazapine for Methamphetamine Use Disorder
Dementia in Severe Schizophrenia
Methylphenidate Treatment and Risk of Psychotic Disorder
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
Clozapine After 1 Failed Antipsychotic Drug Trial in First-Episode Psychosis
Health Plan Disenrollment and Mortality After Initiation of Medications for Opioid Use Disorder
Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks
Spirituality and Harmful or Hazardous Alcohol and Other Drug Use
Efficacy and Safety of the Neuroplastogen TSND-201 for the Treatment of PTSD
One-Year Actigraphy Study of Sleep and Rest-Activity Rhythms as Markers of Relapse in Depression
Psychological and Psychosocial Interventions for People With Schizophrenia and Co-Occurring Substance Use Disorders
Mental Disorders as a Risk Factor of Acute Coronary Syndrome
Yoga for Opioid Withdrawal and Autonomic Regulation
Processing Speed Impairment in Schizophrenia
Role of Serotonin in the Neurobiology of Schizophrenia and Association With Negative Symptoms
Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression
Contrasting Risk Profiles for Suicide Attempt and Suicide Using Danish Registers and Genetic Data.
Pragmatic Comparative Effectiveness of Primary Care Treatments for Posttraumatic Stress Disorder
Brief Cognitive Behavioral Therapy for Suicidal Military Personnel and Veterans
Heart Rate Variability Biofeedback for Substance Use Disorder
Measures of General Intelligence and Risk for Alcohol Use Disorder
Progression of Transdiagnostic Stages From Childhood to Young Adulthood
Regional Specificity of Cortical Layer 3 Dendritic Spine Deficits in Schizophrenia
Occurrence of Psychosis and Bipolar Disorder in Individuals With Attention-Deficit/Hyperactivity Disorder Treated With Stimulants
Collaborative Care for Opioid Use Disorder in Primary Care
The Role of Energy Homeostasis in Depression Pathophysiology and Its Heterogeneity
Incidence and Nature of Antidepressant Discontinuation Symptoms
Profiles of Genetic Risks for Psychotic Disorders
Esketamine Monotherapy in Adults With Treatment-Resistant Depression
Mental Health Antecedents and Correlates of 2 Distinct Developmental Pathways to Suicidal Ideation
Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence
Increased Prescribing of Attention-Deficit/Hyperactivity Disorder Medication and Real-World Outcomes Over Time
Framework for Brain-Derived Dimensions of Psychopathology
Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans
Simvastatin as Add-On Treatment to Escitalopram in Patients With Major Depression and Obesity
Health Outcomes of Discontinuing Antipsychotics After Hospitalization in Older Adults
Positive Emotion Dysregulation in Opioid Use Disorder and Normalization by Mindfulness-Oriented Recovery Enhancement
59
Surgical Approach and Long-Term Operative Recurrence Following Groin Hernia Repair
Prevention of Parastomal Hernia With Funnel-Shaped Intra-Abdominal Mesh vs No Mesh for Rectal Adenocarcinoma Surgery
Small Bites vs Large Bites for Closure of Abdominal Midline Incisions
Sex Differences in Arterial Grafting in Patients Undergoing Dialysis and Coronary Artery Bypass Grafting
Veterans Hospitals vs Non-Veterans Centers in the Prevention of Limb Loss
Oncologic Risk of Missed Appendiceal Tumors in Acute Appendicitis
Evolving Inguinal Hernia Repair Practice at the Veterans Health Administration
Contemporary Outcomes of Cholecystectomy
Firearm Mortality and Equitable Access to Trauma Care in Chicago
Severe Splenic Injuries in Patients With Multiple Trauma
Long-Term Outcomes After Laparoscopic vs Open Adhesiolysis for Small Bowel Obstruction
Emergency Medical Individual Clinician Volume and Mortality in Trauma Patients
Delayed Diagnosis of Anastomotic Leak and Failure to Rescue After Colon Resection
Development and Internal Validation of a Pretransplant Biomarker Panel for Mortality Prediction Following Liver Transplant
Bed Capacity and Utilization at Hospitals With Trauma Centers
Postoperative Sleep Dynamics Across Surgical Risk Using Wearable Device Technology
A Population-Level Evaluation of Emergency General Surgery Models of Care and Clinical Outcomes
Intrathecal Morphine for Enhanced Recovery After Laparoscopic Colorectal Surgery
Molecular Analysis of Mixed-Type and Branch-Duct Intraductal Papillary Mucinous Neoplasms
Perioperative Use of Tranexamic Acid in General Surgery
Recurrence in Patients With Lymph Node-Negative Pancreatic Neuroendocrine Tumors
Neighborhood Deprivation, State Laws, and Firearm Injury in the US
Data and the Art of Surgical Preference Card Maintenance
Laparoscopic vs Open Distal Gastrectomy With D2 Lymphadenectomy for Clinical T4a Gastric Cancer
Preoperative Hemoglobin A1C, Glycemic Status, and Postoperative Outcomes in General Surgery
Postmarket Surveillance of Mesh Performance After Inguinal Hernia Repair
Mesh Weight in Reoperation for Recurrence After Laparoscopic Inguinal Hernia Repair
Biological vs Synthetic Mesh in Laparoendoscopic Inguinal Hernia Repair
Long-Term Risk of Mesh Infection Requiring Removal After Elective Ventral Hernia Repair
Non–β-Lactam Antibiotic Use, β-Lactam Allergy, and Surgical Site Infections
Child and Adolescent Firearm-Related Homicide Occurring at Home
Obesity Treatment With Bariatric Surgery vs GLP-1 Receptor Agonists
Diagnostic Accuracy of Imaging in Assessing Nonviability of Disappearing Colorectal Liver Metastasis
Postoperative Pulmonary Complications in Conventional Laparoscopic vs Robot-Assisted Abdominal Surgery
Prevention of Incisional Hernias With Prophylactic Synthetic Mesh Placement During Stoma Reversal
Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures
Transoral Endoscopic and Minimally Invasive Thyroidectomy
Acute Normovolemic Hemodilution in Adult Cardiac Surgery
Parathyroidectomy and Risk of Incident Diabetes in Patients With Primary Hyperparathyroidism
Prehabilitation With Exercise and Nutrition to Reduce Morbidity of Major Hepatectomy in Patients With Sarcopenia
Use of Glucagon-Like Peptide-1 Agonists Among Individuals Undergoing Bariatric Surgery in the US
Generating a New CPT Code Set for Adult and Pediatric Appendectomy
Standardized Perioperative Protocols and Variance in Pediatric Surgery
Global Scaling of a Surgical Infection Prevention Program to 5 Low-Resource Countries
Reoperation for Chronic Postoperative Inguinal Pain
Near-Infrared Autofluorescence for Parathyroid Detection During Endocrine Neck Surgery
Open Anterior Mesh Repair vs Modified Open Anterior Mesh Repair for Groin Hernia in Women
Applying Large Language Models for Surgical Case Length Prediction
Allocation Out of Sequence in Lung Transplant
Intercostal or Paravertebral Block vs Thoracic Epidural in Lung Surgery
A Predictive Tool for Ability to Remain at Home After Cancer Surgery in Older Adults
Peer and Patient Feedback to Increase Adherence to Postoperative Opioid Prescribing Guidelines
Postoperative 20% Albumin Infusion and Acute Kidney Injury in High-Risk Cardiac Surgery Patients
Hospital Ownership and Surgical Outcomes in East, Central, and Southern Africa
Familiarity of the Surgeon-Anesthesiologist Dyad and Major Morbidity After High-Risk Elective Surgery
Clinical Outcomes of Laparoscopic vs Robotic-Assisted Cholecystectomy in Acute Care Surgery
Hemodynamic Impact of Cipepofol vs Propofol During Anesthesia Induction in Patients With Severe Aortic Stenosis
Role of Preoperative Antibiotic Treatment While Awaiting Appendectomy
Major Adverse Cardiac Events After Gastric Bypass vs Sleeve Gastrectomy
39
Symptom-Based Dosing for Neonatal Opioid Withdrawal
Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults
Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia
Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures
Discontinuation of Levothyroxine in Adults Aged 60 Years or Older
National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data
Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients
Treatment for Brain Metastases With Stereotactic Radiation vs Hippocampal-Avoidance Whole Brain Radiation
Emergency Department–Initiated Buprenorphine for Opioid Use Disorder
Oral Nalbuphine in Idiopathic Pulmonary Fibrosis–Associated Cough
Antibiotic Therapy for Uncomplicated Acute Appendicitis
Minor Papillotomy for Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum
Acetaminophen (Paracetamol) or Opioid Analgesia Added to Ibuprofen for Children’s Musculoskeletal Injury
Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis
Spinal Manipulation and Clinician-Supported Biopsychosocial Self-Management for Acute Back Pain
Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults
Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger
Intraoperative Driving Pressure–Guided High PEEP vs Standard Low PEEP for Postoperative Pulmonary Complications
Liberal or Restrictive Postoperative Transfusion in Patients at High Cardiac Risk
Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury
Rituximab for Relapsing Nephrotic Syndrome in Adults
Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction
RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons
Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults
A Fall Prevention Program Integrated in Primary Health Care for Older People in Rural China
Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma
Dalbavancin for Treatment of Staphylococcus aureus Bacteremia
Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function
Lorundrostat in Participants With Uncontrolled Hypertension and Treatment-Resistant Hypertension
Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients
Meningeal Embolization for Preventing Chronic Subdural Hematoma Recurrence After Surgery
Robotic vs Laparoscopic Surgery for Middle and Low Rectal Cancer
Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients
Spironolactone vs Amiloride for Resistant Hypertension
Midurethral Sling vs OnabotulinumtoxinA in Females With Urinary Incontinence
77
Caveolin-1 deficiency improved glucose metabolism via modulation of β-cell autophagy in high-fat diet-fed mice
Molecular analysis of a new patient COX15 mutation provides insight into the etiology of fatal infantile cardioencephalopathy
Small RNA ASpks2 promotes Mycobacterium tuberculosis survival in macrophages via targeting polyketide synthase 2
PIEZO1 variants that reduce open channel probability are associated with familial osteoarthritis
Targeting Nipah virus replication: A fluorescence polarization assay for high-throughput modulators screening against the NTAIL–XD interaction
The butyrate-producing Gram-positive human gut bacterium, Hoskinsella mucinilytica, selectively targets host mucin N-acetylhexosamines
Bisphenol-A impairs hippocampal neurogenesis by disrupting Kinesin-1-dependent mitochondrial trafficking
Aromatic residue-rich amino-terminal segments of temporin L self-assemble into collagen-mimetic peptides with cell-adhesion properties
The Welander TIA1 mutation dedifferentiates insulin-producing cells — reversal by a GLP-1 receptor agonist
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation
Aspartate treatment ameliorates metabolic dysfunction-associated fatty liver disease through upregulation of CBS and suppression of ferroptosis
Dynamic assessment of the allocation of copper to cytochrome c oxidase using size-exclusion chromatography (SEC) combined with inductively coupled plasma mass spectrometry (ICP-MS)
Attenuated lamin A–prohibitin2 interaction leads to mitochondrial dysfunction in LMNA 289 A>G–mediated dilated cardiomyopathy
Nitric oxide mediates ET-1-induced-inhibition of NPPB-sensitive Cl− currents in the early distal convoluted tubule of the mouse kidney
A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites
Acid ceramidase ASAH1 is a key regulator of epidermal ceramide levels and composition
Loss of ATM causes R-loop–associated transcriptional dysregulation and attenuates the related response to DNA damage
CLDN5 as a novel modulator of podocyte adhesion to extracellular matrix via β1-integrin binding
The retaining Kdo transferase that synthesizes Escherichia coli K13 capsule is deeply divergent from structurally homologous enzymes
Deregulated translation of the transcription factor Myt3 predisposes islet β cells to dysfunction under obesity-induced metabolic stress
A luminescent reporter assay to quantify SORL1 ectodomain shedding and Retromer-dependent endosome recycling activity
Identification of receptor-binding domains of Bacteroidales antibacterial pore-forming toxins
Molecular impacts of Meier–Gorlin syndrome mutations on human origin licensing
Temperature downshifts induce biofilm formation in Pseudomonas aeruginosa through the SiaABCD signal and functional module
Nanobodies against Clostridioides difficile CDTb provide a toolkit for potent toxin neutralization and highly sensitive quantitation
Neurofascin stabilization by contactin-associated protein-like 2 and CTCF alleviates mitochondrial dysfunction in Schwann cells during facial nerve injury
The cytochrome c oxidase subunit COX6B1 is required for redox-sensitive early assembly and late stabilization of complex IV
Enhanced lysosomal activity prevents infection with PrPSc and the seeding activity of α-synuclein & tau prions
B3GNT8-Mediated Glycosylation Maintains Intestinal Homeostasis and Protects Against Colitis
KANK1 regulates the positioning of liprin-α1 and the spatial organization of insulin granule fusion in pancreatic β cells
Structural basis for heme binding by the Shr protein from Streptococcus pyogenes.
EGFR-Targeted Gadolinium Contrast Agents for Enhanced Molecular Magnetic Resonance Imaging of Tumors
Mitochondrial movement in pancreatic alpha cells requires Miro2 and is regulated by glucose
Rab2A modulates liver fibroblast growth factor 21 (FGF21) expression and systemic metabolism via apolipoprotein B-CREBH signaling
Glyoxalase 1 is a proadipogenic gene
Metformin attenuates O-GlcNAc modification to improve renal function via AMPK/mTOR signaling in diabetic nephropathy
Cell wall arabinogalactan is responsible for Fungitell® cross reactivity in nocardiosis
Acetoacetate ameliorates skin fibrosis by modulating TGF-β1–Smad2/3 signaling pathway
A disintegrin and metalloproteinase domain with thrombospondin motifs 18 (ADAMTS18) cleaves fibronectin and negatively regulates its fibrillogenesis
Long non-coding RNA enhances SARS-CoV-2-mediated apoptosis through epigenetic repression of angiotensin-converting enzyme 2
Lipopolysaccharide-Induced Cytokine Signaling Activates a Temporal Innate Defense Program and Represses Pancreatic β-Cell Identity
Differential modulation of polycystin-2 gain-of-function channels by cysteine-reactive compounds, amphiphilic substances, and S4-S5 linker mutations
Compartmentalized thymidine phosphorylation by mitochondrial nucleotide kinases TK2 and CMPK2
Structure-based identification of salvianolic acid B as an inhibitor targeting Salmonella InvC ATPase
Dominant-negative NARS1 R534∗ mutation causes wild-type subunit poisoning and heterodimer predominance in cells
Adductome-based identification of lysine monomethylation as a key post-translational protein modification in autoimmune diseases
Phosphoglycerate dehydrogenase interacts with and inhibits the protein kinase TAK1 to mitigate septic shock
A biophysical and molecular characterization of the interaction between the Alzheimer risk factor BIN1 and the neuronal scaffold protein p140Cap
Pharmacologic stimulation of insulin granule acidification increases β-cell zinc content and augments β-cell-targeted drug delivery
Argonaute 1 contributes to the transcriptional silencing of HIV-1
Molecular recognition of fungal methylated glucosylceramides by ETD151 defensin
Nootropic benzothiazoles promote dendritic spine formation by targeting fascin-1
Mechanisms of mitochondrial reactive oxygen species action in bone mesenchymal cells
Sidt2 Inhibits Islet β-Cell Dedifferentiation by Regulating Insulin Secretion
ZFP36L1 and L2 as novel antiviral factors for Crimean-Congo hemorrhagic fever virus via interaction with viral nucleoprotein
Peroxynitrite detoxification by Trypanosoma cruzi heme peroxidase supports parasite survival in macrophages
Association of protein arginine deiminase 4 with the myosin-9 motor complex
Functional analysis of amino acid substitutions within human AGT1 in a cell-based platform to support the diagnosis of primary hyperoxaluria type 1
Leber's hereditary optic neuropathy–associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis
Characterization of ADAMTS9 proteoglycanase activity: Comparison with ADAMTS1, ADAMTS4, and ADAMTS5
Extensive citrullination of human serum albumin is physiological and not inherently immunogenic in rheumatoid arthritis
PTH stimulation of Rankl transcription is regulated by SIK2 and 3 and mediated by CRTC2 and 3 through action of protein phosphatases 1, 2, 4, and 5
Secreted EMC10 inhibits muscle GLUT4 activity and glucose uptake in mice
Evidence against efficient spontaneous disassembly of prions into small oligomers
CryoEM structure of Rv2531c reveals cofactor-induced tetramer–dimer transition in a tuberculin amino acid decarboxylase
Induction of the zinc finger transcription factor GATA2 promotes kidney inflammation-related gene expression
Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons
Mitochondrial tRNA processing defects reprogram mitochondrial and cellular homeostasis
The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4
Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice
Targeted removal of the 16S rRNA anti-Shine-Dalgarno sequence by a Mycobacterium tuberculosis MazF toxin
High uric acid exacerbates nonalcoholic steatohepatitis through NLRP3 inflammasome and Gasdermin D-mediated pyroptosis
Blockade of the estrogen receptor alpha–pregnane X receptor axis protects ovariectomized mice against ethanol-induced hepatotoxicity
Engineering an antimicrobial chimeric endolysin that targets the phytopathogen Pseudomonas syringae pv. actinidiae
NOTCH2 disrupts the synovial fibroblast identity and the inflammatory response of epiphyseal chondrocytes
Covalent Binding of Thioredoxin to TXNIP is Required for Diet-induced Insulin Resistance in the Liver
The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state
126
Development of a Radiographic Scoring System to Estimate Acetabular Protrusion Risk in Patients with Osteolytic Periacetabular Metastases.
High-Grade 3-Column Osteotomies Are Not Interchangeable: Schwab-Grade-III PSO Versus Schwab-Grade-V VCR in Treating Severe Kyphoscoliosis with an Average 9-Year Follow-up.
Effectiveness of Intraosseous Morphine for Pain Control in Total Knee Arthroplasty: A Double-Blinded, Randomized Trial.
Technology Assistance Mitigates the Volume-Dependent Risk of Hip Dislocation Following Total Hip Arthroplasty.
Survivorship of Femoroacetabular Impingement Surgery at Mean 10-Year Follow-up: A Prospective, Multicenter Cohort Study.
Surprisingly Low Rates of Aseptic Loosening in 575 Rotating-Hinge Total Knee Arthroplasties.
Significant Anxiolytic Effect and Enhanced Recovery Benefits of Perioperative Low-Dose Olanzapine in Patients with Anxiety Undergoing THA: A Randomized Controlled Trial.
Intraoperative Bone-Quality Assessments Are Reliable Compared with Opportunistic CT-Based Hounsfield Unit Measurements.
One-Stage Versus Two-Stage Exchange Arthroplasty for Periprosthetic Joint Infection: A Prospective Randomized Trial.
Clinical Outcomes Following Open Tibial Fractures in Latin America: A Multicenter Prospective Study.
Surgical Treatment of Recurrent Lumbar Disc Herniation: To Fuse or Not To Fuse: A Single-Center Analysis of Clinical and Radiographic Characteristics and Surgical Outcomes of 450 Patients.
Greater Valgus Alignment in Pediatric and Adolescent Patients with a Primary ACL Tear Compared with Healthy Controls.
Three-Dimensional Geometry of the Normal Scapula: A Software Analysis.
Outcomes and Complications of Vertebral Body Tethering in Skeletally Immature Patients with Idiopathic Scoliosis.
Pain Outcomes Following Modern External Ring Fixation Compared with Internal Fixation for Severe Open Tibial Fractures: A Secondary Analysis of a Prospective Randomized Trial (FIXIT).
Periprosthetic Joint Infection Following Total Knee Arthroplasty Is Associated with a Significantly Elevated Risk of Mortality: A Population-Level Database Study.
Results of a Novel Osteotome System for Femoral Stem Extraction in Revision Total Hip Arthroplasty
[18F]-Fluoride PET/CT Analyses of Postoperative Bone Mineralization Adjacent to Acetabular Cups in Total Hip Arthroplasty: A Randomized Clinical Trial.
Mild Lateral Femoral Condyle Cartilage Damage Does Not Affect the Outcomes of Medial Unicompartmental Knee Arthroplasty: A Mean 6-Year Follow-up Study.
Cost-Effectiveness of Surgery Versus Functional Bracing for Humeral Shaft Fractures in Adults: A Prespecified Economic Evaluation of the Finnish Shaft of the Humerus (FISH) Trial.
Radiographic Measurement of Psoas Muscle Width: A Simple and Reliable Screening Tool for Sarcopenia.
Impact of Stem Design on Periprosthetic Femoral Fracture Risk
Minimal Movement Restrictions Do Not Increase Hip Dislocations Following Total Hip Arthroplasty
Minimizing Missed Diagnoses of Tibial Plateau Fractures
Predictive Factors for Fast Healing Following Surgery for Knee Osteochondritis Dissecans.
Transthyretin Amyloid May Drive Fibrosis and Proliferation of Tenosynovial Fibroblasts in Carpal Tunnel Syndrome.
Increased Critical Shoulder Angle Impairs Tendon-Bone Healing in a Rat Model of Chronic Rotator Cuff Tears.
Compensatory Load Sharing by Residual Rotator Cuff Subregions Preserves Glenohumeral Mechanics in Partial and Massive Tears.
Femoral Head Perfusion Varies Widely Following Surgical Reduction for Infantile Developmental Dysplasia of the Hip: Preliminary Findings from a Prospective Study of Contrast-Enhanced Ultrasound.
Autoclaving Effectively Sterilizes Contaminated Retained Cement in Orthopaedic Surgical Trays.
Decreased Robot-Related Complications Following the Development and Adoption of a Standardized Safety Protocol
Prevention of Postoperative Coronal Imbalance in Patients with Adolescent Idiopathic Scoliosis with a Major Lumbar Curve
Microbial Resistance Patterns in Periprosthetic Joint Infection of the Knee: A 24-Year Longitudinal Study.
Impact of the Femoral Pin Tracker on Soft-Tissue Tension in Robotic-Assisted Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.
A Dedicated Trauma Operating Room for Hand Surgery Reduces After-Hours Cases and Costs without Affecting Wait Times: A Retrospective Single-Center Cohort Study.
The Trapezius Aponeurosis Insertion on the Acromion: An Anatomical Study with a Possible Implication for Dynamic Stabilization of the Acromioclavicular Joint.
The Prevalence of Subtalar Arthritis Following Pilon Fractures.
Fluoroscopy-Guided Lateral Tibial Plateau Fracture Fixation with and without Needle Arthroscopy: A Biomechanical and Reduction-Quality Comparison.
Low Cognitive Function and Somatic Psychological Symptoms Are Correlated with Greater Risk of Delirium After Total Knee Arthroplasty: A Prospective Cohort Study.
Thigh Muscle Changes in the ACL-Deficient Knee: A 4-Year Longitudinal MRI Study of 1,207 Patients.
Effect of Tourniquet Use on 3D Cement Penetration and Mid-Term Implant Stability in Primary Total Knee Arthroplasty: A Randomized Controlled Trial.
AI-Driven CT-MRI Image Fusion and Segmentation for Automatic Preoperative Planning of ACL Reconstruction: Development and Application.
Bracing Outcomes and Risk of Curve Progression in Adolescents with Idiopathic Scoliosis and Autism Spectrum Disorder.
Physical Activity and 4-Year Radiographic Medial Joint Space Loss in Knee Osteoarthritis: A Joint Model Analysis.
Clinical Application of an Ultrasonic Bone Scalpel in the Treatment of Osteoid Osteoma: A Single-Center Pilot Study.
Synovial Fluid MicroRNA Biomarkers Enable Accurate Diagnosis of Hip and Knee Periprosthetic Joint Infections
Oral Corticosteroids Reduce Pain After Total Knee Arthroplasty: A Higher Dose of Dexamethasone Effectively Controlled Pain During Motion: A Dose-Response Randomized Placebo-Controlled Trial.
Diagnostic Utility of a Rapid Myeloperoxidase Test in Synovial Fluid for Chronic Periprosthetic Joint Infection
Chemical Disinfection of an Accidentally Contaminated and Irreplaceable Inorganic Element During Orthopaedic Surgery Is a Safe Option
Infection and Nonunion Rates in Open Fractures
Timing of Debridement, Antibiotics, and Implant Retention for Early Periprosthetic Joint Infection
The Ultrasound-Assisted Patellar Glide Test: A Novel Examination Method for Quantifying Patellar Instability
Incidence, Characteristics, and Management of Concomitant Ipsilateral Upper-Extremity Fractures in Pediatric Monteggia Fracture-Dislocations: A 13-Year Single-Institution Case Series.
The Impact of Cervical Multifidus Sarcopenia on Outcomes After Laminoplasty for Cervical Ossification of the Posterior Longitudinal Ligament.
Betamethasone and Triamcinolone Acetonide Have Comparable Efficacy as Single Intra-Articular Injections in Knee Osteoarthritis: A Double-Blinded, Randomized Controlled Trial.
Risk Factors for Nonunion Following Lateral Locked Plating of Distal Femoral Fractures
Normalization of Subchondral Bone Density Patterns After Surgical Treatment for Capitellar Osteochondritis Dissecans: A Quantitative Analysis.
Postoperative Abstinence Restores Osseointegration Impaired by Ethanol Consumption in a Murine Tibial Implant Model.
Five-Year Radiographic and Clinical Outcomes of Pyrocarbon Hemiarthroplasty for Glenohumeral Arthritis and Osteonecrosis.
Helical Blade Versus Lag Screw Fixation in the Cephalomedullary Nailing of Geriatric Hip Fractures.
The Latarjet Procedure May Induce Pathokinematics with Posterior Humeral Head Subluxation: An Experimental Dynamic Radiostereometric Study.
Posterior Cruciate Ligament (PCL) Versus Combined PCL and Posterolateral Corner Reconstruction in Isolated PCL Grade-III Injuries.
Debridement of Unstable Chondral Lesions During Arthroscopic Partial Meniscectomy Provides No Long-Term Benefit: Patient Outcomes 9 Years After the Original ChAMP Trial.
Quantifying Changes in 3D Acetabular Morphology in Normal Hips Based on the Development of Secondary Ossification Centers.
The Broken Wing Sign: A New Clinical Test to Detect Gluteus Medius Pathology with and without Fatty Infiltration.
Congenital Cervical Scoliosis at the Craniovertebral Junction: Clinical Characteristics and Surgical Strategies in 27 Patients with Mid-Term Follow-up.
Prophylaxis Against Complex Regional Pain Syndrome Recurrence with Vitamin C in Total Knee Arthroplasty: A Propensity Score-Matched Analysis of 960 Cases.
Mean Body Mass Index Does Not Increase or Decrease at 10 Years After Primary Total Hip or Knee Arthroplasty.
Assessment of the Mechanical Performance of an Affordable External Fixator (AEFIX) Designed for Resource-Limited Settings.
Pediatric Spine Frailty Index Predicts Morbidity and Mortality Following Spinal Deformity Surgery.
Fifteen-Year Mortality Following Periprosthetic Joint Infection in Total Knee Arthroplasty: A Registry Study of 8,642 Revisions for Infection.
Distinct 3-Dimensional Morphologies of Arthritic Knee Anatomy Exist: CT-Based Phenotyping Offers Outlier Detection in Total Knee Arthroplasty.
Efficacy and Safety of Tranexamic Acid Combined with Absorbable Hemostat in Reducing Perioperative Blood Loss in Total Knee Arthroplasty: A Prospective, Blinded, Randomized Controlled Trial.
Predicting Anterior Cruciate Ligament Reconstruction Revision Risk: An Enhanced Machine Learning Analysis of the Danish Knee Ligament Reconstruction Registry.
Impact of Childhood Obesity on Capital Femoral Epiphysis Morphology: A Large-Scale, Automated 3D-CT Study and Potential Implications for SCFE Pathogenesis.
Outcomes of Extra-Articular Subtalar Arthrodesis for Valgus Deformity of the Hindfoot in Patients with Cerebral Palsy: A Radiographic and Pedobarographic Study.
Conversion of Fused Knees to Total Knee Arthroplasty: The 21 to 31-Year Clinical Results and Patient Satisfaction.
Weight Loss Before Total Knee Arthroplasty Was Not Associated with Decreased Postoperative Risks.
Minimized Medial Soft Tissue Release with Bone-Recut Adjustment Improves Short-Term Outcomes: Compared with Medial Release in Posterior-Stabilized Total Knee Arthroplasty.
Cement Mantle Screws in Periprosthetic Hip Fracture Fixation Near Well-Fixed Femoral Stems May Not Impact Short-Term Femoral Stem Survivorship.
The Smallest Worthwhile Effect as a Promising Alternative to the MCID in Estimating PROMs for Adult Idiopathic Scoliosis.
From Asymptomatic Flatfoot to Progressive Collapsing Foot Deformity: Peritalar Subluxation Is the Main Driver of Symptoms.
PROMIS and ODI Tools: Clinically Useful Markers of Abnormal MRI Findings in Pediatric Patients with Back Pain.
A Unifying Radiographic Description of Legg-Calvé-Perthes Disease at Skeletal Maturity: The Head, Acetabulum, Trochanter Classification.
Migration of Cemented and Uncemented Implants in Total Knee Arthroplasty with an Asymmetrical Tibial Component: A Randomized Controlled Trial with a 2-Year Model-Based Radiostereometric Analysis Follow-up.
Bupivacaine-Meloxicam Extended-Release Solution Compared with a Standard Periarticular Injection in Primary Total Knee Arthroplasty: A Randomized Clinical Trial Showing Similar Efficacy in Postoperative Analgesia.
Coronal and Sagittal Balance Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis.
Ten-Year Outcomes of Hip Arthroscopy for the Treatment of FAI and Labral Tears in Patients with a Workers' Compensation Claim.
Orthopaedic Manifestations in Hypermobile Ehlers-Danlos Syndrome.
The Timing of Direct Oral Anticoagulant Usage Did Not Impact Outcomes Following Hip Arthroplasty for Femoral Neck Fractures.
Incidence and Prediction of Postoperative Urinary Retention Following Lumbar Decompression.
A Multicenter Study of Intertrochanteric and Pertrochanteric Fragility Fractures: Spanning Fixation Mitigates the Risk of Peri-Implant Fractures.
A Prospective, Randomized Comparison of Functional Bracing and Spica Casting for Femoral Fractures Showed Equivalent Early Outcomes.
The T4-L1-Hip Axis Objectifies the Roussouly Classification Using Continuous Measures.
The Cost-Effectiveness of Continuous Pressure Measurement in the Diagnosis of Acute Compartment Syndrome.
Differences in Orthopaedic Surgeon Merit-based Incentive Payment System (MIPS) Performance, Demographics, and Patient Populations Based on Patient Social Risk.
High Failure Rates of Polyethylene Glenoid Components in Stemless Anatomic Total Shoulder Arthroplasty for Primary and Secondary OA.
Measurement of Value in Uncomplicated Total Knee Arthroplasty: Patient-Level and Provider-Level Value Analyses of a 1-Year Episode of Care.
Comparing the in Vitro Efficacy of Commonly Used Surgical Irrigants for the Treatment of Implant-Associated Infections.
Outcomes Associated with Choice of Prophylactic Antibiotics in Open Fractures
Higher Reoperation Rates in Planned, Staged Treatment of Open Fractures Compared with Fix-and-Close
Alcohol-Based Versus Aqueous Skin Antisepsis Before Surgical Fixation of Open Fractures
Deep Infections After Open and Closed Fractures
Performance of the OTA-OFC3 Classification System for Open Fractures
A Deep Learning-Based Clinical Classification System for the Differential Diagnosis of Hip Prosthesis Failures Using Radiographs: A Multicenter Study.
Local Antibiotics and the Risk of Antimicrobial Resistance in Extremity Fractures Complicated by Fracture-Related Infection
Chlorhexidine Gluconate Bathing Has Limited Ability to Prevent Surgical Site Infection Following Operative Fixation of Extremity and Pelvic Fractures
Differences in Practice Patterns in the Use of Temporary External Fixation for the Management of Open Lower-Extremity Fractures
Intraneural Ganglion Cysts Arising from the Hip Joint as Rare Causes of Sciatic Neuropathy: A Case Series of 13 Patients Treated with Hip Arthroscopy.
PGE2 Ameliorates Aging-Aggravated Rotator Cuff Muscle Atrophy.
Immobilization Time for Conservative Treatment of Distal Radial Fractures in Elderly Patients: A Randomized Controlled Trial.
Long-Term Mortality Associated with Periprosthetic Infection in Total Hip Arthroplasty: A Registry Study of 4,651 Revisions for Infection.
Five-Year Functional Outcomes After Acetabular Labral Repair with and without Bone Marrow Aspirate Concentrate.
Completely Displaced Midshaft Clavicular Fractures with Skin Tenting in Adolescents: Results from the FACTS Multicenter Prospective Cohort Study.
Perioperative Opioid Counseling for Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial.
Functional and Radiographic Outcomes of Bone Grafting for Severe Glenoid Defects in Reverse Shoulder Arthroplasty: A Minimum 5-Year Follow-up.
Three Hundred Periprosthetic Tibial Fractures Around a Total Knee Replacement: Classification and Outcomes from a Single Institution.
The Effect of Traction and Spinal Cord Morphology on Intraoperative Neuromonitoring Alerts in Adolescent Idiopathic Scoliosis.
Primary Total Knee Arthroplasty in Patients with BMI of ≥50 kg/m2: A Cohort Study with Long-Term Follow-up.
Surgical Correction of Severe Scoliosis Leads to Changes in Central Airway Resistance Evaluated with CT-Based 3D Reconstruction and Impulse Oscillometry.
Immediate Weight-Bearing Compared with Non-Weight-Bearing After Operative Ankle Fracture Fixation: Results of the INWN Pragmatic, Randomized, Multicenter Trial.
The Effect of Implant Constraint and Ligament Repair on Compartment Balancing After Medial Collateral Ligament Injury in TKA.
Acute Interpositional Fat Autograft Does Not Protect Against Bar Formation in Physeal Fractures.
Effects of Depression and/or Anxiety on the Outcomes of Hip Arthroscopy for Femoroacetabular Impingement and Labral Tears: A Minimum 5-Year Follow-up Study.
A Too-Long Anterior Process of the Calcaneus: Defining Normative Values for the Calcaneonavicular Distance Using MRI in a Pediatric Population.
Intraoperative Direct Sonication Versus Conventional Sonication in the Diagnosis of Periprosthetic Joint Infection: Comparison of Diagnostic Accuracy and Time to Positivity of Fluid Culture.
3
Stepwise assembly of α-hemolysin from intermediates to the mature pore in native erythrocytes
Submembrane liprin-α1 clusters spatially localize insulin granule fusion
An ethanol-induced loss of the lipid droplet–associated segregase VCP/p97 leads to hepatic steatosis
6
Galaxolide triggers trophic cascades from microbes to fish: Community sensitivity and molecular insights reveal underestimated ecological risks
Effects of architectural spatial design on bacterial and fungal diversity and pathogenic potential in student dormitories under hot-humid climates
Cu-doped biomass-derived carbon quantum dot modified BiOBr/g-C3N4 photocatalyst to eliminate antibiotics, antibiotic resistant bacteria, and resistance genes
Research on the influence of dust collection pipeline and vacuum hood structure on the dust removal effect of polishing workshops
Experimental study of local exhaust dust control characteristics from partial enclosure during bulk material falling in an industrial building
Natural bio-photosensitizers in sludge: Extracellular polymeric substances (EPS)-driven persulfate activation for sustainable antibiotic degradation
172
Real-world impact of treatment on growth in children with X-linked hypophosphatemia
Acromegaly is associated with an increased incidence of primary malignant tumors: data from a national study in Sweden
Associations of endocrine disrupting chemicals with anogenital distance across infancy
Increased MAP-1 and lectin complement activation capacity in Klinefelter syndrome
Antifracture Efficacy of 5- or 10-Yearly Zoledronate in Women Aged 50 to 60 Years: Secondary Analyses of a Randomized Trial
International real-world study on osilodrostat efficacy and safety in adrenal Cushing syndrome
Efficacy of Liquid-chromatography and Radioimmunoassay in False-positives’ Drop-off in CAH Newborn Screening
Circulating levels of ghrelin and hyperphagia in patients with rare genetic neurodevelopmental disorders
Comparing surrogate indexes for insulin resistance as predictors of type 2 diabetes
Antithyroid drug treatment in pregnancy: a first report from the Danish PRETHYR multicenter study
Partial pressure of oxygen-guided adrenal venous sampling in primary aldosteronism
Health-related quality of life in children with multiple endocrine neoplasia (MEN) and their siblings
Timeliness of antiresorptive consolidation after anabolic therapy for primary fracture prevention: A US cohort study
Pregnancy-specific Reference Intervals for TSH and FT4: Novel Insights From Preconception-gestation Longitudinal Data
Automatic acromegaly detection using deep learning on hand images: a multicenter observational study
Genotype-phenotype heterogeneity among patients with lipodystrophy harboring rare POLD1 variants
High normal parathyroid hormone and cardiovascular and total mortality: sex and age disparities in the ELSA-Brasil study
The use of semaglutide as an add-on therapy in patients with latent autoimmune diabetes in adults
Impact of serum prolactin on cognitive function, brain structure, and function in type 2 diabetes mellitus
Associations between radioactive iodine treatment for hyperthyroidism and cancer incidence and mortality
Glucocorticoid trajectories in preterm infants—born too soon, wired differently
Cigarette smoking exposure and clinical outcomes in Graves' disease
Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway
Severity of MASH activity by iron-corrected MRI predicts insulin resistance and cardiometabolic risk in type 2 diabetes
GLP-1 receptor agonists and the risk of fragility fractures in older adults with type 2 diabetes
Hyperthyroidism and Birth Defects: The Roles of Maternal Thyroid Function and Thyroid Autoantibody Positivity
Magnesium sulfate may unmask subclinical excess vasopressinase-induced arginine vasopressin disorder
<atl>Integrative genetic and liver transcriptomic analyses identify iTRIB1AL/i as a target for steatotic liver disease</atl>
Natural history of pituitary incidentalomas in pediatric patients: a single-center, retrospective analysis
Subclinical ocular alterations in Graves' disease: The FUMO score, a new tool to predict Graves' orbitopathy progression
Weight loss reduces intermuscular adipose tissue and liver fat compared to exercise: implications for muscle quality and metabolic health
Heart ventricular function in hospitalized patients with severe hypothyroidism and myxedema coma
Clinical spectrum of extreme insulin resistance syndromes treated with rhIGF-1: A single-center experience
High Body Mass Index as a Causal Risk Factor for Vascular-Related Dementia: A Mendelian Randomization Study
Therapeutic Plasma Exchange in Severe Thyrotoxicosis: Clinical Observations From a Case Series
GH Response to Glucagon in Transition: Role of Body Mass Index and Etiology in Childhood-onset GH Deficiency
<atl>Expanding the clinical tumor phenotype of the iEPAS1/i -asssociated tumor syndrome</atl>
Personalized Drug Screening and Risk Assessment in Patient-Derived Gastroenteropancreatic Neuroendocrine Neoplasms
Cerebrospinal fluid and plasma leptin dynamics following bariatric surgery in women
Somatic Drivers in Aldosterone-producing Adenomas and Nodules: Insights from a Brazilian Cohort of Primary Aldosteronism
Radiological Surveillance for Pituitary Adenomas in Multiple Endocrine Neoplasia Type 1: A Longitudinal Cohort Study
Bone turnover in arginine vasopressin deficiency: a comparative study with primary polydipsia and healthy controls
Discordance Between Online Information and Male Hypogonadism Clinical Guidelines: A Global Multilingual Content Analysis
Fasting vs Nonfasting, Dose-adjusted Levothyroxine Ingestion in Hypothyroidism: A Randomized Clinical Trial
Implementation of a Spanish-Language, Direct-to-Patient Primary Aldosteronism Testing Program
Patient-Reported Outcomes in Palopegteriparatide-Treated Adults with Hypoparathyroidism: PaTH Forward Trial Extension
Secukinumab in Moderate-to-Severe Graves Orbitopathy: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study
Clinical and Pathological Spectrum of Acromegaly: Distinguishing GH PitNETs, Mammosomatotrophs, and Mixed Tumors
The Role of Obstructive Sleep Apnea and CPAP Therapy in the Functional Hypogonadism of Male Patients With Severe Obesity
Secondary Hypogonadism and Effects of Testosterone Replacement Therapy on Cardiovascular Events
Inflammatory Markers Link Steroid Profiles to Bone Status in Patients with Autonomous Cortisol Secretion
Validation and Limitations of the PANOMEN-3 Predictive Model for Tumor Recurrence and Progression in Pituitary Tumors
Impact of Growth Hormone on Skeletal Muscle Strength, Power, Endurance, and Agility in Prepubertal Boys With Short Stature
Aromatase Inhibitors Treatment Alone or With GH Increases Final Height in Short-statured Pubertal Boys—Real-world Data
Direct Healthcare Cost of Fractures in Patients With Type 1 Diabetes: A Population-Based Cohort Study in Denmark
Reproductive Hormones During Minipuberty Suggest Subtle Testicular Impairments in Boys With Hypospadias
Interim Effects of Zoledronate, Denosumab, or Teriparatide on Bone Microarchitecture in Type 2 Diabetes: A Pilot Trial
Persistent Renin Suppression After Unilateral Adrenalectomy for Primary Aldosteronism: Implications for Adverse Outcome?
