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Healing of infected tendons is hindered by mechanical dysfunction, tissue adhesion, and immune imbalance. Here, Li et al. develop a multifunctional Janus hydrogel with asymmetric adhesion, antibacterial properties, and pH-responsive release of tendon stem cell-derived exosomes for infected tendon repair.

A composite sorbent combining LiCl with MOF material Ni₂Cl₂(BTDD) enables high water uptakes while low desorption temperature, achieving solar-driven water yield over 1 L m^‒2 day^‒1, which has been confirmed in field tests even across diverse regions.

To overcome inefficient recycling of carbon fibre waste, the authors develop a rapid, commercially attractive solid-flames upcycling technique that converts waste fibres into graphene-grafted carbon fibres and graphene powders.

Functional-group translocation allows modification of molecular architectures and functional group positions, but methodologies capable of achieving precise stereocontrol during such migrations are limited. Here, the authors present a photoenzymatic strategy for cyano translocation that achieves precise stereocontrol.

This study shows that the deletions of BAI1 and BAI3, but not of BAI2, enhance axonal and dendritic growth while reducing excitatory synapse formation in murine mixed neuron-glia cultures. BAI3's interaction with specific ligands is crucial for these processes, highlighting its key role in neuronal development.

Off-the-shelf, on-demand allogeneic CAR-T cells could represent a therapeutic alternative to autologous products for cancer therapy. Here the authors report the preclinical characterization of off-the-shelf CRISPR-Cas9– edited IL-13Rα2-specific allogeneic universal CAR-T cells and the results of a first-in-human phase I trial in patients with high-grade glioma.

Chen et al. report a tailored self-assembled monolayer to create a localized 2D/3D perovskite heterojunction. This strategy reduces interfacial loss, achieving photovoltages >90% of thermodynamic limit for wide-bandgap cells, and enables perovskite-organic tandem solar cells with efficiency of 27.11%.

Transition-metal-catalyzed nitrene strategies exhibit high efficacy for intermolecular N–H insertion, but nitrene-mediated N–N coupling under metal-free conditions has rarely been explored. Herein, the authors report the selective N–N coupling using sulfilimines as nitrene precursors.

Macrophages play an important role in repair and regeneration of damaged nerves in spinal cord injury (SCI). Here, Guo et al. investigate effects of endoplasmic reticulum-mitochondria crosstalk on macrophage phenotype and develop a targeted nanorobot inhibiting the Ero1α/MAMs/mtCa²⁺ axis, promoting M2 polarization and neural repair as a therapeutic strategy to treat SCI.

Xiao et al. report the synthesis of a fullerene derivative bearing four piperazidine groups to engineer the tin halide perovskite/C60 interface, enabling the photovoltaic devices with a power conversion efficiency of 22.49% and an output power density of 64.1 μW cm-2 under 1,000 lux white light illuminance.

Chronic non-healing wounds infected with antibiotic-resistant bacteria present a growing global health challenge. Here, Han et al. develop high-entropy alloy-based Janus artificial enzymes with pH-gated redox biocatalysis for sequential therapy of drug-resistant bacteria and inflammatory wounds.

DNA demethylation enzyme TET1 is a known oncogene in leukemia. Here, the authors discover that TET1 is involved in GPX4-dependent and -independent ferroptosis in acute myeloid leukemia via the regulation of GSH synthesis enzyme GCLC and BH4 synthesis enzyme GCH1.

The mechanical properties of inorganic solid electrolytes for Li batteries are typically characterised by a high Young’s modulus above 15 GPa and hardness above 1 GPa. Here, authors develop a cost-effective and mechanically compliant inorganic solid electrolyte, with reduced Young’s modulus and hardness of 1.41 and 0.22 GPa, respectively, for practical all-solid-state Li batteries.

The authors report the time-reversal symmetry breaking superconductivity in the thin-flake kagome material RbV3Sb5, manifesting primarily as an unconventional form of hysteresis that is not observed in CsV3Sb5. They also observe reentrance of superconductivity during an in-plane field-sweeping process at 400 mK.

Zinc-metal batteries are restricted by their inherent high activity of aqueous electrolyte. Here, authors report the design of a new class of zinc-based hybrid metal halide solid-state electrolytes, offering a promising avenue for all-solid-state zinc batteries.

Japonica subspecies has a lower nitrogen use efficiency (NUE) than that of indica rice. Here, the authors show that natural variations in the NIN-like protein 4 (OsNLP4) encoding gene are responsible for the divergence and introgression of the indica OsNLP4 allele into elite japonica cultivar can increase NUE and grain yield.

