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Fe3GaTe2 is a room temperature van der Waals ferromagnet, which, despite having a centrosymmetric crystal structure, has both a large Dzyaloshinskii-Moriya interaction and hosts topological spin textures. Here, Xia, Luo, Malik and coauthors unravel this mystery, showing the critical role of field cooling in the breaking of inversion symmetry in Fe3GaTe2.

Magnetic systems can exhibit flat bands where the magnon bands have little to no energy dispersion. Here, Luo, Chen, and coauthors show the nearly flat bands of the van der Waals antiferromagnet, CrOCl, and demonstrate quasi one-dimensional magnon transport.

Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The exchange is needed for testosterone production.

Recently, a discrepancy arose in predicting the pairing symmetry of high-temperature superconductor La₃Ni₂O₇. Xia et al. find that a slight increase in Ni-e_g crystal field splitting sensitively alters the pairing symmetry of La₃Ni₂O₇ from d-wave to s-wave.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Perovskite–silicon solar cells rely on buffer layers that avoid damaging the perovskite, but common tin-oxide layers force thicker transport layers that increase optical loss. The authors replace this layer with thermally evaporated antimony oxide, enabling thinner C₆₀ and higher-efficiency perovskite–silicon solar cells.

XA-Novo is a mass spectrometry–only de novo antibody sequencing workflow that reconstructs full-length antibodies from single samples or mixtures, enabling rapid sequence recovery and functional re-expression for antibody research and drug discovery.

This study identifies NAT10-mediated RNA ac4C modification as a key regulator of colonic epithelial aging. Through N4-acetylation regulation of DYRK1A, NAT10 promotes intestinal senescence, highlighting a potential therapeutic target for elderly-onset colitis.

Arginine addiction induced by argininosuccinate synthase (ASSN1) deficiency has been exploited to treat ASS1-deficient cancers. Here, the authors show an alternative therapeutic approach where ASS1 activity is increased by the pesticide spinosyn A and is shown to inhibit breast cancer cell proliferation.

Pulmonary fibrosis is a progressive lung disease characterized by scarring and impaired function, with vascular endothelial cells playing a key role in disease progression. Here, the authors show that endothelial mechanosensitive PIEZO1 promotes fibrosis by activating the CAPN2-STAT3-IL-33 signaling axis, identifying a promising therapeutic target for treatment.

While the snowdrift game, a social dilemma where individuals choose between cooperation and self-interest, has been extensively studied, the adaptive costs of cooperation remain underexplored. Here, the authors integrate the Kuramoto model into the snowdrift game, utilizing the synchronization level to characterize the degree of coordination among players, revealing explosive transitions in cooperation and synchronization that offer a nuanced understanding of game dynamics.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Xiangdong Fu and colleagues report characterization of a major rice grain yield QTL at the DEP1 locus.

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Staple crop production in China involves high levels of synthetic fertilizer use and losses to the environment. Using a localized nitrogen management model for wheat, maize and rice, this study estimates the environmental and economic benefits of improving nitrogen use efficiency at the county level.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Psychedelics and their non-hallucinogenic analogues were compared, revealing that serotonin 2A receptor (5-HT_2AR)-mediated G_i signalling is essential for hallucinogenic effect, with the functional mechanisms underlying this providing insights for designing therapeutic drugs without hallucinogenic effects.

In nasopharyngeal carcinoma (NPC), cisplatin is known to be associated with poor treatment compliance and notable side effects therefore more effective platinum drugs are expected. Here this group updates the 10-year survival analysis results of a multicenter, randomized, phase 3 trial evaluating the efficacy of lobaplatin and fluorouracil induction chemotherapy plus concurrent chemoradiotherapy on 502 NPC patients.

Enzalutamide, an approved drug for prostate cancer, acts on TMPRSS2 expression, a key mediator for SARS-CoV-2 infection. Here, the authors characterize the anti-SARS-CoV-2 effects of Enzalutamide in prostate cancer cells, lung cancer cells, human lung organoids and in hACE2-transduced Tmprss2 knockout mice and show lack antiviral action in human lung cells and human lung organoids, likely due to the AR-independent TMPRSS2 expression in mouse and human lung epithelial cells.