Population prevalence, penetrance, and mortality for genetically confirmed MODY
Prospective Assessment of Mood and Quality of Life in Cushing syndrome before and after Biochemical Control
Maternal Thyroid Hormone Imbalance and Risk of Autism Spectrum Disorder
Effect of Vosoritide therapy on IGF-I and Endogenous C-type Natriuretic Peptide in Hypochondroplasia
Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome
MECP2 Rare Variants in Boys With Central Precocious Puberty
TRIAC Therapy Relieves Hyperthyroid Symptoms, Lowering T4, T3, and Metabolic Rate in Resistance to Thyroid Hormone β
Percutaneous Laser Ablation for Thyroid Nodules: Efficacy and Safety in 1492 Patients With Median Follow-up of 10 Years or More
Higher circulating testosterone linked to higher CAD risk in men: Mendelian randomisation and survival analyses
Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-Daily Oral Paltusotine Treatment
EUS-guided radiofrequency ablation as a minimally invasive treatment for insulinomas – a single center experience
Adult Growth Hormone Deficiency, Replacement Therapy, and Outcomes in Long-Term Childhood Cancer Survivors
The Relation Between Systemic Inflammation and the Menopause Transition: The Study of Women's Health Across the Nation
The Beneficial Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Anemia in Type 2 Diabetes-A Real-World Study
Immune Checkpoint Inhibitor Therapy for Aggressive Pituitary Neuroendocrine Tumors
Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case–Control Study in Sweden
Platelet Function and Markers of Atherothrombotic Risk in Individuals With Parathyroid Disorders
Handgrip Strength and Trajectories of Preclinical Obesity Progression: A Multistate Model Analysis Using the UK Biobank
Bioactive Insulin-like Growth Factor (IGF)-I Concentrations in Children on Growth Hormone Therapy
Body Composition by DXA in Patients With Klinefelter and Kallmann Syndrome: The Kama Study
Muscle and liver insulin resistance are associated with distinct plasma protein profiles; data from the DiOGenes trial
Rates and Pattern of Antifracture Drug Use in 6475 Adults and Children With Osteogenesis Imperfecta
Influence of obesity and IL-6 on human postprandial amino acid and protein metabolism at whole-body and tissue level
Development of a Machine Learning-based Model for Methimazole Dosage Adjustment in Youth With Hyperthyroidism
Osilodrostat-associated Adrenal Gland Shrinkage: A Case Series of Patients With ACTH-dependent Cushing's Syndrome
The Importance of Disease Specific Growth Charts for Children with Congenital Adrenal Hyperplasia
Clinical and Biochemical Phenotype Across the Genotypic Spectrum of 21-Hydroxylase Deficiency in 457 Individuals
Mineralocorticoid receptor antagonist pre-adrenalectomy in primary aldosteronism
Sleep Disturbances in Patients With Cushing Syndrome and Mild Autonomous Cortisol Secretion: A Cross-sectional Study
Comprehensive Molecular Studies in 88 Japanese Patients With Congenital Hypogonadotropic Hypogonadism
Association of IGF-1 levels with height from childhood to adulthood: An observational and Mendelian randomization study
Functional Domain Mapping of TPO: Insights from Six Variants in Sudanese Kindreds with Congenital Hypothyroidism
Genomic Insights into Short Stature in Children Born Small for Gestational Age: A Korean Multicenter Exome Study
Statins Do Not Affect Bone Anabolism in Older Women Treated With Teriparatide
Psychiatric and Sleep disorders in Patients with Non-Functional Adrenal Tumors
Serum anti-müllerian hormone as a biomarker of functional testicular reserve: a comparative analysis
Adverse outcomes in patients with hypothyroidism undergoing bariatric surgery: A retrospective study using TriNetX
Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies
Overnight Dexamethasone Suppression Test: Enhanced Accuracy with Late-Afternoon Cortisol and Morning/Late-Afternoon ACTH
Cortisol Testing to Diagnose Adrenal Insufficiency Following Adrenalectomy for Mild Autonomous Cortisol Secretion
Assessment of GFR Estimation Methods in Patients with Obesity
Longitudinal Characterization and Sonographic Staging of Testicular Adrenal Rest Tumors
Enhancing Accuracy of Newborn Screening for 21OHD: Strategic Use of 21-Deoxycortisol in a Large-Scale Tokyo Cohort
Association Between Testosterone Replacement Therapy and Prostatic Disorders in Elderly Hypogonadal Men
Risk Factors Pituitary Adenomas Development in Multiple Endocrine Neoplasia Type 1: A Nationwide Study of 240 Cases
Trends In Reported Outcomes for Growth Hormone Therapy In Children With Growth Hormone Deficiency
Clinical Utility of Salivary Steroid Profiling for the Differential Diagnosis of Adrenal Diseases
Metabolic Dysfunction-Associated Steatotic Liver Disease in Klinefelter Syndrome: High Prevalence Uncovers an Unmet Need
Effects of subclinical hypothyroidism on nephropathy complicating type 2 diabetes: The Fremantle Diabetes Study Phase II
Challenges in Estimating Renal Function in X-linked Hypophosphatemia because of formula Overestimation and FGF23 Effects
Genetic and Clinical Characteristics of Monogenic Diabetes in Japan: A Nationwide Study by the Japan Diabetes Society
Facial Analysis in Acromegaly Using Machine Learning: Toward Earlier Diagnosis
Early Growth Hormone Treatment Enhances Growth and Nutritional Status in Silver-Russell Syndrome
A Recurrent Splice Variant Sheds Light on 11β-Hydroxylase Deficiency in a Unique Large Cohort
Changes in Trabecular Bone Score and Their Determinants in Young and Middle-aged Men: A Longitudinal Observational Study
Identification of gut microbiome signatures and metabolites associated with albuminuria in type 2 diabetes
A Global Approach to the Long-Term Follow-up of 17 Families with Bilateral Macronodular Adrenal Disease
Brief, Low-impact, High-intensity Osteogenic Loading in Postmenopausal Osteoporosis: A Quasi-experimental Case-series Study
Impact of minimal dose strategy before anti-thyroid drug discontinuation on relapse risk in Graves’ disease
Children with diabetes and at least one non-autoimmune feature should be considered for monogenic diabetes testing
Association of Glucose Response Shape in OGTT With Markers of Pancreatic Health and Inflammation Across Diverse Ages
The time of the hypertonic saline infusion test for the diagnosis of AVP deficiency can be shortened with LC-MS/MS
Tolvaptan vs Fluid Restriction in Moderate-Profound Hyponatremia: An Open-Label Randomized Clinical Trial
Thyroid function and all-cause mortality in the context of multimorbidity: results from two population-based studies
Clinical Characteristics and Outcomes of Graves’ Disease in Individuals with Prior Hypothyroidism
Basal cortisol as a predictor of passing Short Synacthen Test and the utility of the 60-minute post-stimulation cortisol
Hyperglycemic Hypernatremic Hypertonic State: A Predominant HHS Subtype and Its Clinical and Diagnostic Features
Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism
Myofibrillar Protein Synthesis Rates Do not Differ With Low and High Estradiol Concentrations Across the Menstrual Cycle
The Significance of High Expression of Circulating miR-222-3p in Patients With Unilateral Primary Aldosteronism
A PTH Value at 6 Hours Postsurgery Predicts the Diagnosis of Transient and Permanent Hypoparathyroidism
Course of Pregnancies and Occurrence of Acute Pancreatitis in Women With Chylomicronemia
Therapeutic Plasma Exchange and Changes in Calcium, Phosphate, Parathyroid Hormone, and Fibroblast Growth Factor-23
Trends of Diabetes in Youth (TrenDY) during COVID-19 across the United States
Expanded Steroid Profiling Identifies Novel Newborn Screening Markers for Congenital Adrenal Hyperplasia
Impact of Abdominal and Thigh Intermuscular Adipose Tissue on Glucose and Cardiometabolic Risk in Adults With Obesity
Measuring Hypothyroidism Disease Control Using a TSH-based “Time-in-range”
Near-Adult Height Outcomes in Patients Treated With rhIGF-1 for Severe Growth Failure: Real-World IGFD Registry Data
Incidence of Adrenal Masses Eventually Discovered in Patients Screened for Primary Aldosteronism
Circulating Gene Expression Assay as a Diagnostic and Prognostic Biomarker for Pancreatic Neuroendocrine Tumors in MEN1
Treatment of Hypothyroidism that Contains Liothyronine is Associated with Reduced Risk of Dementia and Mortality
The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications
Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study
Integrative Machine Learning Approach for Predicting Resistance to First-Generation Receptor Ligands in Acromegaly
Maturity-Onset Diabetes of the Young (MODY) in a Racially/Ethnically Diverse Pediatric Population
Genetics of Growth Hormone Deficiency: Insights from a Cohort of 203 Patients
Maternal Thyroid Function During Pregnancy and Early Adolescent Regional Differences in Cerebral Gray Matter Morphology
Defining puberty and spectrum of hypogonadism in Alström Syndrome
PHEX Protein in the Parathyroid Gland Contributes to Phosphate Sensing
Clinical and Genetic Characteristics of Adult Nonautoimmune Hypothyroidism: A Single-Institution Study
Multiple or Single Endocrine Abnormalities Associated With Immune Checkpoint Inhibitors
Prediabetes Subgroups, Type 2 Diabetes Risk, and Differential Effects of Preventive Interventions
Fragility of Evidence for the Efficacy of Anti-Fracture Medications
Coproporphyrinogen oxidase deficiency causes primary adrenal insufficiency and 46,XY DSD
Influence of Preexisting Psychiatric Morbidity on Liothyronine Use in Hypothyroidism: A Swedish Nationwide Cohort Study
TSH Receptor Antibody Test Utilization Patterns from a National Reference Laboratory: TRAb, TSI, or Both?
Hair Cortisone Levels and the Metabolic Syndrome: Stronger Links in Younger Compared to Older Adults
A missense mutation in close proximity of ALS-linked PFN1 mutations causes only early-onset Paget’s disease of bone
The USP8 Mutational Status in Combination With Postsurgical Cortisol Levels for Predicting Recurrence of Cushing Disease
Clinical Characteristics and Response to Growth Hormone Treatment in 27 Children With Heterozygous NPR2 Variants: Real-World Data
MCT8 Deficiency in Females
CCNA2 and CCND2 are differentially involved in β-cell proliferation in perinatal Japanese autopsied subjects
Hypothyroidism in Danish Pregnant Women Across Decades
High-Throughput Proteomics and Immunohistochemistry of Orbital Connective Tissue in Graves’ Orbitopathy
Role of Sex Hormones in Mediating Adiposity Changes From Weight Loss in People With Type 2 Diabetes: Look AHEAD Sex Hormone Study
Controlled Antenatal Thyroid Screening Study III: Effects of Gestational Thyroid Status on Brain Microstructure
Thyrotrophin Receptor Antibody: Objective and Quantitative Inflammatory Indicator in Patients With Thyroid Eye Disease
The Combination of Aromatase Inhibitors and GH Treatment for Idiopathic Short Stature in Male Adolescents
Optimal Levothyroxine Dosing Strategy for Immune Checkpoint Inhibitor-related Hypothyroidism: A Retrospective Study
Reassessing the Role of Copeptin in Emergency Department Admissions for Hypotonic Hyponatremia
Arginine-Vasopressin Dynamics in Relation to Food Intake and 8-Week Intranasal Oxytocin Treatment in Adults With Obesity
Serum 5-Hydroxyindoleacetic Acid Measurements for the Diagnosis and Follow-up of Carcinoid Syndrome
Regional Brain Structure Alterations in Diabetes but Not Prediabetes: the Shanghai Changfeng Study
Effectiveness of the Dual GIP/GLP1-Agonist Tirzepatide in 2 Cases of Alström Syndrome, a Rare Obesity Syndrome
73
Skin-resident Langerhans cells drive neuropathic pain via chemokine-dependent neuron-immune communication
Overnutrition in mice impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations
Variants in human CD48 lead to impaired T-cell immunity and increased inflammation
Rapid and profound decay of inducible and intact HIV genomes in early treated Thai children
Epigenetically controlled endothelial promyelocytic leukemia drives liver inflammation and fibrosis
Sex and ovarian hormone cycles alter effects of stimulant drugs on mouse dopaminergic signaling
Chloride homeostasis dysfunction drives hyperactivation of corticotropin-releasing factor-expressing neurons in the amygdala in stress-induced hypertension
Smac mimetic combined with eCD4-Ig reverses latency without reducing SHIV reservoirs in rhesus macaques
Estrogen deficiency and risk of hearing loss in pediatric Turner syndrome
RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis
MEK inhibitor Mirdametinib promotes fracture healing in osteofibrous dysplasia RASopathy
α4 Integrin blockade impairs CD8+ T cell neuroimmune surveillance following SIV infection
Distinct HIF1α and HIF2α functions control skeletal muscle metabolism and erythropoiesis
Postnatal Slc26a4 gene therapy improves hearing and structural integrity in a hereditary hearing loss model
Immune correlates of HIV-1 rebound during broadly neutralizing antibody treatment in young children
Variation in antiviral immunity and inflammation pathways precedes HIV-1 infection in a high-risk African cohort
Distinct neuronal alterations distinguish two subtypes of sporadic Creutzfeldt-Jakob disease with shared dysfunctional pathways
A Trypanosoma cruzi trans-sialidase peptide demonstrates high serological prevalence among infected populations across endemic regions
Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK–STAT signaling
Reduced glycoprotein hormone β-5 links male aging and testosterone decline to increased adiposity
Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis
A protein-based pneumococcal vaccine elicits broad immunity associated with multifunctional antibody responses in humans
Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound
Concomitant COX-1 and COX-2 suppression is not sufficient to induce enteropathy associated with chronic NSAID use
Dermal fibroblasts respond to IL-4 and IL-13 and promote T cell recruitment in atopic dermatitis
A midbrain–cortical circuit mediated by claustrum neuronal ensemble orchestrates drug-paired context memory processing
Higher drinking frequency corresponds to lower synaptic density in people with alcohol use disorder
Single cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes
Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver–induced hepatocellular carcinoma by driving ITGB1-mediated β-catenin activation
Functional Characterization of SDHB Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships
Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis
Subcutaneous white adipose tissue–derived extracellular vesicles maintain intestinal homeostasis via IgA biosynthesis in aging mice
Secretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity
Selective targeting of HIV infected clones by cognate peptide stimulation and antiproliferative drugs
Stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress
BAF60a-dependent chromatin remodeling preserves β-cell function and contributes to the therapeutic benefits of GLP-1R agonists
Distinct colitis-associated macrophages drive NOD2-dependent bacterial sensing and gut homeostasis
SGLT2 inhibition protects kidney function by SAM-dependent epigenetic repression of inflammatory genes under metabolic stress
Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritis
Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes
Fatty acid transport protein-2 inhibition enhances glucose tolerance through α-cell-mediated GLP-1 secretion
Endothelial STING and STAT1 mediate IFN-independent effects of IL-6 in an endotoxemia-induced model of shock
TIE2 activation by antibody-clustered endogenous angiopoietin-2 prevents capillary loss and fibrosis in experimental kidney disease
Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome
A pathogenic variant of AMOT leads to isolated X-linked congenital hydrocephalus due to N-terminal truncation
Intermittent ischemia/reperfusion as a potent insulin-sensitizing intervention via blood flow enhancement and muscle decanoyl-l-carnitine suppression
Histamine H1 receptor inverse agonists improve structure and pain in an osteoarthritis mouse model
Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models
A noncanonical parasubthalamic nucleus–to–extended amygdala circuit converts chronic social stress into anxiety
Pharmacological targeting of the IL-17/neutrophil axis attenuates calcific deposits in rat models of calciphylaxis
Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity
An IFN/STAT1/CYBB axis defines protective plasmacytoid DC–neutrophil crosstalk in Aspergillus fumigatus–infected mice
Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression
The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation
Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus
NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models
Cancer-associated SPOP mutations enlarge nuclear size and facilitate nuclear envelope rupture upon farnesyltransferase inhibitor treatment
Efficacy and safety of a therapeutic humanized FSH–blocking antibody in obesity and Alzheimer’s disease models
Gut-specific histamine 3 receptor signaling orchestrates microglia-dependent resolution of peripheral inflammation
Purinergic signaling modulates CD4+ T cells with cytotoxic potential during Trypanosoma cruzi infection
Angiopoietin-like protein 2 mediates vasculopathy driven fibrogenesis in a mouse model of systemic sclerosis
SOX2 regulates foregut squamous epithelial homeostasis and is lost during Barrett’s esophagus development
Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis
Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates
The macrophage-intrinsic MDA5/IRF5 axis drives HIV-1 intron-containing RNA-induced inflammatory responses
B cell deficiency induces cytotoxic memory CD8+ T cells during influenza-associated bacterial pneumonia
CXCL10 secreted by SPRY1-deficient epidermal keratinocytes fuels joint inflammation in psoriatic arthritis via CD14 signaling
The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity
The tumor microenvironment of non–small cell lung cancer impairs immune cell function in people with HIV
Trapα deficiency impairs the early events of insulin biosynthesis and glucose homeostasis
Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease
GluN2B suppression restores phenylalanine-induced neuroplasticity and cognition impairments in a mouse model of phenylketonuria
NK cell activation and CD4+ T cell α4β7 expression are associated with susceptibility to HIV-1
14
Postoperative Hepatic Arterial Infusion With Oxaliplatin After Surgery of Four or More Colorectal Liver Metastases: A Randomized Phase II Trial.
Results From the Genetic Information and Family Testing Study: A Cluster-Randomized Trial.
Fullerene for Reducing Acute Radiation Dermatitis in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Phase II, Double-Blind, Randomized Controlled Trial.
Phase II Clinical Study of Adebrelimab and Bevacizumab Combined With Cisplatin/Carboplatin in Patients With Triple-Negative Breast Cancer With Brain Metastases (ABC Study).
Nivolumab ± Ipilimumab in Patients With Pretreated Advanced Neuroendocrine Carcinoma: The GCO-001 NIPINEC Randomized Phase II Trial.
Axitinib and Long-Acting Octreotide in Advanced Extrapancreatic Neuroendocrine Tumors: A Randomized, Double-Blind, Placebo-Controlled, Phase III Clinical Trial (AXINET, GETNE 1107).
Alliance A222001: Oxybutynin Versus Placebo for the Treatment of Hot Flashes in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer.
New Validated Staging System for Light Chain (AL) Amyloidosis With Stage IIIC Defining Ultra-Poor Risk: AL International Staging System.
Randomized Phase II Trial of Pazopanib Versus Placebo in Patients With Advanced Extrapancreatic Neuroendocrine Tumors (Alliance A021202).
Response-Adapted Surgical and Radiotherapy De-Escalation in Resectable Cutaneous Squamous Cell Cancer Using Pembrolizumab: The De-Squamate Study.
Stereotactic Radiosurgery in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases: A Multi-Institutional, Phase II, Prospective Clinical Trial.
Phase II (Alliance A091802) Randomized Trial of Avelumab Plus Cetuximab Versus Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma.
Randomized Phase Ib Clinical Trial of DB-020 Intratympanic Injections to Reduce High-Dose Cisplatin Ototoxicity.
Development and Validation of a Novel Prediction Model for Hearing Loss From Cisplatin Chemotherapy.
17
Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment
Immune profiling links autoimmune hepatitis to human herpesvirus 6 and relaxin receptor antigens
Transcription of HIV-1 is heterogenous among authentic latent CD4+ T cell clones
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood
Dynamics of natural and pharmacologic control of an SIV variant with an envelope trafficking defect
Xbp1 controls the reparative function of intestinal ILC2s during colitis
Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state
A high-throughput zebrafish screen identifies novel candidate treatments for kaposiform lymphangiomatosis (KLA)
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes
Structural and genetic basis of HIV-1 envelope V2 apex recognition by rhesus broadly neutralizing antibodies
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis
Neonatal microbiota colonization primes maturation of goblet cell–mediated protection in the pre-weaning colon
iPlasmodium falciparum/i infection induces T cell tolerance that is associated with decreased disease severity upon re-infection
Breast cancer gene-1 (BRCA1) potentiates maladaptive repair after kidney injury
Identification of a seasonal influenza vaccine–induced broadly protective neuraminidase antibody
Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patients
HMCN1 variants aggravate epidermolysis bullosa simplex phenotype
34
Quantitative regression of qFibrosis with resmetirom: Exploratory histologic endpoints from the MAESTRO-NASH phase III clinical trial
Kupffer cell plasticity regulates hepatic immunity in mycobacterial infection
Genetic evidence that FGF21 signaling reduces problematic alcohol use and alcohol‐related liver disease
Global epidemiology of bacterial infections in patients with cirrhosis: A systematic review and meta-analysis
Longitudinal changes in cardiometabolic risk factors are associated with changes in liver stiffness in adults with MASLD
Incidence and implications of abstinence-induced recompensation in alcohol-related cirrhosis
Use of intracranial pressure monitoring and risk factors for the development of intracranial hypertension in acute liver failure
Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis
Intratumour Ploidy Heterogeneity and Clonal Evolution in Hepatocellular Carcinoma
Predicting hepatic decompensation using non-invasive tests in a contemporary multicentre cohort of patients with cACLD
Utilization of liver grafts obtained from donation after medical assistance in dying: A Canadian multicenter experience
Refining the Baveno VII criteria for clinically significant portal hypertension: an individual-patient data meta-analysis
Microbial metabolism dysfunction induced by transarterial chemoembolization aggravates postprocedural liver injury in HCC
Consensus position statements for the standardized application of histological grading and staging systems in MASH clinical trials
Prognostic value of liver stiffness measurement vs. biochemical response in primary biliary cholangitis
Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis
Phase II INTEGRIS-PSC trial of bexotegrast, an αvβ6/αvβ1 integrin inhibitor, in primary sclerosing cholangitis
Risk of alcohol-related liver disease and cause-specific mortality in individuals seeking treatment for alcohol use disorder
Alcohol activates ATF4/LPLA2-mediated BMP metabolism to enhance HBV-induced hepatocellular carcinogenesis
Effect of Hypertension on Long-term Adverse Clinical Outcomes and Liver Fibrosis Progression in MASLD
Identification and validation of RIPK3 as a novel biomarker to predict outcomes in patients with acutely decompensated cirrhosis
Patient-derived liver organoids recapitulate liver epithelial heterogeneity and enable precision modeling of alcohol-related liver disease
Rivaroxaban to prevent complications of portal hypertension in cirrhosis: The CIRROXABAN study
B cells drive CCR5+CD4+ tissue-resident memory T cell cytotoxicity via IL-15Rα-IL-15 signaling in primary biliary cholangitis
Effect of rifaximin in patients with severe cirrhosis and ascites: A randomized double-blind placebo-controlled clinical trial
Prevalence, severity and determinants of steatotic liver disease among individuals with metabolic and alcohol risk from the community
Impact of first and further decompensation in patients with compensated ACLD due to MASLD
Efficacy and safety of time-restricted eating in metabolic dysfunction-associated steatotic liver disease
Clinical utility of phosphatidylethanol to detect underreported alcohol use and enhance steatotic liver disease subclassification
Dissecting metabolic dysfunction- and alcohol-associated liver disease (MetALD) using proteomic and metabolomic profiles
Personalized survival benefit estimation from living donor liver transplantation with a novel machine learning method for confounding adjustment
Cause-specific mortality in patients with steatotic liver disease in the United States
A non-inferiority randomised controlled trial of a Shorter Acetylcysteine Regimen for Paracetamol Overdose – the SARPO trial.
Safety and efficacy of elafibranor in primary sclerosing cholangitis: The ELMWOOD phase II randomized-controlled trial
203
Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control
Schistosoma mansoni Infections Are Associated With Fecal Calprotectin Markers of Gut Inflammation After Accounting for HIV, Hepatitis B, and Malaria
A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage
<atl>Asymptomatic screening for iNeisseria gonorrhoeae/i among gay and bisexual men attending public sexual health services in Australia and associations with patterns of ceftriaxone consumption: a retrospective observational study</atl>
<atl>Hidden Infections, Emerging Resistance: Underdiagnosed iPlasmodium vivax/i and multidrug resistance-1 ( ipvmdr1/i ) gene Amplification in the Guiana Shield</atl>
Comparison of Immune Activation and Gut Barrier Dysfunction between Long COVID and HIV infection
<atl>A Genomic Analysis of Community-Associated iC. Difficile/i Infection Demonstrates Integration With National and International Strain Clusters and Limited Direct Transmission</atl>
Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity
Genomic Surveillance Reveals Emergence and Spread of Macrolide-Resistant Mycoplasma pneumoniae in Australia During the 2023–2024 Epidemic
The Natural History of Mycoplasma genitalium in the Pharynx and Rectum in a Cohort of Men Who Have Sex With Men: Prevalence, Incidence, Duration, and Symptoms
<atl>Predicting risk of iPlasmodium vivax/i microscopy-detected episodes using serological markers in patients with iPlasmodium falciparum/i malaria: a multi-country diagnostic performance evaluation</atl>
Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study
Incidence of Herpes Zoster Infection (Shingles) Among Adults Living With and Without HIV in British Columbia, Canada: A Population-Based Study
Real-world effectiveness of sequential pneumococcal vaccination in older adults: a cohort study
Identification and Validation of Rhizopus-Specific Glucoamylase as a Novel Biomarker for Diagnosing Mucormycosi
Treatment Monitoring and Outcome Prediction in Invasive Aspergillosis Using Immunologic Markers
Middle East Respiratory Syndrome Coronavirus–Specific T-Cell Responses in Dromedary Camel Abattoir Workers in Nigeria Suggests Frequent Zoonotic Spillover
Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia
2024-2025 COVID-19 mRNA Vaccine Effectiveness against Severe Disease
Safety, tolerability, and pharmacokinetics of 6-diazo-5-oxo-L-norleucine (DON) in Malawian adults with and without malaria: a Phase I dose-escalation clinical trial
RNA Polymerase III suppresses varicella zoster virus in human neurons
Gut Microbiota and Intestinal Monodomination as a Predictor for Bacteremia in Allogeneic Hematopoietic Cell Transplant Recipients
Addition of Clofazimine Enhances the Activity of Standard Treatment Regimen in a Mouse Model of Tuberculous Meningitis
Longitudinal symptom transitions predict incident tuberculosis risk in serial active case finding
Association of Plasma Biomarkers of Immunothrombosis With Death in Patients With Coronavirus Disease 2019 on Extracorporeal Membrane Oxygenation
Optimizing On-Demand Tenofovir Disoproxil Fumarate/Emtricitabine Dosing in Women for HIV Prevention
Immune-Based Cytokine Signatures of Prolonged Pandemic-Associated Chilblains
Molecular and Serological Evidence of Oropouche Virus Circulation in Asymptomatic Blood Donors During the 2023–2024 Outbreak in Manaus, Brazil
Variable Staphylothrombin Activity in Staphylococcus aureus Bloodstream Infections
Efficient sensing of a four-segmented Rift Valley fever virus vaccine candidate by human monocytes
Increased Diversity and Introduction of Multidrug-Resistant Strains of Neisseria gonorrhoeae Following Cessation of COVID-19 Pandemic–Related Travel Restrictions: An Observational Genomic Epidemiologic Study
Mitochondrial Haplogroups and Left Ventricular Diastolic Dysfunction in People Living with and without HIV
The Influence of National Antibiotic Consumption on Neisseria Gonorrhoeae Antibiotic Resistance in Norway, 2003–2024
Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for TB Meningitis
<atl>Optimized Mass Spectrometry to Uncover iM. tuberculosis/i Biomarkers in Extracellular Vesicles from Asymptomatic Tuberculosis Patients</atl>
Epidemiological, clinical, and virological characterizations of Yezo virus infections, an emerging tick-borne orthonairovirus disease in Japan
Unsuppressed viraemia and lower CD4 count associated with faster telomere attrition in African children with perinatal HIV on long-term antiretroviral therapy
Frailty in People with HIV is Linked to Inflammation, Bone Health, and T cell Exhaustion
Influence of Chlamydia trachomatis Sequence Variation on pgp3 Antigenicity
Genomic Evolution of Influenza A Virus During the 2024-2025 Season, the Johns Hopkins Health System: Antigenic Drift Reduces Serum Neutralization
Limited sex-based differences in viral outcomes of ART-treated SIV/SHIV infection
Dynamics of Intact and Defective Human Immunodeficiency Virus Type 1 (HIV-1) Proviruses During Decades of Suppressive Antiretroviral Treatment in Young Adults With Perinatal HIV
High Prevalence and Genotypic Diversity of Persistent Chlamydia Trachomatis Infections Among South African Adolescent Girls and Young Women: A Tale of Two Cities
Repeat influenza vaccination effects in 2021/22 and 2022/23 in a community-based cohort in Hong Kong
Influenza vaccination effectiveness against influenza-associated hospitalization in children and the effects of repeated vaccination
Mycobacterium tuberculosis–Specific CFP-10/ESAT-6 CD4 and CD8 T-Cell Non-IFN-γ+ Responses Are Common in Young Kenyan Children Despite Low Reported Tuberculosis Exposure
Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress
Inflammasome activation and oxidative stress in SARS-CoV-2 infection and symptomatic rebound
A monovalent SMAC mimetic as a potential host-directed therapy for tuberculosis
Mitochondrial DNA Fragment Dynamics in Acute and Chronic Human Immunodeficiency Virus: Insights From Human and Nonhuman Primate Models
Longitudinal changes in cognition and brain imaging in persons with HIV
Cross-reactive H5N1 neuraminidase antibodies by age and influenza A imprinting cohorts of the past century: population-based serosurvey, British Columbia, Canada
The Effect of a 5-Day Course of Azithromycin on Streptococcus Pneumoniae Carriage and Antimicrobial Resistance Among Kenyan Children Discharged From Hospital
Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
CSF Hypo-Inflammation Drives Mortality in HIV-Associated Tuberculous Meningitis
Persistent T Cell Immunity following Nipah Virus Infection: Evidence from Malaysian Survivors
Incidence and Severity of Postacute Sequelae of SARS-CoV-2 Infection in the Omicron Era: A Prospective Cohort Study
Functional and transcriptional senescence profiles of CD8+ T cells associate with the presence of carotid plaques in people living with HIV
Estimating HIV-1 Viremic Time from Reservoir Sequence Diversity with Uncertainty Quantification
Douching Is Associated With Dysregulated Rectal Mucosal Immunity in Sexual Minority Men
A threshold in anti-EBNA-1 antibody titers distinguishes salivary EBV shedders from non-shedders
Quantifying the role of importation on sustained malaria transmission in a low-to-moderate burden region of Southwest Uganda
TRAF1 Inhibits Macrophage Killing of Sporothrix schenckii by Enhancing NOS2 Expression and Activity
Methicillin-Resistant Staphylococcus aureus Bacteremia Relapses Show Diverse Genomic Profiles but Convergence in Bacteremia-Associated Genes
Efficacies of Sequenced Monotherapies of Mycobacterium avium Lung Infection in Mouse
In Vivo Risk Assessment of Yellow Fever Virus Transmission Through Breastfeeding, and Mechanistic Insights
Weekly Oral Prophylaxis With MK-8527 Protects Rhesus Macaques From Intrarectal Challenge With Simian–Human Immunodeficiency Virus
Microbial Dominance in Diabetic Foot Osteomyelitis using Nanopore Sequencing Techniques Predicts Positive Response to Surgical Intervention
IL-4 Correlates With Bone Mineral Density in Men, and IL-4 Depletion May Drive Bone Loss in Men With HIV
Chronic malaria is associated with trauma-related splenic rupture requiring splenectomy
Digital anorectal examination to self-detect primary syphilis: a prospective cohort study
Defining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea
Manufacture of Clostridioides difficile Spores for Experimental Infection of Human Volunteers
Anti-neuraminidase antibody responses in older adults after consecutive vaccinations with enhanced influenza vaccines: a randomized controlled trial
Durability of the Mumps Antibody Response After the Third Dose of MMR Vaccine
Partial post-exposure protection by topical inserts containing tenofovir alafenamide fumarate/elvitegravir in a macaque model of rectal SHIV infection
The Impact of Corticosteroid Therapy on West Nile Virus-Infected Patients: A Retrospective Cohort Study
Improved immune response against influenza A viruses with receipt of a recombinant influenza vaccine in healthcare personnel with prior low antibody response to egg-based influenza vaccines, Israel, 2019-20
Chlamydia trachomatis-specific T Cell Immunity Reflects Widespread Exposure in South African Adolescents and Young Women
Long-Acting Antiretroviral Therapy for Breastfeeding Women With HIV Experiencing Barriers to Adherence in Zimbabwe: Modeling Clinical Impact and Cost-effectiveness
A Phase 1 Double-Blinded Trial to Evaluate Safety, Immunogenicity, and Dosing of Measles-Vectored Chikungunya Virus Vaccine (MV-CHIK) in Healthy Adults
New Viability Assays for Acanthamoeba castellanii Trophozoites and Cysts Allow Rapid Assessment of Drug Activity
[18F]Fluorodeoxyglucose Positron Emission Tomography for Diagnosis and Monitoring of Acute Staphylococcus aureus Vascular Graft Infection in a Rat Model
<atl>Safety and immunogenicity of a iKlebsiella pneumoniae/i tetravalent bioconjugate vaccine (Kleb4V) administered to healthy adults: A first time in human phase I/II randomised and controlled study</atl>
Large Reductions in Invasive Pneumococcal Disease and Related Morbidities Among Children in New Zealand After Change from PCV10 to PCV13
Evaluation of Phenotypic and Genotypic Susceptibility Testing Methods for Newer β-lactam/β-lactamase Inhibitor Combinations in Multidrug Resistant Pseudomonas aeruginosa
<atl>Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam against Metallo-β-Lactamase-Producing Carbapenem-Resistant iAcinetobacter baumannii/i : A Genomics-Informed Mechanism-Based Model</atl>
STAT1, STAT2 and T Cells Mediate Interferon-Dependent Protection Against Neurobrucellosis
Estimation of prevention-effective CAB-LA concentrations among men who have sex with men (MSM) and transgender women (TGW) in HPTN 083
Resistance Analysis of Low-Level Virologic Rebound During HIV-1 Treatment with Lenacapavir and Broadly Neutralizing Antibodies Teropavimab and Zinlirvimab
Adenovirus 40 and 41 antibodies associated with protection from infection in a Bangladeshi birth cohort
Childhood tuberculosis and risk of frailty in later life: evidence from a nationally representative study in Brazil
Cabotegravir and Rilpivirine concentrations and HIV-1 RNA suppression in genital fluids and rectum in people with HIV on long-acting intramuscular Cabotegravir plus Rilpivirine antiretroviral therapy
Gut microbiota predicts the risk of future COVID-19 hospitalization and mortality: insights from the population-based HELIUS Study
Non-invasive detection of occult yet significant liver pathology in ALT-normal chronic hepatitis B: a multicenter study
Natural History of Nipah Virus in Hamsters: Strain, Route, and Sex-Associated Variability Characterized using Large Datasets to Inform Pre-Clinical Study Design
Characteristics and Antiadhesion Activity of Chicken Single-Chain Fragment Variable Antibodies Against Helicobacter pylori Adhesin
HIV Reservoir Dynamics and Bacteriome Composition Along the Gut Axis
Establishment of a Cynomolgus Macaque Model for Human Adenovirus Type 55–Induced Respiratory Disease
Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies
Foreign Combatants Wounded in Ukraine colonized by Extensively Drug-Resistant organisms: A Potential Source of Global Dissemination
Serum IgG1 and IgG3 Antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in Men of Subfertile Couples
Relationship Between Group 3 Innate Lymphoid Cells and Th17 in Human Nasopharynx-Associated Lymphoid Tissue and the Association With Pneumococcal Carriage
Refined transgenic mouse models which recapitulate the natural features of chronic wasting disease with rapid prion disease onsets
Evaluating the impact of unadjusted confounding and study design on estimated pathogen-attributable diarrhea incidence among children in the MAL-ED cohort
Decreased Microbiota-Driven Tyrosine Metabolism Is Associated With Symptomatic COVID-19 in Children
A randomized phase 1 study investigating gut microbiome changes with moxifloxacin vs. oral vancomycin: Implications for iClostridioides difficile/i risk
Autoantibodies Against Type I Interferons are a Prominent Feature in SARS-CoV-2 Fatal Disease and Hospitalization
Single-cell transcriptome profiling reveals the immune dysregulation characteristics of mice infected by iBrucella abortus/i
A Framework for Assessing the Opportunity for Advanced Research, Development, and Regulatory Approval of Medical Countermeasures: A Component of BARDA’s Emerging Infectious Diseases Strategy
Trichomonas vaginalis Among Cisgender Women Taking Doxycycline Postexposure Prophylaxis
Prevalence of Candidate Vaccine Targets and Genomic Features of Pediatric Invasive Streptococcus Agalactiae in Japan
Increased plasmacytoid dendritic cells and inflammation persist in people with HIV years after tuberculosis
The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial
Insights on Recurrent and Sequential iClostridioides difficile/i Infections From Genomic Surveillance in Minnesota, USA, 2019–2021
iNAT/i2 Polymorphisms and Antituberculosis-Induced Hepatotoxicity in Thai People Living With HIV: Insights From a Pharmacogenetic–Pharmacokinetic Cohort Study
Seasonal Variation and Interspecies Dynamics Among Plasmodium falciparum and ovale Species in Bagamoyo, Tanzania
Real-world Prevalence of Nonintegrase INSTI Resistance-Associated Mutations and Virological Outcomes in People Who Have Recently Acquired HIV-1 in the United Kingdom
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV
Mesenteric Ischemia and Bacterial Translocation Precipitate the Intoxication Phase of Yellow Fever
Disparate Kinetics of Viable Virus Shedding in Immunocompromised Patients: SARS-CoV-2 Versus Influenza Virus—A Prospective Real-World Cohort Study
Updating the Epidemiology of Blastomycosis and Histoplasmosis in the United States, Using National Electronic Health Record Data, 2013–2023
Gene Editing of a Carcinogenic Liver Fluke Tetraspanin Impairs Parasite Surface Biogenesis and Extracellular Vesicle Uptake by Human Host Cells
The Source-Sink Dynamics of iPlasmodium vivax/i May Undermine Malaria Elimination Efforts in the Amazon: An Epidemiological and Population Genomic Study
VH3810109 Efficacy, Safety, Pharmacokinetics, and Incidence of Antidrug Antibodies in Adults With HIV-1 Naive to Antiretroviral Therapy: BANNER Study Results
Prevalence of Symptoms Associated With Long COVID Among Adolescents in the United States, Summer 2022
c-Myc inhibits macrophage antimycobacterial response in iMycobacterium tuberculosis/i infection
Genetic Landscape of a Cohort of Children With Varicella Zoster Virus Encephalitis, Cerebellitis, and Stroke
How iCYP2D6/i Polymorphism Modulates the Community-Wide Risk of iPlasmodium vivax/i Infection: A Panel Study in Amazonian Brazil
Molecular Epidemiology of Clinical Infections Caused by Serratia marcescens Complex in a Tertiary Care Hospital System: Insights From Whole-Genome Sequencing
Virological and Immunological Outcomes of Combined Therapeutic Interventions and Dendritic Cell Therapy in People With HIV
Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary iClostridioides difficile/i Isolates
Relative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccination Against Hospitalizations and Deaths According to Frailty Score: A Post Hoc Analysis of the DANFLU-1 Randomized Trial
Alterations of the Upper Respiratory Microbiome Among Children Living With HIV Infection in Botswana
Emergence of Two New Lineages of the Cosmopolitan Dengue Virus Serotype 2 in Yunnan, China, 2024
Real-world Effectiveness of the Adjuvanted Recombinant Zoster Vaccine in ≥50-year-old Adults With Autoimmune Diseases
Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage
Impact of Case Detection and COVID-19-Related Disruptions on Tuberculosis in Vietnam: A Modeling Analysis
Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses
Influenza-associated excess mortality associated with influenza B in Hong Kong, 2014-2023
Deriving Dosages for Levofloxacin Tuberculosis Preventive Treatment for Young People Exposed to Rifampicin-Resistant Tuberculosis
Brain imaging and whole blood targeted transcriptomic analyses to characterise cerebral infarctions in children with tuberculous meningitis
Comparability of gastrointestinal microbiome and bile acid profiles in patients with first or multiply recurrent iClostridioides difficile/i infection
Robust COVID-19 Mortality Risk Assessment: Validation of a Two-Step Algorithm from the National COVID Cohort Collaborative
Association of a novel IgG3 allele with malaria in children from the Sepik region of Papua New Guinea
Pneumococcal serotype distribution and coverage of existing and pipeline pneumococcal vaccines
Longterm kinetics of vibriocidal antibody responses after iV. cholerae/i infection in the Democratic Republic of Congo
External validation of paediatric pneumonia and bronchiolitis risk scores to predict mortality in children hospitalised in Kenya: a retrospective cohort study
Plasma Proteomics Reveals Distinct Signatures in Occult and Microfilaremic Loa loa Infections
Elimination of HIV Reservoirs Harboring Intact Proviruses
Impact and Cost-effectiveness of Regular Self-digital Anorectal Examination on Syphilis Among Gay, Bisexual, and Other Men Who Have Sex With Men: A Mathematical Modeling Study
Bacterial and Viral Coinfections in Adult Patients Hospitalized With COVID-19 Throughout the Pandemic: A Multinational Cohort Study in the EuCARE Project
Rapid High-Sensitivity Detection of Antibodies to iTrypanosoma cruzi/i With a Recombinant Tc24 Antigen-Based Magneto-Immunoassay: A Pilot Study
Transcriptome Analysis of Monocytes Treated With Dengue Virus Nonstructural Protein 1 Revealed a Shift in Transcripts Involved in Self-Propagated Proinflammation and Antiviral Responses
Antiviral Monocytes Increase Prior to Detectable HIV-1 Rebound Viremia
Leveraging Lyme Disease Surveillance to Simulate Powassan Virus Prevalence
Structure of ClfA002 in Complex With Neutralizing Antibody AZD7745 Provides Insight into Its Broad Neutralization Mechanism in iStaphylococcus aureus/i Infection
Risk assessment of Oropouche virus transmission by mosquitoes in Europe
Global trends in antibiotic expenditure: analysis of pharmaceutical sales data, 2013 to 2023
Secreted Chorismate Mutase: A Novel Prognostic Factor in Mycobacterium intracellulare Pulmonary Disease
Single-Cell Transcriptomics Reveals Depletion and Dysregulation of Mycobacterium tuberculosis–Specific Th1 and Th17 Cells Early After Acquisition of Human Immunodeficiency Virus
Influenza-Specific T-Cell Responses to Vaccination Are Independent of Underlying Hematological Malignancy: Analysis of a Randomized Influenza Vaccination Trial
COVID-19 Risk in Patients with Autoimmune Diseases Using Biologics or Small Molecules: A Population-Based Cohort Study
Safety, Pharmacokinetics, and Acceptability of a Tenofovir Rectal Microbicide Douche Among Young Men Who Have Sex with Men: The DREAM ATN Study (ATN 163)
Risk of Cancer After Tuberculosis Disease Among People With HIV in Denmark: A Nationwide Population-Based Cohort Study
Safety and Diagnostic Performance of Recombinant Fusion Protein ESAT6-CPF10 Skin Test in A Large Population: A Phase 4 Clinical Trial
Long-acting Injectable Containing Lopinavir Eliminates Reliance on Ritonavir Pharmacokinetic Enhancement
Estimated US trends in SARS-CoV-2 spike antibody concentrations and correlation to risk of first-time infections based on blood donations, 2022
The Gut Microbiome and Its Resistome as Predictors of Clinical Infections and Phenotypic Antibiotic Resistance in Hematopoietic Stem Cell Transplant Recipients
Evaluating the Breadth and Reliability of Influenza Vaccine Protection Indicators: A Secondary Analysis of an Animal Challenge Trial
Elevated Soluble Urokinase-Type Plasminogen Activator Receptor Levels, Organ Dysfunction, and Death in Children Hospitalized With Malaria: Considerations for Use as a Risk Stratification Tool
Priming or Boosting iPlasmodium falciparum/i Transmission-Blocking Responses With Recombinant Vaccines or Gametocyte Extract
Newly Diagnosed Individuals in Molecular HIV-1 Clusters in Rhode Island Over 3 Decades
Cytolethal Distending Toxin-increased DNA damage and ploidy involve the YAP/TAZ-TEAD signaling pathway
Mitochondrial DNA Haplogroups, Biomarkers of Inflammation and Immune Activation, and Risk of Diabetes in Veterans With and Without Human Immunodeficiency Virus
Decrease in Incidence of Diarrhea Due to iCryptosporidium/i in Bangladeshi Children Is Associated With an Increase in Anti-iCryptosporidium/i Antibody Avidity
Deletion of Galectin-3 Renders Mice Less Susceptible to iCandida auris/i Skin Infection by Enhancing Antifungal Activity of Neutrophils
Reduced Metformin Concentrations in Obese Women With Human Immunodeficiency Virus Treated With Dolutegravir
Further Evidence for Plausible Transmission of Fishborne Trematodiases in the United States: Game Fish Carry Human-Infectious Trematodes and Are Eaten Raw
Host Determinants for the Spread of Panton-Valentine Leukocidin–Positive Staphylococcus aureus in Sub-Saharan Africa
Using Machine Learning Algorithms to Identify Key Predictors of Invasive Mold Infection Surveillance
The Effect of COVID-19 Vaccination on the Risk of Persistent Post–COVID-19 Condition: Cohort Study
Seroepidemiological Reconstruction of Long-term Rift Valley Fever Virus Circulation in Nouakchott, Mauritania
SARS-CoV-2 Infection of Human Lung Air-Liquid Interface Cultures Reveals Basal Cells as Relevant Targets
γ-Aminobutyric Acid-Induced Monocytic Reactive Oxygen Species Impair CD4 Restoration in Treated Adults With HIV-1
Anal Sex and Tenofovir Douche Sequence Impacts Colorectal Distribution of HIV Surrogate and Douche: DREAM-02
Longitudinal Analysis of Nasopharyngeal Microbial Risk Markers for Fatal Acute Febrile Illness in a Zambian Birth Cohort
Genome-Scale Meta-analysis of Host Responses to iStaphylococcus aureus/i Identifies Pathways for Host-Directed Therapeutic Targeting
Tracing the Origin of the 2022 Dengue Virus Epidemic in Karachi, Pakistan, Through Genome Analyses
Single-Cell Targeted Transcriptomics Reveals Subset-Specific Immune Signatures Differentiating Asymptomatic and Cardiac Patients With Chronic Chagas Disease
Estimating Zika Virus Seroprevalence in a Dengue Virus–Endemic Population: The Use of Blood Donors and Multiplex Serology to Monitor Arbovirus Outbreaks in the Dutch Caribbean
Evaluating the Diagnostic Utility of 16S Oxford Nanopore Technology Sequencing in Patients With Central Nervous System Infections and Its Usefulness in Antimicrobial Stewardship
Mind the Clinic-Community Gap: Re-evaluation of Test Performance and False Positive Results in Community-Wide Tuberculosis Screening
Seroprevalence of Dengue, Zika, and Chikungunya Viruses in Humans and Colocated Macaques in Thailand and Cambodia
Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants
Household Molecular Epidemiology of Streptococcus pyogenes Carriage and Infection in The Gambia
Estimating Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza Using Linked Public Health Information Systems, California, 2023–2024 Season
iStreptococcus pyogenes/i Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan
Gastrointestinal Dysmotility, Autonomic Function, and Small Intestinal Bacterial Overgrowth Among People With Well-Controlled HIV
Time to Reappraise the Antibiotic Treatment for Methicillin-Susceptible Staphylococcus aureus Infective Endocarditis: Data From the Experimental Model
Characterization of Serotype-Specific Dengue Virus T-Cell Inhibition
Safety, Tolerability, and Pharmacokinetics of Once-Monthly Oral Islatravir: A Phase 2a Study in Participants at Low Risk for Acquiring Human Immunodeficiency Virus Type 1
Heterogeneous Antiretroviral Drug Exposure in Male and Female Genital Tract Tissues
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The S1-insula Circuit Differentially Modulates Alcohol Drinking and Aversive Behavior in Mice
5imilar Response Dynamics Represent Opposite Behaviors and Rewards in Frontal Cortex
Controlling spatio-temporal sequences of neural activity by local synaptic changes
Primary Neural Degeneration after Cochlear Implantation: Histological and Electrophysiological Evidence from a Mouse Model
Motor-to-limbic design of direct synaptic communication between dopamine neurons in the midbrain
Epigenetic Repression of the Serotonergic Neuron Phenotype Following Adolescent Binge Drinking Is Restored through Inhibition of Proinflammatory Signaling by Exercise and Glycyrrhizic Acid
Insular input to the prelimbic cortex underlies social affective behavior in rats.
