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High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

A reversible suspended animation state in C. elegans is triggered by crowding in liquid. It reshapes gene activity, metabolism and organelles, uncovering lysosomal and neuronal signals that control survival and reawakening.

Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.

Protein oligomerization can regulate cellular functions. Here, authors identify a small molecule that selectively induces WDR5 oligomerization using nanopore screening and show it disrupts cancer-driving interactions, highlighting a potential anti-tumor strategy.

Protein complexes are the machinery of life, yet mapping their structures across different species is challenging. This study presents an atlas of 1.1million cross-kingdom structures, revealing 181,671 high-confidence complexes that uncover new higher-order structures and evolutionary links.

Erbium-based fiber lasers are widely used but hard to integrate on chips at an industrial scale. Here, authors demonstrate the first wafer-scale erbium-doped silicon-nitride waveguide lasers with broad C+L-band tunability, high output power, and fiber laser-class coherence.

Foam cells play a key role in plaque destabilization in atherosclerosis, but their monitoring and regulation remain challenging. Here, the authors present a nanoagent that integrates multimodal imaging for plaque imaging and targeting. The platform allows for controlled drug release, promoting lipid efflux, reducing inflammatory signalling, and enhancing plaque stabilization in animal models.

Here authors report a 50-fold luminescence enhancement in oriented MOF films via molecular rotor realignment during solvent evaporation. This mechanism is a step towards real-time sensing of volatile compounds.

In a phase 1 trial enrolling six patients with heterozygous familial hypercholesterolemia, treatment with lipid nanoparticles designed for base editing and inactivation of PCSK9 in hepatocytes showed preliminary evidence of reduced low-density lipoprotein levels without the occurrence of serious adverse events or evidence of off-target editing.

Developing earth-abundant catalysts for the chlorine evolution reaction is vital for a sustainable chlor-alkali industry. Here, the authors report a cerium modified cobalt oxide where cerium induces active site transfer from oxygen to cobalt atoms, achieving high activity and long-term stability.

The reprocessability of covalent adaptable networks often comes at the expense of mechanical performance and thermomechanical stability. Herein, the authors introduce a dynamic N-hydroxyphthalimide-urethane bond to achieve thermomechanical stability and reprocessability in covalent adaptable networks.

Polar molecule-based magnetic materials capable of multistate switching have garnered significant interest for their potential applications in next-generation memory devices, sensors, and energy conversion. Here the authors report a trinuclear cyanide-bridged FeCo compound that exhibits photo- and thermo-induced ferroelectric phase transition and solvent-switched on-off ferroelectricity.

Plants commonly experience root damage, but whether microplastics can enter roots via wounds is still unclear. This study suggests that microplastics can enter roots via wound entry mode and move to aerial parts, potentially contaminating plant-based foods and posing health risks.

Androgenetic alopecia is the most common type of hair loss, but its drivers remain poorly elucidated. Here, the authors show that hyperactive contraction of the follicle connective tissue sheath impairs hair growth by activating mechanosensitive signaling, suggesting a tractable therapeutic target.

Conventional methods for constructing 2,5-dihydropyrroles often rely on elaborate multi-step procedures or complex starting materials. Herein, the authors describe a palladium-catalyzed chemodivergent protocol for synthesizing functionalized 2,5-dihydropyrrole scaffolds from readily accessible 1,3-enynes and anilines.

Near-infrared-II carbon dots offer exceptional deep-tissue penetration for biomedical imaging, but challenges remain in their synthesis and photoluminescence mechanisms. In this work, the authors designed and synthesized a series of carbon dots (CDs-1 to CDs-3) through extension of aniline-based frameworks, achieving tunable emission extending into the NIR-II region, and applied these CDs in deeptissue NIR-II imaging of the hepatobiliary system.

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

Lee et al. report a mechanism regulating mRNP export mediated by N⁶-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases.

Random access memory has multiple data registers and uses addresses to specify which register should be read or modified. Now a quantum random access memory has been demonstrated that uses quantum addresses to return data in superposition.

