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The authors present bioinspired solid-state proton diode membranes that achieve rectified proton transport by constructing an inherent water-content gradient and asymmetric transport pathways, enables efficient force-electric conversion.

Global Burden of Disease analysis found that in 2023, suboptimal diet was estimated to be responsible for 4 million deaths and 97 million morbidity burdens from ischemic heart disease.

Maternal obesity is known to cause systemic lipid dysregulation, yet its effect on lipid reprogramming during the maternal-to-zygotic transition (MZT) remains unknown. Here, they show that obesity disrupts very-long-chain fatty acids (VLCFAs) storage in oocytes, impairing peroxisomal protein import in 2-cell embryos.

Developing durable, water-repellent textiles without using harmful fluorinated chemicals is challenging. Here, authors use a one-step molecular assembly to covalently bond superhydrophobic silica shells directly onto fibers, resulting in high wear resistance and breathability.

The authors identify a KAT8 K145 lactylation switch that enhances TIP60 dependent p53 K120 acetylation and proapoptotic transcription, implicating this axis in doxorubicin cardiotoxicity and its mitigation by glimepiride.

Neighborhood social determinants of health influence cardiovascular risk, but early-life exposure effects remain unclear. Here the authors show that higher early adulthood neighborhood social determinants of health indices are associated with higher middle-aged coronary artery calcification.

A dated phylogeny of 16,585 vascular plant species native to China reveals three major centres of endemism, including a potential new global biodiversity hotspot.

Stabilizing 4d/5d metals as single atoms for catalysis is challenging due to their strong tendency to cluster. Here, the authors develop a hydrogen embrittlement-like assisted thermal activation strategy that prepares Ru-based single-atom catalysts, which achieve high performance in fuel cells.

The design of metal-free carbon catalysts is limited by unclear active sites and defects. Here, the authors combine statistical analysis with theoretical calculations to identify effective sites, guiding the synthesis of nitrogen and fluorine co-doped carbons for efficient hydrogen peroxide production.

A graphene-inspired porous polymer network acts as a molecular sieve, efficiently separating ethane from ethylene and purifying methane. Its finely tuned pores deliver record selectivity, offering a new path toward cleaner and energy-efficient natural gas processing.

Pre-harvest sprouting (PHS) causes severe yield and quality loss in cereal crops worldwide. Here, the authors report a cyclic nucleotide-gated channel/Ca^2 + -permeable channel encoding protein negatively regulate PHS and its involvement in modulating of calcium and hormonal signaling pathways in wheat.

The immune mechanism of radioresistance in cancer patients remains to be explored. The authors here show that CXCL13 is upregulated in tumor regions upon radiation, which recruits immune suppressive CXCR5⁺ monocytes. Blocking CXCR5/CXCL13 interactions facilitate tumor control following radiation.

Here, the authors show that the Saccharibacteria Nanosynbacter lyticus strain TM7x elicits limited immune activation in the oral cavity, and binds to gingival epithelial cells via a T4P-dependent mechanism, leading to clustering of TLR2 receptors and subsequent caveolin-mediated endocytosis.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

Neuromorphic devices are currently constrained by their limited functionality. Zhi et al. report a ferroelectric heterostructure device that integrates Boolean, optoelectronic synaptic and photodetection operations, offering a pathway to realizing integrated sensing-memory-computing systems.

Ordered antihedgehog polar lattices are engineered in antiferroelectric PbZrO₃ thin films via interfacial dislocation networks. The authors reveal that these ordered topological structures originate from mismatch.

This study presents a prefusion-stabilized vaccine candidate against Hantaan virus. The DNA and mRNA-LNP formats induce lasting neutralizing immunity in female mice, highlighting a promising advance in vaccine development.

Single-atom catalysts promise efficient reactions, but readily aggregate at high temperatures, limiting durability. Confining single metal atoms in liquid metal stabilizes them, enabling long-lasting ethane dehydrogenation at high temperature.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

A new optical imaging study demonstrates that norepinephrine and the state of arousal influence hemodynamic correlations across cerebral cortex, calling for a conceptual shift in interpreting functional magnetic resonance imaging data.

A brain–machine interface is used in monkeys to investigate the biophysical underpinnings of cortical high gamma-band activity, a signal that is often studied in the context of many brain functions.

