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Leveraging electron-phonon coupling allows for modulating self-trapped exciton formation for broadband white-light emission. Using transient spectroscopy and DFT calculations, Zhang et al. correlate the structural distortion with self-trapped exciton formation in 2D halide perovskites.

Bacteria can infect tumour cells which may affect the biological characteristics of the tumour or even the therapeutic outcome. Here authors show that Stenotrophomonas, upon entering tumour cells, trigger endoplasmic reticulum stress, leading to STING degradation and inhibition of MHC-II⁺ macrophages, which ultimately cause tumour progression and immunotherapy resistance.

In patients with hypopharyngeal squamous cell carcinoma (HPSCC), resistance to the standard-of-care induction chemotherapy often occurs. Here, using longitudinal single-cell transcriptomic profiling of HPSCC samples from patients receiving induction chemotherapy, the authors identify a ZNF683-high natural killer (NK) cell population as a predictor of chemotherapy response.

Despite high efficiencies, all-perovskite tandem solar cells are hindered by thermal instability. Guo et al. address this issue by introducing a multi-Lewis-base modulator, which suppresses the formation of dense Cs-rich films in Pb-Sn perovskites to concurrently deliver high performance and stability.

Behçet’s syndrome is a chronic inflammatory disease with oral ulcers being the most common symptom. Here authors present results from a phase 2 randomized double-blind placebo-controlled clinical trial that shows that systemic low dose interleukin-2 could be safely administered to these patients, and the therapy may improve their quality of life.

This study reveals a hierarchical development of the brain’s structural connectome from infancy to childhood, characterized by distinct sensorimotor-association trajectories and alignment with multiple neurobiological hierarchies.

Grain number per panicle (GNP) is a yield-determining trait of rice. Here, the authors identify a GSK3-like kinase-encoding gene GNP2 and a bZIP transcription factor-encoding gene GNP5, demonstrating their synergistic regulation of GNP and showing that specific allele combinations of these genes enhance rice yield in field conditions.

Compact MXene fibers with near-gigapascal strength are continuously fabricated by radial confinement and axial stretching under room temperature. Large-area textiles made from the fibers show superior electromagnetic interference shielding capacity.

Stone tools illustrate behavioural complexities in Middle Pleistocene hominin populations. Here, the authors present small dimensional flakes and hafted tools from Xigou, central China, dated to ~160–72 thousand years ago that demonstrate early, complex technological advancements.

Liu et al. report Chinese normative lifespan brain charts showing later neurodevelopmental milestones than those detected in Western cohorts. Individual deviations from these norms are valuable in assessing clinical risk and outcomes.

Early growth response 1 (EGR1) was localized to the nucleoli in several human cell types and identified as a positive regulator in rDNA transcription, providing insights into how EGR1 promotes cancer cell growth

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Self-charging batteries integrate energy conversion and storage but are limited by solid-state electrodes. Here, the authors report an organic self-charging flow battery that charges within 8 minutes to 94% capacity, matches various multivalent metal negative electrodes, and demonstrates high stability.

Chen et al. identify a brain-to-bone communication axis whereby extracellular vesicles from aged brain neurons transport WDFY1 protein to distal bone, driving bone-fat imbalance and promoting osteoporosis.

A photocatalytic synthetic route to deuterated N-heteroarenes over an atomically dispersed palladium photocatalyst in D₂O is developed. By recycling used D₂O and photocatalyst, up to 1.157 kg of deuterated N-heteroarenes can be obtained using only 4.5 litres of D₂O (19.7 equiv.).

A cellular neural network that incorporates transistors and multilevel non-volatile memristor synapses can be used for efficient image and video processing.

Zhang et al. characterize the mitochondrial inner membrane subdomain organizer (MISO) protein, which responds to inner mitochondrial membrane stress by inducing membrane subdomains promoting homeostatic fission and mtDNA degradation.

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

Colorectal cancer has high recurrence and metastasis rates making treatment difficult. Here, the authors report on peptide modified cell membrane coated cobalt based metal-organic frameworks which degrades and forms, in situ, photothermal materials with H₂S, allowing for immune-photothermal therapy.

Integrated behavioural & metabolomic profiling across the mouse lifespan reveals sex-specific brain metabolic reprogramming underlying divergent trajectories of age-related cognitive decline.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Human Glucose-6- phosphate Transporter (G6PT1) is critical for systemic glucose homeostasis. By integrating multiple cryo-EM structures with functional validation, the study elucidates the molecular mechanism of G6PT1 and its dysregulation in glycogen storage disease.

Rechargeable zinc batteries are hindered by sluggish ion transport and unstable interfaces. Here, the authors design a zwitterionic gel-ligand-channel where molecular crowding promotes ion liberation, enabling fast ion migration and interfacial kinetics even at −60 °C.

The study finds elevated CO₂ reduces methylmercury production across 45 freshwater lakes spanning 1200 longitudinal kilometers, specifically 54–96% in eutrophic ones, by shifting methanogenic pathways, highlighting the need to integrate climate drivers for methylmercury risk predictions.

Skeletal muscle is central to whole-body energy balance. Here, Yang et al. show that MLL4-dependent enhancer activation is a key regulatory node for the governance of muscle metabolic efficiency and systemic metabolism via the control of muscle AMPK.

It is unclear how early-life urbanicity influences adult neurobehavioral traits. This study reveals that earlier menarche mediates the relationship between early-life urbanicity and adult neurobehavioral traits associated with mental disorders.

Atomically dispersed catalysts show promising activity for electrochemical reactions but often suffer from limited stability. Here, the authors report an atom-ordering strategy that forms triangular Co sites to activate the substrate for durable alkaline hydrogen production.

The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and altered ubiquitination, which reveals the role of p53 R181C mutation in tumor development.

Using EMTracer, EndoMTracer, and MMTracer, this study shows that myofibroblasts in kidney fibrosis mainly originate from resident fibroblasts, not full or partial EMT, EndoMT, or MMT, guiding research toward fibroblast-targeted therapies.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Sequencing of 144 ancient genomes from Shimao city and its satellites presents pedigrees among tomb owners spanning up to four generations showing predominantly patrilineal descent structure across Shimao communities, and possibly sex-specific sacrificial rituals.

A layer-by-layer thermal evaporation strategy enables thermally evaporated inverted perovskite solar cells with a power conversion efficiency of 25.19%, maintaining about 95% of their initial efficiency after 1,000 h of operation.

A trispecific T cell engager has been developed to redirect bystander T cells, overcoming immunosuppression and enhancing antitumour immunity across multiple solid tumour types, alongside a machine learning-based tool to predict its efficacy.

A cross-ancestry GWAS meta-analyses of brainstem structures identify 713 associations. It reveals shared/distinct genetic architectures across ancestries/substructures and overlaps with neuropsychiatric disorders and physiological functions.

This study discovers that tRNA directly binds and regulates the membrane protein FKS1, a β-1,3-glucan synthase essential for fungal cell wall formation. Cryo-EM and biochemical analyses show how tRNA and GSR1 control FKS1 activity and fungal growth.