Optimal foraging requires coordinating decisions with movements
Timing, Movement, and Reward Contributions to Prefrontal and Striatal Ramping Activity
Activation by alcohol of prefrontal layer 5 pyramidal neurons depends on ascending dopaminergic input
Manifold Interactions between the Action-Mode Network and Sensorimotor Cortex during Human Motor Learning
Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training
Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans
Acceleration and Velocity Dissociate Temporal Phases of Postural Control in Rhesus Macaques
Improving emotion control in social anxiety by targeting rhythmic brain circuits
Repurposing Dexmedetomidine: Early Pharmacological Hypothermia Enhances Neuroprotection and Improves Locomotor and Bladder Functional Recovery After SCI
The co-modification of brain activity, functional connectivity and behavior following learning
GABA and Glx distinctively predict motor learning and retention in young and older adults
Neural Tuning for Ordinal Processing: Convergent Patterns in Human Brains and Artificial Networks
The Parafascicular Role in Updating Action from a Spatial to a Visual Strategy Is Driven by Its Glutamatergic Mesencephalic Locomotor Region Inputs
Corticotropin-releasing factor and somatostatin neurons in the central amygdala mediate dynamic defensive behaviors during fear extinction
Dopamine Dynamics in the Nucleus Accumbens Reflect Confidence in Detecting the Occurrence and Non-Occurrence of Visual Signals in Perceptual Decision-Making
Mesocorticostriatal reinforcement learning of state representation and value with implications for the mechanisms of schizophrenia
Anterior insula activity during alcohol and social reward self-administration and choice in male and female rats.
Integration of memory and sensory information in skilled sequence production
Punishments enhance reward learning by modulating striatal prediction errors
Edinger-Westphal neurons contribute to emergence from desflurane and sevoflurane anesthesia in mice
The tuned cortex: Convergent expertise-related structural and functional remodeling across the adult lifespan
Environmental enrichment preserves retrosplenial parvalbumin density and cognitive function in female 5xFAD mice
Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk
Causal Evidence for Prefrontal-Motor Coupling in Reward-Responsive Goal-Directed Behavior
Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery
Most Ventral Pallidal Cholinergic Neurons Are Bursting Basal Forebrain Cholinergic Neurons with Mesocorticolimbic Connectivity
A distinct circuit for biasing visual perceptual decisions and modulating superior colliculus activity through the mouse posterior striatum
Molecular signatures of Id2- and Ascl4-induced wiring of adult hippocampal neurons
Amelioration of Symptomatic Alzheimer’s Disease after Selective Impairment of p75NTR Function in Adult Forebrain Excitatory Neurons
Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy
Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging
Rostral Ventromedial Medulla (RVM) Projects to the Lateral Hypothalamic Area (LHA) to Drive Aversion and Anxiety
Dopamine responses in medial frontal cortex are more consistent with a generalized arousal signal than signed reward prediction errors.
Neuronal Activity Suppresses NEUROD-Dependent Transcription and Genome Organization
Neuronal features of visual attention in the mouse superior colliculus depend on learned behavioral relevance
Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
Specific Glutamatergic Projection to Claustrum for Regulating Methamphetamine Abstinence Anxiety-Like Behaviors
Reduced Pavlovian value updating alters decision-making in sign-trackers
Local neuronal ensembles that co-reactivate across regions during sleep are preferentially stabilized
Domain-general neural effects of associative learning and expectations on pain and hedonic taste perception
Functional near-infrared spectroscopy reveals functional rewiring between macaque motor areas following post-infarction recovery of manual dexterity
Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients
Prefrontal default-mode network interactions with posterior hippocampus during exploration
Is the whole the sum of its parts? Neural computation of consumer bundle valuation in humans
Medial Frontal Theta Reduction Impairs Rule Switching via Prediction Error
Chemogenetic Inhibition and Optogenetic Depotentiation of the Prelimbic Cortex to Paraventricular Thalamus Pathway Attenuate Abstinence-Induced Plasticity and Heroin Seeking in Rats
Altered regional brain activity underlying the higher postoperative analgesic requirements in abstinent smokers: A prospective cohort study
Behavioral relevance of early neural coding of low-level odor features in humans
Too little and too much: balanced hippocampal, but not medial prefrontal, neural activity is required for intact novel object recognition in rats
The psychedelic psilocin suppresses activity of central amygdala corticotropin releasing factor receptor 1 neurons and decreases ethanol drinking in female mice
Switching between newly learned motor skills
The Hidden Benefits of Noise: Low-Frequency tRNS and Dynamic Visual Noise Enhance Visual Processing
DMT-induced shifts in criticality correlate with self-dissolution
Experience-dependent plasticity to visual sequences in mouse anterior cingulate cortex reflects familiarity
Ventral striatal cholinergic interneurons regulate decision making or motor impulsivity differentially across learning and biological sex
Dual Role of LH-GABA Neurons in Encoding Alcohol Reward and Aversive Memories
Dopamine and temporal discounting: revisiting pharmacology and individual differences
Frontoparietal Hubs Leverage Probabilistic Representations and Integrated Uncertainty to Guide Cognitive Flexibility
Widely used CaMKII regulatory segment mutations cause tight actinin binding and dendritic spine enlargement in unstimulated neurons
Identifying Key Regulators in Odorant Receptor Trafficking
Differential and temporally dynamic involvement of primate amygdala nuclei in face reality and reward information processing
Complementary yet dissociable influences of medial and lateral orbitofrontal cortex over cue-guided decisions involving reward magnitude and uncertainty
Superior colliculus projections drive dopamine neuron activity and movement but not value
Noise-induced hearing loss enhances Ca2+-dependent electrical activity in lateral cochlear efferents
The Top-Down of Prefrontal Cortex to the Hippocampus Glutamatergic Pathway Regulates Reward Memory of Methamphetamine
Dissociable Neural Connectome Mapping of Reward and Punishment Responsiveness in Young Adults: Associations with Genetic Variability and Neurotransmitter Profiles
Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1)
Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking
Mediodorsal Thalamic Input to Striatum Contributes to Early Action Learning
Largely Intact But Less Reliable and Distributed Neural Representations of Subjective Value in Human Opioid Addiction
Reduction in Reward-Driven Behavior Depends on the Basolateral But Not Central Nucleus of the Amygdala in Female Rats
Striatal Gradient in Value-Decay Explains Regional Differences in Dopamine Patterns and Reinforcement Learning Computations
Acute Restraint Stress and Pain Modulation Depend on the Interaction between the Periaqueductal Gray and the Lateral Septum
Beta and High Gamma Oscillations in the Cortico-striatal Network Reflect Reward Certainty on a Probabilistic Reversal Learning Task
mWAKE in the Central Amygdala Regulates Fear Learning and Memory
Disrupted Neurogenesis from Basal Intermediate Precursor Cells Alters the Postnatal Neocortex in the TcMAC21 Mouse Model of Down Syndrome
Mechanisms of Long-Term Nonexternally Reinforced Preference Change: Functional Connectivity Changes in a Longitudinal Functional MRI Study
Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure
Motor Sequence Learning Involves Better Prediction of the Next Action and Optimization of Movement Trajectories
Altered Molecular Composition of a Specific Subset of Prefrontal Cortical Excitatory Synapses in Schizophrenia
Structural Regeneration and Functional Recovery of the Olfactory System of Adult Zebrafish Following Brain Injury
Stimulus contingency and task context encoding within the anterior cingulate-amygdala-cerebellum associative learning network
First application of a novel brain template: Motor training improves cortico-cerebellar connectivity in cerebellar ataxia
Impaired Online and Enhanced Offline Motor Sequence Learning in Individuals with Parkinson's Disease
Early cortical sensitivity and speeded target selection underlie incidentally learned prioritization of visual features
The orbitofrontal cortex underlies consolidation of Pavlovian anticipatory arousal responses in macaque monkeys
CaMKIIβ-mediated Phosphorylation Enhances Protein Stability of Spastin to Promote Neurite Outgrowth
Nicotine Withdrawal Drives Aversive Behaviors by Recruiting Inhibitory Interpeduncular Nucleus Inputs to the Laterodorsal Tegmentum in Mice
Stress-responsive neuronal ensembles and β-adrenergic signaling in the basolateral amygdala modulate the infra-limbic cortical activity and govern the delayed stress-induced fear extinction deficit.
Atypical Retinal Ganglion Cell Function in a Mouse Model of Fragile X Syndrome
Neurophysiological Evidence of Sensory Prediction Errors Driving Speech Sensorimotor Adaptation
Stress-sensitization of neurons in the dentate gyrus is dependent on neuronal interleukin-1 receptor signaling and is associated with increased synaptic plasticity, perineuronal nets, and excitatory/inhibitory input imbalance.
The Trembling Hand Unraveled: Motor Dynamics and Choice Inconsistency
Modulation of Dopamine Neurons Alters Behavior and Event Encoding in the Nucleus Accumbens during Pavlovian Conditioning
Phonological Representations of Auditory and Visual Speech in the Occipito-temporal Cortex and Beyond
Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis
HDAC3 Serine 424 Phospho-mimic and Phospho-null Mutants Bidirectionally Modulate Long-Term Memory Formation and Synaptic Plasticity in the Adult and Aging Mouse Brain
Basal forebrain-ventral tegmental area glutamatergic pathway promotes emergence from isoflurane anesthesia in mice
Oddball evoked deviant responses reflect complex context dependent expectations in mouse V1
Threonine-53 Phosphorylation of Dopamine Transporter Dictates κ-Opioid Receptor-Mediated Locomotor Suppression, Aversion, and Cocaine Reward
Exploring Neural Dynamics in the Auditory Telencephalon of Crows using Functional Ultrasound Imaging
Orbitofrontal-hippocampal state coding dynamics during reversal learning
Robustness of working memory to prefrontal cortex microstimulation
Specializations in amygdalar and hippocampal innervation of the primate nucleus accumbens shell
Chemogenetic disruption of monkey perirhinal neurons projecting to rostromedial caudate impairs associative learning
The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response
The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice
The molecular substrates of second-order conditioned fear in the basolateral amygdala complex
Time-Dependent Actions of Corticosterone on Infralimbic Cortex Pyramidal Neurons of Adult Male Rats
CXCL12 engages cortical inhibitory neurons to enhance dendritic spine plasticity and structured network activity
73
Neurophysiological sensitivity to envelope and pulse timing interaural time differences in cochlear implanted rats with different hearing experiences
Influence of age and biological sex on sweating in children exercising in warm and hot environments with comparison to adults
Oleuropein‐based olive leaf extract enhances muscle mitochondrial bioenergetics response to moderate – but not maximal – intensity exercise in humans
Diving into the unknown: Evidence of enhanced skeletal muscle lactate efflux potential and blood–muscle exchange in competitive breath‐hold divers
Angiotensin‐converting enzyme 2 enhances megalin‐mediated albumin endocytosis in proximal tubule cells by restraining Angiotensin II/AT1R
Mechanical sensitization of sensory afferents after passive transfer of fibromyalgia IgG
Maximal exercise at high altitude does not exacerbate inflammation in the human brain
The effect of sildenafil on resting and exercise diffusing capacity in trained and untrained individuals: A randomized crossover trial
Exercise training induces mitochondrial biogenesis, while high‐fat diet increases the ability of mitochondria to use long and short‐chain fatty acids
Multiple bursting patterns in lateral habenula neurons: Experiments and computational model
Robust immune cell infiltration and macrophage senescence occur within a week of recovery after limb immobilization in older adult skeletal muscle
Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling
Regulation of basal and tumour necrosis factor α‐induced fibroblast gene expression by peptidylarginine deiminase 2
Dry and humid heat acclimation induces similar adaptations and cross‐acclimation benefits in trained male cyclists
Augmenting erythropoiesis using recombinant human erythropoietin at sea level blunts the high altitude induced increase in erythropoiesis
Profound neuronal differences during exercise‐induced hypoalgesia between athletes and non‐athletes revealed by functional near‐infrared spectroscopy
Translational studies of chronic supplementation with a mitochondria‐targeted antioxidant to improve physical function with ageing
Intramuscular neutrophil‐derived immunometabolic niches locally boost insulin‐responsive GLUT4 translocation after muscle contraction
Gait analysis for functional evaluation in a surgical hindlimb suspension model of muscle atrophy
Compromised synaptic signal from prefrontal cortex to mediodorsal thalamus in Alzheimer's disease models and its rescue by kinase inhibitors
Mutations in ammonia transporter RhBG that impair NH3/NH4+ transport in patients with chronic kidney disease
Intracerebral age‐independent reduction of endothelium‐dependent hyperpolarization and nitric oxide signalling in the Dp16 mouse model of Down syndrome
A novel stromal cell source of RANKL during sustained osteoclast activation in disuse osteoporosis
Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males
Kidney disease impairs tendon function in rats
On the role of descending drive and group III/IV muscle afferent feedback in modulating corticomotoneuronal excitability during knee‐extensor exercise
Motivational sharpening of the interaction between spatial attention and motor control: insights from the monkey dorsal premotor cortex
Effect of varying driving pressure and respiratory rate on ventilator‐induced lung injury in healthy and injured lungs: An experimental animal study
Cross‐modal predictive oculomotor control: visually acquired prediction transfers to vestibular‐driven eye movements
AltitudeOmics: Breathing variability at rest and during exercise across 16 days of acclimatization to hypobaric hypoxia
Role of reactive oxygen species in mediating peripheral hypoxic vasodilation and sympathoexcitation at high altitude
Endocrine and androgenic response to altitude training in professional cyclists
Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations
Utility of local capillary supply indices: Insights from computational image‐based modelling
Long‐term passive heat acclimation enhances maximal oxygen consumption via haematological and cardiac adaptation in endurance runners
Isolating the effects of carbohydrate and lipid availability on exercise‐induced skeletal muscle signalling in males
Histamine mediates food intake, but not muscle adaptations, following 10 weeks of resistance training in humans
Exercise and hypoxia independently stimulate platelet liberation of brain‐derived neurotrophic factor and platelet factor 4
NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men
Effects of ageing on neural onset and offset responses in core and belt auditory cortex of alert macaque monkeys
Visual modulation of vestibular‐evoked balance response disturbed by posterior cortical atrophy
PKMζ is necessary for long‐term depression and long‐term potentiation in the medial prefrontal cortex
Molecular responses in abdominal subcutaneous adipose tissue after a session of endurance exercise: effects of exercise intensity
A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes
Soft tissue accumulations of phosphate are not always associated with serum phosphate or with calcifications in mouse models of hyperphosphatemia
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study
Determinants of maximal oxygen uptake in highly trained females and males: a mechanistic study of sex differences using advanced invasive methods
The influence of biological sex on the metabolic basis of skeletal muscle fatigue iin vivo/i
Learning to stand with delays alters sensorimotor control but does not cause instability when returning to natural balance
Enteric glial S100B controls rhythmic colonic functions by regulating excitability and specificity in gut motor neurocircuits
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting iNotch1/i upregulation in an MDM2‐dependent manner
5‐HTsub7/sub antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity
Effects of a combined energy restriction and vigorous‐intensity exercise intervention on the human gut microbiome: A randomised controlled trial
The hyperaemic and metaboreflex response of the diaphragm during fatiguing diaphragmatic work in humans
Effects of ageing and exercise training on cerebrovascular vasomotor reactivity, depressive behaviour and the hippocampal transcriptome
Post‐exercise hot water immersion enhances haemodynamic and vascular benefits of exercise without further improving cardiorespiratory fitness, glucose, lipids or inflammation
Out of the single‐neuron straitjacket: Neurons within assemblies change selectivity and their reconfiguration underlies dynamic coding
Capillary‐to‐sarcolemma distance and location of cytochrome c oxidase: Insights for maximal O2 uptake and muscle lactate release in trained athletes
Muscle‐specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism
Exhaustive exercise abolishes REV‐ERB‐α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice
Shared and distinct adaptations to early‐life exercise training based on inborn fitness
Passive dehydration increases oxidative stress and mTOR signalling pathway activation in young men following resistance exercise
Functional sympatholysis of neuropeptide Y‐mediated vasoconstriction in humans
Non‐homogeneous distribution of inhibitory inputs among motor units in response to nociceptive stimulation at moderate contraction intensity
Mitochondrial haplotype and sex modulate responses to endurance exercise training
Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise
Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal injury in humans
Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres
Impact of medial calcification on arterial mechanics and haemodynamics
Load and muscle‐dependent changes in triceps surae motor unit firing properties in individuals with non‐insertional Achilles tendinopathy
The skeletal muscle response to high‐intensity training assessed by single‐nucleus RNA‐sequencing is blunted in individuals with type 2 diabetes
Mechanisms of sympathetic excitation during cycling exercise in heart failure with reduced ejection fraction
Adverse effects of high‐fat diet consumption on contractile mechanics of isolated mouse skeletal muscle are reduced when supplemented with resveratrol
52
Arterial graft choice and outcomes within the Veterans Administration: A 20-year review of 47,525 patients
Transapical beating-heart approach is advantageous for surgical septal reduction therapy in pediatrics
Itaconate supplementation leads to improvement in donor lung function after extended hypothermic preservation
Pulses that predict: Postoperative perfusion index and outcomes in high-risk pediatric cardiac surgery
Large Airway Bronchial Wash Lipidomics as Novel Biomarkers for Chronic Lung Allograft Dysfunction
Prospective evaluation and successful outcomes using vacuum bell therapy for pectus excavatum in selected pediatric patients: Analysis of a prospective cohort study of 240 patients
Sex-specific outcomes after thoracic aortic surgery
Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2)
Optimizing patient blood management through intraoperative goal-directed fluid therapy protocol within an enhanced recovery after cardiac surgery program
Protein-losing enteropathy following Fontan completion: A 30-year national cohort study in Sweden
Impact of normothermic regional perfusion on ex vivo lung perfusion outcomes in donation after circulatory death lung donors
The harvesting technique affects the production of nitric oxide and endothelin in the internal thoracic artery graft
Oxygen extraction trajectories during cardiopulmonary bypass impact postoperative outcomes in coronary artery bypass grafting
A decade of reoperative adult cardiac surgery with Del Nido cardioplegia
Long-term survival and operative outcomes of the Bentall procedure for aortic root aneurysm, aortic dissection, and endocarditis
Short-term outcomes of thrombolysis versus surgical pulmonary embolectomy in patients with high-risk pulmonary embolism
Long-term clinical outcomes and morphology of no-touch saphenous vein grafts
Randomized, Sham-Controlled Trial of Intraoperative Ticagrelor Removal to Reduce Perioperative Bleeding
Optimal size matching leads to a favorable outcome for single-lobe living-donor lung transplantation
More is not better: The role of the leukocyte filter in ex vivo lung perfusion
Venoarterial extracorporeal membrane oxygenation versus off-pump lung transplantation: Interim analysis of a prospective, randomized clinical trial
VALUE Trial: Phase 1 safety and feasibility study of same-day discharge after video-assisted thoracoscopic surgery lung resection
Short- and long-term outcomes of chest wall resection and reconstruction for breast cancer
Combined inflation and cooling method improves lung function in uncontrolled donation after circulatory death
Prediction of graft patency during the year following coronary artery bypass grafting: Preoperative computed tomography–derived fractional flow reserve versus intraoperative transit-time flow measurement
Pleural Space Complications After Lung Transplantation
Minimally invasive resection of non–small cell lung cancer after chemoimmunotherapy: A multicenter study in academic hospitals
Outcomes of esophageal diversion and long-term prognosis: A single-institution experience
Improving timely transplantation while reducing cancellation of scheduled surgery
The Safety and Efficiency of Overlapping Video-Assisted Thoracoscopic Lobectomies in a High-Volume Center: A Retrospective Cohort Study
Stroke After Aortic Arch Surgery with Short Circulatory Arrest Times: The Role of Cerebral Perfusion Strategies
When the Gold Standard Fails: Propensity-Matched Comparison of Peroral Endoscopic Myotomy after Heller Myotomy vs. Index Peroral Endoscopic Myotomy
Prognostic impact of low muscle mass on clinical outcomes in patients who undergo lung transplant
Salvage Esophageal Reconstruction with Colonic Conduit: A Single Center 25-Year Experience
Lung Transplant Outcomes After Implementation Of a Hospital-Based 10C Controlled Hypothermic Organ Preservation Unit
The arterial switch operation into the third and fourth decades of life
Bloodless Heart Transplantation in Patients Who Refuse Transfusion: An 11-Year Case Series
Three-decade evolution from open to endovascular aortic repair of late anastomotic pseudoaneurysm of the descending thoracic or thoracoabdominal aorta
1,000 Cases of Ex Vivo Lung Perfusion for Lung Transplantation: A Single Centre Experience
Association Between Subclavian Vein Patency and Health-Related Quality of Life Outcomes Among Patients with Venous Thoracic Outlet Syndrome
Impact of the Composite Allocation Score on Racial/Ethnic Disparities in Lung Transplantation Waitlist Outcomes
Redo Coronary Artery Bypass Grafting in Patients with Patent Bilateral Internal Thoracic Artery Grafts: Exceptions to a Lifetime Warranty
Tissue perfusion pressure: A novel hemodynamic measure to assess risk of acute kidney injury after cardiac surgery
Long-Term Outcomes of Diaphragmatic Relaxing Incisions during Challenging Primary and Revisional Hiatal Reconstruction: A Propensity-Matched Analysis
Predicting and Diagnosing Pneumonia in Patients Undergoing Elective Cardiac Surgery via Machine Learning Analysis of Exhaled Volatile Carbonyl Compounds
2022: Perioperative and critical care year in review for the cardiothoracic surgery team
Early outcomes and follow-up of robotic-assisted multivessel coronary artery bypass with in situ bilateral internal thoracic artery: report of 221 patients in a single center
Diagnostic Effectiveness and Safety of Robotic-Assisted Bronchoscopy for Subsolid Pulmonary Nodules – A Multicenter, Prospective, Observational Study
Intercostal Cryoanalgesia for Acute Pain after VATS Lung Resection (CRYO-VATS): a randomized controlled preliminary trial
Outcomes of adult-to-adult living-donor lobar lung transplantation: A single institution experience
Reduced left atrial compliance exacerbates primary graft dysfunction after lung transplantation.
Early Outcomes of Lung Transplantation under the Composite Allocation Score System
9
Adolescents’ Relationships With Their Parents and Peers as Mediators Between Economic Circumstances and Emotional Symptoms: A Multicountry Longitudinal Analysis
Examining Features of Atypical Depression in Youth From the Texas Youth Depression and Suicide Research Network Research Registry
Attention-Deficit/Hyperactivity Disorder Subtypes Defined by Cognition Have a Distinct Neural and Clinical Profile and Differ in Response to Atomoxetine
Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis
Waves of Change: A Nationwide Analysis of Acute Pediatric Healthcare Encounters Attributed to Substance Use Before, During, and Following the COVID-19 Pandemic
Preadolescent Benefits of Parent-Child Interaction Therapy Emotion Development for Preschool Depression: 4 Year Follow Up
Exploring the Behavioral and Emotional Manifestation of Polygenic Risk for Psychiatric Disorders Among Schoolchildren
Antidepressant Treatment Quality of Depressed Youth: A National Evaluation of Medicaid Patients
Enduring Mental Health in Childhood and Adolescence: Prevalence, Prediction, and Genetic Architecture
59
Topical vs Systemic Corticosteroids for DRESS Syndrome: Real-World Outcomes from a Multi-Center Retrospective Cohort
Hydroxychloroquine Use and 5-Year Cardiometabolic Profile and Cardiovascular Risk in Isolated Discoid Lupus Erythematosus: A Retrospective Cohort Study
Disparities of itch severity in outpatient clinics as measured by the ItchyQuant
Topical combined 5-fluorouracil and calcipotriene for actinic keratosis and superficial keratinocyte carcinoma: Modified Delphi expert panel guidelines from ITSCC
Impact of early treatment of psoriasis on disease recurrence—Results from the STEPIn study
Sequential small-molecule therapy for lymphocytic cicatricial alopecia: A multicenter prospective cohort pilot study
Efficacy and safety of fish oil supplementation combined with low-dose isotretinoin for moderate-to-severe acne vulgaris: A randomized controlled non-inferiority trial
Early androgenetic alopecia as a possible indicator of diabetes mellitus and its link to cardiovascular risks: A cross-sectional study
Efficacy of oral JAK inhibitors combined with 308-nm excimer laser in pediatric progressive vitiligo: A multicenter study
Cartilage grafts for alar reconstruction in nasolabial interpolation flap surgery may negatively affect breathing function and cosmesis: A retrospective study
The 487-gene expression profile test guides systemic therapy selection to improve outcomes for patients with atopic dermatitis: Results from a prospective trial
Tumor necrosis alpha inhibitor therapy is associated with increased long-term risk of nonmelanoma skin cancer and melanoma: A retrospective cohort study
Efficacy and safety of sodium-glucose cotransporter-2 inhibitors in patients with psoriasis and comorbid type 2 diabetes: A population-based target trial emulation
Hyperkalemia incidence in females over 45 years old on spironolactone for dermatologic conditions: A retrospective cohort study
Safety and tolerability of combination oral spironolactone and low-dose oral minoxidil for hair loss in adult females: A retrospective cohort study
Infection risk among psoriasis biologic-new users: a cohort study on the French National Health Data System
To test or not to test? Revisiting the value of baseline screening and monitoring tests among biologic treatments for psoriasis using an evidence-based assessment
Surgical excision versus topical 5% 5-fluorouracil and photodynamic therapy in the treatment of Bowen's disease: long-term results of a multicenter randomized controlled trial
KLRB1 and IL12RB1 are pretherapeutic predictors of time to relapse in patients of psoriasis treated with IL-17 blockade
Efficacy of Dupilumab for the Treatment of Moderate to Severe Chronic Hepatic Pruritus: An Open-Label, Single-Arm, Exploratory Study
Efficacy and Safety of Ruxolitinib Cream in Patients With Mild to Moderate Hidradenitis Suppurativa: Results From a Randomized, Double-Blind, Vehicle-Controlled Phase 2 Study
Bimekizumab demonstrated a favorable safety profile and high levels of efficacy with up to 2 years of treatment in patients with moderate to severe hidradenitis suppurativa: Pooled results from two phase 3 randomized, controlled trials and their open-label extension
Joint Position Statement from the National Psoriasis Foundation Medical Board and the International Psoriasis Council on Routine Testing for Latent Tuberculosis Infection Prior To and During Treatment of Psoriasis Patients with IL-17 or IL-23 Inhibitors
Ultraviolet induced fluorescent dermoscopy for the diagnosis of skin tumors: A multicenter study
Clinical Practice Guidelines for the Management of Basal Cell Carcinoma in Gorlin Syndrome
Prevalence, incidence, and risk factors for dermatologic conditions in people with HIV in the modern antiretroviral era: A cohort study in Washington, DC
Saturated saline immersion for the Treatment of Refractory Plantar Warts: An open-label, one-arm, single-center trial
A randomized, double-blind, placebo-controlled phase 2 study of eltrekibart, a novel septa-specific monoclonal antibody to CXCR1/2 ligands, in adults with hidradenitis suppurativa
Examining the Impact of Child Atopic Dermatitis on Maternal Depression: A Longitudinal Cohort Study
Risk factors for recurrence or relapse after a first episode of adult IgA vasculitis: a multicenter retrospective study
Efficacy and Safety of Cosibelimab in Advanced Cutaneous Squamous Cell Carcinoma: Results From a Pivotal Open-label Study With a Median Follow-up of ≥2 Years
Impact of Immunosuppression on Cutaneous Squamous Cell Carcinoma Outcomes
Comparative risk of reactivation of hepatitis B and C after treatment with biologics and targeted synthetic DMARDs in psoriasis and psoriatic arthritis: a 15-year multicenter cohort study
Novel TYK2 inhibitor D-2570 in moderate to severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase 2 trial
Effectiveness of Biologics on synovitis and enthesitis using Musculoskeletal ultrasound assessment in subclinical psoriatic arthritis: A 12-week observational real-world study
Intralesional acyclovir versus cryotherapy in treatment of plantar warts: A randomized controlled trial.
Real-world treatment patterns in patients with generalized pustular psoriasis (GPP):
Efficacy and Safety of Ruxolitinib Cream for the Treatment of Moderate to Severe Chronic Hand Eczema: Results From a 16-Week, Multicenter, Randomized, Double-Blind Study
Chronic skin conditions and life trajectories: development and validation of “Dermatology Long-Term Life Impact Measure (DLLIM)”
Establishment of standardized definitions and a core set of outcome characteristics following hidradenitis suppurativa surgery developed by an expert Delphi consensus
Disparities in Survival and Tumor Characteristics in Patients With Single and Multiple Primary Merkel Cell Carcinomas
Genomic and clinical characterization of anogenital basal cell carcinoma: a retrospective and prospective cohort study
Caged-hypocrellin mediated antimicrobial photodynamic therapy as a dual-action strategy for fungal clearance and immune response regulation in drug-resistant Candida auris wound infections
The Effect of Isotretinoin Treatment for Acne Vulgaris on Height in Adolescents: A Retrospective Cohort Study Using the Rochester Epidemiology Project
Systemic risk profiles of topical ruxolitinib and oral Janus kinase inhibitors in patients with atopic dermatitis: A retrospective cohort study from the TriNetX network
Type 2 Immunity Links Eczematous and Lichenoid Eruptions Caused by Immune Checkpoint Inhibitors
Efficacy and safety of sequential treatment with cryotherapy followed by 1% topical tirbanibulin for actinic keratoses in organ transplant recipients: a randomized clinical trial
Diagnosis and Management of Yellow Nail Syndrome: An International Multi-Institutional Retrospective Cohort Study of 111 Cases by an Expert Panel
Satellitosis/in-transit metastasis in cutaneous squamous cell carcinoma: Risk factors and the prognostic significance
Trametinib Treatment for Early-Stage Extracranial Arteriovenous Malformations: A Multicenter, Prospective, Single-Arm Pilot Study
Oral tofacitinib in comparison with dexamethasone oral mini-pulse therapy for the treatment of active nonsegmental vitiligo: A randomized controlled trial
The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies
Ocular and Auditory Comorbidities in Patients with Vitiligo: A Nationwide Population-Based Study in the Republic of Korea
Global, regional and national burdens of atopic dermatitis from 1990 to 2021: a trend analysis from the Global Burden of Disease Study 2021.
