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Molecular devices offer the potential for the scalability and energy efficiency required to develop energy-sustainable AI. Zhang et al. report a single-molecule neuromorphic device that consumes 6.34 aJ per operation and support both short-term to long-term memory, featuring over 10 distinct conductance states.

Phenomena emerging in the quantum limit of solids often stem from electron-impurity or electron-electron interactions. Here, the authors provide evidence that linear magnetoresistance in tellurium originates from high-temperature phonon scattering in the quantum limit.

Wearable bioelectronic skins are essential for health monitoring technologies, but many designs lack the durability and abrasion resistance of human skin. This study presents a bilayered stretchable conductor with a silver particle-impregnated layer that enhances abrasion resistance, conductivity and performs well in harsh environments while maintaining accurate signal capture.

Blue light promotes DNA repair in plants via cryptochrome signalling. Here the authors report that this occurs via suppression of COP1 mediated degradation of the repair factor ADA2b and propose that together photoreceptors and COP1 balance genome stability with growth under fluctuating light.

The integration of carbon capture and electrochemical conversion is an emerging strategy to valorize CO₂. Here the authors demonstrate that altering CO₂–amine speciation in aprotic media enhances CO₂ uptake and suppresses hydrogen evolution, achieving promising Faradaic efficiency towards CO production, including with flue gas feedstocks.

A rare variation in the promoter of qRBG1/OsBZR5 is associated with larger rice grains. OsBZR5 is found to negatively regulate grain size in rice, a biological role opposite to other OsBZR members. A regulatory module of OsGSK2–qRBG1–OsBZR1–D2–OFP1 is further revealed.

RNA-sequencing’s conversion of molecules to reads confines analysis to relative fold-changes, a metric unreliable across batches. Here, the authors introduce TranScale, a spike-in method with 100 biomimetic standards that converts reads into absolute quantities to resolve systemic biases.

Phase-change memories require effective ovonic threshold switching (OTS) selectors to eliminate leakage currents. A charge-triggered switching mechanism is identified in amorphous elemental selenium and shown to make it an effective OTS selector that can achieve a leakage current of 4 × 10⁻¹² A.

High-throughput and low-input quantitative citrullinome analysis integrated with deep learning reveals association between citrullinome landscape and rheumatoid arthritis severity, as well as rheumatoid arthritis-sera reactivity of identified citrullinated peptides.

Freestanding membranes of hexagonal oxides remain difficult to obtain. In this work, a water-soluble crystalline hexagonal BaAl₂O₄ is found to serve as a sacrificial layer for obtaining freestanding membranes with six-fold or three-fold symmetry.

Tip-focused radiofrequency perforation enables soft, bloodless implantation of flexible electronic hairs, advancing semi-implantable electrophysiology for prosthetics and human–machine interfaces.

An enzyme that specifically recognizes dephospho-CoA (dpCoA)-capped RNAs is used to quantify dpCoA-RNAs in cells.

Immune checkpoint inhibitors (ICIs) have shown limited efficacy in recurrent high-grade astrocytoma (rHGA). Here the authors report the results of a Phase 1/randomized Phase 2b trial of laser interstitial thermal therapy followed by anti-PD1 pembrolizumab in patients with rHGA.

This study reports a Ag₂(Se_1-xS_x)_1.05-based fully printed origami thermoelectric generators, achieving a high power density of 21 W m⁻² at a temperature difference of 80 K. It enables low-cost, battery-free wearables and Internet-of-Things applications.

This study demonstrates that a single antibody exhibits distinct binding modes with SARS-CoV-2 WT and Omicron variants, correlating with neutralization loss. The underlying mechanisms offer insights into enhanced neutralization.

The efficient mass transport is the key factor to advancing the flow-electrocatalytic chemosynthesis. Here, the authors design a flow-through architecture in flow electrolyzer, reinforcing mass transport in the electrolyte to achieve the high efficiency of continuous oxime electrosynthesis.

Plants utilize anion channels to adapt to environmental stresses. Here, authors elucidate the coordinated regulatory mechanisms within the SLAH family and demonstrate that tRNA molecules directly bind to and inhibit the SLAH1 anion channel.

SARS-CoV-2 mainly transmits via respiratory droplets. Here Deng et al. show that SARS-CoV-2 can infect rhesus macaques via ocular conjunctival inoculation.