Wang, Guo, Zhang and colleagues obtain four cryo-electron microscopy snapshots that show how IscB is kept off by two RNA lids, with a car-pedal-like guide shift activating cleavage after ~11-nt pairing. They also engineer hinge regions that boost flexibility and improve genome editing in cells.

Integrating in-memory computing features into pixel-level active drivers presents a promising strategy for intelligent display applications. Here, the authors report the fabrication of in-pixel processing active display arrays integrating micro-LEDs with 2D MoS₂ in-memory transistors, showing small footprint, up to 5 kHz operation speed and > 3 × 10⁵cd·m^⁻2 luminance.

Machine learning was used to screen a library of diverse lipids on the basis of their spatial conformation and identify an LNP formulation that enabled organ-targeted mRNA delivery and tumour suppression. The work highlights the critical role of ionizable lipid conformation in LNP engineering.

Clean energy transitions have reduced atmospheric heavy metal pollution in Chinese cities and future efforts can create further reductions of 10.25% to 30.38% according to downscaled data and emissions trajectories modelling.

This study shows that the Cantor alloy (CoCrFeNiMn), inert to hydrogen at room temperature, forms a stoichiometric hydride under high-pressure, high-temperature conditions, supported by X-ray, neutron diffraction, and ab initio calculations.

A clinical trial testing whether monitoring ctDNA clearance during treatment for nasopharyngeal cancer could be used to inform decisions about an individual’s subsequent therapeutic programme shows promising results.

Staphylococcus aureus can aggregate within human synovial fluid and lead to joint infections. Here, the authors reveal that the fatty acid kinase system and its downstream saeRS regulator control S. aureus aggregation within synovial fluid.

SCOPE-DTI introduces a large semi-inductive DTI dataset and optimized deep learning framework for drug-target interaction prediction. It integrates 3D structural modeling and bilinear attention, with experimental validation of drug targets and open access tools for broad research use.

The authors from the ALICE collaboration identify multiple species of mesons and baryons and measure the anisotropic flow with non-flow removal techniques in pp and p-Pb collisions at the LHC, identifying the hallmark of quark flow associated with an expanding quark-gluon plasma.

Phage therapy is emerging as a promising alternative to antibiotics for treating various infections. However, there have been no prior studies on the use of bacteriophages for peritonitis in patients undergoing peritoneal dialysis. Authors present a successful case of treating refractory peritonitis in a 71- year-old male patient on peritoneal dialysis using bacteriophages combined with antibiotics.

Quantum computers often exhibit a bias in the type of error that is the most common or severe. Entanglement has now been demonstrated for qubits encoded with an error correction code that is designed to efficiently handle biased errors.

CAR-M therapy shows promise for liver fibrosis but limited anti-inflammatory activity reduces efficacy. Here the authors show that TRIM13-engineered, FAP-targeted CAR macrophages sustain anti-inflammatory function and reduce liver fibrosis in mice.

Here the authors present the colloidal synthesis of InAs and GaAs nanocrystals with a cubic morphology through a cation exchange reaction with Cu₃As. The chemical bond covalency determines their kinetic-controlled characteristics, influencing their structural ordering. A cellular automaton model captures the cube-to-sphere transition, corresponding to a cubic-to-hexagonal symmetry change.

The Taiwan Precision Medicine Initiative recruited and genotyped more than half a million Taiwanese participants, almost all of Han Chinese ancestry, and performed comprehensive genomic analyses and developed polygenic risk score prediction models for numerous health conditions.

SLC6A6 localizes to the inner mitochondrial membrane and mediates mitochondrial taurine import, which sustains mitochondrial tRNA modifications and cell growth.

Nitrogen deposition on forest canopies enhances long-term nitrogen retention in woody biomass, whereas deposition on the understory favors retention in understory vegetation and soil, as demonstrated by a UAV-based nitrogen addition experiment using an isotopic tracer approach.

Temperature and accumulated forcing are the primary drivers of changes in reproductive season length of woody species, exerting opposite effects that produce divergent phenological responses to warming, based on observations of 102 species across China from 1980 to 2008.

A pharmacophore-oriented 3D molecular generation method, which efficiently generates diverse, drug-like molecules is proposed. It successfully identifies new inhibitors in real-world drug discovery.