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A soft, biodegradable, wireless sensing device can monitor pressure, temperature and strain over long distances (up to 16 cm), maintaining accuracy across varying positions and angles.

Sutures are ubiquitous in post-surgical practice, but their capabilities can be enhanced. Here, the authors developed a bioabsorbable body-coupling electrotherapy suture that combines high tensile strength, flexibility, and degradability, and converts body-energy to speed up wound repair.

Moiré structures often exhibit long-range order. Here, the authors use scanning tunneling microscopy to identify an incommensurate moiré structure with a short-range-ordered charge density modulation.

Cascaded nonlinear optics has long enabled advances in short-wavelength generation, but equivalent approaches for long wavelengths remain underdeveloped. Here, the authors demonstrate a chip-based lithium niobate platform that delivers tunable mid-infrared light, opening new possibilities for sensing, spectroscopy, and communications.

The pathophysiologic functions of small nucleolar RNAs (snoRNAs) remain to be studied. Here the authors report that snoRNA SNORA49 suppresses liver cancer stem cell renewal through transcriptional inhibition of the stemness factor SOX9.

Analysis combining multiple global tree databases reveals that whether a location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

While antivirals like nirmatrelvir/ritonavir and molnupiravir are known to reduce severe COVID-19, their impact on cardiovascular outcomes is unclear. Here, the authors use a target trial emulation design to show that nirmatrelvir/ritonavir significantly lowers long-term cardiovascular risks among hospitalized patients, highlighting its potentials over molnupiravir for mitigating post-COVID-19 cardiovascular complications.

Adaptable control is essential for metasurfaces. Xingqi Xuan and colleagues propose a cyber-managed system with energy harvesting modules, offering a flexible solution for closed loop electromagnetic field manipulation and sensing.

This study shows that the transcriptional targets of NANOG recruits UTP15 to gene promoters in mESCs. There, UTP15 supports the formation of Pol II condensates, thereby activating pluripotency gene transcription independently of its classic role.

Tip-focused radiofrequency perforation enables soft, bloodless implantation of flexible electronic hairs, advancing semi-implantable electrophysiology for prosthetics and human–machine interfaces.

Alphaherpesvirus infections pose a health challenge due to the lack of effective broad-spectrum antiviral strategies. Here, the authors identify a broadly neutralizing antibody, 16F9, which targets glycoprotein B, offering cross-protection against multiple viruses and demonstrating robust efficacy in mouse models, paving the way for antiviral interventions.

This study presents a two-step chemical reprogramming strategy that converts fibroblasts into functional retinal pigment epithelium cells, offering a safe and scalable alternative for vision restoration in retinal degenerative diseases.

cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Highly ionically conductive and flexible solid-state composite battery electrolytes are engineered by alternately stacking inorganic Li_xM_yPS₃ (M = Cd or Mn) nanosheets with lithium-containing organic polymers in a perpendicular orientation to the surface of the electrodes.

Hepatocyte-specific GPR110 mediates metabolic dysfunction-associated steatohepatitis progression by regulating hepatic oestrogen sensitivity in a sex-specific manner, specifically in female mice.

Catalytic breakdown of highly persistent fluorinated pollutants is hindered by limited proton availability and catalyst degradation. This study shows that in situ proton-supplying sites enable low-temperature, long-lasting decomposition of stubborn PFAS gas.

PanoSpace enhances low-resolution spatial transcriptomics data to reconstruct continuous tissue maps at single-cell resolution. In cancer tissues and mouse brain, it refines cell localization, identity, gene expression and microenvironmental interactions.

The inability of intrinsically photosensitive retinal ganglion cells to shift the circadian clock in the suprachiasmatic nucleus during daytime is caused by light-dependent depolarization block of these cells.

Surface reconstruction during reactions often generates unique active sites that boost catalytic performance. Here, the authors show that supported Ni₃InC₀.₅ nanoparticles undergo CO₂-induced surface oxidation, forming defective In₂O₃₋ₓ layers and inverse In₂O₃₋ₓ/Ni interfaces during CO₂ hydrogenation.

A single umbilical cord blood unit of CD34⁺ HSPCs produces a high number of CD19 CAR-iNK cells using a modified cell culture method.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

Topological metamaterial clothing based on metallic conductive textiles can be used to create robust biosensing networks on the human body that can monitor vital signs during exercise.

Challenges remain in optimizing efficiency and stability of monolithic perovskite/Cu(In,Ga)Se₂ (CIGS) tandem solar cells. Here, authors develop a composite-structured intermediate recombination layer and achieve maximum efficiency of 28.04% and 30.71% for 0.51 cm² and 0.15 cm² cells, respectively.

High-throughput chemical ligand discovery is challenged by false positives. Here, authors introduce a scalable enantioselective affinity-selection mass spectrometry approach for proteome-wide ligand discovery with high sensitivity and selectivity

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Noise-induced hearing loss is commonly attributed to direct damage to sensory hair cells. Here, the authors reveal that non-sensory supporting cells play a critical role in the damage through Gasdermin D-mediated exacerbation of hair cell oxidative stress.

The genetic mechanisms of why polyploid plants exhibit adaptive advantages over diploids are unclear. Here, the authors assemble the autotetraploid alfalfa genome, incorporate it into a pangenome analysis, and reveal the trade-off between adaptive advantages and evolutionary constraints mediated by tetra-copy core genes.

Growth signaling has been involved in the biological program of aging. Here the authors identify ARMH4 as a pro-aging factor by enhancing IGF1R/FGFR1 signal transduction and their expressions, thereby forming a positive feedback circuit in aging.

Multi-ancestry genome-wide association meta-analyses of polycystic ovary syndrome in women of East Asian and European ancestries identify 94 independent susceptibility regions, including 73 novel loci.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

A natural variant of RCN2 enhances nitrogen assimilation and grain yield in rice by restricting chromatin loop extrusion and competitive interaction with the OsSPL14–SLR1 regulatory module.