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The impact of fluorine doped tin oxide (FTO) on device longevity has been overlooked. Here, the authors employ thermal evaporated yttrium oxide to strengthen structural stability of FTO, achieving maximum efficiency of 26.48% and 28.47% in regular and all-perovskite tandem structures, respectively.

Hou, Li, Moi et al., find that long-term endocrine therapy does not alter overall gut microbiota composition in breast cancer patients, but recurrence is linked to reduced microbial diversity and specific bacterial signatures. These gut microbiota patterns predict poorer outcomes independent of established genetic risk scores, suggesting added value for recurrence risk stratification

A miniaturized and low-power-consumption system is designed to allow the accurate sensing and wireless transmission of internal temperature and strain signals inside lithium-ion batteries with negligible influence on their performance, improving their safety.

Helium accumulation in structural ceramics causes early failure, making damage control important. Here, defect landscape engineering is proposed as a general strategy to suppress helium-induced degradation, involving the deliberate creation of vacancy clusters prior to helium exposure.

Sweet potato weevils (SPWs) pose one of the most significant challenges to sweet potato production. This study identifies two major SPW-resistant genes, SPWR1/2, and provides new insights into the mechanism of sweet potato defence against SPWs.

Prostate cancer diagnosis require MRI analysis, however, scoring can vary between clinicians. Here, the authors develop ProAI to detect prostate cancer from imaging.

Challenges remain in optimizing efficiency and stability of monolithic perovskite/Cu(In,Ga)Se₂ (CIGS) tandem solar cells. Here, authors develop a composite-structured intermediate recombination layer and achieve maximum efficiency of 28.04% and 30.71% for 0.51 cm² and 0.15 cm² cells, respectively.

Previous studies on biodistribution of microplastics showed discrepancies. This study provides quantitative data to date on how nanoplastics distribute and eliminate from the body using carbon-14-radiolabelled particles in rats.

Wide-bandgap perovskite solar cells suffer from instability under rapid thermal cycling. Here, Sun et al. investigate the degradation mechanism, showing that temperature-induced structural strain, phase transition, and increased non-radiative defects drive the degradation processes.

Zhang et al. found that histone deacetylase 1 (HDAC1) condensation is responsible for temozolomide resistance in glioblastoma by recruiting CCCTC-binding factor and remodeling chromatin in a deacetylase-independent manner. Disrupting the HDAC1 condensates with resminostat restores the sensitivity to temozolomide.

The authors conducted a genome-wide association study of bipolar disorder (BD) in Han Chinese and integrated PGC4 East Asian and European datasets, discovering 23 novel loci, prioritizing 39 credible risk genes and implicating BD-related cell types and druggable targets.

This study demonstrates a low-energy photon device based on the kagome metal RbV₃Sb₅. It demonstrates that Fermi surface reconstruction, driven by a phase transition, leads to the emergence of van Hove singularities near the Fermi level.

Here the authors reveal a study of 486,956 Han Chinese individuals showing that most people with genetic variants affecting drug response do not have the predicted adverse events, highlighting the challenges of implementing pharmacogenetics in clinical practice.

An in-depth analysis of tissue biopsies from patients with multiple myeloma and CAR T cell therapy-associated immune-related adverse events (CirAEs) after treatment with commercial BCMA-targeted CAR T cell therapy shows that CD4⁺ CAR T cells mediate off-tumor toxicities and that high CD4:CD8 ratio at apheresis, robust early CAR T cell expansion, ICANS and ciltacabtagene autoleuce treatment are independently associated with the development of CirAEs.

Lithium sulfur batteries are a promising next generation storage technology. Their performance, however, is subject to the parasitic shuttle effect. Here the authors report a cathode material comprising porous vanadium nitride nanoribbon and graphene to provide anchoring for polysulfides.

Insertion of a long DNA sequence into the host genome is challenging in mammalian cells. Here, the authors develop a recombinase (Redα/β)-enhanced DNA integration approach, which enables efficient and precise kilobase-scale DNA insertion in both primary cells and mouse embryos.

Energy consumption is a challenge in AI hardware. The authors introduce a volitional neuromorphic device that mimics human visual attention, achieving high energy efficiency and precise object tracking with minimal data redundancy.

The authors reveal that the ferroelectric to antiferroelectric phase transition in Pb(Zr_0.97Ti_0.03)O₃-1wt%Nb₂O₅ at low temperatures is an irreversible process exhibiting relaxation behavior and diffusional kinetics.

