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Functional-group translocation allows modification of molecular architectures and functional group positions, but methodologies capable of achieving precise stereocontrol during such migrations are limited. Here, the authors present a photoenzymatic strategy for cyano translocation that achieves precise stereocontrol.

Using the 2008 Wenchuan Earthquake, the authors show that earthquake-triggered landslides increased mountain carbon storage by ~10% from 2008 to 2020, as vegetation recovery and sediment burial retained carbon, revealing earthquakes and landslides function as long-term carbon capacitors.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

Multimodal immune profiling of ART pregnancies reveals systemic immune hyperactivation in gestational diabetes, characterized by activated CD8⁺ T cells, altered immune repertoires, and inflammatory signaling driven by FOS/JUN and KLF6.

Lactate fuels cancer growth by activating ERK signaling through GCN5-mediated lactylation of ERK, which disrupts ERK–MEK interactions. Development of a cell-penetrating peptide blocking lactylation slows KRAS-mutant tumor development.

Molecular organometallic catalysts typically struggle to activate only one of two identical C–H bonds in arenes for mono-selective C–H activation. Now mono-selectivity has been achieved for Pd(II)-catalysed ortho- or meta-C–H activations using commercial proteins or designed peptides as ligands.

Tuning the interfacial structure of silver nanoclusters via steric hindrance modulates their photoluminescence. Locking the ligand shell endows the clusters with room-temperature photoluminescence, thereby enabling atomic-level design of optical devices.

Radical ligand transfer is a common reactive pathway in 3d transition metals. Here the authors describe it for 5d transition metals in dinuclear gold complexes, for the formal addition of unactivated C(sp³)–Cl bond in gem-dichloroalkanes and Freon-22 to different kinds of alkenes.

Direct observation of the Migdal effect in neutron–nucleus collisions is reported, which resolves a long-standing gap in experimental validation.

Currently, there is a lack of clear understanding on how glioma cells exploit neural electrophysiological signaling to drive hyper-invasive behavior. Here, the authors integrate custom microfluidics with machine learning-based signal decoding to uncover a mechanism by which tumors actively reprogram neural firing patterns, synchronizing with their microenvironment to enhance invasiveness.

The synthesis of benzocyclobutenes is reported through Pd(II)-catalysed γ,δ-methylene C(sp³)–H bond activation and [2 + 2] annulation between aliphatic carboxylic acids and dihaloarenes, using bidentate carboxyl-pyridone ligands. Regiocontrol is achieved in benzocyclobutene formation through the differentiation of reactivity between the aryl iodide and bromide sites.

A peptide-based PD-L1-targeted nanorobot disrupts cancer cell membranes via pH-responsive fibril formation, and enhances T cell infiltration and immune activation, inducing a potent anticancer response in animal models of colorectal cancer.

Strongly coupled light–matter systems could offer enhanced manipulation of topological phenomena. Now, tunable non-Hermitian effects are demonstrated with exciton–polaritons induced by a twist degree of freedom.

Here they show that gasdermin-E (GSDME) acts as a key driver of abdominal aortic aneurysm (AAA) by triggering senescence in vascular smooth muscle cells, a process reversible with senolytic drugs, highlighting a promising therapeutic target of AAA.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Abnormal T cell proliferation often triggers autoimmune disorders. Here the authors show that T cell-specific deficiency of the enzyme N-acetyltransferase 10 ameliorates experimental autoimmune encephalitis potentially by RACK1-mediated regulation of T cell metabolism and expansion.

KP.3.1.1 S S31del confers enhanced immune escape and increased infectivity, which is counterbalanced by NSP10 S33C. The opposing effects of these mutations highlight the complex interplay of viral genomic elements in shaping their overall fitness.

A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Fibroblast growth factors (FGFs) are involved in renal pathophysiology. Here the authors use genetic models to show that podocyte FGF4 is protective of diabetic kidney disease progression, and that treatment with recombinant FGF4 reduced renal injury and fibrosis in diabetic mouse models.

Efforts to develop P2X7 drugs are hampered by species differences. Here, authors reveal the structural basis for these disparities and show that transgenic mice provide a powerful model for testing selective inhibitors with greater clinical relevance.

Previous clinical studies suggested that Insulin-like growth factor binding-protein 7 (IGFBP7) is elevated in early stages of diabetes. Here authors showed tubule and glomerular-specific IGFBP7 promotes diabetic kidney disease.

An integrated surface-enhanced Raman scattering navigation instrument allows the intraoperative classification of malignant-grade prostate tumours by simultaneously assessing tissue acidity and prostate-specific antigen enzymatic activity.

Cutaneous tuberculosis is an infectious disease associated with extracellular matrix remodeling and granuloma-driven fibrosis. Here, the authors present an in vitro model of this disease using skin organoids infected with Mycobacterium tuberculosis, and describe infection-induced alterations in specific pathways and cell populations.

Here they show that PPARα-dependent mitochondrial programming promotes the differentiation of pluripotent stem cell-derived β cells. Targeting mitochondria has the potential to improve β cell replacement efforts for the treatment of type 1 diabetes.

A directional electrodynamic decomposition method using a LaNiO₃ sacrificial layer is proposed for freestanding films. It boosts oxide film release rate to 600 mm² /min via electric field-enhanced adsorption energy and electron transfer.

Dinuclear gold complexes have fundamentally expanded catalytic possibilities beyond that of the mononuclear systems. Here the authors report a bidentate mixed-ligand system that can catalyze efficient three-component carbonylative amidation of unactivated alkyl bromides with amines and CO under mild conditions.

In this work, authors present their goal-directed subgroup identification (GD-SI) framework, reconciling biological heterogeneity with clinical actionability, and offering a scalable infrastructure for precision trial design and personalized sepsis management.

Many spatial RNA monitoring assays can be hindered by barriers that limit short-transcript detection and mask cellular diversity. Here, the authors show TDDN-FISH – Tetrahedral DNA Dendritic Nanostructure–enhanced Fluorescence In Situ Hybridization. This is a rapid, enzyme-free method that uses self-assembling DNA nanostructures, thus accelerating RNA detection.

Insulinomas develop from pancreatic β-cells and secrete insulin, but the underlying genetic defects are largely unknown. In this study, Cao et al. identify recurrent T372R mutations in the transcription factor YY1, and validate this hotspot mutation in 30% of insulinomas.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

The reactive nitrogen (Nr)-driven atmospheric multiphase buffering can induce unintended Concomitant Pollution. Given the importance of NH₃ in this process, rising global NH₃ emissions has positioned Concomitant Pollution as an urgent challenge.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Osteoporosis was revealed to pyroptosis-related inflammation. Here, the authors show multifunctional microsphere can retard osteoporosis by restoring bone homeostasis thorough pyroptosis blockade and hydrogen-mediated modulation of inflammation.

The RNA-binding protein SAIR1 forms phosphorylation-regulated condensates in guard cells, which link PAMP–MPK3/6 signalling to stomatal immunity. This finding reveals how biomolecular condensates regulate spatially specific immune responses in plants.

Cell state plasticity of neuroblastoma cells is linked to therapy resistance. Here, the authors develop a transcriptomic and epigenetic map of indisulam (RBM39 degrader) resistant neuroblastoma, demonstrating bidirectional cell state switching accompanied by increased NK cell activity, which they therapeutically enhance by the addition of an anti-GD2 antibody.