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Bulk superconductivity has been observed up to 96 K in pressurized bilayer nickelate single crystals which were synthesized under ambient pressure.

Hirschsprung disease, characterized by the absence of ganglion cells leading to functional bowel obstruction, can be treated with surgery. Here, the authors report that preoperative nutritional support in children with Hirschsprung disease reduced the risk of postoperative enterocolitis by comparison to standard of care in a randomized controlled trial.

Saline-alkaline stress affects worldwide crops production, but the tolerance mechanisms have not been fully elucidated. Here, the authors show that EF-hand Ca2 + -binding-protein coding gene ZmNSA1 can regulate root H + efflux, Na + homeostasis, and saline-alkaline tolerance in maize.

MultiSuSiE is an extension of the Sum of Single Effects fine-mapping model that allows causal effect sizes to vary across ancestries. Applying MultiSuSiE to quantitative traits in All of Us identifies fine-mapped variants not implicated by other methods.

An annotation-free vision–language model based on contrastive learning performs pathology localization and clinical diagnosis on a wide variety of medical image datasets.

Currently, there is a lack of clear understanding on how glioma cells exploit neural electrophysiological signaling to drive hyper-invasive behavior. Here, the authors integrate custom microfluidics with machine learning-based signal decoding to uncover a mechanism by which tumors actively reprogram neural firing patterns, synchronizing with their microenvironment to enhance invasiveness.

Endocytosis of TFR1 plays a crucial role in extracelluar iron uptake. Here the authors revealed that PKCβII facilitates the endocytosis of TFR1 and increases cellular iron levels through the phosphorylation of AAK1, thus promoting ferroptosis of tumor cells.

The ALICE Collaboration provides details on the microscopic mechanism that ends up creating antideuteron in high-energy proton–proton collisions at the Large Hadron Collider.

LRBA deficiency is associated with autoimmune disease and CTLA4 loss; this study identifies LRBA as a negative regulator of antitumor immunity and introduces LC427 as a promising small-molecule inhibitor of the CTLA4-LRBA interaction for cancer immunotherapy.

Shang, Zhao, Ying and colleagues report that the mechanosensor PIEZO1 senses blood shear stress in hematopoietic stem cells, driving proliferation and myeloid bias. This axis links mechanical force to inflammation-induced aging, and PIEZO1 emerges as a potential therapeutic target.

Researchers repurpose Prussian Blue and Vitamin C to treat dangerously high potassium levels in mice. This approach safely traps potassium without releasing harmful sodium, offering an potential option for heart and kidney patients.

The retina offers a window into systemic health, but its molecular links to cardiometabolic disease remain unclear. Here, the authors show that metabolomic profiling on retinal nerve fibre layer combined with machine learning reveals shared metabolic states that predict cardiometabolic risk and bridge health inequities.

Efficient and durable energy storage is vital for renewable integration. Here, the authors design an aqueous iron-cerium redox flow battery using a universal complexing agent that enhances stability and efficiency, achieving long cycle life and high performance in neutral conditions.

Shell-isolated nanoparticle enhanced Raman spectroscopy (SHINERS) has enhanced the sensitivity of Raman spectroscopy for applications in materials and life sciences. Here, the authors develop its femtosecond stimulated version (SHINE-FSRS) for in-situ monitoring of molecular dynamics on ultrafast scales.

Proton-exchange membrane water electrolysers rely on iridium to catalyse their anodic reaction, and while ruthenium is a less costly alternative due to its similar activity, it is not as stable. Now, a hierarchical machine-learning catalyst discovery workflow, termed mixed acceleration, is put forward to predict catalyst synthesis, activity and stability, and identify promising RuO_x-based water oxidation catalysts.

This research quantifies hospital admissions in Shanghai for mental and behavioral disorders linked to humid heat, projecting a 68.2% increase by the 2090s under high greenhouse gas emissions and emphasizing the importance of mitigation strategies to reduce future morbidity burdens.

Receptor engagement is a determinant of alphavirus entry. This work reveals how Western Equine Encephalitis Virus uses very-low-density lipoprotein receptor (VLDLR) to invade our cells and finds that a single polymorphism in the E2 glycoprotein determines the receptor’s tropism.