Outcomes and Mortality in Calciphylaxis: A Multicenter Update
Safety and Efficacy of Topical Simvastatin Plus Cholesterol Cream vs Topical Simvastatin Cream Alone for Porokeratosis Ptychotropica: A randomized, single-blind, split-body, placebo-controlled investigator-initiated trial
Skin Clearance, Duration of Treatment-free Interval, and Safety of Tapinarof Cream 1% Once Daily: Results from ADORING 3, a 48-week Phase 3 Open-label Extension Trial in Adults and Children Down to 2 Years of Age with Atopic Dermatitis
Enhanced metastatic risk stratification for Cutaneous Squamous Cell Carcinoma by combining clinical guidelines with the Erasmus MC model: Results from Two Nationwide Nested Case-Control Studies
Efficacy, Safety, and Recurrence in Seborrheic Dermatitis: A Dose-Dependent Analysis of Oral Isotretinoin (10 mg vs. 20 mg)
42
Phenotype Classification of Intact Cells by NMR Spectroscopy through Machine Learning Approaches
A Deep-Red-Absorbing Osmium(II)-Based Photosensitizer Evokes Pyroptosis by Targeting Glutamine Metabolism and Impairing Cell Redox Homeostasis
Cryo-Structural Insights into Enzymatic Peptide Self-Assembly Driving Extrinsic Lytic Cell Death
Coupled Hydrogen-Bond–Electrostatic Recognition of Phosphatidylglycerol Drives the Design of Resistance-Suppressing Miniature Peptidomimetics
Photocatalytic Activation Strategy for Sequential Prodrug Release to Overcome Resistant Biofilms
A “Lung-Trap” Theranostic Strategy for Precision Management of Drug-Resistant Bacterial Pneumonia and Bacteremia
A Small Molecule That Inhibits the Quorum Sensing Receptor AgrC in Staphylococcus aureus
Mechanistic Insights into Unary Peptide–Membrane Interactions Enable Stable Encapsulation and Trigger-Responsive Peptidyl Liposomes
Chemical Evolution of Natural Product for Discovery and Mechanistic Exploration of Antibiotic against MRSA
Wall Teichoic Acids Are Direct Molecular Targets of Antimicrobial Peptides in Gram-Positive Bacteria
Enzyme-Responsive Hemostatic Elastin-like Polypeptides for Fibrin Stabilization and Coagulation Restoration in Thrombocytopenia
Proteome-Mining and Chemical Activation of Hidden Bioactive Fragments as Antimicrobial Assemblies
Advanced Molecular Tweezers Effectively Target Membranes Lacking Choline Headgroups for Broad-Spectrum Antiviral Efficacy
Structure-Guided Semisynthesis of Blasticidin S–Amicetin Chimeras as Selective Ribosome Inhibitors
PGLa and Magainin 2 Can Porate Membranes via Transient Hourglass-Shaped Toroidal Pores
Potent Racemic Antimicrobial Polypeptides Uncovered by a Stereochemical Series of Cationic d/l Backbones
Deciphering Ibogaine’s Matrix Pharmacology: Multiple Transporter Modulation at Serotonin Synapses
DNA Modulates Structural Transitions and Oligomerization Kinetics of the Functional Amyloid CRES
A Fluorescence-Afterglow Reporter for In Vivo Differentiation of Three Tumor Immunophenotypes
Synthesis of Heparan Sulfate Hexadecasaccharides and Their Molecular Interaction with Mycobacterial Heparin-Binding Hemagglutinin for the Detection of Mycobacterium tuberculosis
Actifensin Evolution in the Human Oral Cavity over the Past 100,000 Years
Chirality-Driven Metal–Phenolic Artificial Enzymes Enable Renal Targeting and Antioxidative Therapy Enhancement for Acute Kidney Injury
Unanticipated Quinoline Modification on Vancomycin as an Effective Strategy to Alter the Antibacterial Profile and Combat Multidrug Resistance
Selection of Ruthenium Polypyridyl Complex-Modified Aptamers for Photodynamic Therapy against Streptococcus Pneumonia
Distinct Target Site of Lenacapavir in Immature HIV-1 and Concurrent Binding with the Maturation Inhibitor Bevirimat
Bacterial Phospholipid-Inducible Helix-Transformable Antimicrobial Polypeptides
Gelatinase-Responsive Short Peptide Conjugate as a Precision Therapy Against Methicillin-Resistant Staphylococcus aureus
A Bioinspired Lipopeptide Surmounts Therapeutic Dilemmas of Gram-Positive and Gram-Negative Polymicrobial Infection
Lanthanide Core–Satellite Nanoprobes with Dually Activatable Magnetic Resonance and Second Near-Infrared Fluorescence Signals for Perioperative Image-Guided Cancer Surgery
Chemical Synthesis of Oligosaccharides Derived from Streptococcus Pneumoniae Serotype 35B and D Provides Molecular Insight in l-Ficolin Binding
Flexible Double Bonds-Enhanced Photodynamic Therapy toward Antibacterial Resistance
Macrocyclic Phage Display for Identification of Selective Protease Substrates
Automated Glycan Assembly of iPorphyromonas gingivalis/i Lipopolysaccharide Epitopes for Vaccine Design
Eggerthella lenta Produces a Cryptic Pro-inflammatory Lipid
Expanding the Chemical Space of Antimicrobial Peptides via Enzymatic Prenylation
Displaying In Vivo “Assembly–Disassembly” Cascade with “Off–On–Off” Magnetic Resonance Imaging Signals in Tumor
Insights into the Mechanisms of Small Molecule-Induced Agonism and Antagonism of a Quorum Sensing Receptor in Pseudomonas aeruginosa
Chemotype- and Target-Driven Genome Mining for a New Natural Product Inhibitor of Bacterial Peptide Deformylase
One-for-All Photoactivatable Manganese-Based Carbon Monoxide-Releasing Molecules (CORMs) for Synergistic Therapy of Mycobacterial Infection
ATP-Ion Complexation and Lithium’s Bioactive Form in Cellular Solutions
Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR
Pyrazolone-Modified Photosensitizers for Precise Cell Membrane Rupture to Enhance Cancer Immunotherapy
26
Visual Acuity and Cardiovascular Mortality in 2.52 Million Older Adults in China
Mechanical Thrombectomy and Catheter-Directed Thrombolysis in Acute Pulmonary Embolism
Culture-Negative IE in the Modern Diagnostic Era
Renin-Aldosterone Profiles and Cardiorenal Outcomes in Hypertension
Chlorhexidine vs Povidone-Iodine Alcohol Solutions for Cardiac Implantable Electronic Devices A Prospective Randomized Study
Underutilized Potential of a Nationwide Community First Responder System
Association of Autonomic Dysfunction With Long COVID Evaluation Using Quantitative Autonomic Testing
High-Dose vs Standard-Dose Influenza Vaccine in Chronic Kidney Disease The DANFLU-2 Trial Subgroup Analysis
Risk of Hyperkalemia With Empagliflozin, Finerenone, or Both: Secondary Analysis of CONFIDENCE Randomized Trial
Myocardial Amyloid Burden in Transthyretin Amyloidosis
PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery A Multicenter, Randomized Trial
Frailty Scale Captures Multidimensional Vulnerability and Predicts Mortality in Heart Failure
Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM: Exploratory Analysis from ATTRibute-CM
Timing of Mortality Benefit in Outcomes Trials in Transthyretin Amyloidosis
Effect of ECMO Flow Variations on Pulmonary Capillary Wedge Pressure in Patients With Cardiogenic Shock
Influence of Type 2 Diabetes on the Effects of Tirzepatide in Patients With Heart Failure and a Preserved Ejection Fraction With Obesity A Prespecified Stratification-Based Analysis
Adiposity-Related Anthropometrics and Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction A Participant-Level Pooled Analysis of Randomized Clinical Trials
Outcomes of Percutaneous Mechanical Aspiration in Right-Sided Infective Endocarditis A Multicenter Registry
Long-Term Outcomes After Fractional Flow Reserve vs Intravascular Ultrasound to Guide PCI The FLAVOUR Trial Extended Follow-Up
Using Compression Stockings to Prevent Recurrence of Vasovagal Syncope A Randomized Sham-Controlled Trial
Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B
Effects of Vutrisiran on Cardiac Function and Outcomes in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Relation Between the Incidence of In-Hospital Cardiac Arrest and Survival in Older Patients
Early Increase in Serum Transthyretin by Acoramidis Independently Predicts Improved Survival in TTR Amyloid Cardiomyopathy
Vutrisiran Improves Survival and Reduces Cardiovascular Events in ATTR Amyloid Cardiomyopathy HELIOS-B
Effect of Empagliflozin on the Mechanisms Driving Erythropoiesis and Iron Mobilization in Patients With Heart Failure The EMPEROR Program
97
Exploring Current Emergency Medical Services Approaches to Manage Agitated Older Adult Patients: An Analysis of Statewide Protocols
The Association Between Hospital Harms and 1‐Year Mortality Following a Hip Fracture in Ontario, Canada: A Cohort Study
The Effect of an Early Cognitive Intervention on Global Cognition in Older Hospitalized Adults With Delirium
Transdermal Buprenorphine for Pain Management in Older Patients With Multiple Rib Fractures
Patient and Clinician Perspectives on Chronic Pain Communication in Advanced Kidney Disease
Two Brief Steps, Better Foresight: Cognitive Screening and Adverse Outcomes in Older Adults Admitted From the Emergency Department
Evaluating the Joint Effects of Dementia and Frailty on Burdensome Transitions Among Long‐Term Care Residents in Ontario, Canada
Primary Care Practitioners' Approaches to Deprescribing Opioids for Older Adults With Chronic Pain: A Qualitative Analysis
The Bright Side of Life: Optimism and Risk of Dementia
Association of Geriatric Emergency Department Care With Hospitalization and Mortality in Older Adults
Burden and Risk Factors of CGM-Detected Hypoglycemia in Older Adults With Type 2 Diabetes
Naturalistic Driving Outcomes and Sensorimotor Function in Cognitively Normal Older Adults
Barriers to the Implementation of Local Anesthesia for Older Adults Undergoing Inguinal Hernia Repair
Association Between Different Analgesic Use and Hypertension Among Medicare Beneficiaries With Osteoarthritis
<atl>Quality of Medicare Skilled Home Health for People Living With Dementia in the scpUS/scp : National Patterns and Implications</atl>
<atl>Variation in Psychotropic and Non‐Psychotropic Prescribing in Nursing Homes: A Multi‐Level scpEMR/scp ‐Based Retrospective Cohort Study</atl>
Long‐Term Outcomes Associated With Peripheral Nerve Blocks for Hip Fracture Surgery: A Retrospective Comparison of Medicare Data
European Working Group on Sarcopenia in Older People Algorithm: Step‐by‐Step Relation With Length of Hospitalization
Surgical Stabilization of Rib Fractures in Geriatric Trauma Patients: A National Trauma Data Bank Review
Association of Geriatric Consult Services With Geriatric Processes of Care and Clinical Outcomes in US Trauma Centers
Older Age Is Associated With Long‐Term Retention in Buprenorphine Treatment for Opioid Use Disorder
Impact of the 2015 Dutch Long‐Term Care Reform on Nursing Home Use and Access for People With Dementia
“By the Skin of Our Teeth”: U.S. Hospital, Regional, and State Experiences of Scarcity During the COVID-19 Pandemic
The Role of Brain Structure in Explaining Physical Functioning in Male Veterans With Impaired Kidney Function
Sensorimotor Impairment and Incident Dementia in the US Medicare Beneficiaries
The End of Life With Dementia in Asian Countries: Barriers, Facilitators and a Research Agenda for Advancing a Palliative Approach
Perceived Pain Following Hypnotic Deprescribing in Older Adults
Efficacy of a Multicomponent Intervention for Frailty or Physical Function in Prefrail or Frail Older Adults: FRAILMERIT Multicenter Clinical Trial
Increase in Fall-Related Fatalities in the Home Following the COVID-19 Pandemic Onset
A Health Communication Strategy to Promote Dementia Risk Reduction: The CULTIVAMENTE Pragmatic Cluster-Randomized Trial
Disseminating Acute Care for Elders Principles in a Geriatric Observation Unit: Preliminary Data
A Peer Support Intervention for Black Family Caregivers of Persons Living With Dementia: A Feasibility Study
Functional Decline and Loss of Independence After Traumatic Injury in Older Adults With Dementia
Perioperative Optimization of Frail Older Adults Undergoing Elective Colorectal Surgery
A Retrospective Chart Review of the Prevalence, Characteristics, and Discharge Destinations of Patients Hospitalized as “Social Admissions”
What Matters Most to People Living With Dementia and Their Care Partners During Emergency Department Visits
Capacity for and Utilization of Dual‐Energy X‐Ray Absorptiometry Within the Veterans Health Administration
Leading Cause of Death and Life Expectancy Among US Superagers
Predictors of a Gabapentinoid–Loop‐Diuretic Prescribing Cascade in U.S. Nursing Home Residents
Sarcopenic Obesity, Not Sarcopenia or Obesity Alone, Is Independently Associated With Urinary Incontinence in Older Women
The Changing Landscape of the Providers of Home‐Based Medical Care in Traditional Medicare
Trends in Initiation of Buprenorphine for Opioid Use Disorder Among Older Adults
Predictors of Advance Directive Changes in Ontario Nursing Home Residents: A Case–Control Study
Effectiveness of Exercise in Older Adults Discharged From the ER After Minor Injuries: The CEDeComS Stepped-Wedge Trial
Association Between Herpes Zoster and Risk of Incident Fragility Fractures in scpUS/scp Veterans: A Matched Cohort Study
Role and Expectations of Family Caregivers in Hospital at Home in the scpUS/scp and Canada
Perceptions of Older Adults and Caregivers on the Life Story Questionnaire in the Transition to Long‐Term Care in Côte‐Nord Region
Cataract Surgery Under General Anesthesia in Older Adults With Advanced Cataracts and Dementia: Visual Acuity and Visual Function Outcomes
Association Between Frailty and Patients' Experience of Cancer Treatment and Care
scpSGLT2/scp Inhibitors in Older Adults With Cardiovascular Disease: A Systematic Review and Meta‐Analysis
A Qualitative Study of Health Priorities of People With Dementia and Care Partners in Emergency Department and Hospital Care in a Public Safety‐Net Setting
Caregiver Emotional Wellbeing Is Related to Nursing Home Admissions Among Veterans
scpCAPABLE/scp for People After Hospitalization: A Randomized Trial
Clinical and Prognostic Utility of the Essential Frailty Toolset in Older Patients With Heart Failure
Potential Overtesting of Nursing Home Residents With Diabetes in Ontario, Canada
Patients With Dementia Undergoing High‐Risk Inpatient Surgery Have Poor Outcomes
Safety of Baclofen and Tizanidine in Older Adults: A Retrospective Cohort Study in a Large Integrated Health Care System
Physical Resilience After Hip Fracture: Unpacking the Roles of Resistance and Recovery
Caregiving Network Characteristics and Mental Health Care Utilization by Older Adults
Communication Surrounding Treatment Preferences for Older Adults With Dementia During Emergency Medical Services Response
Age-Related Changes in the Clinical Picture of Long COVID
Prevalence and Prognostic Implication of Sarcopenia Among Patients With Stage B Heart Failure: The PAPRIKA-HF Cohort Study
Patterns of Benzodiazepines and Hypnotic Drugs Dispensing After Hip Fracture Among Older scpUS/scp Adults Previously on the Drugs
Arthritis and Functional Limitations Among Home Healthcare Aides: 2021–2023, Behavioral Risk Factor Surveillance System
Information and Counseling Gaps on Perioperative Neurocognitive Disorders Among Older Adults
Improving Osteoporosis Clinic Access With Nurse‐Led Telephone Call for Veterans on Bisphosphonates
Can an Innovative Physical Therapy Program Improve Executive Function? A Study Among Veterans With Slow Gait Speed
Impact of Concern About Falling on Physical and Social Activities of Older Adults With Hypertension
Rosacea Is an Underdiagnosed Disease Among Subjects Aged Over 70 Years
Under Documentation of Anemia in Older Ambulatory Patients
Identifying a Set of Quality Indicators for Older Adults Hospitalized After Injury: An Expert Consensus Study
Antipsychotic Use and Successful Discharge Rates in Heart Failure‐Related Hospitalizations
Does Cannabis Use Reduce Symptoms of Depression, Anxiety, Pain, and Insomnia Among Older Adults? A Systematic Review
Pattern and Associated Factors of Benzodiazepine Discontinuation Among Older Adults Following Hospitalization
Mitochondrial Fitness Science Communication: A Qualitative Study
Recent Innovations in Peer Programs for Socially Isolated Older Adults: Implications for Public Health Emergency Preparedness
Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men
Effects of Eczema on the Quality of Life of an Older Population in Northern Finland: A Retrospective Cohort Study
The Trajectories of Neuromuscular Aging (TRAJECTOR‐AGE Clinical Trial): Study Rationale and Methodological Protocol
Nutritional Impairment and Quality of Life Trajectories Among Older Adults With Advanced Cancer
“I Don't Wake Up Completely”: Older Adults' Trade‐Offs Between Nighttime Ambulation Safety and Sleep Quality
A Multimodal Fall Prevention Intervention in the Setting of the Emergency Department
Treatment Burden Among Older Adults in the United States, 2022
Mapping the Final Journey: End‐Of‐Life Frailty Trajectories and Cause of Death
Use of Nursing Homes Among Medicaid Beneficiaries Newly Diagnosed With Cancer
Data Resource Profile: The Veterans Affairs—Health and Retirement Study Aging Veteran Cohort
Clinician Perspectives on Increased Gabapentinoid Prescribing in Nursing Homes
Short‐ and Long‐Term Effect of Multidomain Lifestyle Intervention on Frailty: Post Hoc Analysis of an RCT
Self‐Perceptions of Aging Predict Recovery After a Fall: Prospective Analysis From the English Longitudinal Study of Aging
Tooth Loss and 12‐Year Mortality Risk in 8494 Older Adults From Ireland
A Large Language Model Approach to Identifying Preoperative Frailty Among Older Adults From Clinical Notes
Frailty Burden and Efficacy of Initial Invasive Strategy in Chronic Coronary Disease: The ISCHEMIA Trials
Emergency Department Utilization Among Co‐Residing Family Caregivers of Persons Living With Dementia
Post‐Discharge COVID‐19 Symptoms Predict 1‐Year Functional Decline, Falls, and Emergency Department Visits: A Cohort Study
Undocumented Dementia Diagnosis During Skilled Home Health Care: Prevalence and Associated Factors
Perceived Timeliness of Prior Authorization Approvals for Medicaid Home‐ and Community‐Based Services
Depression and Antidepressant Prescription in Hospitalized Centenarians
62
Efficacy and Safety of Atrasentan in Patients with IgA Nephropathy Receiving Sodium-Glucose Cotransporter 2 Inhibitors: Placebo-Controlled, Crossover Trial.
Systemic Proteome Profiling to Differentiate Primary Glomerular Diseases.
Discoidin Domain Receptor 1 Translocation to the Mitochondria Promotes Oxidative Stress and Apoptosis in Acute Kidney Injury.
Subclinical Primary Aldosteronism and eGFR Decline Over Time.
A HaloTag Knock-In Resource for In Vivo and In Vitro Analysis of Endogenous Polycystin-2 Localization, Turnover, and Transport.
Development and Validation of a Multivariable Prediction Model for Kidney Failure in Early Autosomal Dominant Polycystic Kidney Disease.
α-Klotho Promotes Cell Death and Suppresses Inflammation through TNF-Cellular Inhibitor of Apoptosis Protein 1 Signaling in Autosomal Dominant Polycystic Kidney Disease.
Systemic Phosphate Elevations Induce FGF23 Production in Skeletal Muscle to Reduce Renal Phosphate Reabsorption in Mice
PACS-2 Alleviates Kidney Fibrosis by Inhibiting Tubular Epithelial Cell G2/M Arrest through CDKL1 Kinase
Peritoneal Dialysis Initiation Patterns by Health Service Area during an Era of Expansion
Structural Plasticity of Aged Podocytes Revealed by Volume Electron Microscopy
Renal Resistance on Hypothermic Machine Perfusion and Acceptance of Deceased Donor Kidney Allografts
Ultrasound Localization Microscopy to Assess the Intrarenal Microvasculature in Autosomal Dominant Polycystic Kidney Disease
Mapping of PLA2R Epitopes in Idiopathic Membranous Nephropathy and Clinical Relevance of Epitope Profiles
Inhibition of Interleukin-33 in Diabetic Kidney Disease
Integrin Alpha1 Beta1 Promotes Interstitial Fibrosis and Cyst Growth in a Mouse Model of Polycystic Kidney Disease​
Matrix Stiffness Directs Early Injury and Ketogenesis Programs to Prime Kidney Repair
Bone Mineral Density and the Risk of Fracture according to eGFR in Postmenopausal Women
A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia
Streamlining the Histopathological Workflow in Diabetic Kidney Disease with Artificial Intelligence.
Automatically Measuring Kidney, Liver, and Cyst Volumes in Autosomal Dominant Polycystic Kidney Disease.
A Five-Plasma Protein–Based Algorithm for Predicting Incident CKD in Type 2 Diabetes
Spatial Transcriptomics Reveals Injured Cells, Signature Genes, and Communication Patterns in the Cyst Microenvironment of Polycystic Kidney Disease.
Bmpr2 Drives Aberrant Activation and Injury of Glomerular Endothelial Cells in Lupus Nephritis.
Erythroid ACKR1 Deficiency Aggravates Immune-Mediated Kidney Disease.
Accuracy of Identification of Cardiovascular Events with ICD Diagnosis Codes versus Physician Adjudication in CKD and Kidney Failure.
High Phosphate and Low Protein Mediate Arterial and Cutaneous Vascular Calcification in CKD Mice.
Metabolic Dysregulation of 27-Hydroxycholesterol Sensitizes Proximal Tubular Epithelial Cells to Ferroptosis in Ischemic Acute Kidney Injury.
Effect of Finerenone on Morbidity and Mortality in CKD.
Mycophenolate Mofetil versus Cyclophosphamide for Initial Therapy in Childhood-Onset Proliferative Lupus Nephritis: A Prospective, Multicenter, Randomized Trial.
Epidermal Growth Factor Receptor Activation Stimulates SOX9 Expression in Injured Renal Proximal Tubule Epithelial Cells.
Pyruvate Dehydrogenase and Cellular Metabolism in Calcineurin Inhibitor-Induced Kidney Fibrosis.
Differential Cell-Specific, Regulatory Roles of FcγRIIB through IgG in IgA Nephropathy.
Enhanced Expression of the Female-Biased Gene Gsta2 in Male Proximal Tubule Cells Improves Renal Resilience to Ischemia-Reperfusion Injury.
Dysregulated Bone Marrow Contributes to Glomerular Injury through Soluble Factors.
Validation of the Klinrisk Machine Learning Model for CKD Progression in a Large Representative US Population.
Microbes and Glomerular Filtration Rate in Health and CKD in Mice.
Structured Application of Genetic Testing in a Pediatric Kidney Clinic.
KRT20 Suppresses Exosomal Secretion of PRDX2 and Ferroptosis in Acute Kidney Injury.
Effects of Dapagliflozin on Health-Related Quality of Life in Patients with CKD.
Genetic Variation and Ultrafiltration with Peritoneal Dialysis: A Genome-Wide Association Study.
Measurement, Estimation, and Correlates of the Glomerular Filtration Rate before and after Bariatric Surgery.
Higher versus Lower Phosphate Targets for Patients Undergoing In-Center Hemodialysis: A Randomized Controlled Trial.
Identification of Renal Transcripts Associated with Kidney Function and Prognosis in ANCA-Associated Vasculitis.
Predictive Value of the Oxford Classification for the Effect of Glucocorticoid Therapy in IgA Nephropathy.
Telomere Dysfunction in Renal Tubular Epithelial Cells Leads to Kidney Fibrosis.
Transcriptomic Patterns in Adult and Pediatric Patients with IgA Nephropathy or IgA Vasculitis with Nephropathy.
A Multiomics Study of Circulating Proteins and Kidney Stone Risk.
Biomarkers of Kidney Failure and All-Cause Mortality in CKD.
Cardiac LIM Protein, Kidney Fibrosis, and Vascular Change after Acute Cardiorenal Syndrome.
Discontinuation of Renin-Angiotensin System Inhibitors during Acute Kidney Injury Episode and All-cause Mortality: Target Trial Emulation Studies.
Use of eGFR Slope Thresholds as End Point Components in a Kidney Disease Progression Hierarchical Composite End Point.
Kidney Parameters with Tirzepatide in Obesity with or without Type 2 Diabetes.
Obesity, Underweight, and Accuracy of eGFR Using Cystatin C and Creatinine in a Northern European Population.
Cdc42 Activation in Anti-nephrin Antibody-Induced Nephropathy.
Voclosporin Overdose-Induced Peroxisomal Structural Changes and AKI Are Prevented by Renal Indole Detoxifier, INMT.
mTORc1 in Distal Convoluted Tubule (DCT) and Renal Potassium (K+) Handling.
Safety and Efficacy of Vadadustat for the Treatment of CKD-Related Anemia within and outside the United States.
Engineered Neuromedin U Promotes Type 2 Innate Immunity and Renoprotection in Acute Kidney Injury.
Histologic Features Associated with Kidney Survival in Scleroderma Renal Crisis.
Proximal Tubule Cells Contribute to the Thin Descending Limb of the Loop of Henle during Mouse Kidney Development.
Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.
24
Menopausal hormone therapy and risk of liver cancer in a swedish population-based cohort study
Antidepressant adherence and breast cancer recurrence risk in women with major depressive disorder: a retrospective cohort
Quality of life and care experiences in a US multi-institutional neuroendocrine tumor cohort
Risk of fracture following androgen receptor pathway inhibitors in men with advanced prostate cancer
Opioid use after breast cancer in Denmark: a nationwide study of social and clinical factors
Subsequent breast cancer risk after benign biopsy in racially diverse women: Siteman Cancer Center
Joint associations of accelerometer-measured physical activity and cardiovascular-kidney-metabolic syndrome stages with the risks of cancer and all-cause mortality
Development and validation of a risk prediction model for acute care use among older advanced cancer patients on clinical trials
Neighborhood deprivation on increasing deficit accumulation in older breast cancer survivors and non-cancer controls
Tattoos and risk of cutaneous melanoma and non-melanoma skin cancer in France
FaceAge as a biomarker for prognosis and treatment stratification in large-scale oncology cohort
Liver fat and clinical outcomes in individuals with stage I-iii Colon or rectal cancer
An immunosuppressive tertiary lymphoid structure is associated with adverse prognosis in gastric-type endocervical adenocarcinoma
Redefining neurocognitive outcomes after radiation for brain metastases: a patient-level meta-analysis of recovery following initial decline
Lipid biomarkers of habitual alcohol intake and associations with pancreatic cancer risk
Tattooing and risk of melanoma: a population-based case-control study in Utah
Basal cell carcinoma risk prediction in survivors of childhood cancer
Thyroid hormones and epithelial ovarian cancer risk and survival: results from the European Prospective Investigation into Cancer and Nutrition study
Stereotactic MRI Guided Adaptive Radiotherapy: a pooled analysis of a master prospective trial
Trends in the incidence of cancers related to HIV-AIDS in Harare, Zimbabwe 1990-2019
Association of opioid and benzodiazepine coprescribing with adverse events among older adults with cancer
Colon, colorectal, and all cancer incidence increase in the young due to appendix reclassification
Breast implant illness after reconstruction with silicone breast implants
Metformin use and risk of colorectal cancer in patients with inflammatory bowel disease: a nationwide, Population-Based cohort study
60
Insights from the BLISS-LN Phase 3 study of biomarker associations with kidney response to belimumab in lupus nephritis
Estrogen protects female mice with chronic kidney disease from fibroblast growth factor 23-induced left ventricular hypertrophy
The calcimimetic etelcalcetide restores cardiac function in chronic hyperphosphatemia via calcium sensing receptor–cAMP activation
Independent association between acute kidney injury and kidney function trajectory
Roles of WNK1 and mTORC2 in aldosterone-independent regulation of potassium secretion in the distal nephron.
Clinical and Histologic Predictors of Non-Diabetic Kidney Disease in Patients with Diabetes Mellitus
Reduced podocyte stiffness is a feature of proteinuric kidney disease
N-propargylglycine restores survival by preventing calcium oxalate stone formation, tubular injury, and kidney dysfunction in a lethal mouse model of primary hyperoxaluria type 2
Anti-PLA2R1 IgG-mediated podocyte PLA2R1 cleavage drives glomerular subepithelial immune complex deposition in membranous nephropathy
Evidence from multicenter clinical studies and humanized mouse models indicates that glomerular mesangial IgA2 deposition contributes to the pathogenesis of IgA nephropathy
Tubular cell-specific platelet-derived growth factor-B drives formation of fibrogenic niches in kidney fibrosis
Increased Smoothened signaling promotes kidney fibrosis through inhibiting autophagy in fibroblasts
Klotho in the kidney distal convolution regulates urinary Klotho excretion and kidney calcium reabsorption, but not phosphate homeostasis
Association between the gut microbiota and estimated glomerular filtration rate in two Swedish population-based cohorts
A population-based, regression discontinuity analysis examined the effects of nationwide alerting for acute kidney injury on health care and patient outcomes
Endothelial prolyl hydroxylase 3 mitigates maladaptive inflammation to promote post-ischemic kidney repair
A Drosophila model for Dent’s disease type 1 revealed impaired endoplasmic reticulum export of Cubilin as pathogenic mechanism
Podocyte-derived endothelin-1 and endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis
A secondary analysis of the TESTING trial predicted individual patient response to corticosteroid treatment in IgA nephropathy
Genotype-phenotype characteristics and disease progression of FAN1-related karyomegalic tubulointerstitial nephropathy
Population-based estimated Glomerular Filtration Rate distributions and associated health outcomes provide opportunities for early identification of and primary prevention of chronic kidney disease
Sodium glucose transporter 2 inhibition maintains kidney antibacterial response by decreasing complement C1q
Parathyroid hormone suppression profiles following oral calcium challenge in kidney transplant recipients
Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction
Aldehyde dehydrogenase 1 A1 regulates the transcription of PD-L1 and its targeting with disulfiram together with PD-L1 immunotherapy synergistically delays cyst growth in ADPKD
Mitochondrial protein TOMM7 alleviates diabetic kidney disease by regulating mitophagy via intracellular redistribution of phospholipase PLA2G6
A national cohort study examined the risk of severe infection and infection-related mortality in patients with chronic kidney disease with lupus nephritis in comparison to other chronic kidney disease etiologies
Sodium glucose cotransporter 2 inhibition does not improve active lupus nephritis in MRLlpr/lpr mice
A randomized controlled trial evaluated the effect of pravastatin on kidney disease outcomes in adult patients with early-stage autosomal dominant polycystic kidney disease.
Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function
Inactivation of Pkd2 in adult mice results in delayed cyst formation and identifies sex as a major modifier of disease severity.
Heterogeneity in the relationships between albuminuria and glomerular structure in type 1 and type 2 diabetes.
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1)
Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development
Patient anti-PLA2R1 autoantibodies cause membranous nephropathy in human PLA2R1 transgenic mice
Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.
Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
The Single Cell Landscape of the Human Vein After Arteriovenous Fistula Creation and Implications for Maturation Failure
Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis.
A stronger type I interferon signature distinguishes ANCA-associated vasculitis phenotypes and predicts kidney prognosis
Causal assessment of CKD-MBD biomarker alterations on CKD progression through a g-formula analysis in the EQUAL Study
Kidney-resident macrophages limit toxin-induced inflammation through their hallmark functions
Protein UHRF1-mediated dual dysregulation of molecular chaperone GRP78 induces endoplasmic reticulum stress and aggravates diabetic nephropathy
The Coming of Age for Polycystic Kidney Disease
Angiopoietin-like 4 exacerbates renal tubular epithelial cell pyroptosis in acute kidney injury via integrin β5/FAK signaling pathway
Integrated spatial and functional metabolic profiling identified the thick ascending limb as a mitochondrial vulnerability hub in acute kidney injury
Phosphoenolpyruvate carboxykinase 1-mediated cataplerosis is required to maintain mitochondrial fitness and to avoid kidney disease progression
Iohexol clearance, but not estimated GFR, reveals a steeper GFR decline in patients with prediabetes
Integrating estimated glomerular filtration rate and kidney replacement therapy criteria within the definition of kidney failure
The randomized DIALIZE-Outcomes trial evaluated sodium zirconium cyclosilicate in hemodialysis
Kidney hepcidin protects the collecting duct against ferroptosis in ischemia/reperfusion-induced acute kidney injury
Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease
Medium chain fatty acids are potent binding competitors to improve protein-bound uremic toxin clearance during hemodialysis
Protein kinase ROCK1 activates mitochondrial fission linking to oxidative stress and muscle atrophy
Chemical chaperone 4-phenylbutyrate treatment alleviates the kidney phenotype in a mouse model of Alport syndrome with a pathogenic variant in Col4a3
The enzyme SMPDL3b in podocytes decouples proteinuria from chronic kidney disease progression in experimental Alport Syndrome
Clinical relevance of computationally derived tubular features and their spatial relationships with the interstitial microenvironment in minimal change disease/focal segmental glomerulosclerosis
The Mayo MGRS Prediction Tool calculates the risk of finding monoclonal gammopathy of renal significance in a kidney biopsy in patients with monoclonal gammopathy
The metabolite alpha-ketoglutarate inhibits vascular calcification partially through modulation of TET2/NLRP3 inflammasome signaling pathway
Regulation of podocyte surface proteins by the enzyme A Disintegrin And Metalloproteinase 10 (ADAM10)
2
Mesoscale Modeling of Hydrogels Under Frictional Shear Stress
Enhanced Diffusion and Retention of Proteoglycan Replacements in Cartilage through Thermoresponsive Polyelectrolytes
13
A cytomegalovirus-encoded lncRNA blocks cell-cycle progression
Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks
Molecular basis for anti-jumbo phage immunity by AVAST type 5
Filament-mediated repurposing of toxic dITP for immunity in the Kongming system
Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle
The Ppl protein senses 3′-hydroxyl DNA overhangs and NTP depletion to halt phage infection
Alternative start codon selection shapes mitochondrial function and rare human diseases
Molecular mechanism of Eco8-mediated anti-phage defense
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity
A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
FMRP drives mRNP targets into translationally silenced complexes
Microprotein SMIM26 drives oxidative metabolism via serine-responsive mitochondrial translation
Activation of bacterial programmed cell death by phage inhibitors of host immunity
162
Polysubstance use disorders among US adults
Alzheimer’s disease-like brain pattern biomarker: capturing risks and predicting disease onset
Multiscale characterization of cortical signatures in positive and negative schizotypy: a worldwide ENIGMA study
Rapid rescue of despair behaviors by sonogenetic neuromodulation of the mPFC-DRN pathway
Microglia respond to and induce anxiety and grooming in mice using calcium signaling
Multi-omics and electrophysiological examination of GABAA receptors in the dorsolateral prefrontal cortex of humans with alcohol use disorder
The Cognitive benefits of nitrate in patients with alcohol use disorder: unraveling the oral microbiome ectopic colonization pathway
Characterization of the chromosome 7 locus associated with suicidal behavior
A prefrontal cortex-nucleus accumbens circuit attenuates cocaine-conditioned place preference memories
Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis
Neural representations of dynamical state and trait impulsivity in individuals at risk for internet gaming disorder
Cross-disorder comparison of brain structures among 4836 individuals with mental disorders and controls utilizing danish population-based clinical MRI scans
Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate microglial activation and alleviate depression-like behaviors in male mice
A longitudinal DNA methylation atlas and its link to brain structure and mental health
Stress-induced plasminogen activator inhibitor-1 (PAI-1) as a blood biomarker and brain risk factor for PTSD
Brain structural abnormalities in treatment-resistant schizophrenia
Cortical morphometry might predict currently prescribed vs. discontinued medications in bipolar disorder, even after controlling for the cumulative dose effects: An ENIGMA mega-analysis
A ventral striatal learning signal reflecting individual differences in the success of fear extinction
Microbiota-Driven microglia reprogramming reverses depressive-like behaviors through Peripheral-to-Central immune crosstalk
The dynamic impairment of synaptic transmission in the PCx-IL engram circuit contributes to early olfactory memory decline in Alzheimer’s disease
Prediction of self-harm in people with newly-diagnosed depression: development and validation of risk prediction models
Computational mechanisms of learning and forgetting differentiate affective and substance use disorders
Neuroanatomy reflects individual variability in impulsivity in youth
A genome-wide investigation of depression among individuals with and without irritability
NADPH oxidase-1 suppression prolongs the antidepressant-like effect of ketamine
BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior
Large-scale proteomic analyses before depression diagnosis reveal novel pathophysiological insights
Peripheral immune–redox signatures associate with cortical network alterations in anhedonic depression
Elevated pre-supplementary motor area activity during reward expectancy: An impulsivity-related neural marker of vulnerability to bipolar and externalizing disorders
Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders
The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression
Combining neurobiological markers and a sociodemographic risk score to predict adolescent depression – An IDEA RiSCo prospective cohort study
The global burden of mental and substance use disorders among adolescents and young adults
A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection
Dual regulatory roles of CPT1C in chronic stress-induced depression-related outcomes
Biomarker for craving and acamprosate treatment response in patients with alcohol use disorder: insights from multi-omics
Trends and patterns of medical stimulant use by US adults
Methamphetamine induces long-lasting dysbiosis of the gut microbiota
Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion
Sex differences in placebo and antidepressant response to intranasal esketamine for treatment-resistant depression
Exploring the impact of cognitive profiles on the response to magnetic seizure therapy and electroconvulsive therapy
A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants
Dynamic interactions between gut microbiome and host lipidome in antenatal depression: a large longitudinal study
Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample
Cross-Platform and cross-species lipidomic profiling identifies promising biomarkers for adolescent major depressive disorder
Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression
A genetic atlas of relationships between circulating metabolites and liability to psychiatric conditions
Spatiotemporal mapping of brain organisation following the administration of 2C-B and psilocybin
Translational reprogramming of dentate gyrus peptidergic circuitry gates antidepressant efficacy
Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors
Differential protein network and biological functions atlas from multi-tissue proteomics in patients with depression
Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis
Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide
Delay discounting correlates with depression but does not predict relapse after antidepressant discontinuation
Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders
Audiovisual gamma stimulation restores hippocampal neurogenesis and neural circuit plasticity in aging mice
Astroglial kappa opioid receptor-mediated reduction of glutamate exchanger xCT in the prelimbic cortex underlies chronic stress-induced depressive-like behaviors
Common alterations of whole and subregion-specific amygdala intrinsic functional connectivity across psychiatric disorders: a meta-analysis
Homeostatic scaling ensures behavioural stability during corticosterone negative feedback
Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue
Prediction of postoperative delirium after cardiac surgery by the interplay between preoperative plasma p-tau181 and IL-6 and heart-brain axis related factors: results from the prospective observational study FINDERI
The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
Decoding depression: stress-derived formaldehyde initiates depressive symptoms in mouse and human
Fshr gene depletion prevents recognition memory loss, fat accrual and bone loss in Alzheimer’s mice
Downregulation of integrin α3 in ADHD mirrored in mutant mouse model by dopamine-dependent hippocampal AMPAR expression
Associative memory neurons are recruited in PFC-centered circuits to encode schizophrenia-like behavior by dopaminergic receptor-II
MRI-derived estimation of biological aging in patients with affective disorders in a 9-year follow-up - a prospective marker of future recurrence
Antidepressant-like effects of extinction learning as an animal model of behavioral therapy
Syn III participated in rTMS-modulated emotional rescue in the prefrontal cortex under simulated space composite environment
Gut microbiota modulates synaptic plasticity, connectivity, and dopamine transmission in the VTA-mPFC pathway in bipolar depression
Unraveling sexually dimorphic offspring behaviors: maternal premating stress and the neuro-microbial-metabolic network
Deliberate self-harm and suicide in individuals with cannabis-related hospital contacts in Ontario, Canada
Structural brain abnormalities and aggression in schizophrenia: mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
Genetic architecture of suicidal ideation continuum: latent profile analysis of data using the million veteran program cohort
Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation
MAO-B status in alcohol use disorder: a [11C]SL25.1188 PET imaging study of putative astrogliosis
Cognitive trajectories of psychosis risk: temporal patterns and association with progression
Brain morphometry, stimulation charge, and seizure duration in electroconvulsive therapy
Mapping the reciprocal interactions between antidepressants and the gut microbiome: novel targets for the personalisation and optimization of drug response
Investigating the disturbance in cortical glutamate and GABA function in psychosis and its origins and consequences
NLRP3-mediated trained immunity of microglia is involved in the recurrence-like episode of depressive disorders
Quantitative monitoring of ketamine’s impact on synaptic density using 11C-UCB-J PET imaging in the corticosterone mouse model of anxiety/depression
The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents
Age-varying distinct neuroanatomy in young children with autism spectrum disorder and fragile X syndrome
Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine
Psilocybin mitigates chronic behavioral and neurobiological alterations in a rat model of recurrent intimate partner violence-related brain injury
The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects
Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group
Altered acetylcholine modulations and corticoaccumbal pathway in P11-linked social dysfunction
Immunometabolic blood biomarkers of developmental trajectories of depressive symptoms: findings from the ALSPAC birth cohort
Rapid antidepressant effect of single-bout exercise is mediated by adiponectin-induced APPL1 nucleus translocation in anterior cingulate cortex
Stress induces behavioral disorders by promoting microglial phagocytosis via decreasing neuronal Dkk3
Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit
Relapse risk prediction in patients with first-episode bipolar disorder: development, external validation, and pharmacotherapy associations of a machine learning model
Neuropharmacology of halogenated DMT analogs: psychoplastogenic and antidepressant properties of 5-Br-DMT, a psychedelic derivative with low hallucinogenic potential
GRIN2A null variants confer a high risk for early-onset schizophrenia and other mental disorders and potentially enable precision therapy
Genome-wide association study provides insights into the genetic basis of Lewy body dementia
Regulation of stress susceptibility by chromatin-binding protein PHF6 in the pituitary intermediate lobe
Hippocampal SGK1 promotes vulnerability to depression: the role of early life adversity, stress, and genetic risk
Posttranslational regulation of CREB-binding protein expression by F-box leucine-rich repeat-containing protein 19 and ubiquitin-specific peptidase 14 in the paraventricular nucleus participates in chronic stress-induced symptomatology via the modulation of the hypothalamic‒pituitary‒adrenal axis
DNA hypomethylation at specific CG-sites within TRAK1 is linked to the neurocognitive profile in Klinefelter syndrome
Development and validation of a prognostic model and risk calculator for the estimation of bipolar-spectrum disorder risk in hospitalised adolescents with non-psychotic/non-bipolar mental disorders
Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants
Generalizable stratification based on thalamo–somatomotor functional connectivity predicts responses to antidepressants in patients with depression
hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic development
A low frequency damaging SORCS2 variant identified in a family with ADHD compromises receptor stability and quenches activity
Aging reduces motivation through decreased Bdnf expression in the ventral tegmental area
Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors
Sustained antidepressant actions of ketamine involve TAMM41-mediated transfer of astrocytic sigma-1 receptor to neuron
Mechanistic insights into taxane-induced psychiatric adverse events: a global pharmacovigilance and experimental investigation
Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling
Cerebral glutamate levels over two years in initially antipsychotic-naïve first-episode patients with psychosis are related to clinical symptoms and cognition
Interrelations between dopaminergic-, gabaergic- and glutamatergic neurotransmitters in antipsychotic-naïve psychosis patients and the association to initial treatment response
Hippocampal Cofilin and CFL1 gene variants are linked to Alcohol Use Disorder phenotypes
Autophagy controls the hippocampal postsynaptic organization and affects cognition in a mouse model of Fragile X syndrome
Semaphorin 3A-mediated perineuronal nets formation incubates depressive-like behaviors in male mice via activating parvalbumin-expressing interneurons
Genetic and epigenetic analysis of plasma glial fibrillary acidic protein (GFAP) levels in PTSD
Dopaminergic frontostriatal pathways in major depressive disorder and childhood sexual abuse: a multimodal neuroimaging investigation
Global burden of diseases attributed to mental and substance use disorders in reproductive-age women: an ecological analysis for the Global Burden of Disease Study 2021
GABAA receptor availability in clinical high-risk and first-episode psychosis: a [11C]Ro15-4513 positron emission tomography study
Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth
Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models
Heavy adolescent drinking makes the adult brain more vulnerable to ethanol by permanently altering the age-dependent interplay between alcohol, GIRK channels and activin
Defective Hoxb8 microglia are causative for both chronic anxiety and pathological overgrooming in mice
Effects of esketamine on electrophysiology and metabolic reprogramming in brain organoids: insights into antidepressant mechanisms
Intermittent theta burst stimulation for non-suicidal self-injury in adolescents with major depressive disorder: a randomized, sham-controlled trial
Projection-specific roles of basolateral amygdala Thy1 neurons in alcohol-induced place preference
Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations
Effects of pre-gestational exposure to the stressors and perinatal mirtazapine administration on the excitability of hippocampal glutamate and brainstem monoaminergic neurons, hippocampal neuroplasticity, and anxiety-like behavior in rats
A single glucocorticoid response element regulates sociability in a sex-specific manner
Social hierarchy and resilience affect stress-induced PTSD via Uba7 gene expression and subsequent inflammation in microglia of the mPFC
A study of gene expression in the living human brain
Genetic and environmental aetiologies of the transition from nonsuicidal self-injury to suicide attempt: a longitudinal twin study
Pathogenic microbiota disrupts the intact structure of cerebral organoids by altering energy metabolism
An amygdala-cortical circuit for encoding generalized fear memories
Acute and chronic stress differentially regulate pain via distinct ensembles in the paraventricular nucleus of hypothalamus
Brain structure characteristics in children with attention-deficit/hyperactivity disorder elucidated using traveling-subject harmonization
Interleukin 13 signaling modulates dopaminergic functions and nicotine reward in rodents
5-HT2C receptors in the nucleus accumbens constrain the rewarding effects of MDMA
Effects of antipsychotics on human cognitive function: causal evidence from healthy volunteers following sustained D2/D3 antagonism, D2/D3 partial agonism and placebo
Adult hippocampal neurogenesis-mediated cognitive behavior participates in stress resilience to anxiety and depression-like behaviors in postpartum dams
Disease clusters and their genetic determinants following a diagnosis of depression: analyses based on a novel three-dimensional disease network approach
Targeting complement C3/C3aR pathway restores rejuvenation factor PF4 and mitigates neurocognitive impairments in age-related perioperative neurocognitive disorders
A medial habenula neural circuit controlling anxiety-like behaviors in response to acute stress
Alterations in miR-151a-3p of plasma-derived exosomes and associated multimodal neuroimaging patterns in major depressive disorder
Characteristics of brain network connectome and connectome-based efficacy predictive model in bipolar depression
Stress-induced reduction of sodium leak currents causes social deficits by impairing dorsal dentate gyrus-medial septum glutamatergic projection
Long term safety of ADHD medication in patients with schizophrenia spectrum disorders
Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study
Parvalbumin interneurons gate amygdala excitability and response to chronic stress via kainate receptor-driven tonic GABAB receptor-mediated inhibition
Single-cell transcriptomics reveals Sox6 positive interneurons enriched in the prefrontal cortex of female mice vulnerable to chronic social stress
Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions
Investigation of brain white matter and social cognition in schizophrenia and schizotypal personality disorder using neurite orientation dispersion and density imaging
Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer
Single-molecule DNA analysis implicates brain mitochondria pathology in bipolar disorder
Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder
A neural substrate of comorbid depressive symptoms in alcohol use
Whole-blood transcriptomic analysis reveals preoperative complement inhibitor deficiencies linked to postoperative delirium
Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome
Hippocampal ensembles regulate circuit-induced relapse of extinguished fear
Retinoic acid-mediated homeostatic plasticity drives cell type-specific CP-AMPAR accumulation in nucleus accumbens core and incubation of cocaine craving
11
Injury-Retention Strategy for Discriminative Magnetic Resonance Imaging and Enhanced Antioxidant Therapy of Drug-Induced Liver Injury
Modulation of Peptoid Nanostructure for Antibiofilm Hydrogel Interfaces
Neutrophil-Mediated Drug Delivery Nanoplatform Constructed from Celastrol Loaded Liposome for Targeted Therapy of Rheumatoid Arthritis
Dual Chemical Regulations for Combined Anti-Resorption and Osteo-Anabolism to Reverse Osteoporosis
Sugar-Responsive Enzyme–Polyphenol ‘Tooth Nanoarmor’ for Long-Lasting Caries Prevention via Glucose Depletion and Biofilm Suppression
Boosting Cancer Chemotherapy through Targeted Akkermansia muciniphila Modulation by Tumor-Repopulating Cell-Derived Microparticles
A Metal–Phenolic Network-Coated Coacervate System Mediates Mitochondrial Modulation and Bone Homeostasis Restoration for Postmenopausal Osteoporosis Therapy
Noninvasive Optoacoustic Imaging of Oxygen Saturation Reveals Hypoxic Hematopoietic Bone Marrow during Systemic Inflammation
Co-Assembled Cryptotanshinone Derivative and Glycyrrhizic Acid Carrier-Free Hydrogel: A Synergistic Approach to Acne Treatment
Enhancing 1O2 Production with Biomimetic Pt Catalysts through Electronic Structure Modification
A Nanosystem Alleviates Severe Acute Pancreatitis via Reactive Oxygen Species Scavenging and Enhancing Mitochondrial Autophagy
84
Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex
Translation-dependent degradation of cas12 mRNA triggered by an anti-CRISPR
A spatial atlas of the healthy human liver from live donors
Evolution of pandemic cholera at its global source