Yang and colleagues have previously reported a clinically guided culture method to generate allogeneic CAR-NKT cells by engineering human hematopoietic stem and progenitor cells. As potential application, here the authors describe the design and characterization of allogeneic CD33-targeting CAR-NKT cells, showing anti-tumor activity in preclinical models of bone marrow-resident myeloid malignancies.

Monitoring charge carrier dynamics and photocatalytic reaction rates in individual photocatalyst particles is a challenging task that can help us to understand structure–reactivity relationships. Here single-molecule fluorescence imaging is coupled with femtosecond interferometric scattering microscopy to investigate these properties in 2D InSe flakes.

A simple cut can wake up a dormant plant. New research uncovers how a wound instructs buds to resume cell division and sugar transport, driving them to sprout.

Dissipative many body systems provide quantum-enhanced sensitivity to external near gap-closing points. Here, the authors demonstrate record sensitivity in a Rydberg-atomic platform in correspondence of folded hysteresis trajectories under external microwave driving

Through integrated multi-omics and experimental validation, this study reveals that altered gut microbiota and bile acid metabolism activate TLR3 to induce urothelial injury in interstitial cystitis, identifying a pathway with therapeutic potential.

A model, trained to generate synthetic, patient-specific angiography images, reduced radiation exposure to patients and clinicians by two-thirds in a multicenter randomized controlled trial involving 1,068 patients.

Dendrobium is a genus of mostly epiphytic and lithophytic orchids. Here, the authors conduct comparative genome analysis for 24 chromosome-level genome assemblies and genome skimming sequencing data for 204 species in this genus, and reveal genomic variation, biosynthesis and evolutionary adaptation in Dendrobium orchids.

Shang, Zhao, Ying and colleagues report that the mechanosensor PIEZO1 senses blood shear stress in hematopoietic stem cells, driving proliferation and myeloid bias. This axis links mechanical force to inflammation-induced aging, and PIEZO1 emerges as a potential therapeutic target.

He et al. report a lanthanide-doping strategy for dual-halogen-alloyed perovskite microplates, which promotes phase segregation and facilitates ion migration in the alloyed case, while suppressing it in the phase-segregated state, resulting in dual-wavelength lasing in visible spectral region.

IBI318 is a recombinant bispecific IgG1 antibody that targets PD-1 and PD-L1. Here the authors report the results of a phase II trial of IBI318 combined with the receptor tyrosine kinase inhibitor lenvatinib in patients with advanced non-small cell lung cancer with acquired resistance to first-line immune checkpoint inhibitors.

The heat shock protein GP96 has been utilized as a potent adjuvant in vaccine formulations. Here, the authors present a viral vaccine platform based on the design of SARS-CoV-2 and HPV antigens fused to the N-terminus of GP96 and show that this vaccine design favor intact antigen delivery to the lymph nodes and induces potent long-term humoral and T cell responses after mice immunization

Nitrogen-fixing bacteria offer a promising route to reduce reliance on synthetic fertilizers, but their effectiveness is hindered by environmental stresses that limit survival on leaf surfaces. This study introduces a nanocoating strategy that enables robust foliar colonization of Klebsiella variicola, enhancing nitrogen fixation and improving rice yield under low-fertilizer conditions.

Wang, Chu, Chen, Wei and colleagues discover a subset of tumour-associated macrophages expressing SLC2A1 whose spatial proximity to CD8⁺ T cells drives resistance to anti-PD-L1 treatment in non-small-cell lung cancer.

Traditional fullerene-based electron transport layers in tin perovskite solar cells are costly and limit power conversion efficiency. Tianpeng Li et al. report low-cost fluorinated polymers as alternatives, achieving a certified 14.51% efficiency on 1-cm² devices.

Insufficient efficacy is one of the major impediments for further application of sup-tRNA therapies. Here, authors engineer the body sequence of sup-tRNA^Arg and restored retinal function and vision-guided behavior in a mouse model carrying the RPE65-R44X nonsense mutation.

Thiamine pyrophosphate (TPP) is the biologically active form of vitamin B1 and servers as an essential metabolic cofactor regulating energy production, redox homeostasis, and carbon assimilation. Here, the authors show that optimizing TPP metabolism can enhance yield and quality in maize, rice and rapeseed.

Initially anode-free sodium batteries promise high energy density but suffer from poor rate and low-temperature capability. Here, authors introduce a fluorinated sodiophilic interphase (BiF3@Al) which enables fast Na plating/stripping, demonstrating extended lifetime under harsh conditions.

Limited genomic resources constrain our understanding of fern evolution and conservation. Here, the authors present the genome of Brainea insignis, a monotypic endangered fern, and identify evolutionary signatures to guide conservation strategies from comparative and population genomic analyses.