Halide solid electrolytes typically require high lithium content, raising costs and exacerbating air sensitivity. Here, authors leverage anion clusters to synthesize an amorphous electrolyte with low lithium content of 2.4 wt%, high ionic conductivity of 1.5 mS cm^-1, and good air-stability.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

The growth of the smallest aerosol particles is critical to their impacts on climate and air quality. Here, the concentration gradient of nanoparticles is shown to be an important microphysical mechanism for their rapid initial growth.

Self-assembled monolayers are efficient hole-selective contacts but suffer from aggregation and adhesion issues. To address these, Wang et al. introduce a dimeric molecular design that forms a hydrogen-bond network, enabling 28.4% certified efficiency in all-perovskite tandem solar cells.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Cadmium-modified Fe₂O₃ enables selective electrochemical urea synthesis by suppressing CO₂ reduction and hydrogen evolution. The incorporation of Cd tunes the Fe electronic structure, weakens CO adsorption and promotes the protonation of key C−N intermediates, resulting in high urea productivity.

Conversion-type batteries with high energy storage efficiency are important to minimize the energy loss during energy storage. Here, authors develop a rechargeable battery with a maximum energy storage efficiency of 99.5% based on S-Cl synergistic chemistry and Cl₂ mediating role.

More environmentally friendly methods of extracting uranium from alternative sources are needed for the sustainable development of the nuclear power industry. This work proposes a spontaneous extraction process driven by droplet falling that enables the extraction of uranium from salt lakes.

Xia, Zhang, Peng, Chen et al. find that Leydig cells and macrophages show bidirectional mitochondrial transfer through extracellular vesicles, ensuring Leydig cells have functional mitochondria. The exchange is needed for testosterone production.

Perovskite–organic-based solar cells typically show poor reverse-bias stability. By modulating the deep trap state in the bulk-heterojunction region, organic and perovskite–organic tandem solar cells show largely improved stability under reverse biases up to –40 V.

A protein-language-based model enables improved discovery of evolutionarily distant antimicrobial peptides (AMPs). High-confidence AMPs showed strong antibacterial activity, with the most potent demonstrating efficacy in a mouse model of E. coli infection.

Cai et al. analyze accelerometer data from UK Biobank participants using machine learning to separate sporadic from bouted moderate-to-vigorous physical activity (MVPA) and link them to mortality and cardiovascular outcomes. They find that 150 min/week of sporadic MVPA yields maximal mortality benefit, and adding bouted MVPA offers further gains.

Bioresorbable piezoelectric materials are key for bioelectronic–tissue integration but remain challenging to realize. Here, the authors develop flexible Rochelle salt/PLLA nanofibers that enable effective nerve regeneration and wireless monitoring of intestinal motility.

The study of highly active electrodes in organic electrosynthesis remains an under-investigated component of the subfield. This work introduces a bottom-up route to prepare chitin-derived composite carbon aerogel electrodes (CCAEs), which can be directly used as electrodes in organic electrosynthesis systems.

The efficiency of perovskite/Cu(In,Ga)Se₂ tandem solar cells is limited by halide segregation in the perovskite layer. Zhang et al. use 2-pyrrolidinone to slow the crystallization of halide intermediates, ensuring a homogeneous distribution and achieving a power conversion efficiency of 27.3%.

Mechanical response of semiconducting polymers affects their electrical properties, yet the detail remains elusive. Zhong et al. examine the multiscale structural evolution of conjugated polymer thin films during uniaxial deformation and link it to mechanical resilience and solar cell performance.

The lack of high-energy positive materials hinders the development of magnesium metal batteries. Here, authors design an anion receptor-mediated electrolyte that enables the electrochemical cooperation between fluoride and magnesium, and develop a high-performance Mg | |FeO0.7F1.3 battery prototype.

Chen et al. engineer TRANSFER (trogocytosis-inspired receptor transfer and functional effector release), a method to deliver functional cargos from donor to recipient cells in a specific manner via direct cell–cell contact.

Acidic electrochemical CO₂ reduction promises efficient carbon use, but maintaining stable acidity at high current remains a major challenge. Here, the authors demonstrate a membrane-free CO₂ hydrogenation electrolyzer that stabilizes pH and enables efficient and stable formic acid production.

Low temperature is a major factor limiting productivity in rice. Here the authors show that theCTB4a gene confers cold tolerance to japonicavarieties adapted to cold habitats at the booting stage of development, and propose that CTB4a acts via an interaction with the beta subunit of ATP synthase.

Surface plasmon-mediated steady-state and on-demand electronic spin modulation effectively activates light-driven plasmonic catalysis, facilitating polarization reactant activation and preferential reaction pathway modulation.