The DNA virome varies with human genes and environments
Insulin resistance prediction from wearables and routine blood biomarkers
Intestinal interoceptive dysfunction drives age-associated cognitive decline
B cell imprinting in children impairs antibodies to the haemagglutinin stalk
Capturing dynamic phage–pathogen coevolution by clinical surveillance
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity
Merlin: a computed tomography vision–language foundation model and dataset
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity
Peripheral immune-inducer dendritic cells drive early-life allergic inflammation
A membrane-bound nuclease directly cleaves phage DNA during genome injection
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones
Mucosal vaccination clears Clostridioides difficile colonization
Integrase anchors viral RNA to the HIV-1 capsid interior
Striatum-wide dopamine encodes trajectory errors separated from value
A pore-forming antiphage defence is activated by oligomeric phage proteins
Bacterial immune activation via supramolecular assembly with phage triggers
Mosquito–capsid interactions contribute to flavivirus vector specificity
A prophage-encoded abortive infection protein preserves host and prophage spread
Cholinergic modulation of dopamine release drives effortful behaviour
Psychedelics elicit their effects by 5-HT receptor-mediated G signalling
Common variation in meiosis genes shapes human recombination and aneuploidy
Microbiota-induced T cell plasticity enables immune-mediated tumour control
Albumin orchestrates a natural host defence mechanism against mucormycosis
Evidence accumulation from experience and observation in the cingulate cortex
Mimicking opioid analgesia in cortical pain circuits
Prefrontal neural geometry of learned cues guides motivated behaviours
Prevalence of Alzheimer’s disease pathology in the community
Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes
Correlates of HIV-1 control after combination immunotherapy
CD8 T cell stemness precedes post-intervention control of HIV viremia
Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation
Long-read metagenomics reveals phage dynamics in the human gut microbiome
Thalamocortical transcriptional gates coordinate memory stabilization
Building compositional tasks with shared neural subspaces
Integrator dynamics in the cortico-basal ganglia loop for flexible motor timing
Viral NblA proteins negatively affect oceanic cyanobacterial photosynthesis
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology
Spatial fibroblast niches define Crohn’s fistulae
Adenosine signalling drives antidepressant actions of ketamine and ECT
Multi-omic profiling reveals age-related immune dynamics in healthy adults
Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21
The astrocytic ensemble acts as a multiday trace to stabilize memory
Isolation, engineering and ecology of temperate phages from the human gut
Spatial metabolic gradients in the liver and small intestine
Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22
Monoclonal antibodies protect against pandrug-resistant Klebsiella pneumoniae
Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death
The Panoptes system uses decoy cyclic nucleotides to defend against phage
Transitions in dynamical regime and neural mode during perceptual decisions
Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus
Programmable antisense oligomers for phage functional genomics
Rate and noise in human amygdala drive increased exploration in aversive learning
Maternal stress triggers early-life eczema through fetal mast cell programming
Cocaine chemogenetics blunts drug-seeking by synthetic physiology
A compressed hierarchy for visual form processing in the tree shrew
mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury
Remodelling of corticostriatal axonal boutons during motor learning
Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life
A gut sense for a microbial pattern regulates feeding
Prophages block cell surface receptors to preserve their viral progeny
Microbiota-driven antitumour immunity mediated by dendritic cell migration
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics
Feline infectious peritonitis epizootic caused by a recombinant coronavirus
Nutrients activate distinct patterns of small-intestinal enteric neurons
The spatiotemporal distribution of human pathogens in ancient Eurasia
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Engrafted nitrergic neurons derived from hPSCs improve gut dysmotility in mice
Kupffer cell programming by maternal obesity triggers fatty liver disease
Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin
Multi-timescale reinforcement learning in the brain
Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy
A multidimensional distributional map of future reward in dopamine neurons
Protein-primed homopolymer synthesis by an antiviral reverse transcriptase
Dynamic basal ganglia output signals license and suppress forelimb movements
Sequence diversity lost in early pregnancy
Dopaminergic action prediction errors serve as a value-free teaching signal
Targeting symbionts by apolipoprotein L proteins modulates gut immunity
Striatum supports fast learning but not memory recall
Dopamine D1–D2 signalling in hippocampus arbitrates approach and avoidance
2
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia
Inducing bacterial calcification for systematic treatment and immunomodulation against methicillin-resistant Staphylococcus aureus
2
Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis
A SETD2–CDK1–lamin axis maintains nuclear morphology and genome stability
4
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment
Dual cytosine modification through hydroxylation and arabinofuranosylation in phages
Structural insights into type-I and type-II Lamassu antiphage systems
Structure and mechanism of an actin-dependent bacterial phosphoryl AMPylase
903
Bifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis
Impaired glucose tolerance and mild diabetes induce β-cell dysfunction in mice
Escalating transmissibility of severe fever with thrombocytopenia syndrome in a high-endemic region of China
Resolving mesoscale brainstem-prefrontal-striatal pathways underlying decisions upon salient events using submillimeter-resolution fMRI
RNA targeting therapy for a prenatally enriched potassium channel associated with severe childhood epilepsy and premature death
Clec3b⁺ fibroblasts are the primary effectors of portal fibrosis following activation via a KLF4/periostin axis
Uromodulin p.His36Tyr promotes macrophage pyroptosis via App-Cd74 signaling to drive renal inflammation in ADTKD
The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning
True cyst formation underlies persistence and drug tolerance in Tritrichomonas foetus
Generation of an autophagy-targeting influenza A virus as live attenuated vaccine
The role of Pth1r in posterior cranium cartilage regulation and craniosynostosis
V- and VL-scores unveil viral signatures and origins of protein families
Face aging rate quantifies change in biological age to predict cancer outcomes
CFTR mediates Cl- transport in osteocytes to sustain cell viability and skeletal homeostasis
Quantifying phage-host dynamics using droplet microfluidics
A family of ribosome hibernation factors widespread in Archaea
Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity
Nonergodicity and Simpson’s paradox in neurocognitive dynamics of cognitive control
Acute sleep rebound following sleep restriction is associated with reduced mortality risk
Identification of synovial lymphatic system in the temporomandibular joint and their roles in arthritis and pain
Coupled cross-sectional and longitudinal non-negative matrix factorization reveals dominant brain aging trajectories in 48,949 individuals
RAISE: A computational tool for evaluating sarbecovirus spillover potential
Dorsal prefrontal cortex drives perseverative behavior in mice
Stringent selection drives convergence toward omicron-like SARS-CoV-2 receptor-binding motifs
Structures of dye-bound transthyretin amyloid fibrils from abdominal fat biopsies
Suppression of astrocyte BMP signaling improves molecular signatures and functional deficits in a fragile X syndrome mouse model
Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity
Small RNA genomics of Aedes aegypti mosquitoes discovers infectious viruses that trigger an RNA interference response
Predicting individual differences of fear and cognitive learning and extinction
TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network
Quinone-mediated, tissue-adaptive double-network hydrogel for instant hemostasis and wet-tissue adhesion
A pharmacokinetic and pharmacodynamic drug-drug interaction study of dorzagliatin and empagliflozin in patients with type 2 diabetes and obesity: an open-label phase I trial
Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial
Low dose IL-2 therapy restores regulatory T cells in patients with systemic lupus erythematosus in a dose-dependent manner: a phase IIb trial
Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids
Chemotherapy-induced activation of caspase-1 and IL-1α release by cancer cells remotely skews myelopoiesis to drive pro tumorigenic systemic neutrophil-dominant inflammation
Collagen hybridizing peptide imaging and delivery of therapeutic antibody in rheumatoid arthritis models
Phage homing endonuclease amplifies anti-defense genes to evade bacterial immunity
Improved dynamic MRI of the wrist and heart at 0.55 T enabled by rapid 3D printed flexible coils
Hotspot pocket-based discovery of urea transporter selective inhibitors
Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD
Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis
Rare regulatory mutations disrupt mesenchymal molecular programs driving endocardial cushion formation in bicuspid aortic valve
Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks
Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo
γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response
Structural analyses uncover protease-adhesin interactions and c-di-GMP receptor regulation in sulfate-reducing bacteria
Cryo-EM reveals structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations
Dynamics of oscillatory power support the integration of perceptual and mnemonic information within the premotor cortex
Target Trial Emulation of Vaccine Effectiveness in 5- to 17-years-olds with Prior SARS-CoV-2 Infection
Cross-species transcriptomics identify mineralocorticoid receptor pathway overactivation as a central driver of ocular rosacea
SARS-CoV-2 vaccination and infection elicit cross-neutralizing responses against clade 3 and 4 sarbecoviruses
A microbiome catalog of Chinese traditional artisanal cheeses provides insights into functional and microbial diversity
Dynamic structures of dengue virus serotype 2 secreted NS1 and their interactions with heparan sulfate
N-Glycans modulate tilting of HIV-1 envelope glycoprotein
An anti-adhesive compound modulating the production of Staphylococcus aureus cell wall-anchored proteins
A deep learning–based digital biopsy for predicting early recurrence in gastric cancer
Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay
Wireless electrostimulation implants enable sphincter neuromuscular improvement toward mixed urinary incontinence
Post-acute organ complications within one year following COVID-19 hospitalization and related socioeconomic inequalities
Temporal predictions shape somatosensory perception
Unexpected detection of Mycobacterium tuberculosis DNA in US-born patients in putative association with clinical syndromes
Multiomics characterization of acute child illness and mortality in Africa and South Asia
Proinsulin regulators identified with CRISPR screen and in vivo mouse QTL mapping
An ancient genome of Streptococcus pyogenes from a pre-Columbian Bolivian mummy
Structural atlas of the intact jumbo phage phiKZ
Hydroxylation of the HIV-1 antisense protein promotes immune evasion of HIV-1 via modulation of TBK1
JAK inhibitors alleviate EGFR-inhibitor-induced diarrhea by protecting intestinal stem cells from adaptive-immune-exacerbated injury
A group 1 hemagglutinin stem vaccine elicits broad humoral responses against influenza in phase 1/2a study
Host–microbiome archetypes differentiate infection from pathogen carriage in the human lower airway
Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM
CBP/p300 is critical for the expansion and maintenance of functional pancreatic α cell mass
Sex-specific increased reactivity of the PVT and prolonged PVT→CeA circuit engagement following psilocin administration
Cabozantinib and temozolomide in patients with advanced progressive neuroendocrine tumors: a phase 2 study
Rapid evolution of Klebsiella pneumoniae biofilms in vitro delineates adaptive changes selected during infection
HIV-1 uncoating location dictates sites of integration
CD73high fibroblasts orchestrate keratinocyte inflammation in the psoriasis-associated epithelial immune microenvironment
Fc-free single-chain antibody mRNA therapy for airway infection of multidrug-resistant Pseudomonas aeruginosa
Serpina1e mediates the exercise-induced enhancement of hippocampal memory in male mice
Hemostatic Tough Adhesives seal tissue and control hemorrhage
Proviral NUP153 binding to viral proteins and RNA regulates structural–nonstructural protein ratios in orthoflavivirus infection
A deep representation learning model to predict response to vagus nerve stimulation
Daily steps offset risks of sedentary behavior in the All of Us research program
Lactate metabolism reprogramming through orthogonal tandem catalysis to reverse intervertebral disc degeneration
Small nucleolar RNA drives self-renewal of intestinal stem cells via initiation of transcription
Complex temporal dynamics of phage-bacteria populations in an animal-associated marine system
An in vivo fitness gene of Toxoplasma, MIC11, is essential for PLP1-mediated egress from host cells
Real-world evidence for comparative safety of second-line antihyperglycemic agents in older adults with type 2 diabetes
A urea-activated nanocarrier for site-specific SGLT2 inhibition and metabolic rescue against cardiovascular-kidney-metabolic syndrome
Influence of the broadly neutralizing antibody VRC01 on HIV breakthrough virus populations in antibody-mediated prevention trials
ZFP36L2 is an interferon β -induced inhibitor that restricts the nuclear export of HIV-1 transcripts
Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance
Enhanced reward coding and condition-independent dynamics in optogenetically identified corticostriatal neurons in monkeys
Generalization of fear learning is shaped by inhibitory sensory processing in mice
Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse
A single viral enzyme drives tRNA-dependent hypermodification of DNA at adenine
Subcellular reorganization upon phage infection reveals stepwise assembly of viral particles from membrane-associated precursors
Sgk1 upregulation in hippocampus-projecting amygdala neurons underlies the delayed onset of PTSD-like avoidance behavior
Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still’s disease
Manifold topological deep learning for biomedical data
Revealing abrupt transitions from goal-directed to habitual behavior
Concurrent chemoradiotherapy plus nimotuzumab versus chemoradiotherapy alone for locoregionally advanced nasopharyngeal carcinoma with a suboptimal response to induction chemotherapy: a randomized phase 2 trial
A prospective multicenter trial of deep learning auto-segmentation for organs at risk in thoracic radiotherapy
Small intestinal microbial fiber metabolism dysfunction in celiac disease
Pathogenic variants in the cohesin loader subunit MAU2 underlie a distinct Cornelia de Lange Syndrome subtype
Hemoadsorption combined with hemodialysis versus hemodialysis alone on mortality in end-stage kidney disease: a randomized, open-label, multicenter trial
Role of the primate ventral striatum as a neural hub bridging option valuation and action selection
Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthritis via Nav1.7 axis
A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites
Ultrasmall oral modulate gingival immunoactivation through type IV pili and TLR2-dependent endocytosis
Accumulation of virtual tokens towards a jackpot reward enhances performance and value encoding in dorsal anterior cingulate cortex
Valeric acid from oral microbiome suppresses esophageal cancer growth by disrupting eEF1A1 -mediated translational output
Single-bacterial cell insights into mechanisms of ceftriaxone resistance in Neisseria subflava
SMART: spatial multi-omic aggregation using graph neural networks and metric learning
Molecular evolution and spatial transmission of severe fever with thrombocytopenia syndrome virus
Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife
Cortex-wide characterization of decision-making neural dynamics during spatial navigation
IgA autoantibodies promote inflammation, Th17 polarization and fibrotic responses in hidradenitis suppurativa
Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals
Mitochondrial metabolic imbalance drives diploidization in mouse haploid embryonic stem cells via NADPH overload
Post-pandemic changes in population immunity have reduced the likelihood of emergence of zoonotic coronaviruses
Unveiling the biodiversity of large DNA viruses in intertidal mudflats via metagenomics
Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut
Cross-order detection of bacteriophage transduction in microbial communities using RNA barcoding
Sequential sequencing reveals the architecture and complexity of genomic variants in patients with Alport syndrome
An epithelial morphogenetic program for maximal urine concentration
In-utero exposure to chikungunya and child morbimortality: a population-based study using linked routine data
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats
Genomic inference of sites of transmission during regional spread of blaNDM Klebsiella pneumoniae in Michigan
Loss of polarity by Cdc42 depletion and oncogenic Kras activation in the mouse intestinal epithelia leads to a necrotizing enterocolitis (NEC)-like disease
Rapid dynamics of dorsal raphe serotonin neurons regulate the strength of visual attention
Prasugrel inhibits TLR7-driven autoimmunity in systemic lupus erythematosus by acetylating cGAS
Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model
Neural circuit models for evidence accumulation through choice-selective sequences
Bidirectional regulation of social memory by two distinct types of GABAergic neurons in the lateral septum
Massively parallel quantification of mutational impact on IAPP amyloid formation
Dynamics of phage-host interactions in Bacteroides fragilis resolved by single-cell transcriptomics
Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics
Wireless, non-invasive, high-resolution thrill sensor for continuous vascular access monitoring of hemodialysis patients
Noradrenaline causes a spread of association in the hippocampal cognitive map
Unpacking sources of transmission in HIV prevention trials with deep-sequence pathogen data
Frazzled/DCC directs spatial progenitor integration ensuring steady-state intestinal turnover
Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation
Periplasmic gatekeeping of phage DNA entry by an rSAM enzyme matured effector with HxS repeats
Post-infection sequelae of COVID-19 and other infectious diseases—a nationwide Danish study with 40-month follow-up
A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice
Recycling senescent cell lipids for targeted senotherapy
A genus-wide interaction atlas across NS4B orthologues identifies a conserved role for UFMylation in orthoflavivirus replication
A genetic toolkit for the human gut bacterium Mediterraneibacter gnavus identifies capsular polysaccharides as a competitive colonization factor
Cortical-limbic circuit dynamics of approach-avoidance conflict in humans
Intrinsic capacity and stroke risk in a multiple cohort study
Biological valorization of methane and nitrogen gas-derived ammonia via methanotrophic bacteria for gut-beneficial nutrients
Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice
Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses
The role of amygdala GABA neurons in controlling stress and reproduction in female mice
CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters
Infection-acquired protection against SARS-CoV-2 infection and clinical severity by number of prior infections
Epilepsy-associated variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination
Heterogeneity in lysosomal dynamics and metabolic functions along the kidney proximal tubule
CXCR4-tropic HIV-1 infection in an immunocompetent monkey model
Transcriptional regulation of the pneumococcal capsule can dictate serotype-specific infection
A human cerebral organoid model of West Nile virus encephalitis shows innate immunocompetency
Recurrent and novel evolutionary pathways drive in vitro HIV-1 lenacapavir resistance with diverse phenotypic consequences
Assessing the micromechanical architecture of joint tissues with speckle rheological microscopy
The genetic basis of dermatophytosis skin infection susceptibility
Tudor domain-containing protein 9-targeting siRNA nanoparticles alleviate lung injury in preclinical models by promoting neutrophil cuproptosis
Segmented filamentous bacteria are worldwide human gut commensals
Dolutegravir restores gut microbiota in late-stage HIV-1 unlike darunavir: an open-label, randomized clinical trial
Contrast-free identification of glioma blood-brain barrier status via generative diffusion AI and non-contrast MRI
HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV
Proteomics-based machine learning model for predicting secondary infection in HBV-related liver failure
sRNA centered signaling activates nitrate respiration and enhances virulence in host environments
Epitope-spanning antigenic variation reprograms immunodominance and broadens immunity in sequential influenza vaccination
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of
Attention-related modulation in the superior colliculus encodes perceptual sensitivity, but not perceptual choice
SOD1 lactylation impair its enzymatic activity by conformational change to aggravate intervertebral disc degeneration
Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure
Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
TRIM13 in situ engineering boosts anti-inflammatory capacity of CAR-Ms for liver fibrosis therapy
Post-treatment SIV control is associated with specific features of viral persistence before and after treatment interruption
Chiral peptidoglycan mimics target bacterial wall biosynthesis for pathogen intervention
Gut microbiome composition and strain-sharing in multiplex autism spectrum disorder families
Excess FGFR3 signaling in achondroplasia disrupts turnover of resting zone chondrocytes via CREB signaling
Photochemical nanomotors reverse anxiety- and depressive-related behaviors in rodents via spatiotemporal polarity dynamics tuning
Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse model
DUSP26 protects against acute kidney injury by dephosphorylating p53 at serine 312
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells
A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a -associated program
A ketogenic diet enhances aerobic exercise adaptation and promotes muscle mitochondrial remodeling in hyperglycemic male mice
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis
Intestinal pathogens override hunger-driven decision-making via immune regulation of central serotonin signaling in
Regional nonsense constraint offers biological and clinical insights into genetic disease
Evaluating spatially targeted HIV interventions and harm reduction services among people who inject drugs in a high-burden setting
The genetic landscape of human functional brain connectivity
and prebiotic interventions restore early-life high-fat/high-sugar diet-induced alterations in feeding behavior in adult mice
Conformational landscape of HIV-1 Env from closed to fully open
Maintenance of intestinal CX3CR1+ macrophage homeostasis defines post-treatment control in SIV-infected macaques
Context-dependent translation inhibition as a cancer therapeutic modality
Using electronic health records to assess the relationship between colonization pressure and nosocomial pathogen acquisition
Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices
Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms
Small heterodimer partner protects against osteoarthritis by inhibiting IKKβ/NF-κB-mediated matrix-degrading enzymes in chondrocytes
Developmental plasticity enables an intestinal tapeworm to adapt to dietary stress
In situ structures of the portal-neck-tail complex of bacteriophage T4 inform a viral genome positioning mechanism
The effects of a second pregnancy on women’s brain structure and function
Pyrimidinergic calcium signaling links tubular metabolism to fibrosis in kidney disease
Mitochondrial heteroplasmy is a risk factor for the development of chronic lymphocytic leukemia
A bacterial YopJ-family acetyltransferase suppresses host immune response by ε-acetylation of JAK1
Inferring latent behavioral strategy from the representational geometry of prefrontal cortex activity
Biomimetic metal-drug coordination nanoplatform to counteract drug resistance in via energy disruption
Activity in human dorsal raphe nucleus signals changes in behavioural policy
GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotection
Brain-derived neurotrophic factor and the derived dodecapeptide function as Toll-like receptor 4 antagonists in acute lung injury
Loss-of-function variants in the CAPN1 activator cause X-linked spastic ataxia
The interplay of sleep characteristics with health factors and gut microbiome
Sustained physical activity offers benefits beyond activity volume in chronic disease prevention
Competing cognitive pressures on human exploration in the absence of trade-off with exploitation
A missense variant in leads to lobodontia
Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation
Multi-modal AI for opportunistic screening, staging and progression risk stratification of steatotic liver disease
Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection
Treg-γδ T cell axis determines sexual dimorphism in hepatocarcinogenesis
Granulomas microenvironment-guided sono-immunotherapy to treat and prevent recurrence of tuberculosis
Opposite effects of chronic HIV infection and antiretroviral medication on organismal and organ-specific biological aging
A synthetic system for RNA-responsive pyroptosis based on type III-E CRISPR nuclease-protease
An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models
Final survival analysis of induction chemotherapy with lobaplatin and fluorouracil versus cisplatin and fluorouracil followed by concurrent chemoradiotherapy in nasopharyngeal carcinoma: a multicenter, randomized, phase 3 trial
Latent transition analysis for longitudinal studies of post-acute infection syndromes
Molecular mechanism of action of small molecule SMT-738 on bacterial lipoprotein transporter LolCDE
A 7 T fMRI dataset of synthetic images for out-of-distribution modeling of vision
Multicountry genomic analysis underscores regional cholera spread in Africa
Recombinant zoster vaccine is associated with a reduced risk of dementia
Devaluation of response-produced safety signals reveals circuits for goal-directed versus habitual avoidance in dorsal striatum
Combined bacteriophage and antibiotic therapy for refractory peritoneal dialysis-related peritonitis caused by Klebsiella pneumoniae
Discovery of antimicrobial peptides targeting via a pre-trained and fine-tuned few-shot learning-based pipeline
Urinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial
Cryo-EM structures of bacteriophage T4 portal-neck assembly intermediates reveal a viral genome retention mechanism
Identification of protein precursor for thyroid hormone synthesis in basal chordate ascidian
Hierarchical picot-fiber hydrogel coating with ultralow friction and high wear resistance
Mycobacterium tuberculosis modulates phosphorylation of host ATP6V1E1 to promote intracellular survival
A montmorillonite-based oral fermentation system enables long-lasting in-situ biosynthesis to restore intestinal homeostasis
Immune-mediated protection and enhancement of dengue drives patterns of infant cases in Brazil
Automated diagnostic of cervical spondylosis on multimodal medical images with a multi-task deep learning model
Miniature endoscope for high resolution electrophysiological recordings from the colon of live mice
promotes colorectal cancer metastasis by maintaining enhancer-promoter loops through releasing neutrophil extracellular traps
HCMV infection disrupts barrier functions and promotes epithelial–mesenchymal transition in a cholangiocyte organoid model
Daratumumab in systemic lupus erythematosus: a single-arm phase 2 trial
Prefrontal chandelier cells encode stimulus salience to influence learning in male mice
A microphysiological human mini-bladder reveals urine-urothelium interplay in tissue resilience and UPEC recurrence in urinary tract infections
Biomarker-integrated prognostic stagings for Alzheimer’s Disease
A digital platform with activity tracking for energy management support in long COVID: a randomised controlled trial
Microbiota-induced EI24 improves homeostasis but impedes function of alveolar macrophages via metabolic regulation
Safety and biologic activity of a bispecific T cell receptor targeting HIV Gag in males living with HIV: a first-in-human trial
Early detection of aberrant cell fate and repair using circulating progenitor cells in patients with heterotopic ossification
Molecular signatures of resilience to Alzheimer’s disease in neocortical layer 4 neurons
High-throughput methods leveraging robotics and computer vision for the development of therapeutic phage cocktails
Geographic spillover of antimicrobial resistance from mass distribution of azithromycin
VSIG10L is a major determinant of esophageal homeostasis and inherited predisposition to Barrett’s esophagus
Prenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques
Domain-specific schema reuse supports flexible learning to learn in the primate brain
Ultra-fast self-gelling self-expanding self-propelling high-adhesion procoagulant hemostatic powder for non-compressible hemorrhage hemostasis in pigs
Electrographic cue-reactivity co-localizes with accumbens deep brain stimulation in a case of opioid use disorder
Large-scale capsid-mediated mobilisation of bacterial genomic DNA in the gut microbiome
Oligoprotein type I interferon signatures, but not variants, increase risk of systemic lupus erythematosus in UK Biobank
Targeting mGlyR with nanobodies for depression
A stabilized tandem antigen chimera that elicits potent malaria transmission-reducing activity
Interaction and functional specialization across a distributed neural circuit for flexible task control in macaques
Bradyzoite subtypes rule the crossroads of development
An H5N1 clade 2.3.4.4b virus vaccine that elicits cross-protective antibodies against conserved domains of H5 and N1 glycoproteins
Using the linear references from the pangenome to discover missing autism variants
A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems
Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome
Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice
Longitudinal plasma proteomic signatures of elite and viremic spontaneous HIV controllers
A bacterial defense system targeting modified cytosine of phage genomic DNA
No evidence of immediate or persistent analgesic effect from a single dose of psilocybin in three mouse models of pain
An ultra-long-acting dimeric bictegravir prodrug defined by a short pharmacokinetic tail
Impact and cost-effectiveness of doxycycline post-exposure prophylaxis in Australian men who have sex with men
Multimodal analysis disentangles the genetic and microbial associations between inflammatory bowel disease and other immune-mediated diseases across a harmonized population framework
Endothelial cell responses in sepsis are attenuated by targeting truncated procalcitonin
Unbiased clustering of acute-on-chronic liver failure patients using machine learning in a real-world ICU cohort
High-entropy alloy Janus artificial enzymes for pH-gated sequential redox therapy of drug-resistant bacterial infection
Endothelin-3 and T-type Ca2+ channels drive enteric neural crest cell calcium activity, contractility and migration
Differential membrane lipid disruption by lipopeptide antibiotics, colistin and turnercyclamycins
Vibrio cholerae serotype impacts pathogenicity
Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne
Structure of a bacteriophage reveals cell wall adsorption mechanism in Gram-positive infecting siphophages
Impact of a single fecal microbiome transplantation in adult women with anorexia nervosa: an open-label feasibility pilot trial
Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis
Identification of antimicrobial peptides from ancient gut microbiomes
Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity
Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling
Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenza
Genomics reveal persists during long-term urinary catheterization despite antimicrobial therapy and catheter exchanges
Intranasal unadjuvanted LcrV boosts parental OMV primed lung immunity against pneumonic plague in mice
The interconnected wirings between medial prefrontal cortex and claustrum and their governing roles in the methamphetamine reward memory in male mice
Time-dependent deployment of medial prefrontal cortical representations in male mice
The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion
Once and thrice weekly interval training in adults with central obesity: a randomized controlled trial
Dual-action bisphosphonate hydrogel preserves cortical bone integrity and restores healing cascade in osteoporotic fracture-related infection
Arachidonic acid induces pyroptosis via a non-autophagic function of mitophagy and enhances immunotherapy in a PDAC model
Timely bespoke phage-antibiotic combination to treat refractory Pseudomonas aeruginosa mediastinitis and vascular graft infection
Antisense oligonucleotides to polymorphisms expand targets and rescue patient-derived neurons in vitro
Endothelial IRE1α promotes thrombospondin-1 mRNA decay and supports metabolic stress adaptation of pancreatic islets
Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Hepatokine fibrinogen-like protein 1 drives liver-kidney crosstalk to promote renal fibrosis
Computational and neural mechanisms underlying the influence of action affordances on value learning
Antecedent enhancer activity predicts future susceptibility to seizures in mice
Dynamins maintain nuclear envelope homeostasis and genome stability
Co-occurrence of diverse defense systems shapes complex microbe-virus relationships in deep-sea cold seeps
AI-enabled electrocardiogram alert for potassium imbalance treatment: a pragmatic randomized controlled trial
Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome
Prehospital real-time AI for trauma mortality prediction: a multi-institutional and multi-national validation study
Efficacy and safety of low-dose interleukin 2 for Behçet’s syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial
Adjuvanted influenza vaccination increases pre-existing H5N1 cross-reactive antibodies
Disturbances of paraventricular thalamic nucleus neurons in bipolar disorder revealed by single-nucleus analysis
Efficacy and safety of cAMP signalling-biased GLP-1 analogue ecnoglutide monotherapy versus placebo in patients with type 2 diabetes (EECOH-1): a multi-centre, randomised, double-blind, placebo-controlled, phase 3 trial
Sirt6 deficiency in mast cells promotes adipose fibroinflammation in obesity through galectin-3 signaling
Individual and population-level risk factors for new HIV infections among adults in Eastern and Southern Africa
A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice
Distinct antidepressant therapies act on a common brain network
Acute exercise rewires the proteomic landscape of human immune cells
Methionine restriction alleviates kidney fibrosis through epigenetic repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis
Distinct diet-microbiome associations in autism spectrum disorder
Rhomboid protease GlpG regulates type 1 pili quality control and virulence in pathogenic E. coli
Molecular characterisation of the Bacillus subtilis SpbK antiphage defence system
Viral entry shapes HCMV latency establishment
IL-17a induces age-related olfactory dysfunction by impairing regeneration and promoting respiratory metaplasia in mice
Multi-omics analysis identifies a microbiota–bile acid–TLR signaling axis driving bladder injury in interstitial cystitis
Effectiveness of the 2024–2025 KP.2 COVID-19 vaccines in the United States during long-term follow-up
In vivo electrochemical reduction-induced reconfiguration of Prussian blue for metal counterion-free potassium removal in hyperkalemia
Meta-analysis of 22,710 human microbiome metagenomes defines an oral-to-gut microbial enrichment score and associations with host health and disease
Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis
Regional activity within the human amygdala varies with season, mood and illuminance
Distinct mechanisms of transcriptomic habituation to repeated stress in the mouse hippocampus
Constructing the human brain metabolic connectome with MR spectroscopic imaging reveals cerebral biochemical organization
Rational design of flavivirus E protein vaccine optimizes immunogenicity and mitigates antibody dependent enhancement risk
Tracing the origin of myofibroblasts in kidney fibrosis
Risk of major adverse cardiovascular events with aripiprazole versus olanzapine, quetiapine, and risperidone in severe mental illness: a target trial emulation
Staphylococcus aureus fatty acid metabolism governs saeRS-mediated aggregation in joint infections
Restoration of PKM1 improves functional maturation of human stem-cell derived-β cell by regulating PEP metabolism
Neisseria meningitidis filamentous phage MDA promotes colonisation by selecting hyperadhesive pili variants
Mapping risks of health conditions in people with atopic eczema in English primary care and hospital data
Preoperative nutritional support in children with Hirschsprung disease: a prospective multicenter open-label randomized controlled trial
MIDAS: rapid, multiplexed molecular profiling for integrated host–pathogen analysis
Reaching elimination of onchocerciasis transmission with long-term vector control and ivermectin treatment in Togo
Utilizing nanoinducers for precision degradation of bacterial protein to mitigate antibiotic resistance
Minor SHIV variants abrogate protective efficacy of broadly neutralizing antibodies in rhesus macaques
Gut microbiota modulates aversive learning and memory of honeybees (Apis mellifera)
Denosumab attenuates knee osteoarthritis progression by inhibiting synovial inflammation via the RANK/TRAF6/FSTL1 signalling
Supporting cells orchestrate noise-induced hearing loss via a Gasdermin D-dependent signaling loop with hair cells
A genome-wide CRISPR screen identifies GRA38 as a key regulator of lipid homeostasis during Toxoplasma gondii adaptation to lipid-rich conditions
Spatially heterogeneous acetylcholine dynamics in the striatum promote behavioral flexibility
NutriSighT: Interpretable Transformer Model for Dynamic Prediction of Underfeeding Enteral Nutrition in Mechanically Ventilated Patients
Cryo-EM structure of renal AL amyloid fibrils from a patient with λ1 light chain amyloidosis
AI-powered SPOT imaging for enhanced myocardial scar detection and quantification
Cascades of effectiveness of next-generation insecticide-treated nets against malaria, from entomological trials to real-life conditions
Sources of essential lipids for via P116 to target liver and atherosclerotic lesions
Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patient
A synthetic cell phage cycle
Development of a replication-defective mpox virus platform for fundamental and therapeutic research
Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy
Persistent pneumococcal colonisation in antiretroviral-treated HIV infection is associated with nasal inflammation
Divergent transcriptional regulation of redox-homeostasis and permeability modulate rifampicin tolerance and sensitivity in Mycobacterium tuberculosis
Encapsulated faecal microbiota transfer in young women with anorexia nervosa: an open-label feasibility pilot trial
A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity
Glucagon-like peptide-1 receptor agonist in large vessel occlusion treated by reperfusion therapy—a phase 2 randomized trial
Circadian rhythm profiles derived from accelerometer measures of the sleep-wake cycle in two cohort studies
Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation
Immunological and transcriptomic profile of chimeric live-attenuated Zika vaccine linked to protection in non-human primates
Impact and cost-effectiveness of the community-led AMETHIST intervention among female sex workers in Zimbabwe
An ER-resident lipid scramblase is crucial for biogenesis and function of apicomplexan parasite secretory organelles
Infectome analysis of small mammals in Southern China reveals pathogen ecology and emerging risks
Concurrent TB and HIV therapies control TB reactivation during co-infection but not chronic immune activation
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations
Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset
Infant gut anellovirus composition associates with early life factors and childhood atopic disease
Gut bacteria-derived sphingolipids alter innate immune responses to oral cholera vaccine antigens
Lactate bridges mesangial cells to the differentiation of follicular helper T cells in lupus nephritis
Pathogenicity, virological features, and immune evasion of SARS-CoV-2 JN.1-derived variants including JN.1.7, KP.2, KP.3, and KP.3.1.1
Gut Phage Biobank: a collection of bacteriophages targeting human commensal bacteria
A B cell-IgA-epithelial axis enhances antitumor immunity and improves outcome in HPV-associated penile squamous cell carcinoma
A corticospinal signature for interindividual pain sensitivity
3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes
In vivo base editing rescues ADPKD in a humanized mouse model
High-resolution analysis of the human T-cell leukemia virus capsid protein reveals insights into immature particle morphology
Anti-neuraminidase and anti-HA stalk antibodies reduce the susceptibility to and infectivity of influenza A/H3N2 virus
Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift
Structures of human glucose-6-phosphate transporter reveal reciprocal antiport mechanism driving glucose-6-phosphate and inorganic phosphate exchange
Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome
An antimicrobial daptide from human skin commensal Staphylococcus hominis protects against skin pathogens
Prefrontal cortex temporally multiplexes slow and fast dynamics in value learning and memory
Lithium exposure causes ferroptosis to induce unexplained miscarriage through non-canonical MBOAT1 pathway
Enhanced neural plasticity in monkey TE compared to TEO during learning of a feature-ambiguous visual categorization task
Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells
PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis
Systematic identification of bacterial factors driving intracellular lifestyle in non-professional phagocytes
IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant mRNA containing expanded CGG repeats
Photo-reversible amyloid nanoNETs for regenerative antimicrobial therapies
Multiplex serology reveals age-specific immunodynamics of respiratory pathogens in the wake of the COVID-19 pandemic
Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice
Biguanide-functionalized peptide mimics effectively combat drug-resistant ESKAPE pathogens and meningitis
An outer membrane vesicle vaccine prevents lung pathology in a macaque model of pneumonic melioidosis
Distinct structural features of Pseudomonas aeruginosa ATP synthase revealed by cryo-electron microscopy
Pre-existing cross-reactive immunity to highly pathogenic avian influenza 2.3.4.4b A(H5N1) virus in the United States
Discovery of a β-arrestin-biased CCKBR agonist that blocks CCKBR-dependent long-term potentiation
Clonal cell states link gastroesophageal junction tissues with metaplasia and cancer
Rehydration rescues mice from lethal infection
Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial
Retro-inversion imparts antimycobacterial specificity to host defense peptides
Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors
Carboxymethylcytosine is a natural base modification and a handle for bacteriophage DNA hypermodification
Occupational physical activity and incidence and mortality of 14 cancers in 404,249 adults
Antibiotic-resistance plasmid amplified among MRSA cases in an urban jail and its connected communities
VIRGO2: an enhanced gene catalog of the vaginal microbiome provides insights into its functional and ecology complexity
Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice
Immunologic and biophysical features of the BNT162b2 JN.1 and KP.2 adapted COVID-19 vaccines
The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviour
Decline in HIV prevalence among female sex workers in Zimbabwe between 2013 and 2023
Nucleophosmin 1 lactylation in graft kidney induces ferroptotic trigger waves that exacerbate delayed graft function
Intranasal cocaine self-administration in male mice
Early intrinsic excitability plasticity of neocortical engram neurons defines memory formation and precision
The Human T-cell Leukemia Virus capsid protein is a potential drug target
A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1
Autoantibody landscape and functional role of anti-C-C motif chemokine receptor 8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trial
Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization
Large-scale characterisation of the nasal microbiome redefines colonisation status
Anti-phage defense mechanism involving phage-encoded DNA binding protein and bacterial reverse transcriptase DRT4
Structural mechanism of the Retron-Eco7 anti-phage defense system
Prolonged disease remission of the chronic immunological skin disorder hidradenitis suppurativa with adjunctive bacteriophage therapy
Microbial Product Cocktails for Personalized Cancer Immunotherapy
Sprint interval exercise disrupts mitochondrial ultrastructure driving a unique mitochondrial stress response and remodelling in men
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
The role of attention in multi attribute decision making
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Primary tuberculous mycobacterial granulomas provide a niche for superinfecting Mycobacterium abscessus
A niche-dependent redox rheostat regulates epithelial stem cell fate
Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in hidradenitis suppurativa skin disease
Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae
Contribution of amygdala to dynamic model arbitration under uncertainty
Dysregulation of homeostatic cytokine receptors drives prolonged T cell activation following acute SARS-CoV-2 infection in humans
Neural correlates of trial outcome monitoring during long-term learning in primate posterior parietal cortex
Identifying the factors governing internal state switches during nonstationary sensory decision-making
The relative contribution of close-proximity contacts, shared classroom exposure and indoor air quality to respiratory virus transmission in schools
Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Stage-dependent patterns of cognitive network connectivity in early psychosis
Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion
Oligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis
The NMDA receptor subunit GluN2D is a potential target for rapid antidepressant action
Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
Harnessing registry data to identify socio-demographic and socio-economic gaps in HIV care in the Netherlands
Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice
Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice
Methylene blue treatment of fatal cerebral malaria and identification of potential blood biomarkers
Estimation of the epidemiological characteristics of scabies
Laser-assisted microbial culturomics
Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1
Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during class switch recombination
Factorized embedding of goal and uncertainty in the lateral prefrontal cortex guides stably flexible learning
The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links
Unraveling the mechanism behind the probable extinction of the B/Yamagata lineage of influenza B viruses
Fasting hijacks proximal tubule circadian control mechanisms to regulate glucose reabsorption via the Nrf1/Sglt2 pathway in mice
An antimicrobial peptide as a potential therapy for bacterial pneumonia that alleviates antimicrobial resistance
Tetrazine-enhanced donor-acceptor-donor metal-organic frameworks for photodynamic antibacterial therapy and wound healing
A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome
Intravaginal delivery of mRNA-encoded antibodies with enhanced breadth and potency for SHIV/HIV protection
Identification of inducible HIV reservoirs in tonsillar, intestinal and cervical tissue models of HIV latency
Prevalence study in Cameroon identifies Brucella abortus as the endemic Brucella species in livestock
A four-gene signature from blood to exclude bacterial etiology of lower respiratory tract infection in adults
The sex-biased chromatin modifier SMC1A promotes autoimmunity by shaping inflammatory pathways in patients with SLE
Ventral tegmental area GABA neurons integrate positive and negative valence
Flexible Use of Limited Resources for Sequence Working Memory in Macaque Prefrontal Cortex
GII.17 norovirus re-emerged in the 2020s as a result of dynamic and adaptive evolutionary processes
High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures
A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling
Solving the where problem and quantifying geometric variation in neuroanatomy using generative diffeomorphic mapping
Post-learning replay of hippocampal-striatal activity is biased by reward-prediction signals
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action
A systematic review and meta-analysis of the impact of vaccination on prevention of long COVID
Structural insights into scaffold-guided assembly of the Pseudomonas phage D3 capsid
In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON
A rapid and dynamic role for FMRP in the plasticity of adult neurons
Neural variability in the medial prefrontal cortex contributes to efficient adaptive behavior
The ANTsX ecosystem for mapping the mouse brain
Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitis
Climate variation and serotype competition drive dengue outbreak dynamics in Singapore
Assembly of the infant gut microbiome and resistome are linked to bacterial strains in mother’s milk
HIV-1 envelope trimer vaccine induces sex-associated differences in antibody responses: a phase 1 clinical trial
Adaptive stretching of representations across brain regions and deep learning model layers
Single versus combination treatment in tinnitus: an international, multicentre, parallel-arm, superiority, randomised controlled trial
Psilocybin alters visual contextual computations
Germline pathogenic variation impacts somatic alterations and patient outcomes in pediatric central nervous system tumors
Variant-specific antibody correlates of protection against SARS-CoV-2 Omicron symptomatic and overall infections
Targeting the ROS-ferroptosis-inflammation cycle with a nanozyme-functionalized hydrogel for intervertebral disc repair
3D multiparametric ultrasound imaging of steatotic liver disease in a study with male rats
Implantable bioelectronics for gut electrophysiology
Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward
Directed evolution of phages in biofilms enhances Pseudomonas aeruginosa control through improved lipopolysaccharide recognition
Experimental phage evolution results in expanded host ranges against antibiotic resistant isolates
Polygenic risk score and cluster-based analysis suggests links between type 2 diabetes and vascular dementia in the KARE study
Mitochondria relay cholesterol signal exacerbates osteoarthritis in mice
Clinical and genomic features of Lynch syndrome differ by tumor site and disease spectrum
Controllability changes pain perception by increasing the precision of expectations
Covid-19 and cardiovascular disease in a total population-study of long-term effects, social factors and Covid-19-vaccination
Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity
Stable intracranial imaging of dura mater-engrafted pancreatic islet cells in awake mice
Gli1-expressing stromal cells are highly reparative precursors of long-lived chondroprogenitors in the fetal murine limb
Multivariate genome-wide analyses of insulin resistance unravel novel loci and therapeutic targets for cardiometabolic health
Long COVID trajectories in the prospectively followed RECOVER-Adult US cohort
A Pseudomonas aeruginosa quorum-sensing metabolite manipulates macrophage ferroptosis through a methylation pathway