Under sustained high greenhouse-gas emissions, the stratospheric quasi-biennial oscillation (QBO) may weaken and eventually disappear, potentially reducing short-term climate predictability, highlighting the risks of continued emissions for the middle and upper atmosphere.

Chaperone-mediated autophagy (CMA) is often dysregulated in cancer, but its mechanisms remain unclear. This study reveals that MST4- mediated LAMP2A phosphorylation regulates CMA by stabilizing lysosomal LAMP2A, thereby promoting GBM tumorigenicity and immune evasion.

Osteoarthritis encompasses multiple pathological processes making it difficult to treat. Here, the authors develop ROS/MMP13 dual-responsive organic selenium hydrogel microspheres (HSPHR) to modulate intra-articular multi-tissue selenoprotein levels, achieving multimodal treatment.

Low outcrossing rate of sterile lines limits hybrid rice seed production. Here, the authors report that mutation of a SET domain-containing protein HER1 leads to enlarged stigma, enhanced stigma exsertion, and hybrid seed production in rice.

Here the authors report a near-infrared K₃LuSi₂O₇:Eu²⁺ phosphor for non-visible light source application. The selective site occupation of Eu²⁺ in LuO₆ and K2O₆ polyhedrons is found to be responsible for the light emission and these insights could serve as design principles for discovery and design of such phosphors.

An aromatic metallo-annulene, comprising a 15-carbon macrocycle enclosing an osmium complex, with the metal residing within the plane of the macrocycle is reported.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

This study reports that the gene SMPED1, located in a previously identified dichogamy-determining region in Alpinia species, controls the timing of sex-organ synchrony, improving our understanding of the evolutionary mechanisms of plant sexual diversity.

In this multicenter phase 1 trial, patients with advanced gastric and gastroesophageal junction cancer were safely treated with the CLDN18.2-targeting antibody–drug conjugate SHR-A1904, leading to encouraging objective response rates.

Inspired by the regenerative capacity of deer antlers, Hao and colleagues report that antler blastema progenitor cell-derived extracellular vesicle treatment counteracts bone loss and epigenetic aging and is neuroprotective in mice and macaques.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

Graphene film-based metamaterials are applied for polarization manipulation of electromagnetic shielding effectiveness, achieving high performance in polarization sensitivity, full polarization shielding, and switching efficiency.

This study discovers that tRNA directly binds and regulates the membrane protein FKS1, a β-1,3-glucan synthase essential for fungal cell wall formation. Cryo-EM and biochemical analyses show how tRNA and GSR1 control FKS1 activity and fungal growth.

Xia et al. report that tumor cell-expressed paired immunoglobulin-like type 2 receptor alpha (PILRα) interacts with the T cell surface protein CD99 to suppress T cell activity, proposing PILRα targeting to enhance antitumor immune responses.

Dispersion engineering is pivotal in nonlinear photonics but traditionally fixed by post-fabrication immutability. Here, the authors demonstrate integrated chalcogenide microresonators with arbitrarily reconfigurable dispersion, providing a scalable and reprogrammable architecture for multifunctional photonic circuits.

Prostate cancer diagnosis require MRI analysis, however, scoring can vary between clinicians. Here, the authors develop ProAI to detect prostate cancer from imaging.

Administrative-driven hierarchical management (ADHM) encourages general practitioners to act as voluntary gatekeepers in China’s non-mandatory medical system. Here the authors show that ADHM lowers cardiovascular events, mortality, and healthcare costs in atrial fibrillation patients compared with usual care.

The synthesis of ionic olefin linked threedimensional covalent organic frameworks (3D COFs) is challenging because of the difficulties in forming stable carbon-carbon double bonds. Here, the authors report a general synthesis of an ionic sp² carbon linked COFs and demonstrate selective capture of ReO₄⁻ ions.

Seawater corrosion can impact the lifespan and reliability of metallic materials for marine applications. This work develops a titanium alloy exhibiting active passivation behavior that ensures its electrochemical and mechanical stability in seawater-like environments.