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Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner. Disrupting the HDAC1 condensates with resminostat restores the sensitivity to temozolomide.

Geochemical data reveals that volcanic pulses caused episodic climatic cooling from ~470 to 445 million years ago, driven by basalt weathering.

A cortical premotor network in HVC, once initiated, can sustain and regulate the sequential production of zebra finch song syllables without major extrinsic inputs.

Light-driven enzymatic catalysis has enabled important abiological transformations in vitro. Now a cellular ene-reductase photoenzyme is integrated with a de novo-designed olefin biosynthetic pathway for photoinduced hydroalkylation, hydroamination and hydrosulfonylation reactions within cells.

Limited genomic resources constrain our understanding of fern evolution and conservation. Here, the authors present the genome of Brainea insignis, a monotypic endangered fern, and identify evolutionary signatures to guide conservation strategies from comparative and population genomic analyses.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

How site-specific tumor microenvironment (TME) drives the metastasis of high-grade serous ovarian cancer (HGSOC) remains unclear. Here, the authors employ an integrated single cell multi-omics approach to map the spatiotemporal heterogeneity of HGSOC metastasis TME and identify an interaction network within the TME driven by SELENOP⁺ macrophages and pre-exhausted CD8⁺ T cells.

Zhao et al. demonstrate that AtMCM10 repairs DNA double-strand breaks by forming liquid-like condensates at damage sites, where it directly anneals single–stranded DNA to promote synthesis–dependent strand annealing–mediated homologous recombination.

LipoID profiles lipid droplet interactions and identifies interorganelle regulators.

The extreme hot and dry conditions of 2023 reduced soil respiration and enhanced net forest carbon sequestration in Canada, offsetting wildfire emissions, according to satellite-based and in situ observations of CO₂ fluxes.

Micromitophagy is found to occur in plant male germline cells, mediated by ATG5–HSP90.2 signalling, and is evolutionarily conserved in angiosperms. This mechanism underpins paternal mitochondrial elimination and supports the zygote-to-embryo transition.

Here, the authors present a high-throughput genetic screen to identify genes that regulate human myoblast fusion.

Zhu, Zhao, Wang et al. describe G-NECNet, a deep learning model for detecting gastric neuroendocrine carcinoma (G-NEC) from H&E-stained biopsy whole-slide images without the need for additional immunohistochemistry. G-NECNet achieves high diagnostic accuracy across multiple datasets.

Glasses exhibit ultra-slow relaxation dynamics in the deeply nonequilibrium regime, which remain poorly understood in both theory and experiment. Zhao et al. introduce a unifying empirical framework to characterize these dynamics, based on which they propose a kinetics-based method for dating glassy materials.

Shang, Zhao, Ying and colleagues report that the mechanosensor PIEZO1 senses blood shear stress in hematopoietic stem cells, driving proliferation and myeloid bias. This axis links mechanical force to inflammation-induced aging, and PIEZO1 emerges as a potential therapeutic target.

A neuromorphic sensing system combining a flexible piezoelectric sensor array, event-triggered circuitry and a memristive chip enables energy-efficient, low-latency edge processing of event-based data through analogue in-memory computing.

Tropical cyclones cool the ocean surface less than previously thought, indicating that current projections may underestimate their future intensity and frequency, according to an analysis of global sea surface drifters data over 1992–2021.

Observations and model work from a Danish temperate wetland during 2007-2023 indicate that the site acted as a carbon dioxide sink and a methane source, and a stable water table at about 9 cm depth can be recommended as the best rewetting solution

Twisted bilayer (tb) MoTe₂ is an ideal platform for investigating the fractional quantum anomalous Hall effect but issues related to air sensitivity make the study of its electronic structure experimentally challenging. As a solution, the authors prepare hBN encapsulated tb-MoTe₂ and using micro-angle resolved photoemission spectroscopy determine the band structure. Furthermore, through in-situ alkali metal deposition, they obtain evidence indicating a direct band gap.

MsbA mediates the transport of lipopolysaccharide across the inner membrane. Here, the authors show specific MsbA-lipid interactions can tune the selectivity for binding ATP over ADP and present five structures of MsbA with one bound to lipid.

This study shows that oceanic extreme warm events, termed marine heatwaves, exacerbate extreme rainfall over land by 20–30%, increasing flood risks for coastal regions.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Electrical doping and charge transfer in 2D antiferromagnet CrSBr reversibly switch its magnetic state, enabling gate-tunable spin valves and ultralow-power spin control without ferromagnetic contacts, advancing fully electrical 2D spintronics.

This umbrella review synthesizes the evidence for safety and efficacy GLP-1 receptor agonists on multiple outcomes including but not limited to metabolic, cardiovascular and renal outcomes.

The proteasome is essential for protein degradation, but its complexity can be lost in vitro. Here, the authors use in-situ cross-linking mass spectrometry and structural modeling to reveal compartment-specific interactions and previously uncharted structural heterogeneity and dynamics.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

Forest management primarily drives the carbon sink enhancement in China from 2001 to 2021, achieving carbon gains at a rate over 4 times higher than afforestation, according to an integrated framework combining remote sensing-driven and climate-driven process models.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

Organoid modeling and single-cell profiling reveal TUBA4A and TUBB4B tubilin proteins-driven vascular smooth muscle cell migration and contractile-to-synthetic phenotypic switching via GJA1/PI3K/AKT/KLF4 pathway in Moyamoya disease.

An amorphous–crystalline silicon nitride nanocomposite at the buried interface of perovskite solar cells enables small-area devices with a certified power conversion efficiency of 26.37%. Modules with an area of 1,252 cm² maintain stable output for 6 months of outdoor operation.

Current lithium-ion batteries fall short in the specific energy required for emerging applications. Here, authors combine a tailored carbonate-based gel electrolyte with a surface modified lithium metal negative electrode to achieve a specific energy of 604.2 Wh kg⁻¹ for a solid-state pouch cell.

Population genomics has primarily focused on sequence polymorphisms rather than gene expression diversity. Here, the conduct RNA-seq for 328 common wheat lines to investigate the role of gene expression variation in shaping agronomic traits and their contributions to modern wheat improvement.

A pigeon-eye-inspired multimodal high-resolution tactile sensor, combined with a tactile language model, allows robots to achieve human-like tactile perception and understanding of their environment.