Heat shock protein DNAJA2 controls insulin signaling and glucose homeostasis by preventing spontaneous insulin receptor endocytosis
Vascularization of neonatal liver lobules presages adult liver size
Cocaine seeking and consumption are oppositely regulated by mesolimbic dopamine in male rats
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction
Extended fear learning enhances excitatory and inhibitory synaptic transmission onto amygdala engram cells
Chromatin remodeling enhances MAP3K8 expression in HAM: a key pathogenesis for therapeutic intervention
131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma
Distinct autoreactive CD19 plasma cell subsets accumulate in lupus-prone mice
Probabilistic classification of late treatment failure in uncomplicated falciparum malaria
Plasma p-tau217 as a biomarker of Alzheimer’s disease pathology in individuals with Down syndrome
TUSC3 regulates ERMA-mediated Mg2+ uptake for synaptic function and neurodevelopment
Physical activity levels may impact on the risk of premature mortality in people with epilepsy
Poly(imidazolium ester) antibiotic forms intracellular polymer-nucleic acid biomolecular condensates and fight drug-resistant bacteria
transmission in China during the COVID-19 pandemic period (2020–2021) compared with the pre-pandemic period (2017–2019)
An intranasal adjuvanted, recombinant influenza A/H5 vaccine primes against diverse H5N1 clades: a phase I trial
Scattering approach to diffusion quantifies axonal damage in brain injury
Salmonella multimutants enable efficient identification of SPI-2 effector protein function in gut inflammation and systemic colonization
In situ gut microbiota editing: enhancing therapeutic efficacy for bacterial colitis by compatible oral hydrogel microspheres with phages
Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions
Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii
Toxoplasma gondii chromatin remodeler SWI/SNF controls parasite division and gene expression
Computational signatures of uncertainty are reflected in motor cortex excitatory neurochemistry
Dnmt1 determines bone length by regulating energy metabolism of growth plate chondrocytes
The pathogenicity island 1 injectisome reprograms host cell translation to evade the inflammatory response
Phage diversity mirrors bacterial strain diversity in the honey bee gut microbiota
Systematic evidence grading evaluates multisystemic associations and risks of vitiligo
Harnessing microbial-derived metabolites in the urinary tract to prevent infection induced catheter encrustation
Complex de novo structural variants are an underestimated cause of rare disorders
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Structural insights into context-specific inhibition of bacterial translation by macrolides
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Neutrophil elastase-activatable ratiometric photoacoustic nanoprobes for imaging atherosclerotic plaque vulnerability
Finerenone versus spironolactone in patients with chronic kidney disease and type 2 diabetes: a target trial emulation
Proteome atlas for mechanistic discovery and risk prediction of diabetic retinopathy
Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus
Prelimbic cortex to ventral tegmental area projection regulates early social isolation stress-potentiated heroin seeking in mice
Structural characterization of atrial natriuretic peptide amyloid fibrils from patients with atrial fibrillation
epDevAtlas: mapping GABAergic cells and microglia in the early postnatal mouse brain
Estimating rates of treatment delay for malaria fevers among children in Sub-Saharan Africa 2006–2022
Rescue of imprinted genes by epigenome editing in human cellular models of Prader-Willi syndrome
Multi-lens ultrasound arrays enable large scale three-dimensional micro-vascularization characterization over whole organs
scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome
DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
The diagnostic potential of proteomics and machine learning in Lyme neuroborreliosis
A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae
Single-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes
Inhibition of PGK1 ameliorates acute kidney injury through inactivating the PKM2/ALOX12/ferroptosis pathway in a study with male mice
Modality-projection universal model for comprehensive full-body medical imaging segmentation
Ambient biothermal stress, preconceptional thyrotropin abnormalities, and the risk of preterm birth: a nationwide Chinese cohort study
A US case-control study to estimate infant group B streptococcal disease serological thresholds of risk-reduction
Targeting VGLL4 maintains extracellular matrix homeostasis and mitigates osteoarthritis in a preclinical model
Bacterial warfare is associated with virulence and antimicrobial resistance
Targeted volume imaging reveals early vascular interactions of Lyme disease pathogen in skin
Neurocomputational basis of learning when choices simultaneously affect both oneself and others
Eosinophil CD48 interactions with Candida albicans Als6 is protective in vitro and in mouse systemic candidiasis
Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia
The microbial metabolite desaminotyrosine protects against graft-versus-host disease via mTORC1 and STING-dependent intestinal regeneration
Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis
Mosquito salivary sialokinin reduces monocyte activation and chikungunya virus-induced inflammation via neurokinin receptors
Investigating the population structure of Moraxella catarrhalis using a cgMLST scheme and LIN code system
Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice
Backtracking metabolic dynamics in single cells predicts bacterial replication in human macrophages
Virus-inspired lipopeptide-derived nucleic acid delivery to cartilage for osteoarthritis therapy
Bacterial sexually transmitted infections and related antibiotic use among individuals eligible for doxycycline post-exposure prophylaxis in the United States
The neural basis for uncertainty processing in hierarchical decision making
Thalamic regulation of reinforcement learning strategies across prefrontal-striatal networks
Ultrapotent human antibodies lock E protein dimers central region of diverse DENV3 morphological variants
Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance
Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival
DLFea4AMPGen de novo design of antimicrobial peptides by integrating features learned from deep learning models
Low circulating miR-190a-5p predicts progression of chronic kidney disease
Empathi: embedding-based phage protein annotation tool by hierarchical assignment
Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia
Single cell transcriptomics of human psoriasis and epidermal specific Ube2l3 deficient mice highlight CXCL16/CXCR6 involvement in psoriasis development
Microbial binding module employs sophisticated clustered saccharide patches to selectively adhere to mucins
Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder
Dopamine dynamics during stimulus-reward learning in mice can be explained by performance rather than learning
Experimental glycopeptide antibiotic EVG7 prevents recurrent Clostridioides difficile infection by sparing members of the Lachnospiraceae family
Amplified copper ion interference and immunomodulation using self-thermophoretic nanomotors to treat refractory implant-associated biofilm infections
Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex
Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors
Exercise facilitates post-stroke recovery through mitigation of neuronal hyperexcitability via interleukin-10 signaling
Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene
Within-host genetic diversity of pneumococcal serotype 3 during one-year prolonged carriage in a healthy adult
Transient rapamycin treatment avoids unwanted host immune responses toward AAV-delivered anti-HIV antibodies
Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer
Mycobacterium tuberculosis-specific T cells restrain anti-cancer drug-induced neutrophilic lung inflammation in tuberculosis
Prenatal exposure to Zika virus shapes offspring neutrophil function in a sex-specific manner
Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases
Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites
Crotonate enhances intestinal regeneration after injury via HBO1-mediated H3K14 crotonylation
Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia
Molecular cartography of the human down syndrome and trisomic mouse brain
Cost-effectiveness analysis of screening for congenital Chagas disease in a non-endemic area
Keratinocyte-specific H4K12 lactylation drives a non-canonical IL-17-dependent signaling in psoriasis progression in mice
Oxidative stress-induced intervertebral disc remodelling and elevated stiffness drive idiopathic scoliosis in preclinical models
Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring
Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration
Rising dengue risk with increasing El Niño–Southern Oscillation amplitude and teleconnections
Serotonin 2A receptor attenuates psoriatic inflammation by suppressing IL-23 secretion in monocyte-derived Langerhans cells
Motion impact score for detecting spurious brain-behavior associations
HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques
High expression of Rex-orf-I and HBZ mRNAs and bronchiectasis in lung of HTLV-1A/C infected macaques
VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior
Transmission dynamics of sequence type 131 in households—a one health prospective cohort study
Quantifying the impact of a broadly protective sarbecovirus vaccine in a future SARS-X pandemic
A single residue in the yellow fever virus envelope protein modulates virion architecture and antigenicity
A conserved long-range RNA interaction in SARS-CoV-2 recruits ADAR1 to enhance virus proliferation
Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex
Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection
Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells
Injectable therapeutic system incorporating neurogenesis-programmed stem cells concomitantly promoting muscle regeneration treats stress urinary incontinence
Macrophage-derived amphiregulin induces myofibroblast transition in adipogenic lineage precursors near Staphylococcus aureus abscess in bone marrow
Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories
An integrated multi-omic natural history study of human development, sexual dimorphism, and the effects of trisomy 21
GPS Pipeline: portable, scalable genomic pipeline for Streptococcus pneumoniae surveillance from Global Pneumococcal Sequencing Project
A galanin-positive population of lumbar spinal cord neurons modulates sexual arousal and copulatory behavior in male mice
Comparative single-cell and spatial profiling of anti-SSA-positive and anti-centromere-positive Sjögren’s disease reveals common and distinct immune activation and fibroblast-mediated inflammation
Optimized in vivo base editing restores auditory function in a DFNA15 mouse model
Efficient and dynamic neural geometry of value and modality encoding in the primate putamen for value-guided behavior
Naiavirus: an enveloped giant virus with a pleomorphic, flexible tail
SARS-CoV-2 infection dynamics in a MHCI-mismatched lung transplant recipient
Social exposome and brain health outcomes of dementia across Latin America
Proximity labeling of axonemal protein CFAP91 identifies EFCAB5 that regulates sperm motility
Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in Behçet’s disease
Caudate serotonin signaling during social exchange distinguishes essential tremor and Parkinson’s disease patients
Emergence of a carbapenem-resistant atypical uropathogenic clone as an increasing cause of urinary tract infection
Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging
Hyaluronidase-enhanced subcutaneous delivery of bNAbs: a phase 1 randomized controlled clinical trial in HIV-uninfected women
Pyroptosis-responsive microspheres modulate the inflammatory microenvironment to retard osteoporosis in female mice
DeMBA: a developmental atlas for navigating the mouse brain in space and time
All-optically controlled phased-array for ultrasonics
NEXN protects against vascular calcification by promoting SERCA2 SUMOylation and stabilization
Granzyme B activated near-infrared-II ratiometric fluorescent nanoprobe for early detection of tumor response to immunotherapy
Recapitulating dengue virus infection with human pluripotent stem cell-derived liver organoids for antiviral screening
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration
Nascent liver proteome reveals enzymes and transcription regulators under physiological and alcohol exposure conditions
Response splicing quantitative trait loci in primary human chondrocytes identify putative osteoarthritis risk genes
Trait anxiety is associated with reduced reward-related replay at rest
Biodegradable ultrasound contrast tape for tracing intestinal motility
Axial nephron fate switching demonstrates a plastic system tunable on demand
Deep genome sequencing reveals extensive genetic heterogeneity in early human placentas
One Health approach uncovers emergence and dynamics of Usutu and West Nile viruses in the Netherlands
Neural correlates of human fear conditioning and sources of variability in 2199 individuals
Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit
Anti-restriction functions of injected phage proteins revealed by peeling back layers of bacterial immunity
Deep learning approach for screening neonatal cerebral lesions on ultrasound in China
Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter
Designed optogenetic tool for bridging single-neuronal multimodal information in intact animals
Coordinated multi-level adaptations across neocortical areas during task learning
Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes
Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus
Plant-derived hydrogel and photosynthetic nano-units for myocardial infarction therapy
Modelling transmission of Middle East respiratory syndrome coronavirus in camel populations and the potential impact of animal vaccination
Restoring mucosal barrier homeostasis by in situ formation of a living-synthetic therapeutic coating
Cholecystectomy-related gut microbiota dysbiosis exacerbates colorectal tumorigenesis
Biosilica nanoparticulate scavengers for the therapy of hepatic ischemia–reperfusion injury in preclinical models
Genkwanin glycosides are major active compounds in Phaleria nisidai extract mediating improved glucose homeostasis by stimulating glucose uptake into adipose tissues
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants
CCR7+ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse
Microalgae-based Intestinal villi-targeting multistage biosystem for irritable bowel syndrome treatment
A chronic Acinetobacter baumannii pneumonia model to study long-term virulence factors, antibiotic treatments, and polymicrobial infections
Immunogenicity and safety of a recombinant gE-Fc fusion protein subunit vaccine for herpes zoster in adults ≥50 years of age: a randomised, active-controlled, non-inferiority trial
Effect of a single low-dose esketamine administration during surgical abortion on postoperative sleep disturbance: a randomized controlled trial
Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation
A decision-space model explains context-specific decision-making
Tonic dopamine and biases in value learning linked through a biologically inspired reinforcement learning model
Dengue virus susceptibility in linked to natural cytochrome P450 promoter variants
The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis
Irreversible furin cleavage site exposure renders immature tick-borne flaviviruses fully infectious
Discovery of multi-target anti-gout agents from Eurycoma longifolia Jack through phenotypic screening and structural optimization
A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells
AI-driven fusion of multimodal data for Alzheimer’s disease biomarker assessment
Mechanisms and interventions promoting healthy frontostriatal dynamics in obsessive-compulsive disorder
In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria
Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation
DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge
Vaccination with adhesin Abp2D provides protection against catheter-associated urinary tract infection
Human cytomegalovirus induces neuronal gene expression through IE1 for viral maturation
Early noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease
Physical and chemical niche of human growth plate for polarized bone development
Real-time prediction of intensive care unit patient acuity and therapy requirements using state-space modelling
Seedless: on-the-fly pulse calculation for NMR experiments
Exome analysis links kidney malformations to developmental disorders and reveals causal genes
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations
Crosstalk between inovirus core gene and accessory toxin-antitoxin system mediates polylysogeny
The HM-TARGET personalised real-time haemodynamic targets in critical care
Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial
Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model
Antimicrobial peptide class that forms discrete β-barrel stable pores anchored by transmembrane helices
IgG autoantibodies in bullous pemphigoid induce a pathogenic MyD88-dependent pro-inflammatory response in keratinocytes
Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors
Perinatal outcomes of symptomatic chikungunya, dengue and Zika infection during pregnancy in Brazil: a registry-based cohort study
Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP
Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection
PAM-flexible adenine base editing rescues hearing loss in a humanized mouse model harboring an East Asian founder mutation
Higher-order and distributed synergistic functional interactions encode information gain in goal-directed learning
Mechanism of substrate recognition and release of human SGLT2
Strengthening phage resistance of Streptococcus thermophilus by leveraging complementary defense systems
Combining mucosal microbiome and host multi-omics data shows prognostic potential in paediatric ulcerative colitis
A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization
March5-mediated Trim28 degradation preserves islet β-cell function in mice
Health risks and genetic architecture of objectively measured multidimensional sleep health
A broad-spectrum antibiotic targets multiple-drug-resistant bacteria with dual binding targets and no detectable resistance
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice
Long-term effect of temporary ART initiated during primary HIV-1 infection on viral persistence
ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections
Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury
A single mutation may contribute to accelerated evolution of SARS-CoV-2 toward Omicron
A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images
CD142-positive synovial fibroblasts drive meniscus destruction in rheumatoid arthritis
An all-in-one pipeline for the in vitro discovery and in vivo testing of Plasmodium falciparum malaria transmission blocking drugs
Distinct role of claustrum and anterior cingulate cortex bidirectional circuits in methamphetamine taking and seeking
Human hippocampal reactivation of amygdala encoding-related gamma patterns during aversive memory retrieval
UCP2 inhibition eliminates pancreatic β cell autoinflammation in T2DM with islet-mitochondrial sequential targeting nanomedicines
PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation
Comparative genomics of the parasite Trichomonas vaginalis reveals genes involved in spillover from birds to humans
Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities
Open-source computational pipeline flags instances of acute respiratory distress syndrome in mechanically ventilated adult patients
Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA
Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics
A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis
Estimation-uncertainty affects decisions with and without learning opportunities
Plasma proteomics for biomarker discovery in childhood tuberculosis
Developing serum proteomics based prediction models of disease progression in ADPKD
Cryo-EM structures of Nipah virus polymerases and high-throughput RdRp assay development enable anti-NiV drug discovery
Near-infrared light-driven metabolic reprogramming of synoviocytes for the treatment of rheumatoid arthritis
Molecular mechanism of drug inhibition of URAT1
Mycobacterium bovis frd operon phase variation hijacks succinate signaling to drive immunometabolic rewiring and pathogenicity
Human spinal cord activation during filling and emptying of the bladder
Evaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study
Eradicating fungal biofilm-based infections by ultrasound-assisted semiconductor sensitized upconversion photodynamic therapy
Paradoxical mTORC1-Dependent microRNA-mediated Translation Repression in the Nucleus Accumbens of Male Mice Consuming Alcohol Attenuates Glycolysis
The defensome of prokaryotes in aquifers
Computational exploration of global venoms for antimicrobial discovery with Venomics artificial intelligence
Host albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway
Carbene formation as a mechanism for efficient intracellular uptake of cationic antimicrobial carbon acid polymers
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay
Vancomycin-resistant enterococci utilise antibiotic-enriched nutrients for intestinal colonisation
Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery
A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice
Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models
Experience-based risk taking is primarily shaped by prior learning rather than by decision-making
Striatal dopamine can enhance both fast working memory, and slow reinforcement learning, while reducing implicit effort cost sensitivity
Identification of gut bacteria reductases that biotransform steroid hormones
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge
Risk assessment and perspectives of local transmission of chikungunya and dengue in Italy, a European forerunner
Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice
A point-of-care diagnostic for drug-induced liver injury using surface-enhanced Raman scattering lateral flow immunoassay
Genetic risk-dependent brain markers of resilience to childhood Trauma
Safety and efficacy of 3- and 5-day regimens of levamisole in loiasis: a randomized, placebo-controlled, double-blind clinical trial
Negativeome characterization and decontamination in early-life virome studies
Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors
The impact of elective surgical hubs on elective surgery in acute hospital trusts in England
Variants in cause a novel oculo vertebral renal syndrome
Impact of doxycycline pre-exposure prophylaxis (doxyPrEP) for sexually transmitted infections on the microbiome of men who have sex with men on HIV PrEP
Immune correlates analysis of mRNA-1345 RSV vaccine efficacy clinical trial
Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123
Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial
Pol θ-mediated end-joining uses microhomologies containing mismatches
Cocaine-context memories are transcriptionally encoded in nucleus accumbens Arc ensembles
Deep molecular profiling of synovial biopsies in the STRAP trial identifies signatures predictive of treatment response to biologic therapies in rheumatoid arthritis
Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment
Ethnic disparities in COVID-19 mortality and cardiovascular disease in England and Wales between 2020-2022
HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation
The clinical effectiveness of sodium-glucose co-transporter-2 inhibitors on prognosis of patients with chronic obstructive pulmonary disease and diabetes
Phage-mediated peripheral kill-the-winner facilitates the maintenance of costly antibiotic resistance
Yanomami skin microbiome complexity challenges prevailing concepts of healthy skin
Dual role of circulating and mucosal Vδ1 T cells in the control of and contribution to persistent HIV-1 infection
Protein kinase A is a dependent factor and therapeutic target in mouse models of fibrous dysplasia
Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti
Acute stress causes sex-specific changes to ventral subiculum synapses, circuitry, and anxiety-like behavior
RNA triphosphatase-mediated mRNA capping is essential for maintaining transcript homeostasis and the survival of Toxoplasma gondii
Proteomic analysis of Down syndrome cerebrospinal fluid compared to late-onset and autosomal dominant Alzheimer´s disease
Frailty and depressive symptoms in relation to cardiovascular disease risk in middle-aged and older adults
Systematic review of post-COVID condition in Nordic population-based registry studies
Structural basis of topoisomerase targeting by delafloxacin
Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses
Context-invariant socioemotional encoding by prefrontal ensembles
Positional BMP signaling orchestrates villus length in the small intestine
Characterizing trachoma elimination using serology
An intracranial dissection of human escape circuits
Macrophage-induced reduction of bacteriophage density limits the efficacy of in vivo pulmonary phage therapy
Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote biofilm formation
Pancreatic islet β-cell subtypes are derived from biochemically-distinct and nutritionally-regulated islet progenitors
Paraventricular hypothalamic input to anterior cingulate cortex controls food preferences in chronic visceral pain mice
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression
Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways
Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models
Binge drinking triggers VGLUT3-mediated glutamate secretion and subsequent hepatic inflammation by activating mGluR5/NOX2 in Kupffer cells
Genomic landscape of virus-associated cancers
The postbiotic ReFerm® versus standard nutritional support in advanced alcohol-related liver disease (GALA-POSTBIO): a randomized controlled phase 2 trial
Selfish mutations promote age-associated erosion of mtDNA integrity in mammals
Oropouche virus infects human trophoblasts and placenta explants
Suppression of gut colonization by multidrug-resistant clinical isolates through cooperative niche exclusion
Immunogenicity and safety of mRNA-based seasonal influenza vaccines encoding hemagglutinin and neuraminidase
A molecularly defined brain circuit module for regulating panic-like defensive state
Increase in H5N1 vaccine antibodies confers cross-neutralization of highly pathogenic avian influenza H5N1
Context flexibly modulates cue representations in visual cortex
Aerobic and resistance exercise-regulated phosphoproteome and acetylproteome modifications in human skeletal muscle
Potential impact and cost-effectiveness of long-acting injectable lenacapavir plus cabotegravir as HIV treatment in Africa
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy
Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis
Genome-wide association meta-analysis of human olfactory identification discovers sex-specific and sex-differential genetic variants
Early NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
A normative principle governing memory transfer in cerebellar motor learning
Confirmation bias through selective readout of information encoded in human parietal cortex
Obesity drives depot-specific vascular remodeling in male white adipose tissue
Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication
PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
Prion-induced ferroptosis is facilitated by RAC3
Abstract rule learning promotes cognitive flexibility in complex environments across species
Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of patients with systemic sclerosis
Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility
Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62
Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype
Distinct neural population code and causal roles of primate caudate nucleus in multimodal decision-making
Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa
Stimulus-specific and adaptive value representations in the basolateral amygdala in male mice
Role of the upper airway microbiota in respiratory virus and bacterial pathobiont dynamics in the first year of life
Molecular basis of the urate transporter URAT1 inhibition by gout drugs
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling
Distinct spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian associations
FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction
Antigen persistence and TLR stimulation contribute to induction of a durable HIV-1-specific neutralizing antibody response
Loss of CD98HC phosphorylation by ATM impairs antiporter trafficking and drives glutamate toxicity in Ataxia telangiectasia
An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis
Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians
Identification of covalent inhibitors of Staphylococcus aureus serine hydrolases important for virulence and biofilm formation
Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI
Integrated plasma and vegetation proteomic characterization of infective endocarditis for early diagnosis and treatment
Bacterial microcompartments and energy metabolism drive gut colonization by
Efficient mRNA delivery to resting T cells to reverse HIV latency
Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts
Dietary carbohydrates alter immune-modulatory functionalities and DNA inversions in Bacteroides thetaiotaomicron
Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism
Blood-triggered self-sealing and tissue adhesive hemostatic nanofabric
Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience
HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials
Impact of unequal testing on vaccine effectiveness estimates across two study designs: a simulation study
Improving cellular fitness of human stem cell-derived islets under hypoxia
Association of distinct microbial and metabolic signatures with microscopic colitis
Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference
Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity
Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype
Combining dynamin 2 myopathy and neuropathy mutations rescues both phenotypes
ACSS2 mediates an epigenetic pathway to regulate β-cell adaptation during gestation in mice
Multidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA
Modulation of host ATP levels by secreted bacterial effectors
A comparison of intramuscular (Zimhi) and intranasal naloxone (Narcan) in reversal of fentanyl-induced apnea: a randomized, crossover, open-label trial
Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans
Single-cell transcriptomic characterization of microscopic colitis
A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning
Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening
Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study
A midbrain circuit mechanism for noise-induced negative valence coding
Myeloid EGFR deficiency accelerates recovery from AKI via macrophage efferocytosis and neutrophil apoptosis
Nucleic acid spheres for treating capillarisation of liver sinusoidal endothelial cells in liver fibrosis
Label-free multimodal optical biopsy reveals biomolecular and morphological features of diabetic kidney tissue in 2D and 3D
Regulating obesity-induced osteoarthritis by targeting p53-FOXO3, osteoclast ferroptosis, and mesenchymal stem cell adipogenesis
Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia with Pseudomonas aeruginosa
Autologous HIV-specific T cell therapy targeting conserved epitopes is well-tolerated in six adults with HIV: an open-label, single-arm phase 1 study
Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy
PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis
Molecular mechanism of thyroxine transport by monocarboxylate transporters
Effectiveness of tirzepatide in patients with HFpEF using a target trial emulation retrospective cohort study
SARS-CoV-2 virus lacking the envelope and membrane open-reading frames as a vaccine platform
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis
Multicenter target trial emulation to evaluate corticosteroids for sepsis stratified by predicted organ dysfunction trajectory
A protein language model for exploring viral fitness landscapes
A clinically applicable AI system for detection and diagnosis of bone metastases using CT scans
Microvascular immunity is organ-specific and remodeled after kidney injury in mice
Estimating transmissibility of Zika virus in Colombia in the presence of surveillance bias
Acellular, bioresorbable, ultra-purified alginate gel implantation for intervertebral disc herniation: Phase 1/2, open-label, non-randomized clinical trials
Dietary amino acids regulate Salmonella colonization via microbiota-dependent mechanisms in the mouse gut
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
Habenula contributions to negative self-cognitions
The risk of Long Covid symptoms: a systematic review and meta-analysis of controlled studies
Tinnitus risk factors and its evolution over time
HiBC: a publicly available collection of bacterial strains isolated from the human gut
Dysregulated mast cell activation induced by diabetic milieu exacerbates the progression of diabetic peripheral neuropathy in mice
Health octo tool matches personalized health with rate of aging
Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes
Extrusion of BMP2+ surface colonocytes promotes stromal remodeling and tissue regeneration
Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men
snCED-seq: high-fidelity cryogenic enzymatic dissociation of nuclei for single-nucleus RNA-seq of FFPE tissues
T cell toxicity induced by tigecycline binding to the mitochondrial ribosome
Vision transformer-based model can optimize curative-intent treatment for patients with recurrent hepatocellular carcinoma
Endemism shapes viral ecology and evolution in globally distributed hydrothermal vent ecosystems
Artificial intelligence driven 3D reconstruction for enhanced lung surgery planning
Ucenprubart is an agonistic antibody to CD200R with the potential to treat inflammatory skin disease: preclinical development and a phase 1 clinical study
11
Mosaic integration of spatial multi-omics with SpaMosaic
Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
Central role of glycosylation processes in human genetic susceptibility to SARS-CoV-2 infections with Omicron variants
Proteome-wide model for human disease genetics
African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk
Genome-wide association study and polygenic risk prediction of hypothyroidism
Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression
Cell-type- and locus-specific epigenetic editing of memory expression
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network
Genome-wide association study of long COVID
8
A habit and working memory model as an alternative account of human reward-based learning
Emergency mental health co-responders reduce involuntary psychiatric detentions in the USA
The human brain modulates sniffs according to fine-grained perceptual features of odours
Quantifying the impact of hair and skin characteristics on fNIRS signal quality for enhanced inclusivity
Representational dynamics during extinction of fear memories in the human brain
Speech sequencing in the human precentral gyrus
Large-scale examination of early-age sex differences in neurotypical toddlers and those with autism spectrum disorder or other developmental conditions
Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9
21
The long noncoding RNA lnc13 restrains inflammatory responses to maintain oral tolerance to gluten
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size
Autologous neutralizing antibodies and polyfunctional T cells contribute to long-term HIV-1 post-intervention control
Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging
Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses
Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332 glycan-independent epitope
Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis
Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints
IgA-driven neutrophil activation underlies severe dengue disease after primary Zika virus infection in humans
Long COVID involves activation of proinflammatory and immune exhaustion pathways
Enteric nervous system-derived VIP restrains differentiation of LGR5 stem cells toward the secretory lineage impeding type 2 immune programs
Single-cell RNA profiling of blood CD4+ T cells identifies distinct helper and dysfunctional regulatory clusters in children with SLE
Influenza vaccine based on AS03-adjuvanted chimeric HA induces long-lived stalk-specific plasma cells in bone marrow and lymph nodes of nonhuman primates
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy
Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis
Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis
The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections
Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease
56
Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure
Citywide premarital genomic screening in a Middle Eastern population
Low-plastic diet and urinary levels of plastic-associated phthalates and bisphenols: the randomized controlled PERTH Trial
Integrated epidemiological and molecular data inform the relationship between precancer and cancer states of esophageal adenocarcinoma
Antisense oligonucleotide-mediated knockdown therapy in two infants with severe epileptic encephalopathy
An international mega-analysis of psychedelic drug effects on brain circuit function
Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial
Deleterious coding variation associated with autism is shared across ancestries
Transmission dynamics of Oropouche virus in Latin America and the Caribbean
Mass azithromycin distribution and antibiotic resistance in the gut and nasopharynx: a cluster-randomized trial
A structure-based mRNA vaccine for Nipah virus in healthy adults: a phase 1 trial
Blood phosphorylated tau elevation as a biomarker in immunoglobulin light chain and transthyretin amyloidosis
Long-term efficacy and safety of the single-dose tetravalent Butantan dengue vaccine
Deciphering the etiology of the 2024 outbreak of undiagnosed febrile illness in Panzi, Democratic Republic of the Congo
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial
A short-acting psychedelic intervention for major depressive disorder: a phase IIa randomized placebo-controlled trial
Innate antiviral and immune functions associated with the HIV reservoir decay after anti-PD-1 therapy
Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial
Fecal microbiota transplantation plus immunotherapy in metastatic renal cell carcinoma: the phase 1 PERFORM trial
Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990–2023: a Global Burden of Disease Study
Single-cell atlas of the developing Down syndrome brain cortex
External trigeminal nerve stimulation in youth with ADHD: a randomized, sham-controlled, phase 2b trial
Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial
Estimating the number of incorrect tuberculosis diagnoses in low- and middle-income countries
Malaria vaccine protection against intradermal or venous parasites: a randomized phase 2b human challenge trial
The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome
Eliminating opioid prescriptions from outpatient minimally invasive gynecologic surgery: a randomized trial
Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial
A meta-analysis of albuminuria as a surrogate endpoint for kidney failure
Cabotegravir and rilpivirine for treatment of HIV infection in Africa: week 96 results from the phase 3b randomized, open-label, noninferiority CARES trial
A full life cycle biological clock based on routine clinical data and its impact in health and diseases
Characterizing the physiology of circulatory arrest in humans
Feasibility, acceptability and clinical outcomes of the BabyScreen+ genomic newborn screening study
Neoadjuvant ipilimumab and nivolumab in resectable cutaneous squamous cell carcinoma: a randomized phase 2 trial
Sonelokimab, an IL-17A/IL-17F-inhibiting nanobody for active psoriatic arthritis: a randomized, placebo-controlled phase 2 trial
Varicella-zoster virus reactivation and the risk of dementia
A consensus blood transcriptomic framework for sepsis
Clinical validation of an AI-based blood testing device for diagnosis and prognosis of acute infection and sepsis
Full-spectrum extract from DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial
Prevention of type 2 diabetes through prediabetes remission without weight loss
Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial
Association between the English National Health Service Diabetes Prevention Programme and incident multiple long-term conditions
Feasibility and clinical utility of expanded genomic newborn screening in the Early Check program
Early-life serological profiles and the development of natural protective humoral immunity to in a high-burden setting
Geographical shifting of cholera burden in Africa and its implications for disease control
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial
Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes
Large language model-based biological age prediction in large-scale populations
Recombinant monoclonal antibody siltartoxatug versus plasma-derived human tetanus immunoglobulin for tetanus: a randomized, double-blind, active-controlled, phase 3 trial
Efficacy, public health impact and optimal use of the Takeda dengue vaccine
T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis
TERN-501 monotherapy and combination therapy with TERN-101 in metabolic dysfunction-associated steatohepatitis: the randomized phase 2a DUET trial
Adjunct-to-insulin therapy using SGLT2 inhibitors in youth with type 1 diabetes: a randomized controlled trial
An international Delphi consensus for reporting of setting in psychedelic clinical trials
Cardiac and liver impairment on multiorgan MRI and risk of major adverse cardiovascular and liver events
5
3d-OT: a deep geometry-aware framework for heterogeneous slices alignment of spatial multi-omics
Bridging the dimensional gap from planar spatial transcriptomics to 3D cell atlases
TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice
Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI
HippoMaps: multiscale cartography of human hippocampal organization
4
A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis
Viral glycoprotein-mimicking peptide-functionalized micelles promote drug delivery to diseased chondrocytes for osteoarthritis alleviation
Bioengineered photosynthetic nanothylakoids reshape the inflammatory microenvironment for rheumatoid arthritis therapy
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages
31
Neuropeptide Y co-opts neuronal ensembles for memory lability and stability
Acetylcholine demixes heterogeneous dopamine signals for learning and moving
Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia
Deconstruction of a memory engram reveals distinct ensembles recruited at learning
A neural signature of adaptive mentalization
Personalized brain decoding of spontaneous pain in individuals with chronic pain
Duration between rewards controls the rate of behavioral and dopaminergic learning
Charting brain morphology in international healthy and neurological populations
Cold and lithium delay forgetting of olfactory memories in Caenorhabditis elegans
The striatal indirect pathway mediates hesitation
A mouse brain atlas based on dendritic microenvironments
Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer’s disease via dysregulation of CCK neurons
Dendritome mapping reveals the spatial organization of striatal neuron morphology
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
Facial expressions in mice reveal latent cognitive variables and their neural correlates
Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits
Differential kinematic coding in sensorimotor striatum across behavioral domains reflects different contributions to movement
A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors
Serotonergic modulation of the BNST–CeA pathway reveals sex differences in fear learning
The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation
Individual differences in decision-making shape how mesolimbic dopamine regulates choice confidence and change-of-mind
Noradrenergic activation of the basolateral amygdala facilitates memory specificity for similar events experienced close in time
Addressing artifactual bias in large, automated MRI analyses of brain development
Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex
A common computational and neural anomaly across mouse models of autism
The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine
Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles
Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways
Autonomic physiological coupling of the global fMRI signal
8
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy
Structure and mechanism of antiphage retron Eco2
Structural basis of glucose-6-phosphate transport by human SLC37A2
Structural basis for retron co-option of anti-phage ATPase-nuclease
Structure and activation mechanism of a Lamassu phage and plasmid defense system
The molecular basis of lamin-specific chromatin interactions
A nanobody-based therapeutic targeting Nipah virus limits viral escape
Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual
38
Dual-engram architecture within a single striatal cell type distinctly controls alcohol relapse and extinction
Human hippocampal ripples prioritize model-based learning
Noninvasive tactile stimulation engaging a thalamic-amygdala circuit ameliorates mood dysfunction in mouse models of depression-like behavior
Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network activity
Alteration of cellular representation in the central amygdala mediates stress-induced analgesia in mice
A septal inhibitory circuit constrains alcohol reward and mediates liraglutide’s suppressive effects on alcohol intake in mice
Circuit and molecular mechanisms underlying incubation of methamphetamine craving in the prelimbic cortex
Dual anterior insula-prefrontal cortex circuits mediate chronic stress-induced social interaction deficits
Representational similarity modulates neural and behavioral signatures of novelty
Soluble α2δ-1, altered in disease CSF, modulates network homeostasis and rescues deficits in a neuropsychiatric mouse model
GABAergic Gbx1 neurons of the superficial dorsal horn are critical elements of a spinal circuit for stress-induced analgesia
A neuromodulatory circuit-to-molecular pathway for reformatting aversive memories during recall
Distinct interneuronal dynamics selectively gate target-specific cortical projections in drug seeking
The representation and valuation of subgoals in the human brain during model-based hierarchical behavior
Cognitive rejuvenation through partial reprogramming of engram cells
Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty
A neural circuit framework for economic choice: From building blocks of valuation to compositionality in multitasking
A multi-region recurrent circuit for evidence accumulation in rats
Tachykinin signaling defines distinct populations of glia in the enteric nervous system
Sympathetic functional units encoded by genetically defined postganglionic neurons
The orbitofrontal cortex updates beliefs for state inference
Structure in noise: Recurrent connectivity shapes neural variability to balance perceptual and cognitive demands in the human brain
Multisensory integration in the mouse ventral visual thalamus mediates stress coping via locus coeruleus-related circuits
Molecular mechanisms mediating engram ensemble retrievability state in mice
An enteric-DRG pathway for interoception and visceral pain in mice
PV-dependent reorganization of prelimbic cortex sub-engrams during systems consolidation
Distinct representations of economic variables across regions and projections of the frontal cortex
Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum
Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health
Ultrabright chemical labeling enables rapid neural connectivity profiling in large tissue samples
Corticotropin-releasing hormone signaling from piriform cortex to amygdala mediates social homophily in opioid addiction
Competitive integration of time and reward explains value-sensitive foraging decisions and frontal cortex ramping dynamics
Opposing, multiplexed information in lateral and ventral orbitofrontal cortex guides sequential foraging decisions in rats
The polypharmacology of psychedelics reveals multiple targets for potential therapeutics
Spontaneous movements and their relationship to neural activity fluctuate with latent engagement states
Adaptive reinforcement learning is causally supported by anterior cingulate cortex and striatum
Machine learning identification of enhancers in the rhesus macaque genome
The paraventricular thalamus mediates visceral pain and anxiety-like behaviors via two distinct pathways
9
Tumor Necrosis Factor-α Inhibition and the Unmasking of CNS Demyelination across a Large United States Health Research Network
Emergency Department Use of Ocular Point-of-Care Ultrasound and Its Utility in Diagnosis at a Tertiary Academic Medical Center
Onset of Ocular Abnormalities in Children with Hearing Loss
Tirzepatide and Reduced Risk of Diabetic Retinopathy and Related Complications: A Multicenter U.S. Cohort Study
Efficacy of an Automated Point-of-Care UVC Disinfection System for Reusable Ophthalmic Devices
High Yield of Systemic Workup in Patients with Acute Isolated Paracentral Acute Middle Maculopathy
Assessing the Efficacy of Ophthalmic Transfers to an Academic Level 1 Trauma Hospital: Diagnostic Accuracy and Intervention Rates
Preoperative Screening Questionnaire for Common Eye Surgeries Safely Reduces the Need for Comprehensive History & Physical Examinations
Long-term Cardiovascular, Renal, and Safety Outcomes of Teprotumumab versus Systemic Glucocorticoids in Thyroid Eye Disease: A Target Trial Emulation
1
Total Synthesis of the Conjugation-Ready Tetrasaccharide Repeating Unit of iAcinetobacter baumannii/i MAR13-1452 (K125) Capsular Polysaccharide for Vaccine Development
44
Capsular specificity in temperate phages of Klebsiella pneumoniae is driven by diverse receptor-binding enzymes
A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context
Emergent spatial structure in the gut microbiota is driven by bacterial growth and gut contractions
Dopamine D2-receptor blockade in humans disrupts the effect of effort on learning
Aberrant dopaminergic activity during consolidation causes age-related memory generalization in Drosophila
Biofilm spatial structure and superinfection immunity modulate inter-phage competition
Structures of the human glucose-6-phosphate transporter provide insights into its transport cycle and substrate recognition
Prenatal and early postnatal periods differentially shape the maturation of human cortical microstructure and myelin
Plug-and-play evolution of the Klebsiella pneumoniae capsule locus enables serotype exchange across genetic backgrounds
Non-peptide dysbiosis metabolites reprogram a peptide quorum-sensing receptor to induce sustained predation in beneficial streptococci
The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice
Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms
Augmentation of frontoparietal gamma-band phase coupling enhances human altruistic behavior
The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination
DNA damage induced by HIV-1 Vpr triggers epigenetic remodeling and transcriptional programs to enhance virus transcription and latency reactivation
A gut-activated NHR-86–CYP pathway mediates the neuroprotective effects of Enterococcus faecium probiotics in a nematode model of amyotrophic lateral sclerosis
Temperate phage evolve to integrate host stress and quorum signals in lysis–lysogeny decisions
Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation
The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins
RNG2 tethers the conoid to the apical polar ring in Toxoplasma gondii to enable parasite motility and invasion
Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems
Transient frontopolar cortex stimulation induces prolonged disruption to counterfactual processing
Chromosome duplication causes premature aging via defects in ribosome quality control
The RNA-binding protein RBM39 scaffolds an m⁶A-dependent RNA decay complex that destabilizes Tat transcripts and restricts HIV-1 reactivation
Neural variability reliably encodes interindividual differences in the perception of pain intensity
Identification of five sleep-biopsychosocial profiles with specific neural signatures linking sleep variability with health, cognition, and lifestyle factors
Plasma membrane recycling drives reservoir formation during Toxoplasma gondii intracellular replication
Catecholamines reduce choice history biases in perceptual decision making.