This study applies generalized linear mixed models (GLMM) and advanced transcriptome wide association study (TWAS) methods to improve the discovery of colorectal cancer risk transcription factors and genes, including potential druggable targets.

Fracto-mechanoluminescence is the emission of light from fracturing solids. Here, the authors show that this emission in Mn halides arises from elastic stiffness, electromechanical coupling, and trap states that activate Mn²⁺ d−d transitions.

The existence of a long-lived, prethermal regime in many-body systems with tunable heating rates, driven by structured random protocols, is observed using a 78-qubit superconducting quantum processor.

Here the authors report a phase 3 clinical trial showing that Ecnoglutide, designed as a cAMP-biased GLP-1R agonist, improved glycaemic control versus placebo in adults with type 2 diabetes inadequately controlled with diet and exercise alone or with a single oral hypoglycaemic agent.

Previous studies on biodistribution of microplastics showed discrepancies. This study provides quantitative data to date on how nanoplastics distribute and eliminate from the body using carbon-14-radiolabelled particles in rats.

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

An iontronic electricity generator is developed based on intrinsic asymmetric interfaces and controllable energy release, which achieves giant power generation through reversible electron-coupled ion oscillation at interfaces.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

The structure of layered oxides dictates their properties as positive electrodes in sodium-ion batteries, but its rational design remains challenging. Here, authors employ electronegativity and configurational entropy as a design descriptor to guide the synthesis of a sodium-deficient layered oxide with an O3 stacking sequence, rendering good thermal and air stability.

Here, the authors document the evolutionary dynamics of angiosperm pollen, using pollen morphology and time calibrated phylogeny. They identify two surges in pollen disparity in the mid-Cretaceous and Paleogene that are associated with environmental changes and important pollen adaptations.

Macrocyclization typically proceeds via thioesterase mediation in type I polyketide synthases. Now, using genome mining and crystallographic analysis, an alternative mechanism for stereoselective macrocyclization in the akaeolide biosynthetic pathway is reported. The mechanism is proposed to proceed via an iminium-catalysed tandem Michael addition and Knoevenagel condensation, using nuclear transport factor 2-like enzymes.

Escalating phosphorus pollution and depleting reserves necessitate sustainable control and recovery strategies. Here the authors develop a microbially enhanced La–Zr-loaded basalt system that achieves over 90% phosphorus removal and recovery, promoting a circular economy and reducing ecological impacts, offering an economically superior alternative to traditional chemical methods.

Electrochemical CO reduction to multi-carbon products offers a carbon-negative approach to produce chemicals, but the intricate reaction pathways lead to a broad spectrum of products. Now it has been shown that alkali cations alter the mechanistic pathways that govern the reaction selectivity involved in the formation of hydrocarbons versus oxygenates.

A global synthesis of >600 studies finds that across agro-ecosystems, grasslands and forests in temperate and tropical zones, increasing plant diversity has a consistently positive effect on plant performance and the suppression of antagonists.

Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

Multimodal brain recordings are no easy task. Here, the authors introduce a neural implant with integrated carbon nanotube field-effect transistors for multimodal recording of electrical and chemical signals.

A Dirac-vortex topological photonic crystal fiber is experimentally realized with broadband single polarization single-mode properties.

Multimodal immune profiling of ART pregnancies reveals systemic immune hyperactivation in gestational diabetes, characterized by activated CD8⁺ T cells, altered immune repertoires, and inflammatory signaling driven by FOS/JUN and KLF6.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitating the discovery of potential effects of genetic variants, including variants associated with disease, on genome structure and function.

This study reports on an AI-powered autonomous experimentation platform that overcomes data scarcity in electronic materials discovery by using an AI advisor for real-time progress monitoring, data analysis and interactive human–AI collaboration. Applied to mixed ion–electron conducting polymers, it rapidly optimized performance in 64 experimental trials, revealing morphology–property relationships and an unreported polymer polymorph.

The gut bacterium Lactobacillus reuteri and its metabolite IAA exacerbate neuropsychiatric lupus by activating microglial AHR/STAT3 signalling, driving neuroinflammation and behavioural deficits.

Large-scale molecular dynamics simulations show that the crystal–melt interfacial energies of MgSiO₃ bridgmanite increase substantially with pressure, potentially forming unusually large bridgmanite crystals and suggesting a new physical mechanism driving magma ocean segregation.

Here the authors report an analysis of two large nationwide cohort studies, the UK biobank and NHANES, suggesting that accelerated biological aging mediate a proportion of the association between social determinants of health and all-cause and cause-specific mortality.