Diagnosing breast cancer through MRI is limited by high false-positive rates and inter- reader variability, leading to unnecessary biopsies. In here, the authors find that the BI-RADS 4 Lesions Analysis System (BL4AS) model improves diagnostic accuracy and reduces unnecessary biopsies as well as inter-reader variability

The insufficient structure and biofunction of cartilaginous implant impede cartilage regeneration. Here, the authors develop anti-swelling and self-activating artificial proteoglycan assemblies for post-microfracture healing by downregulate calcium signaling pathway and reducing ossification.

This work reports the growth of inch-scale diamond wafers with a hardness of 208.3 GPa via high-frequency pulsed local non-equilibrium CVD, revealing a stacking-fault-driven ultrahard mechanism.

Accurately predicting immunotherapy efficacy remains challenging. Here, the authors report a multiplexed blood-based assay using self-assembled, dual-target responsive DNA hydrogels for detection of soluble programmed death-ligand 1 and lactate dehydrogenase which can be used as a tool to help evaluate and predict immunotherapy response.

Realizing the 1.5 °C target could advance WHO Air Quality Guidelines compliance by decades, preventing over one million deaths and delivering significant benefits. The monetized health co-benefits will exceed mitigation costs in most regions.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Snail is involved in the regulation of epithelial-mesenchymal transition and metastasis. Here, the authors show that the metabolite β-hydroxybutyrate promotes pancreatic cancer metastasis through protecting Snail from degradation.

A super-pangenome analysis incorporating 123 newly sequenced bryophyte genomes reveals that bryophytes exhibit a larger number of unique and lineage-specific gene families than vascular plants.

A groundbreaking study reveals how physical confinement triggers ferroptosis. It finds the nucleus acts as a mechanosensor, orchestrating Drp1 and cPLA2 that leads to mitochondrial dysfunction and ultimately, cell death.

SWI/SNF chromatin-remodeling complexes regulate gene expression and division in zoonotic parasite Toxoplasma gondii. Loss of the core ATPases restricts chromatin access, rewires cell cycle programs, impairs growth, and causes abnormal division.

Peripheral nerve transfer can restore motor functions of the upper limbs after peripheral nerve injuries. Here, the authors developed an implantable multisite optogenetic stimulation system for wireless evaluation of peripheral nerve plexus with sub nerve resolution.

Receptor engagement is a determinant of alphavirus entry. This work reveals how Western Equine Encephalitis Virus uses very-low-density lipoprotein receptor (VLDLR) to invade our cells and finds that a single polymorphism in the E2 glycoprotein determines the receptor’s tropism.

Regulating oxidative phosphorylation and restoring redox homeostasis are crucial in neurological disorders. Here, the authors develop a top-down membrane self-assembly strategy to develop stem cell-derived artificial organelles (SAOs) that mimic mitochondrial oxidative phosphorylation without the risks associated with stem cell therapy.

Even though chiroptical luminophores have high potential for optoelectronic innovation and precision bioimaging, their rational engineering remains constrained by synthetic limitations. Here, the authors report a streamlined and programmable asymmetric synthesis platform enabling systematic construction of boron-stereogenic boron dipyrromethenes (BODIPYs) with near-infrared chiroptical activity.

Two-dimensional perovskites enable high efficiency in perovskite photovoltaics but compromise operational stability. Yaghoobi Nia et al. form two-dimensional perovskite co-crystals with neutral templating molecules, improving the stability of perovskite solar modules.

WNT-signaling activation is a promising strategy for adult tissue and organ rejuvenation. The authors report an efficient approach to generate exosomes carrying WNTs and RSPONDINs family ligands that can achieve strong activation of the pathway to regenerate diseased and aged livers.

The underlying mechanisms for drug resistance in Acute Myeloid Leukemia (AML) are not completely understood. Here, the authors show that succinate accumulation, associated with succinate dehydrogenase deficiency, impairs the activity of the ubiquitin-conjugating enzyme UBC12 leading to tumor-promoting protein accumulation and drug resistance in AML.

DNA damage from chemotherapy can activate cGAS–STING and interferon pathways. Here, the authors show that cGAS–STING signaling is specific to DNA rich in CA repeats, whereas DNA not rich in CA repeats is detected by AIM2, resulting in opposing tumor immune responses.

Proton exchange membrane water electrolysis promises green hydrogen production but safety risks in industrial operations remain unexplored. Here, the authors identify water-starvation as the cause of water electrolysis stack deflagration and establish safety precautions for industrial scale-up.