Uropathogenic Escherichia coli proliferate as a coccoid morphotype inside human host cells
Extinction and subsequent updating of innate fear responses to a visual looming stimulus rely on hippocampus-dependent mechanisms.
Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells
Basal forebrain cholinergic input mediates adaptive attention allocation to enhance olfactory discrimination
Attractive serial dependence arises during decision-making
Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.
The prefrontal cortex encodes task-identity information and flexibly adjusts its sensory processes as a function of the specific ongoing task
Genome-wide identification of modulators of Chlamydia trachomatis parasitophorous vacuole stability highlights an important role for sphingolipid supply.
Reward expectation yields distinct effects on sensory processing and decision making in the human brain
Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in the dorsolateral striatum
Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model
The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input
Legionella effector LpPIP recruits protein phosphatase 1 to the mitochondria to induce dephosphorylation of outer membrane proteins
Regulation of working memory switches from striatal dopamine D2-receptor to D1-receptor neurons under high cognitive load.
An auditory cortical-striatal circuit supports sound-triggered timing to predict future events
Neural evidence that humans reuse strategies to solve new tasks
21
COG5 deficiency disrupts cellular copper homeostasis and underlies the impaired mitochondrial OXPHOS function
A machine learning classifier to identify and prioritise genes associated with murine cardiac development
Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling
Transcription factor ZEB2 is essential for ureteral smooth muscle cell differentiation
20-hydroxyecdysone promotes brain development via upregulating MMP2 expression during metamorphosis in Helicoverpa armigera
PERADIGM: Phenotype embedding similarity-based rare disease gene mapping
Exploiting peptide chirality and transport to dissect the complex mechanism of action of host peptides on bacteria
Trans-generational maintenance of mitochondrial DNA integrity in oocytes during early folliculogenesis
DLK orchestrates a modular transcriptional response to axon injury with separate roles for Fos and Jun
Statistical methods to disentangle genetic effects influencing infertility and early fetal viability with a genome-wide application
The role of hypothyroidism in cirrhosis pathogenesis: A retrospective cohort study and multi-omics integration analysis
Mitochondrial-specific perturbation of Drosophila RNase Z in neurons leads to motor impairments, disrupted learning and neurodegeneration
Rare diseases load through the study of a regional population
Ripply3 overdosage induces mid-face shortening through Tbx1 downregulation in Down syndrome models
Parallel regulatory circuits orchestrate biofilm formation in response to c-di-GMP levels and growth phase
A systems genetics approach identifies roles for proteasome factors in heart development and congenital heart defects
Deciphering the RNA-based regulation mechanism of the phage-encoded AbiF system in Clostridioides difficile
Reversion of a RND transporter pseudogene reveals latent stress resistance potential in Brucella ovis
Genetic inference of on-target and off-target side-effects of antipsychotic medications
Genetic disease risks of under-represented founder populations in New York City.
Reversible excision of the wzy locus in Salmonella Typhimurium may aid recovery following phage predation
42
Cost-effectiveness of esketamine versus alternative treatment strategies for treatment-resistant depression in Hong Kong: A multi-armed modeling study
Association between early methadone dose titration and treatment discontinuation and opioid toxicity: A retrospective cohort study
The benefits of investments to combat HIV, tuberculosis, and malaria for primary healthcare from 2000 to 2023: An economic modeling analysis
Trade-offs in diagnostic algorithm, population coverage, and duration of community screening for tuberculosis: A modelling study
Urban and rural prevalence of tuberculosis in low- and middle-income countries: A systematic review and meta-analysis
Physical frailty, genetic risk, mediating biomarkers, and risk of suicide attempt: A prospective cohort study
Effect of enhanced peer PrEP referral with HIV self-testing delivery among young Kenyan women: A randomized controlled trial of peer networks
Physical activity across mid-life and mortality outcomes in Australian women: A target trial emulation using a prospective cohort
Pain and treatment outcomes after initiating methadone vs buprenorphine among medicare patients with opioid use disorder and comorbid chronic pain: A target trial emulation
Evaluating the biomedical and behavioral drivers of HIV incidence decline in adolescent girls and young women in Uganda: A mathematical modeling study
Quantify unmet medical need across the disease landscape – A large language model-based methodology
Oral preexposure prophylaxis use and the risk of bacterial sexually transmitted infections and HIV among African women: A prospective observational cohort study
The genetic architecture of postoperative delirium after major surgery and its relationship with nonpostoperative neurocognitive conditions: A genome-wide association study
Effectiveness of a digital clinical decision support algorithm for guiding antibiotic prescribing in pediatric outpatient care in Rwanda: A pragmatic cluster non-randomized controlled trial.
Medication adherence and its associated factors among oral pre-exposure prophylaxis (PrEP) users in China: The Real-world E-consumer Cohort of PrEP study.
Associations of Creatinine Muscle Index with markers of sarcopenia and mortality in chronic kidney disease: A prospective cohort study
Acceptability and safety of one versus three months of rifapentine and isoniazid to prevent tuberculosis in people exposed in the household or workplace in Brazil: The Ultra-Curto randomized controlled trial
Estimating the global burden of viable Mycobacterium tuberculosis infection: A mathematical modelling study
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: A meta-analysis of genome-predicted serotype prevalence to inform potential vaccine coverage
Evaluation of economic strengthening in South Africa and its impact on HIV, sexually transmitted infections, and teenage births: A modelling study
Ultrasensitive quantification of serum IFN-α and IFN-γ in systemic lupus erythematosus: A cross-sectional observational study
Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study
The association between implant design, age, sex and the rate of major reoperation in patients undergoing primary total hip replacement: A retrospective study of UK National Joint Registry and Hospital Episodes Statistics data
Impact of first-trimester ultrasound on early detection of major fetal anomalies: Nationwide population-based study of over 1 million pregnancies
The association of body mass index with patient outcomes after shoulder replacement surgery: Population-based cohort study using linked national data from the United Kingdom and Denmark
Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis
Clinical and economic impact of genome-wide non-invasive prenatal testing (NIPT) as a first-tier screening method compared to targeted NIPT and first-trimester combined testing: A modeling study
Effectiveness of a brief intervention and text-based booster in the emergency department to reduce harmful and hazardous alcohol use: A pragmatic randomized adaptive clinical trial in Moshi, Tanzania
Comparative risk of post-acute sequelae following SARS-CoV-2 or influenza virus infection: A retrospective cohort study among United States adults
Incidence and prognostic factors of self-harm and subsequent unnatural death in South Africa: A cohort study
Psilocybin-assisted group psychotherapy and mindfulness-based stress reduction for frontline healthcare provider COVID-19-related depression and burnout: A randomized controlled trial
Effect of Paxlovid treatment during acute COVID-19 on Long COVID onset: An EHR-based target trial emulation from the N3C and RECOVER consortia
Machine learning algorithms and their predictive accuracy for suicide and self-harm: Systematic review and meta-analysis
Adherence thresholds for emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis against HIV acquisition in cisgender women: A randomized directly observed dosing study
Nonoperative treatment versus volar locking plating for distal radius fracture in patients aged 65 years or older (DRIFT trial): A randomized controlled trial
Identifying care gaps along the HIV treatment failure cascade: A multistate analysis of viral load monitoring, re-suppression, and regimen switches in Zambia
Predicting knee osteoarthritis progression using neural network with longitudinal MRI radiomics, and biochemical biomarkers: A modeling study
Effect of pre-exposure prophylaxis on risky sexual behaviour of female sex workers in Dakar, Senegal: A randomised controlled trial
The transmission blocking activity of artemisinin-combination, non-artemisinin, and 8-aminoquinoline antimalarial therapies: A pooled analysis of individual participant data
Rapid molecular testing or chest X-ray or tuberculin skin testing for household contact assessment of tuberculosis infection: A cluster-randomized trial
Association of initiating CYP2D6-metabolized opioids with risks of adverse outcomes in older adults receiving antidepressants: A retrospective cohort study
Cost-effectiveness of screening with transcriptional signatures for incipient TB among U.S. migrants
1
Composite Orbital Angular Momentum for Super-resolution Ultrasound Imaging
3
Phage Display Derived Antibodies Against Antimicrobial Peptide FsPDF2 Reveal Stress Response in European Beech
Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance
Expression of mannanase and glucanases in lettuce chloroplasts and functional evaluation of enzyme cocktail against Candida albicans in oral cancer patient samples
241
Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection
Broad neutralization of influenza B hemagglutinin antibodies via receptor mimicry and glycan engagement
Deep mining of the human antibody repertoire identifies frequent and genetically diverse CDRH3 topologies targetable by vaccination
NOD2 drives regenerative fetal-like reprogramming in the intestinal epithelium
Pseudorabies virus triggers ferritinophagy-mediated ferroptosis and neuroinflammation in viral encephalitis
Perception of a bacterial quorum sensing signal activates a tripartite plant immune strategy
Erythroferrone derived from osteoblasts regulates stress erythropoiesis
Antiretroviral therapy blocks natural selection on protective and disease-susceptible HLA-B alleles in HIV-1 infection
A century of suicide: Insights from long-term data in the United States
Mapping fast tissue dynamics with long camera exposures via intensity modulation
Cell-type-resolved transcriptomic landscape of human focal cortical dysplasia
Paramyxovirus infection driven by heteromultivalent sialoglycotope binding
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
A farnesol-sensing triad in Pseudomonas aeruginosa drives interkingdom predation on Candida albicans via signal transduction
A discrete serotonergic circuit involved in the generation of tinnitus behavior
WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma
Recurrent mutations drive rapid HIV escape from two broadly neutralizing antibodies in vivo
Podocin oligomers regulate the ordering of nephrin chains, providing the molecular basis of NPHS2 interallelic interactions
Medial temporal lobe encodes cognitive maps of real-world social networks
Industrialization increases the estrogen-recycling capacity of the gut microbiome
Brain–computer interface–based neurofeedback training enables transferable control of cortical state switching in humans
Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa
Dopamine D1 and D2 receptors differentially control strength and dynamics of abstract decision codes in the primate prefrontal cortex
A scalable embryonic stem cell–based platform for efficient generation of mitochondrial DNA mutant mice
The biased adenosine-rich content of the HIV-1 genome serves as a molecular signature that facilitates efficient packaging
Clade C MERS-CoV camel strains vary in protease utilization during viral entry
Mitochondrial remodeling in skeletal muscle underlies exercise-induced reversal of age-associated functional decline in mice and humans
Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early Legionella infection
Unique structural and ligand-binding properties of the Staphylococcus aureus serine hydrolase FphE
The phospholipid profile of T cells shapes ACSL4 dependency and ferroptosis sensitivity of naive, effector, and memory T cells
Mechanism of 30S subunit recognition and modification by the conserved bacterial ribosomal RNA methyltransferase RsmI
Identification of somatostatin+ inhibitory engrams for extinction in the basolateral amygdala
Catabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response
Reprogrammed SimCells for antimicrobial therapy
Structural insight into the CUB2 domain’s role in enteropeptidase-mediated trypsinogen activation
Reducing PTSD symptoms through unconscious intervention
Smooth-to-rough morphotype switching, a mechanism of phage resistance in Mycobacterium abscessus
Conserved use of tetraspanin CD9 as an entry receptor by rhabdoviruses spanning multiple genera
Locus coeruleus–amygdala circuit disrupts prefrontal control to impair fear extinction
Personalized functional topography–based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression
Predicting individual incubation of opioid craving by whole-brain functional connectivity
Psoriasis-like disease prevents squamous skin tumor development by neutrophil-driven inflammation
Divergent BLA engram circuits orchestrate social preference dynamics in bystander male mice with self-experienced stress
Elevated phthalate exposure and metabolic susceptibility increased breast cancer risk: A 20-y follow-up study in Taiwan
Fear extinction induces maladaptive generalization via noradrenergic and GABAergic systems
NMI promotes the secretion of IL-17 and exacerbates psoriasis
Microbial metabolite oxindole curbs acute lung injury by suppressing CXCL13
Differential disease tolerance mediates sex-biased illness severity in sepsis
Understanding human metacontrol and its pathologies using deep neural networks
The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior
Lamin B receptor upregulation in metastatic melanoma causes nuclear envelope fragility in confined migration during cancer invasion
Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in a Drosophila model of fragile X syndrome
Genetic recording of pancreatic beta cell proliferation
Synaptogyrin-3 plays a critical role in addiction-related dopamine dysfunction and behavioral maladaptations
Probabilistic mapping and automated segmentation of human brainstem white matter bundles
Integration of fear learning and fear expression across the dorsoventral axis of the hippocampus
Ultrasonic vocal communication of negative affective states in laboratory mice
Functional and antigenic constraints on the Nipah virus fusion protein
T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B
Acquired motility of Babesia microti–infected red blood cells
Mammals that can develop type 2 diabetes have a similarly structured β-sheet amyloid oligomer
Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones
A quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen
A fully synthetic Golden Gate assembly system for engineering a Pseudomonas aeruginosa phiKMV-like phage
Pharmacological chaperones mitigate noise-induced hearing loss by attenuating sustained PERK activation
A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction
An accurate cellular assay to determine pathogenicity of coding and noncoding variants in Lynch syndrome genes
Predicting epistasis across proteins by structural logic
Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system
Protein synthesis blockade prevents fear memory reactivation via inhibition of engram synapse strengthening
Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature, and cytoarchitecture
ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration
M cell–dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer’s patches
Neural substrate of conditioned stimulus for associative learning in the hippocampus
Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate Vibrio cholerae motility and biofilm formation
Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis
Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment
Prior novelty invigorates future mesolimbic target detection
Memory B cell development in response to mRNA SARS-CoV-2 and nanoparticle immunization in mice
Legionella effector Ceg10 acetylates RPS20 to inhibit host translation and induce cell cycle arrest
Enhanced insulin signaling via circulating ATG7: A potential therapeutic strategy for diabetes
NPC1 trafficking via VPS41-dependent LAMP carriers regulates endosomal cholesterol homeostasis
Conjunctive population coding integrates sensory evidence to guide adaptive behavior
An ultrapotent human antibody neutralizes all maturation states of Zika virus
Antibiotic-induced microbiota depletion impairs the proregenerative response to a biological scaffold
Maladaptive immunity to the microbiota promotes neuronal hyperinnervation and itch via IL-17A
Intrinsic neuronal network organization of a mammalian peripheral nervous system
Physical exercise increases binding of POMC to blood extracellular vesicles
Dynamic functional connectivity following cochlear implantation: Predicting speech outcomes and exploring brain network dynamics
SPNS1 is an essential cellular factor for EV-A71 by acting as a transporter of viral pocket factor
Glomerular endothelial cells eliminate nicotinamide adenine dinucleotide to instruct CD103+ T cells in human lupus nephritis
Reward-driven adaptation of movements requires strong recurrent basal ganglia–cortical loops
Intracellular Acinetobacter baumannii acts as a transient reservoir in lung infection via a “persist and resist” strategy
The olfactory bulb endocast as a proxy for mammalian olfaction
Genetics of prelingual isolated deafness and Usher syndrome in the Maghreb and Jordan: Harnessing the potential of homozygosity
Recovery of infectious recombinant human norovirus using zebrafish embryos
Asparagine endopeptidase prompts breast cancer–related pericardial calcification by regulating IGF2 and integrin αvβ5
Mysterious illnesses have supernatural and ritualistic cures: Evidence from 3,655 century-old Irish folk cures
Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition
Regulated coexpression of PrP from different species in mice impacts the replication and host range properties of prion strains
Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon
Tattoo ink induces inflammation in the draining lymph node and alters the immune response to vaccination
Growth hormone regulates the stem cell population in the growth plate
Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration
Migration and the persistence of violence
Neural representation of the decisional reference point in monkeys
Coordinated transfer of DNA between Pol θ and Pol δ resets microhomology choice during double-strand break repair
MAPK signaling and angiopoietin-2 contribute to endothelial permeability in capillary malformations
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery
Cognitive correlates of human endurance
Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function
Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease
The SWI/SNF chromatin-remodeling subunit DPF2 regulates macrophage inflammation in intestinal injury via the CACNA1D-mediated MAPK pathway
Estimated impact of 2022–2023 influenza vaccines on annual hospital burden in the United States
Genome synthesis, assembly, and rebooting of therapeutically useful high G+C% mycobacteriophages
Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage
Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning
HIV-1 Vif and Vpr cooperatively modulate the cell cycle to maximize per-cell virion production
The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction
Scaffold vaccination for prevention of orthopedic device infection
The temporal dynamics of self-control
LRP8 is an entry receptor for tick-borne encephalitis viruses
Glycosaminoglycans activate peptidylarginine deiminase 4 by enhancing calcium affinity
Habenula–ventral tegmental area functional coupling and risk aversion in humans
Testing paradox may explain increased observed prevalence of bacterial STIs among MSM on HIV PrEP: A modeling study
Modulating the microbiome as an approach to anticancer drug development
Structural pores not required: Antimicrobial peptides induce ion permeabilization of lipid membranes through transient water channels
Micro-offline gains do not reflect offline learning during early motor skill acquisition in humans
Learning expectations shape cognitive control allocation
Lamin A/C loss promotes R-loop-mediated genomic instability and poor survival in small-cell lung cancer
Logarithmic coding leads to adaptive stabilization in the presence of sensorimotor delays
Spatial gene expression analysis reveals pathological niches in Japanese encephalitis virus neuroinvasion
All the world’s a phage
Physical activity is directly associated with total energy expenditure without evidence of constraint or compensation
Proteolytically activated antibacterial toxins inhibit the growth of diverse gram-positive bacteria
Reconfiguration of brain-wide neural activity after early life adversity
Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility
Emergence of antiphage functions from random sequence libraries reveals mechanisms of gene birth
Precise gene editing of pathogenic Lamin A mutations corrects cardiac disease
Apparent learning biases emerge from optimal inference: Insights from master equation analysis
Microtubule remodeling by the innate immune factor Trim69 compromises dynein-dependent migration of HIV virion cores toward the nucleus
Goblet cells dictate viral tropism and pathogenesis in nasal and intestinal mucosae
The intestinal environment potentiates bacteriophage adaptation in response to phenotypic resistance in Salmonella Typhimurium
Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition
Functional diversity in GII.4 norovirus entry: HBGA binding and capsid clustering dynamics
Exceptionally broad HIV-1 neutralization via bispecific antibody–mediated prepositioning
Mapping macaque to human cortex with natural scene responses
A fixed mutation in the respiratory complex I impairs mitochondrial bioenergetics in the endangered Apennine brown bear
The role of innate immunity, antibiotics, and bacteriophages in the course of bacterial infections and their treatment
FGF21 acting on the noradrenergic nervous system protects against influenza virus infection
Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice
In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation
Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance
De novo design of potent inhibitors of clostridial family toxins
Heterogeneity in the coordination of delta cells with beta cells is driven by both paracrine signals and low-density Cx36 gap junctions
Tubular ACSM3 deficiency impairs medium-chain fatty acid metabolism and aggravates kidney fibrosis
Distinct prelimbic cortex ensembles encode response execution and inhibition
Joint models reveal human subcortical underpinnings of choice and learning behavior
Integrated Ising model with global inhibition for decision-making
Resurfacing promotes antibacterial activity of a lipid A–binding nanobody
Evolving choice hysteresis in reinforcement learning: Comparing the adaptive value of positivity bias and gradual perseveration
Therapeutic restoration of mitochondria–endoplasmic reticulum cross talk for osteoarthritis
Lysosomal reduced thiols are essential for mouse embryonic development
Activation of WNK1 signaling through Piezo1
A unified model of transient poration induced by antimicrobial peptides
Specificities of chemosensory receptors in the human gut microbiota
Flavin-deficient erythrocytes offer protection against malaria parasites
Broad neutralizing antibody response of a monomeric spike–based SARS-CoV-2 bivalent vaccine against diverse variants
SHP2 genetic variants in NSML-associated RASopathies disrupt the PZR–IRX transcription factor signaling axis
Shared metabolism between a bacterial and fungal species that reside in the human gut
Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations
Negative interplay between HIV-1 Gag and amyloid precursor protein centers around competition for VPS4A and TSG101
Identification of broadly inhibitory anti-PfEMP1 antibodies by mass spectrometry sequencing of plasma IgG from a malaria-exposed child
Synergistic action of specialized metabolites from divergent biosynthesis in the human oral microbiome
Dynamic GLUT trafficking at high glucose levels enhances insulin secretion: Dysregulation leads to decreased insulin secretion during type 2 diabetes
Therapeutic CD8+ T cell tissue retention and immunomodulation during ART interruption fail to prevent SIV rebound
DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons
Ensemble approaches for short-term dengue fever forecasts: A global evaluation study
Blood–labyrinth barrier damage mediated by granzymes from cytotoxic lymphocytes results in hearing loss in systemic lupus erythematosus
Structural insights into VRC01-class bnAb precursors with diverse light chains elicited in the IAVI G001 human vaccine trial
Sox11 genes affect neuronal differentiation in the developing zebrafish enteric nervous system
Phosphatidic acid production on the vacuole harboring Legionella pneumophila is a signal for recognition of interferon-induced GTPases
Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission
Striatal and cerebellar interactions during reward-based motor performance
A recurrent de novo damaging variant in EMP2 causes progressive symmetric erythrokeratoderma
A minimal model of panimmunity maintenance by horizontal gene transfer in the ecological dynamics of bacteria and phages
Ultradian rhythms of CRHPVN neuron activity, behavior, and stress hormone secretion
PyReconstruct: A fully open-source, collaborative successor to Reconstruct
Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing
Cell type–specific purifying selection of synonymous mitochondrial DNA variation
Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity
Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field
Different folding mechanisms in prion proteins from mammals with different disease susceptibility observed at the single-molecule level
OMT and tensor SVD–based deep learning model for segmentation and predicting genetic markers of glioma: A multicenter study
HIF1α mediates circadian regulation of skeletal muscle metabolism and substrate preference in response to time-of-day exercise
Motilin stimulates food intake linked to gastric motility in Suncus murinus: Simultaneous recordings of food intake and gastric motility in the conscious state
Hippocampal blood oxygenation predicts choices about everyday consumer experiences: A deep-learning approach
A Mycobacterium tuberculosis secreted virulence factor Rv1435c/hsr1 disrupts host snRNP biogenesis
Genetic ancestry shapes dengue virus infection in human skin explants
Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain
Contribution of glutamatergic projections to neurons in the nonhuman primate substantia nigra pars reticulata for reactive inhibition
Trichomonas vaginalis extracellular vesicles suppress IFNε-mediated responses driven by its intracellular bacterial symbiont Mycoplasma hominis
EIAV encodes an accessory protein that antagonizes the host restriction factor equine tetherin
Genetic contributions to brain criticality and its relationship with human cognitive functions
JunB–HBZ nuclear translocation by TGF-β is a key driver in HTLV-1-mediated leukemogenesis
Structure of the virulence-associated Neisseria meningitidis filamentous bacteriophage MDAΦ
Model-based algorithms shape automatic evaluative processing
Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction
LDL receptor–mediated endocytosis of Escherichia coli α-hemolysin mediates renal epithelial toxicity
Unraveling the role of rat and flea population dynamics on the seasonality of plague epidemics in Madagascar
The great phage escape: Activating and escaping lactococcal antiphage systems
Systemic in utero gene editing as a treatment for cystic fibrosis
N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection
<atl>Repurposing a drug to punish carbapenem-resistant iAcinetobacter baumannii/i</atl>
Predicting high-fitness viral protein variants with Bayesian active learning and biophysics
Protein kinase A signaling regulates immune evasion by shaving and concealing fungal β-1,3-glucan
Projecting neurons from the lateral entorhinal cortex to the basolateral amygdala mediate the encoding of incidental odor–taste associations
Targeting of hyperlipid-producing senescent synovial fibroblasts to ameliorate cartilage degeneration
Macropinosomes are a site of HIV-1 entry into primary CD4+ T cells
Pathophysiologically relevant bisphenol S exposure accelerates aging by disrupting brown adipose tissue–regulated energy metabolism
Phage-induced protection against lethal bacterial reinfection
Ethanol induction of FGF21 in the liver is dependent on histone acetylation and ligand activation of ChREBP by glycerol-3-phosphate
Viral and host network analysis of the human cytomegalovirus transcriptome in latency
The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury
The distribution of highly deleterious variants across human ancestry groups
Autophagy-mediated downregulation of AXL and TIM-1 promotes sustained Zika virus infection
Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles
BRD9 functions as an HIV-1 latency regulatory factor
Physical exercise activates a PVN–NAc oxytocin circuit to relieve stress-induced depressive-like behaviors
X and Y gene dosage effects are primary contributors to human sexual dimorphism: The case of height
Modes of action of a small molecule antiviral compound targeting yellow fever virus NS4B protein
Staphylococcus aureus SaeR/S-regulated factors overcome human complement–mediated inhibition of aggregation to evade neutrophil killing
Behavioral interventions motivate action to address climate change
Real-world implementation of a noninvasive, AI-augmented, anemia-screening smartphone app and personalization for hemoglobin level self-monitoring
A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain
Estrogen-related receptors regulate innate and adaptive muscle mitochondrial energetics through cooperative and distinct actions
RNA sequencing analysis of viromes of Aedes albopictus and Aedes vexans collected from NEON sites
Interferon-induced activation of dendritic cells and monocytes by yellow fever vaccination correlates with early antibody responses
Healthy sleep durations appear to vary across cultures
Population imaging of enterochromaffin cell activity reveals regulation by somatostatin
Next-generation rifamycins for the treatment of mycobacterial infections
9
Integrating microclimate to understand vector development and disease patterns: challenges and lessons from plague in Madagascar’s Central Highlands
Humans choose trunk lean angles consistent with minimal metabolic costs—an integrative experimental and musculoskeletal simulation approach
Homophily in a multi-group vaccination game and its impact on disease dynamics
Interepidemic Rift Valley fever in East Africa: the recent risk landscape and projected impacts of global change
Mourning ritual participation, subjective well-being and prosocial behaviour among the Luhya people of Kenya
Localized Rift Valley fever virus persistence explains epidemic and interepidemic dynamics and guides control strategies.
Indirect feedback hinders explicit sensorimotor adaptation
Temporal power of a cycling sprinter: experiments and effective time theory
Postural stability and optic flow sensitivity following sight restoration from congenital bilateral cataracts.
48
Midbrain Energy Homeostasis Biomarker for Differential Diagnosis of Early-Stage Parkinson Disease: A 1H and 31P MRI Study.
Decoupling Alzheimer Disease Pathologic Abnormalities at PET with Improved Clinical Relevance by Interpretable Adversarial Decomposition Learning.
Deep Learning-based Bone Mineral Density Prediction Using Pediatric Chest Radiographs: A Multicenter Feasibility Study.
Independent Testing of Published CT Models for PD-L1 Status in Non–Small Cell Lung Cancer
Telangiectatic Pulmonary Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia.
Gadoxetate-enhanced MRI Transitional Phase Parenchymal Signal: Effect on Washout and LI-RADS Diagnostic Performance for Hepatocellular Carcinoma.
Revised Criterion for Identifying Small-Bowel Stricture in Crohn Disease at CT Enterography.
MRI-based Risk Scoring System to Predict Early Recurrence after Resection of Solitary Hepatocellular Carcinoma 5 cm or Smaller.
Contrast-Enhanced US Using Perfluorobutane for Diagnosing Small HCC in High-Risk Patients: Comparison with MRI LI-RADS Version 2018.
Ablation and Surgery Show Comparable Long-term Outcomes for T1a Renal Cell Carcinoma: A Danish Nationwide Registry Study.
Quality of Gadoxetate-enhanced MRI versus US during Hepatocellular Carcinoma Screening in Participants with Cirrhosis.
Nodular Transformation-driven Circulatory Remodeling in Biliary Atresia-induced Pediatric Biliary Cirrhosis: A Three-dimensional Phase-Contrast CT Rendering.
Effect of Reporting Mode and Clinical Experience on Radiologists' Gaze and Image Analysis Behavior at Chest Radiography.
Middle Meningeal Artery Embolization for Subdural Hematoma: CT/MRI End Points of the EMBOLISE Trial.
Establishing CT-derived Normative Liver and Spleen Volumes for Children: Validation in Regional and International Datasets.
Ultra-Low-Dose Photon-counting Detector CT for Emphysema Assessment: A Head-to-Head Comparative Study with Low-Dose CT.
Prospective Multicenter Evaluation of Hepatocellular Carcinoma Surveillance under American Association for the Study of Liver Diseases Version 2023 Guidance.
Integrating Contrast-Enhanced Dark-Light-Dark Sign and MRI Features for Rectal Cancer Lymph Node Diagnosis.
Nephrogenic Systemic Fibrosis in Patients with Advanced Renal Dysfunction Following Gadolinium-based Contrast Agents.
T1/T2-weighted Ratio to Improve MRI-guided Focused Ultrasound-induced Chronic Lesion Contrast in Patients with Tremor Syndrome.
Contrast-enhanced US Evaluation of Residual Hepatocellular Carcinoma Following Lenvatinib Combined with Anti-PD-1 Antibody Downstaging Therapy.
Diagnostic Value of Precontrast Low Attenuation as a LI-RADS CT Ancillary Feature for Hepatocellular Carcinoma.
C-FLAIR: Fluid-attenuated Inversion Recovery with Controlled Artifact Suppression in Brain MRI.
Deep Learning-based Opportunistic CT Osteoporosis Screening and the Establishment of Normative Values.
Feasibility of Diffusion-weighted MRI for Detecting Abdominal Aortic Endoleaks after Endovascular Aneurysm Repair.
Spatiotemporal Development and Clinical Correlates of MRI-based Brain Myelination in Term- and Preterm-born Children.
Outcomes of Fluoroscopy-guided Percutaneous Transhepatic Removal of Bile Duct Stones: A Multicenter Retrospective Cohort Study.
Standalone Endovascular Embolization versus Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations in Eloquent Brain.
Liver MRI-derived Proton Density Fat Fraction Predicts Diabetes Risk in Patients with Obesity: A Dose-Response Study.
Identifying Distinct Spatiotemporal Patterns of Juxtacortical Microstructure in Alzheimer Disease Using Diffusion MRI-derived Free Water Fraction.
Colorectal Cancer and Advanced Adenoma after Single CT Colonography or Biennial FIT Screening in the SAVE Randomized Controlled Trial.
Clinical Validation of a Generative Artificial Intelligence Model for Chest Radiograph Reporting: A Multicohort Study.
Prevalence and Incidence of Paramagnetic Rim Lesions in Multiple Sclerosis: A Systematic Review and Meta-Analysis.
Risk Stratification of Sudden Cardiac Death in Nonischemic Dilated Cardiomyopathy: Arrhythmogenic Substrate Assessment in Cardiac MRI.
A Safe MRI- and PET-guided Method for Increasing Osmotic Blood-Brain Barrier Permeability.
Preoperative MRI Segmentation of Paraspinal Muscles Is Associated with Intraoperative Findings of Traumatic Brachial Plexus Injury.
Comparison of a Specialized Large Language Model with GPT-4o for CT and MRI Radiology Report Summarization.
Intratumoral Microbiome-related MRI Model for Predicting Breast Cancer Shrinkage Pattern Following Neoadjuvant Therapy.
Prognostic Value of Global Longitudinal Strain using Automated Measurement in Cardiac MRI.
Noninvasive Tumor Profiling: Quantitative Contrast-Enhanced MRI Markers Predict PD-L1 and CTNNB1 Status in Hepatocellular Carcinoma.
Safety of Gadolinium-based Contrast Agents in Children: A Systematic Review and Meta-Analysis.
Metabolic Dysfunction-Associated Steatotic Liver Disease at Quantitative US: International Prospective Study.
Impact of LI-RADS CT and MRI Ancillary Features on Diagnostic Performance: An Individual Participant Data Meta-Analysis.
A Data-Centric Approach to Deep Learning for Brain Metastasis Analysis at MRI.
Diagnostic Performance of CT/MRI LI-RADS Version 2018 Major Feature Combinations: Individual Participant Data Meta-Analysis.
Intra-articular Knee Injections and Progression of Knee Osteoarthritis: Data from the Osteoarthritis Initiative.
Generative Large Language Models Trained for Detecting Errors in Radiology Reports.
Four-Dimensional Similarity Filter for Cerebral CT Perfusion Maps in Acute Stroke.
37
A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
HNF1B integrates signals in a feed-forward loop driving kidney disease progression
Competence-mediated DNA uptake diversifies Vibrio cholerae sedentary chromosomal integrons
DefensePredictor: A machine learning model to discover prokaryotic immune systems
Protein and genomic language models uncover the unexplored diversity of bacterial immunity
Population genomics of Anopheles darlingi, the principal South American malaria vector mosquito
Distinctive DNA sequence features define epigenetic longevity of inflammatory memory
A sympathetic-eosinophil axis orchestrates psychological stress to exacerbate skin inflammation
Host-derived nitrate fuels indole production by Escherichia coli to drive chronic kidney disease progression
From chronic pain to depression: Neurogenesis-driven microglial remodeling in the hippocampal dentate gyrus
Task learning increases information redundancy of neural responses in macaque visual cortex
Structural modeling reveals phage proteins that manipulate bacterial immune signaling
Imbalance in gut microbial interactions as a marker of health and disease
Implanted flexible electronics reveal principles of human islet cell electrical maturation
DNA origami vaccines program antigen-focused germinal centers
A cellular basis for heightened gut sensitivity in females
The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin
An Aeromonas variant that produces aerolysin promotes susceptibility to ulcerative colitis
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
Ancient origin of an urban underground mosquito
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations
Estrogen-regulated renal progenitors determine pregnancy adaptation and preeclampsia
Machine learning–based penetrance of genetic variants
Recent evolution of the developing human intestine affects metabolic and barrier functions
Mitochondria protect against an intracellular pathogen by restricting access to folate
Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin
A metabolite-based resistance mechanism against malaria
Disassembly activates Retron-Septu for antiphage defense
Attenuation of virulence in Yersinia pestis across three plague pandemics
Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans
Precise targeting of HIV broadly neutralizing antibody precursors in humans
Enhanced ERK activity extends ketamine’s antidepressant effects by augmenting synaptic plasticity
Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense
158
Transcobalamin 1 is a keratinocyte-derived autoantigen driving psoriasis through T helper 17 cell activation
Enhancing biomedical optical volumetric imaging via self-supervised orthogonal learning
High-gradient magnetic separation chip–based small extracellular vesicle isolation for noninvasive subtyping of primary aldosteronism
Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease
SRC-mediated phosphorylation of UBC9 regulates inflammatory and metabolic signaling in alcohol-associated liver disease
Childhood immune imprinting shapes cohort and period influenza mortality
Multimodal platform for ITN efficacy: Surface chemistry, bioavailability, and mosquito behavior
Phosphorylation of PfiA modulates Pf4 phage production through PfiA/PfiT stoichiometric reconfiguration in Pseudomonas aeruginosa
Hemostatic B-knob–triggered microgels (BK-TriGs) to address bleeding in neonates
Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants
A microphysiologic human cervical model recapitulates microbial, immune, and pathogenic properties of sexually transmitted infections
Synergy and antagonism in a genome-scale model of metabolic hijacking by bacteriophages
PRISM: A unified platform for phage isolation and characterization from single-droplet microenvironments
Toward ultimate NMR resolution with deep learning
The human amygdala in threat learning and extinction
Dengue infection elicits skin tissue-resident and circulating CD8+ T cells associated with protection from hospitalization
Bacterial enzyme-responsive hydrogels for triggered delivery of antibiotics to infected wounds
Immunity to hemagglutinin and neuraminidase results in additive reductions in airborne transmission of influenza H1N1 virus in ferrets
Reduced MGE burden, virulence optimization, and acid stress tolerance shape the clonal succession of MRSA ST59
Type 2 lymphocytes restrict type 3 lymphocytes during liver fibrosis and colocalize in fibroblast niches
Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking
Sympathetic nerve aggravates autoimmune skin disease via NE–adrenergic receptor axis: Neuroimmune cross-talk insights from vitiligo
Rapid dopaminergic signatures in movement: Reach vigor reflects reward prediction error and learned expectation
Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages
Selective attention to auditory and visual modalities converges onto noncholinergic basal forebrain neurons
3D reconstruction of human liver tissue at cellular resolution
RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity
VapC36-mediated intrinsic stress adaption is required for copper tolerance and pathogenesis of Mycobacterium tuberculosis
Antigen-specific TH17 cells offset the age-related decline in durable T cell immunity
Stress ensemble in the BNST mediates comorbid anxiety and sleep disruption
Overcoming host restrictions to enable continuous passaging of GII.3 human norovirus in human intestinal enteroids
Animal-associated jumbo phages as widespread and active modulators of gut microbiome ecology and metabolism
The gut-brain vagal axis governs mesolimbic dopamine dynamics and reward events
RIN3 mutations impairing binding of the Alzheimer’s disease–associated protein BIN1 lead to RAB5 hyperactivation and endosomal pathology
Bacteriophages mobilize bacterial defense systems via lateral transduction
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
Lipid self-assembly dependence on hyaluronic acid size reveals biolubrication and osteoarthritic degeneration mechanisms
Whole-brain meso-vein imaging in living humans using fast 7-T MRI
Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol, and infection
Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis
Bacteriocin-transport–inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis
Tracing 2500 years of human betaherpesvirus 6A and 6B diversity through ancient DNA
Integrin inhibition facilitates fibrocartilaginous transformation in connective tissue in osteoarthritis
Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration
SLFN14 functions as a P-TEFb inhibitor to modulate the transcription of HIV-1 and cellular genes
Growth hormone is required for hippocampal engram cell maturation
Interleukin-2 is a potent latency reversal agent in people with treated HIV-1
Caspase-8 expression in CD8+ T cells promotes pathogen restriction in the brain during Toxoplasma gondii infection
A self-assembled nano micelle-exosome with high selectivity and penetrability achieves precise intracartilage lipid delivery
Targeting multiple genetic defects of mitochondrial diseases with a single bacterial lipoate protein ligase
A central CeA-LC-PVH circuit mediates stress-induced osteopenia via skeletal sympathetic nerves in male mice
Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation
Mechanistic insights into 50S precursor recognition and targeting by erythromycin resistance methyltransferase
Substitution of human olfaction by the trigeminal system
Cortical dopaminergic signaling mediates planning of directional movements
Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation
A striosomal accumbens pathway drives stereotyped behavior through an aversive Esr1+ hypothalamic-habenula circuit
Single coadministration of erythrocyte-uricase conjugate and immunosuppressant induces durable immune tolerance for gout therapy
Thiol-polarity dual cascade–triggered two-photon imaging of protein unfolding for early atherosclerosis diagnosis
Structural basis of bacteriophage Ur-lambda infection initiation
Mapping neurophysiological and molecular profiles of heterogeneity and homogeneity in schizophrenia-bipolar disorder
Swallowable expandable fibrous capsules for nonendoscopic sampling of esophageal cells
Evasion of CARD8 activation during HIV-1 assembly
<atl>Cryo-EM structure of bacteriophage Bas63 reveals structural conservation and diversity in the iFelixounavirus/i genus</atl>
Liver-directed AAV gene therapy in mice corrects glycogen storage disease type IX γ2
Pfs230 domain 12 is a potent malaria transmission–blocking vaccine candidate
Engineered probiotic restores GLP-1 signaling to ameliorate fiber-deficiency exacerbated colitis
A network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axis
Thalamo-hippocampal pathway determines aggression and self-harm
Dorsomedial striatum monitors unreliability of current action policy and probes alternative one via the indirect pathway
Bacteriophage-loaded microneedle patches for targeted and minimally disruptive foodborne pathogen decontamination
The two-component nuclease-active KELShedu system confers broad antiphage activity via abortive infection
The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice
Metabolic dysfunction–associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy
Immunopeptidome analysis reveals SERPINB3 as an autoantigen driving eczematized psoriasis
Activatable fluorescent ratiometric probes for early diagnosis and prognostic assessment of acute kidney injury
In vivo expression of VCAM1 precedes nephron loss following kidney tubular necrosis
Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing
Dissociable cortical contributions to impulse control during waiting
Loss-of-function variants in ciliary genes confer high risk for tetralogy of Fallot
Phage lysis protein LysM acts as a wedge to block MurJ conformational changes
Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches
Secretory IgA amplification during immune checkpoint blockade enhances the control of tumor growth by enterotropic T cells
Restriction of HIV-1 infectivity by interferon and IFITM3 is counteracted by Nef
Single-cell atlas of cervical organoids uncovers epithelial immune heterogeneity and intercellular cross-talk during Chlamydia infection
Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail
Exploring nationwide patterns of sleep problems from late adolescence to adulthood using machine learning
Evolutionary selection of trimethoprim-resistant dfrA genes in lytic phages affects phage and host fitness during infection
BDNF-driven synaptic plasticity requires autocrine matrix metalloproteinase–9 activity
Laser speckle particle sizer (SPARSE) informs the size distribution of tissue granularities
Grin2b-mutant mice exhibit heightened remote fear via suppressed extinction and chronic amygdalar synaptic and neuronal dysfunction
Oropouche virus efficiently replicates and is immunostimulatory in vivo in nonhuman primate species
Ethanol ingestion via frugivory in wild chimpanzees
Nipah virus matrix protein uses cortical actin to stabilize the virus assembly sites and promote budding
Label-free and real-time monitoring of photoaging with high spatiotemporal resolution using an nIR fluorescent nanosensor array
Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization
Elucidating the mechanism by which HIV-1 nucleocapsid mutations confer resistance to integrase strand transfer inhibitors
Somatic mtDNA mutations at intermediate levels of heteroplasmy are a source of functional heterogeneity among primary leukemic cells
Investigating the know-do gap in antibiotics prescribing: Experimental evidence from India
HIV-1 manipulates CD96 on CD4+ T cells to subvert antiviral immunity
Microenvironment-driven transformable self-assembly nanoplatform enables spatiotemporal remodeling for rheumatoid arthritis therapy
The discovery of a Legionella phage explains a key determinant of human disease
Bacteriophage immunotherapy with artificial antigen-directed immune labeling against bacterial infection
Intravenous AAV9-ATP7A plus subcutaneous copper histidinate optimizes outcomes in a lethal Menkes disease mouse model
Smarter biopsy decisions in thyroid nodules via dual-modal photoacoustic and ultrasound imaging
Inhibition of craniosynostosis and premature suture fusion in Twist1 mutant mice with RNA nanoparticle gene therapy
Microbiota metabolite taurodeoxycholic acid maintains intestinal tissue residency of innate lymphoid cells via engagement with P2Y10 receptor
A distinct neural ensemble to integrate contradictory information and form long-term memory in Drosophila
Fluid dynamical pathways of airborne transmission while waiting in a line
A sonoelectric niche for noninvasive intervertebral disc regeneration via targeted cell cycle modulation
Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets
Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease
TH17 cells regulate chemokine expression in epithelial cells through C/EBPβ and dictate host sensitivity to colitis and cancer immunity
Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor–associated bullous pemphigoid
Elucidating the characteristics and clonal evolutionary trajectory of influenza neuraminidase broadly reactive B cell
A scalable ultra-long-acting tenofovir phosphonate prodrug sustains HBV suppression
Genetic foundations of interindividual neurophysiological variability
Neuropeptide Y neurons surrounding the locus coeruleus inhibit noradrenergic system activity to reduce anxiety
Improving real-time ultrasound spine imaging with a large-aperture array
A ventral pallidal glutamatergic aversive network encodes abstinence from and reexposure to cocaine
Selective engagement of prefrontal VIP neurons in reversal learning
Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice
Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones
Proteolytic-resistant self-assembling peptide nanofibers combat specific bacterial infections via trap and kill
NRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway
Insights into the spool-like architecture and infection strategy of an enveloped archaeal virus
NRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress
Adaptive reward representations integrate expected uncertainty signals in orbitofrontal cortex
Wearing bacteriophages individually with an adhesive drug-loadable nanohelmet for treating ocular infections
Biorhythms derived from consumer wearables predict postoperative complications in children
Microglial BDNF modulates arketamine’s antidepressant-like effects through cortico-accumbal pathways
Striatal dopamine signals errors in prediction across different informational domains
High-throughput multiplexed gene and cell doping analysis through CRISPR-Cas12a system integrated with blood direct PCR
Atomic-resolution structure of a chimeric Powassan tick-borne flavivirus
Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner
The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel prometabolic targets of the glucocorticoid receptor in muscle
Staphylococcus aureus LukMF′ targets neutrophils to promote skin and soft tissue infection
Autoinducing peptides regulate antibiotic production to potentially shape root microbiome
Mobile human brain imaging using functional ultrasound
Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI
Endothelial CLEC5A drives barrier dysfunction and vascular leakage responsible for lung injury in bacterial pneumonia and sepsis
Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli
Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor
Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making
Enhanced Rap1 small GTPase activity in the ventral hippocampus drives stress-induced anxiety
Complementary corticostriatal circuits orchestrate action repetition and switching
Socioeconomic and temporal heterogeneity in SARS-CoV-2 exposure and disease in England from May 2020 to February 2023
Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling
Fibronectin in the olfactory mucus increases sensitivity of olfactory receptor response to odorants
Sheep serve as amplifying hosts of Japanese encephalitis virus, increasing the risk of human infection
Structural maturation of the matrix lattice is not required for HIV-1 particle infectivity
Suppression of HIV-1 transcription and latency reversal via ectopic expression of the viral antisense transcript AST
A top-down insular cortex circuit crucial for non-nociceptive fear learning
A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury
The Duke Mouse Brain Atlas: MRI and light sheet microscopy stereotaxic atlas of the mouse brain
Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons
Bacterial pathogens hijack host cell peroxisomes for replication vacuole expansion and integrity
Noninvasive prognostic classification of ITH in HCC with multi-omics insights and therapeutic implications
71
Adeno-associated virus gene therapy–mediated CCR5 blockade suppresses virus replication long term in SHIV-infected macaques
Local B cell immunity and durable memory after live-attenuated influenza intranasal vaccination of humans
Expansion of stemlike HIV-specific CD8+ T cells and limited viral epitope diversity characterize durable posttreatment control of HIV
The orphan receptor GPR84 drives inflammation in Buruli ulcer development
A transcriptional atlas of the pubertal human growth plate reveals two populations of stem cells and direct effect of growth hormone
Historic 1994 influenza vaccine cohorts define breadth of antibody and B cell responses toward future influenza A and B viruses
NKX6.1 mRNA copy number is an actionable biomarker associated with islet function and clinical outcomes after islet transplantation
An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans
Quantifying myocardial oxygen consumption and efficiency with motion-resolved cardiac MRI
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestational diabetes–induced glucose intolerance in offspring
AAV8 gene therapy and dietary insults together precipitate cholestatic liver disease in a mouse model of X-linked myotubular myopathy
The TUB variant impairs leptin sensitivity and AgRP neuronal response, leading to obesity
Parenteral vaccination with an adjuvanted mRNA vaccine induces protective mucosal immunity against rotavirus in neonatal mice
Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction
Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma
The E205D mutation in CYP6P3 drives pyrethroid insecticide resistance in the African malaria mosquito vector Anopheles gambiae
Meteorin-like is associated with poor outcome in invasive candidiasis in mouse models and in humans
Crystallized colony-stimulating factor-1 receptor inhibitor protects immunoisolated allo but not xeno transplants in primates
Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis
Dermatomyositis is characterized by JAK1-mediated monocyte-driven vasculopathy and inflammation
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis
A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis
Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses
A rationally designed cocktail of nanobodies elicited by heterologous vaccination confers protection against SFTSV in preclinical models
Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus
snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice
Immunopeptidomics can inform the design of mRNA vaccines for the delivery of Mycobacterium tuberculosis MHC class II antigens
Depletion of plasmacytoid dendritic cells rescues HIV-reactive stem-like CD8+ T cells during chronic HIV-1 infection
Burst-patterned stimulation restores colonic motility in preclinical models
Identifying correlates of viral rebound timing and viral control in SHIV-infected infant macaques after ART interruption
Computationally designed mRNA-launched protein nanoparticle immunogens elicit protective antibody and T cell responses in mice
Low-dose glucocorticoids attenuate crescentic glomerulonephritis by inhibiting the local differentiation of proinflammatory neutrophils
Sprayable extracellular matrix hydrogel reduces postoperative adhesion formation and protects healing tissues in preclinical models
CRISPR activation of the ribosome-associated quality control factor ASCC3 ameliorates fragile X syndrome phenotypes in mice
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Afucosylation of anti-dengue IgG is associated with enhanced susceptibility to dengue virus infection postvaccination
Sex differences in HIV-1 reservoir cell selection are linked to altered innate immune profiles
A randomized, double-blind, placebo-controlled phase 1 trial of the topical pan–lysyl oxidase inhibitor PXS-6302 in mature scars
Functional, immunogenetic, and structural convergence in influenza immunity between humans and macaques
Impaired TIM4-mediated efferocytosis by liver macrophages contributes to fibrosis in metabolic dysfunction–associated steatohepatitis
A soft robotic device for rapid and self-guided intubation
Inhibiting SLC38A2 lowers blood pressure in rodent models of hypertension
Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity
The XBB.1.5 COVID-19 vaccine elicits a durable antibody response to ancestral and XBB.1.5 SARS-CoV-2 spike proteins
<atl>Immune response and clinical severity are shaped by skin-adapted iStaphylococcus aureus/i in chronically infected patients</atl>
Antigen-Fc fusion therapy reduces severity of a model of pemphigus vulgaris without systemic immunosuppression
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation
Synchronized dynamics of dengue across the Americas
An epitope vaccine derived by analyzing clinical trial samples safeguards hosts with prior exposure to S. aureus against reinfection
Proviruses in CD4+ T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia
Nasal and systemic immune responses correlate with viral shedding after influenza challenge in people with complex preexisting immunity
Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
Viral spike antigen clearance and augmented recovery in children with post-COVID multisystem inflammatory syndrome treated with larazotide
NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis
Impairment of stromal-epithelial regenerative cross-talk in Hirschsprung disease primes for the progression to enterocolitis
Human inner ear fluid imbalance detected by optical coherence tomography correlates with hearing loss
Protective envelope dimer epitope–like antibodies are elicited against dengue virus in children after infection and vaccination
Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease
Adenovirus and mRNA vaccines as well as mucosal boosting improve protective efficacy against influenza virus challenge in macaques
A cationic polymer drives glycosaminoglycan assembly and secretion for preclinical osteoarthritis therapy
Metabolic surgery reduces CRC disease progression through circulating bile acid diversion
Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors
A host defense peptide–mimicking prodrug activated by drug-resistant Gram-negative bacterial infections
A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint
Peripherally induced RORγt+ skin-resident regulatory T cells mediate the efficacy of allergen-specific immunotherapy
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
Islet transplantation in immunomodulatory nanoparticle–remodeled spleens
An oral norovirus vaccine generates mucosal immunity and reduces viral shedding in a phase 2 placebo-controlled challenge study
Expanded T cell clones with lymphoma driver somatic mutations accumulate in refractory celiac disease
5
Thermal adaptation, perception and regulation for the elderly under intense urban heat: A cross-activity study
Enhancing urban biosecurity and sustainability through a microclimatic bioaerosol risk management framework
Pedestrians thermal responses under variable exposure conditions during heatwaves
Estimating the real-life infection risk of the SARS-CoV-2 virus in a typical metro compartment
Comprehensive Integration Framework of CFD – Local and Whole Body Hybrid PBPK in Indoor Chemical Exposure Modeling: An Inhalation Exposure Study
28
Non-drug perioperative interventions to reduce postoperative pulmonary complications after abdominal surgery: systematic review and meta-analysis
Home based, tailored intervention to reduce rate of falls after stroke (FAST): randomised trial
Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study
Glucagon-like peptide-1 receptor agonists and risk of substance use disorders among US veterans with type 2 diabetes: cohort study
Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials
Standard chemoradiotherapy with concurrent and adjuvant camrelizumab in patients with high risk nasopharyngeal carcinoma: multicentre, randomised, open label, phase 3 trial
Reliability of urological telesurgery compared with local surgery: multicentre randomised controlled trial
Cast immobilisation versus surgery for unstable lateral malleolus fractures (SUPER-FIN): randomised non-inferiority clinical trial
Effects of lifestyle interventions in pregnancy on gestational diabetes: individual participant data and network meta-analysis
Oral ivermectin versus 5% permethrin cream to treat children and adults with classic scabies: multicentre, assessor blinded, cluster randomised clinical trial
Preimplantation genetic testing for aneuploidy versus no genetic testing in couples undergoing intracytoplasmic sperm injection for severe male infertility: multicentre, open label, randomised controlled trial
Arthroscopic subacromial decompression versus placebo surgery for subacromial pain syndrome: 10 year follow-up of the FIMPACT randomised, placebo surgery controlled trial
Benefits and harms of ADHD interventions: umbrella review and platform for shared decision making
Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial
Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis
Sodium-glucose cotransporter-2 inhibitors and risk of autoimmune rheumatic diseases: population based cohort study
Use of new CORE risk score to predict 10 year risk of liver cirrhosis in general population: population based cohort study
Patterns of war related trauma in Gaza during armed conflict: survey study of international healthcare workers
Trends in the shortfall of English NHS general practice doctors: repeat cross sectional study
Effect of lateral versus supine positioning on hypoxaemia in sedated adults: multicentre randomised controlled trial
Efficacy and safety of anrikefon in patients with pruritus undergoing haemodialysis: multicentre, double blind, randomised placebo controlled phase 3 trial
Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis
ADHD drug treatment and risk of suicidal behaviours, substance misuse, accidental injuries, transport accidents, and criminality: emulation of target trials
Effectiveness of screening and ultra-brief intervention for hazardous drinking in primary care: pragmatic cluster randomised controlled trial
Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis
Effects of a general practitioner-led brief narrative exposure intervention on symptoms of post-traumatic stress disorder after intensive care (PICTURE): multicentre, observer blind, randomised controlled trial
Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study
No-touch versus conventional vein in coronary artery bypass grafting: three year follow-up of multicentre randomised PATENCY trial
19
Deep single-cell decoding of human pancreatic islets reveals T2D β-cell gene expression defects
CDKAL1 dysfunction impairs lysine codon translation in podocytes and accelerates chronic kidney disease
The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling
Simultaneous inhibition of bacterial virulence and anti-phage defense systems by synergistic bacteriophage counter-defense proteins
Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles
Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage
A gut-brain-gut axis orchestrates host responses counteracting microbiome-induced iron insufficiency
Phage-encoded TelN inhibits bacterial Mre11-Rad50 nuclease to protect hairpin telomeres.
Non-coding RNA mediates the defense-associated reverse transcriptase (DRT) anti-phage oligomerization transition.
RTN4IP1 is required for the final stages of mitochondrial complex I assembly and CoQ biosynthesis.
Macrophages form dendrite-like pseudopods to enhance bacterial ingestion
Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection.
Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC.
Structural basis of Fanconi anemia pathway activation by FANCM.
Aldolase-regulated G3BP1/2+ condensates control insulin mRNA storage in beta cells
Morphology-dependent entry kinetics and spread of influenza A virus
Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis
Surface-mediated bacteriophage defense incurs fitness tradeoffs for interbacterial antagonism.
The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.
22
Iron limitation promotes metabolic cross-feeding between cheese ripening bacteria
Phage receptor specificity drives cross-resistance patterns and governs fitness trade-offs during sequential resistance acquisition in Salmonella
A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere
Light restores sporulation in Rhizopus microsporus cured of its endosymbionts, unveiling their role in fitness and virulence
Microoxic conditions promote Escherichia-associated cellulase expression in the giant panda gut
Fecal microbiota transplantation and Akkermansia muciniphila restore neurodevelopment and behavior via the gut-brain axis in autism-like zebrafish
Predator–prey dynamics of Vibrio cholerae on chitin suggest an alternative mode of biofilm formation in marine snow conditions
Rapid resistance evolution against phage cocktails
Sulfoquinovose degradation by cow rumen microbiota
Priority effects drive strain-level community composition of honeybee gut microbiota
Density-dependent feedback and higher-order interactions enable coexistence in phage-bacteria community dynamics
DNA virus–host patterns in lake and marine environments over the last glacial cycle
Gut microbial production of lithocholic acid reprograms pro-resolutive macrophages to enhance vedolizumab responsiveness via the TGR5/FXR-NF-κB axis
Phage infection fronts trigger early sporulation and viral entrapment in bacterial populations
Ecological strategies of bacteria shape inherent phage diversity in Atlantic salmon gut microbiomes
Global distribution of α/β hydrolase family macrolide esterases in Gram-positive bacteria
Competitive fitness of Staphylococcus aureus against nasal commensals depends on biotin biosynthesis and acquisition
Diversity and Evolution of Prokaryotic Viral Lytic Proteins
Sewer microbiomes shape microbial community composition and dynamics of wastewater treatment plants
Function-based selection of synthetic communities enables mechanistic microbiome studies
Vitamin auxotrophies shape microbial community assembly on model marine particles
Decoding the SCFA-CpxAR-OMP Axis as a Dietary Checkpoint against Antimicrobial Resistance Transmission across Gut-Environment Interfaces
43
Comprehensive molecular profiling of Hispanic, Black, Asian, and White atopic dermatitis via tape strip RNAseq and serum proteomics
CD25 expression marks an activated mast cell population in human nasal polyposis
ADAM8 mediates eosinophil and neutrophil infiltration and tissue remodeling in chronic rhinosinusitis with nasal polyps
Deep learning and statistical methods identify novel asthma risk variants in Europeans
Incidence of autoimmune diseases in children with atopy treated with dupilumab
Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores
IL-31 blockade elevates thymus and activation-regulated chemokine by lifting LAMP3+CD1c+ mature dendritic cells from calcitonin gene–related peptide–calcitonin receptor–like neuroimmune suppression in atopic dermatitis
Drug screening identifies Src/Abl inhibitor dasatinib as suppressor of IL-23 signaling in skin inflammation
Establishing the PM2.5-associated inflammatory endotype of chronic rhinosinusitis
Effects of proton pump inhibitors on remodeling and fibrosis in eosinophilic esophagitis
Single-cell and spatial transcriptomics unveil myeloid–lymphoid cross talk and the dermal immune niche underlying palmoplantar pustulosis
IL-2 synergizes with proinflammatory type 3 inducers to amplify mixed type 2–type 3 inflammation in nasal polyps
Staphylococcal superantigen–specific IgE reveals functional superantigen production beyond Staphylococcus aureus in CRSwNP
Inhibition of RIPK1 prevents keratinocyte cell death and reduces skin inflammation in type 1–mediated chronic inflammatory skin diseases
Efferocytosis Deficiency Exacerbates Local Inflammation and Predicts Recurrence in Chronic Rhinosinusitis with Nasal Polyps
Nasal microbiome and phageome profiles are associated with prospective respiratory viral infection risk in school-aged children
Bimekizumab long-term response in psoriasis: Mechanistic insights into efficacy level and durability
Skin tape strips identify age-specific immune, metabolic and barrier dysregulation signatures in children, adolescents, and adults with allergic asthma
Epinephrine and Emergency Medical Services Activation Recommendations During Acute Allergic Reactions in Community Settings: International Consensus Report
Nonsteroidal anti-inflammatory drug–induced acute urticaria/angioedema associated with atopy-related genes’ genetic variants
Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting EET formation and release in CRSwNP
Targeting IL-22RA1 with Temtokibart: A Novel Approach in Atopic Dermatitis: Phase 2a Monotherapy Study Results
Remibrutinib in chronic spontaneous urticaria: 52-Week results from two phase 3 studies
Periostin promotes inflammation and neovascularization in atopic keratoconjunctivitis
Effects of type 3 and neutrophilic inflammation on type 2 chronic rhinosinusitis with nasal polyps
Resolution of Epithelial Dysfunction in Eosinophilic Esophagitis is Mediated by a HIF-1α-CD73-Adenosine Signalling Axis
Unraveling shared genetics across asthma subtypes and 81 asthma-related traits
CB2R-cAMP-Epac1 Pathway Orchestrates Epithelial-Neural-Immune Interactions in Atopic Dermatitis
Prediction and Characterization of Genetically-Regulated Expression of Asthma Tissues from African-Ancestry Populations
Explainable artificial intelligence for predicting inflammatory signatures and spatial molecular heterogeneity from nasal polyp histology
Massively parallel analysis of genotype-dependent enhancer activity among atopic dermatitis genetic risk variants
S-Ruxolitinib: a novel JAK/STAT-targeted therapy through restoring mucosal homeostasis for chronic rhinosinusitis with nasal polyps
Comparative efficacy and safety of biologics and systemic immunomodulatory treatments for chronic urticaria: Systematic review and network meta-analysis
S. aureus upregulation of MUC13 modulates mucosal remodeling in chronic rhinosinusitis via MEK1/2 and WNT2B
Collagen XXIII (COL23A1): A novel risk factor for eczema herpeticum
Inhibition of lysosomal degradation increases expression of mutant ADA2 in DADA2 monocytes
Transcriptomic profiling of vitiligo patients shows polar immune dysregulation in involved and uninvolved skin
Eosinophil-derived neurotoxin and eosinophil cationic protein are key molecules for blister formation in bullous pemphigoid
Opsin 3 in keratinocytes mediates the light-induced exaggeration of atopic dermatitis
Small Proline-Rich Protein 2A Drives Epithelial Remodeling in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps via SAA2 Upregulation
Type 2 cytokines pleiotropically modulate sensory nerve architecture and neuroimmune interactions to mediate itch
Dissecting key contributions of Th2 and Th17 cytokines to atopic dermatitis pathophysiology
Dupilumab-induced inhibition of myeloid dendritic cells function via TIM-3-TGF-β1 feedback loop in treatment of atopic dermatitis
4
Lipocentric Non-Pore-Forming Membrane Depolarization Underlies the Antibacterial Activity of Ribosomal Protein S30
Small Molecules as Modulators to Prevent Mucin Aggregation via Delaying Liquid-to-Solid Phase Transition
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
Nanoclay-Interface-Mediating Charge Redistribution for Effective Wound Healing
33
Clinical and bacteriological effectiveness of three different short-course antibiotic regimens and single-dose fosfomycin for uncomplicated lower urinary tract infections in women (SCOUT): a pragmatic, multicentre, open-label, randomised clinical trial
Efficacy and safety of LEVI-04 in patients with osteoarthritis of the knee: a randomised, double-blind, placebo-controlled, phase 2 trial
Survival outcome of VATS compared with open lobectomy for lung cancer: an individual patient data meta-analysis of randomised trials
Prevention of urinary stones with hydration: a randomised clinical trial of an adherence intervention
Efimosfermin alfa (BOS-580) once per month in people with metabolic dysfunction-associated steatohepatitis with F2 or F3 fibrosis: results from a 24-week, randomised, double-blind, placebo-controlled, phase 2 trial
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on oral antiretroviral therapy: 48-week results of a phase 3, multicentre, randomised, open-label, non-inferiority trial
Switch to fixed-dose doravirine (100 mg) and islatravir (0·25 mg) once daily in virologically suppressed adults with HIV-1 on bictegravir, emtricitabine, and tenofovir alafenamide: 48-week results of a phase 3, multicentre, randomised, controlled, double-blind, non-inferiority trial
TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198
Surgical fixation versus non-surgical care for children with a displaced medial epicondyle fracture of the elbow (the SCIENCE study): a multicentre, randomised controlled, superiority trial and economic evaluation
Deaths potentially averted by small changes in physical activity and sedentary time: an individual participant data meta-analysis of prospective cohort studies
Maternal and neonatal outcomes after infection with monkeypox virus clade I during pregnancy in DR Congo: a pooled, prospective cohort study
Comparison of inhalational methoxyflurane, intranasal fentanyl, and intravenous morphine for treatment of prehospital acute pain in Norway (PreMeFen): a randomised, non-inferiority, three-arm, phase 3 trial
Safety and immunogenicity of a Nipah virus vaccine (HeV-sG-V) in adults: a single-centre, randomised, observer-blind, placebo-controlled, phase 1 study
A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial
Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial
Efficacy and safety of nipocalimab in patients with moderate-to-severe Sjögren's disease (DAHLIAS): a randomised, phase 2, placebo-controlled, double-blind trial
Effectiveness of high-dose influenza vaccine against hospitalisations in older adults (FLUNITY-HD): an individual-level pooled analysis
Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial
A clinical decision tool including a decision tree, point-of-care testing of CRP, and safety-netting advice to guide antibiotic prescribing in acutely ill children in primary care in Belgium (ARON): a pragmatic, cluster-randomised, controlled trial
Once-daily oral icotrokinra versus placebo and once-daily oral deucravacitinib in participants with moderate-to-severe plaque psoriasis (ICONIC-ADVANCE 1 & 2): two phase 3, randomised, placebo-controlled and active-comparator-controlled trials
Efficacy and safety of tirzepatide in children and adolescents with type 2 diabetes (SURPASS-PEDS): a randomised, double-blind, placebo-controlled, phase 3 trial
Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China
The clinical effectiveness of clarithromycin versus endoscopic sinus surgery for adults with chronic rhinosinusitis with and without nasal polyps (MACRO): a pragmatic, multicentre, three-arm, randomised, placebo-controlled phase 4 trial
Antisense oligonucleotide DGAT-2 inhibitor, ION224, for metabolic dysfunction-associated steatohepatitis (ION224-CS2): results of a 51-week, multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
Efficacy and safety of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy versus Roux-en-Y gastric bypass in France (SADISLEEVE): results of a randomised, open-label, superiority trial at 2 years of follow-up
Safety and efficacy of steroidal mineralocorticoid receptor antagonists in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of randomised controlled trials
Safety and efficacy of once-weekly efruxifermin versus placebo in metabolic dysfunction-associated steatohepatitis (HARMONY): 96-week results from a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial
Efficacy and safety of intravenous induction and subcutaneous maintenance therapy with guselkumab for patients with Crohn's disease (GALAXI-2 and GALAXI-3): 48-week results from two phase 3, randomised, placebo and active comparator-controlled, double-blind, triple-dummy trials
Estimating the effect of maternal viral load on perinatal and postnatal HIV transmission: a systematic review and meta-analysis
Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation
Prademagene zamikeracel for recessive dystrophic epidermolysis bullosa wounds (VIITAL): a two-centre, randomised, open-label, intrapatient-controlled phase 3 trial
Once-weekly insulin efsitora alfa versus once-daily insulin glargine U100 in adults with type 2 diabetes treated with basal and prandial insulin (QWINT-4): a phase 3, randomised, non-inferiority trial
Once-weekly insulin efsitora alfa versus once-daily insulin degludec in adults with type 2 diabetes currently treated with basal insulin (QWINT-3): a phase 3, randomised, non-inferiority trial
17
Safety, tolerability, pharmacokinetics, and efficacy of burosumab in infants with X-linked hypophosphataemia: an open-label, multicentre, non-randomised study
3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial
Effect of surgical versus conservative management on cardiovascular outcomes in patients with bilateral adrenal tumours and cortisol excess: an international, retrospective cohort study
11th edition of the IDF Diabetes Atlas: global, regional, and national diabetes prevalence estimates for 2024 and projections for 2050
Comorbidities and mortality in subgroups of adults with diabetes with up to 14 years follow-up: a prospective cohort study in Sweden
Efficacy and safety of tirzepatide added to basal insulin in patients with type 2 diabetes in China (SURPASS-CN-INS): a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial
Cycle characterisation and clinical complications in patients with cyclic Cushing's syndrome: insights from an international retrospective cohort study
Post-treatment renin status and cardiovascular, renal, and mortality outcomes in medically treated primary aldosteronism: a systematic review and meta-analysis
Once-weekly semaglutide 7·2 mg in adults with obesity and type 2 diabetes (STEP UP T2D): a randomised, controlled, phase 3b trial
Risk differences and underlying factors of cardiovascular events and mortality in patients with type 2 diabetes versus type 1 diabetes: a longitudinal cohort study of Swedish nationwide register data
The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada
Association of gestational thyroid function and thyroid autoimmunity with gestational diabetes: a systematic review and individual participant meta-analysis
Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis
Once-weekly IcoSema versus multiple daily insulin injections in type 2 diabetes management (COMBINE 3): an open-label, multicentre, treat-to-target, non-inferiority, randomised, phase 3a trial
Once‑weekly IcoSema versus once‑weekly insulin icodec in type 2 diabetes management (COMBINE 1): an open‑label, multicentre, treat‑to‑target, randomised, phase 3a trial
Surgery for the treatment of arterial hypertension in patients with unilateral adrenal incidentalomas and mild autonomous cortisol secretion (CHIRACIC): a multicentre, open-label, superiority randomised controlled trial
Tirzepatide and muscle composition changes in people with type 2 diabetes (SURPASS-3 MRI): a post-hoc analysis of a randomised, open-label, parallel-group, phase 3 trial
28
Adaptive intervention strategies for malaria vector control in western Kenya: a cluster, sequential, multiple-assignment, randomised, open-label trial
Effects of a peer-support lifestyle intervention on diabetes incidence in India (K-DPP): 9-year follow-up of a cluster-randomised, controlled trial
Association of linezolid interruption and rechallenge with clinical outcomes in patients with rifampicin-resistant tuberculosis in South Africa, 2018–22: an observational cohort study
Strategies to reduce antimicrobial resistance in newborns in low-income and middle-income countries: a systematic review and meta-analysis
Prevalence and outcomes of intrinsic capacity impairments assessed using the WHO Integrated Care for Older People (ICOPE) framework in The Gambia, South Africa, and Zimbabwe: a cross-sectional study
Evaluation of fluorometholone as adjunctive medical therapy for trachomatous trichiasis surgery (FLAME): a parallel, double-blind, randomised controlled field trial in the Jimma Zone, Ethiopia
Medical oxygen and respiratory support requirements for patients hospitalised with COVID-19 in 23 low-income and middle-income countries: a prospective, observational cohort study
HIV testing during systematic screening for tuberculosis among household contacts in high-tuberculosis burden settings: a systematic review and meta-analysis
The effect of long-acting cabotegravir and rilpivirine treatment on drug resistance in South Africa: a modelling study
Scaling an intervention for the engagement of people with HIV who inject drugs into care in Viet Nam: an implementation-effectiveness, cluster-randomised trial
The aetiology and prevalence of preoperative anaemia in patients undergoing major surgery (ALICE): an international, prospective, observational cohort study
Global antibiotic consumption and regional antimicrobial resistance, 2010–21: an analysis of pharmaceutical sales and antimicrobial resistance surveillance data
Causes, associated exposures, and outcomes of cirrhosis and hepatocellular carcinoma in Malawi: an observational cohort and case–control study
Melioidosis in Mali: a retrospective observational study
Plasmodium falciparum carriage in a population under long-term, intensive malaria control in Kedougou region, Senegal: a 1-year cohort study
Screening for asymptomatic tuberculosis among adults with household exposure to pulmonary tuberculosis: a prospective observational cohort study
Global variation in patient factors, interventions, and postoperative outcomes for those undergoing trauma laparotomy: an international, prospective, observational cohort study
Medical oxygen service readiness and service coverage in seven countries in Africa and Asia: a cross-sectional survey and clinical audit
Guiding the development of the tuberculosis screening target product profile using single-screen and multi-screen approaches: a modelling study
Evidence-based decision making for malaria elimination applying the Freedom From Infection statistical framework in five malaria eliminating countries: an observational study
Profile of central line-associated bloodstream infections in adult, paediatric, and neonatal intensive care units of hospitals participating in a health-care-associated infection surveillance network in India: a 7-year multicentric study
Efficacy of non-pyrethroid indoor residual spraying or intensive behaviour change communication in combination with long-lasting insecticidal nets for malaria control in west Africa: a pragmatic, cluster-randomised, controlled trial
Global burden of cancer attributable to HIV: a worldwide incidence analysis
Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older
Clinical impact and cost-effectiveness of the WHO-recommended advanced HIV disease package of care
Protection from killed whole-cell cholera vaccines: a systematic review and meta-analysis
Evidence from two rounds of Population HIV Impact Assessments of progress towards HIV epidemic control in adolescents aged 15–19 years in Eswatini, Lesotho, Malawi, and Zimbabwe: a cross-sectional study
Identifying gaps in the HIV treatment cascade in Africa: a model comparison study
3
Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments
Lifetime and 10-year absolute risk of cognitive impairment in relation to amyloid PET severity: a retrospective, longitudinal cohort study
Safety and effectiveness of the Walk ‘n Watch structured, progressive exercise protocol delivered by physical therapists for inpatient stroke rehabilitation in Canada: a phase 3, multisite, pragmatic, stepped-wedge, cluster-randomised controlled trial
2
Estimated effect of correcting inequalities in minimally invasive surgical resection in patients with colon cancer in England: a population-based study
Equity in cancer genomics in the UK: a cross-sectional analysis of a national cancer cohort
18
Clozapine rechallenge after neutropenia: a retrospective cohort study in the UK
First-episode psychosis and substance use involvement across birth cohorts in Canada: a retrospective longitudinal population-based study
Brief individual psychological intervention for people with probable personality disorder: a multicentre, researcher-masked, randomised, controlled superiority trial in England
Specific midlife depressive symptoms and long-term dementia risk: a 23-year UK prospective cohort study
Comparison of antidepressant deprescribing strategies in individuals with clinically remitted depression: a systematic review and network meta-analysis
Joint detection of risk for psychotic disorders or bipolar disorders in clinical practice in the UK: development and validation of a clinical prediction model
Efficacy and safety of iclepertin for cognitive impairment associated with schizophrenia (CONNEX programme): results from three phase 3 randomised controlled trials
Transdiagnostic effectiveness and safety of clozapine in individuals with psychotic, affective, and personality disorders: nationwide and meta-analytic comparisons with other antipsychotics
The global epidemiology of personality disorder: a systematic review and meta-regression
The prevalence and estimated burden of somatoform disorders: a systematic review and meta-analysis of their epidemiology
Disease relapse, all-cause mortality, and adverse events associated with long-acting injectable antipsychotics versus oral antipsychotics in older people with schizophrenia in Hong Kong: a population-based within-subject analysis
Antipsychotic prescriptions in people with dementia in primary care: a cohort study investigating adherence of dose and duration to UK clinical guidelines
Early-life protective factors for adolescent self-harm and suicidality: a longitudinal cohort study in Australia
Clozapine use and risk of infections in patients with schizophrenia in Hong Kong: a population-based cohort study
Real-world effectiveness of clozapine augmentation with antidepressants: within-subject data evidence from two European nationwide cohorts
Absolute and relative risks of mental disorders in families: a Danish register-based study
Long-acting oral weekly risperidone (LYN-005) for schizophrenia in the USA (STARLYNG-1): a multicentre, open-label, non-randomised phase 3 trial
Efficacy and safety of semaglutide versus placebo for people with schizophrenia on clozapine with obesity (COaST): a phase 2, multi-centre, participant and investigator- blinded, randomised controlled trial in Australia
49
Pulmonary Tuberculosis Detection with MiniDock MTB Using Swab Samples
Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock
IVUS-Guided versus Angiography-Guided PCI in Unprotected Left Main Coronary Disease
Intravascular Ultrasound–Guided or Angiography-Guided Complex High-Risk PCI
Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism
Transdermal Estradiol Patches in Locally Advanced Prostate Cancer
Prehospital Whole Blood in Traumatic Hemorrhage — a Randomized Controlled Trial
Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus
Finerenone in Type 1 Diabetes and Chronic Kidney Disease
Hematopoietic Stem-Cell Gene Therapy for Cystinosis
Cabotegravir plus Rilpivirine for Persons with HIV and Adherence Challenges
Mental Health Outcomes in Children after Parental Firearm Injury
Cardiovascular Outcomes with Tirzepatide versus Dulaglutide in Type 2 Diabetes
Ketamine or Etomidate for Tracheal Intubation of Critically Ill Adults
Daily Mosnodenvir as Dengue Prophylaxis in a Controlled Human Infection Model
Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial
A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy
Safety and Immunogenicity of an rVSV Lassa Fever Vaccine Candidate
Oral Icotrokinra for Plaque Psoriasis in Adults and Adolescents
Selective Decontamination of the Digestive Tract during Ventilation in the ICU
Deferring Arterial Catheterization in Critically Ill Patients with Shock
Common Diseases in Clinical Cohorts — Not Always What They Seem
Belzutifan for Advanced Pheochromocytoma or Paraganglioma
Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer
A Phase 3 Trial of Telitacicept for Systemic Lupus Erythematosus
Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans
Randomized Trial of Targeted Indoor Spraying to Prevent Aedes-Borne Diseases
Nexiguran Ziclumeran Gene Editing in Hereditary ATTR with Polyneuropathy
Medications for Opioid Use Disorder in County Jails — Outcomes after Release
Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension
High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults
High-Dose Influenza Vaccine to Reduce Hospitalizations
Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression
Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease
Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease
Weekly Fixed-Dose Insulin Efsitora in Type 2 Diabetes without Previous Insulin Therapy
Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity
Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation
Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline
A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery
Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes
Adjuvant Cemiplimab or Placebo in High-Risk Cutaneous Squamous-Cell Carcinoma
Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules
Efruxifermin in Compensated Liver Cirrhosis Caused by MASH
Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis
1
What Drives Risky Prescription Opioid Use? Evidence From Migration
1
Trauma at School: The Impacts of Shootings on Students’ Human Capital and Economic Outcomes
12
Shape-sensing robotic-assisted bronchoscopy with integrated mobile cone-beam CT for small nodules: results from the prospective multicentre CONFIRM study
Tool in lesion verification of shape-sensing robotic-assisted bronchoscopy with cone beam CT in sampling peripheral pulmonary nodules
Prognostic impact and safety of early adjunctive corticosteroid therapy in HIV-negative severe pneumocystis pneumonia: a propensity-matched multicentre study
Balloon dilatation for bronchoscope delivery: first-in-human trial of a novel technique for peripheral lung field access
Generalisability of ARDS biological subphenotype models in Asians: an international, multicentre, prospective biomarker study
Efficacy of fentanyl buccal tablet and morphine for exertional dyspnoea in patients with cancer: a double-blind, placebo-controlled, randomised clinical trial
Vibrotactile positional therapy for the treatment of positional obstructive sleep apnoea: a multicentre, randomised controlled trial
Gabapentinoids and risk for asthma exacerbations: a nationwide retrospective cohort study
Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study
Combining tuberculin skin test with follow-on interferon gamma release assay markedly improves screening of household contacts
Dynamic oxygenation subgroup bringing new insights in ARDS: more predictive of outcomes and response to PEEP than static PaO2/FiO2
Serotype 3 associated invasive pneumococcal disease in children: analysis of 15 years of Australian national surveillance data
21
Wastewater surveillance of dengue and chikungunya during the worst arbovirus epidemic in Brazil
Development of Microbial Source Tracking Markers for Detection of Human-Associated Clostridium perfringens
Worker exposure to bioaerosols from sludge dewatering facilities: risks and mitigations
Metatranscriptomics Reveals System-Specific Viral Adaptive Strategies and Prokaryotic Defense Trade-offs Across Anaerobic Digestion Systems
Rapid Elimination of Harmful Cyanobacteria via Synergistic Effects of Photo-oxidation and Flocculation
Carbon composites with photo-allosteric switch for waterborne virus removal
Tracking norovirus diversity at a global scale through wastewater metagenomics
L-norepinephrine induces community shift, oxidative stress response, metabolic reprogramming, and virulence potential in wastewater microbiomes
Inactivation mechanisms of intracellular coliphages in host bacteria by chemical disinfection with ozone, chlorine oxide, chlorine and chloramine
The hospital sink drain biofilm resistome is independent of the corresponding microbiota, the environment and disinfection measures
Estimating the consumption of prescription opioids through wastewater analysis: The patterns of use in Italy
Simultaneously disinfection of amoebae, endosymbiotic bacteria, and resistance genes using a novel two-electron water oxidation strategy
Digital health framework for the predictive surveillance and diagnosis of atopic dermatitis
Action spectrum of Bacillus subtilis spores for validation of polychromatic ultraviolet (UV) systems
Assessment of Endocrine-Disrupting Chemicals in Bottled Water: A Cross-Sectional Study in Algiers and risk assessment in pregnant women
Prevalence and functional impact of the interactions between lysogenic phages and hosts in activated sludge systems: insights from large-scale metagenomics and experimental evidence
Contrast-Enhanced Micro-Computed Tomography for 3D Imaging of Biofilms in Opaque Materials: Insights from Water Treatment Plant Sand Filters
Bioluminescent-reporter phagosensor for quantitative detection of viable Escherichia coli in water
Engineering intermolecular C-F…C=O interactions in covalent organic framework promotes dual-path H2O2 photosynthesis for sustainable disinfection
Responses of Viral Communities in Aerobic Biofilms under Antibiotic Stress
Predicting Naegleria fowleri Freshwater Habitat Suitability in the United States for the Present-Day and Future using Ecological Niche Modeling
1
Humor for health: a randomized controlled trial of clown visits in Palestinian hospitals

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