The tunability of the polarization state of light-emitting diodes (LEDs) based on conventional semiconductors is usually limited. Here, the authors report the realization of mid-infrared LEDs based on a Weyl semiconductor, layered Te, showing the electrical tunability of the degree of linear polarization of the emitted light from ~100% to 36%.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Direct enantioselective α-C(sp³)–H functionalization of Lewis-basic N-alkyl anilines has remained a significant challenge in synthetic chemistry. Now it has been shown that a metallaphotoredox-catalysed radical approach, with a sterically hindered aryl ketone photocatalyst, enables site-selective, enantioselective (hetero)arylation with exceptional functional group tolerance.

Mechanistic insight into how SARS-CoV-2 nsp14 methyltransferase activity installs m⁷G on host RNAs to drive stress-granule assembly.

A groundbreaking study reveals how physical confinement triggers ferroptosis. It finds the nucleus acts as a mechanosensor, orchestrating Drp1 and cPLA2 that leads to mitochondrial dysfunction and ultimately, cell death.

A matrix-confined molecular layer of compact surface coverage and good conductivity is developed as charge transport substrate to fabricate perovskite solar-cell devices with high efficiencies, which shows application potential for scalable production.

Maintaining facial warmth and humidity while ensuring adequate oxygen intake in cold environments is challenging for facial masks. Here, the authors design a MetaMask that recovers heat and moisture from exhaled air to warm inhaled air to 26.2 °C in a − 20 °C environment, while maintaining sufficient oxygen levels.

Avian influenza A H5N1 has recently caused infections in humans following spillover events into cattle. Here, the authors investigate the genetic basis for the expanded host range of the virus.

Cancer cells exploit altered metabolic pathways to dynamically regulate epigenetic methylations. Here, the authors show the canonical metabolic and nonmetabolic functions of PRPS2 in enhancing ATP utilization and SAM biosynthesis, promoting RNA m⁶A methylation for lung tumorigenesis and metastasis.

Semaglutide, a GLP-1 receptor agonist, may offer neuroprotective benefits after stroke, but its effects in large vessel occlusion (LVO) are unknown. Here the authors show, in a phase 2 randomized trial, that semaglutide is safe after endovascular therapy and may improve recovery in patients not receiving intravenous thrombolysis.

In this work, authors show that micro- and nanoplastics at environmentally relevant levels promote conjugative transfer of antibiotic resistance genes between bacteria by altering oxidative stress, membrane permeability and energy metabolism.

Precisely controlling structural colours in polymeric materials remains a major challenge. Here, the authors develop a colour design model, enabling inverse design of structural colours in bottlebrush block copolymers.

Seawater electrolysis for green hydrogen is hindered by corrosive chloride ions. Here, the authors report a substrate-adaptive sacrificial corrosion strategy for creating highly active anodes that resist seawater corrosion and break thermodynamic selectivity limits.

Intestinal mucin 1 (MUC1) is a glycosylated protein that maintains intestinal epithelial barrier (IEB) integrity. Here, the authors show that reduced intestinal MUC1 levels and glycosylation facilitate metabolic dysfunction-associated steatotic liver disease (MASLD) progression by impairing IEB integrity, via clathrin-mediated endocytosis and NEDD4-mediated lysosomal degradation of MUC1 (triggered by decreased glycosylation).

Polysubstituted arenes are ubiquitous structural cores in natural products and drugs but their synthesis through programmable arene modification remains a challenge. Now, a palladium- and norbornene-catalysed Catellani-type reaction of aryl ketones, through successive acylation and deacylation, allows the synthesis of polysubstituted arenes.

Zhao et al. demonstrate that ZmCRY1s, blue-light receptors in maize, interact with GL2 in blue light to promote C32 aldehyde accumulation thereby modulating epidermal wax composition and enhancing UV-B tolerance, revealing a light-regulated wax biosynthetic mechanism critical for maize stress adaptation.

Deep-sea sediments are a key sink for molybdenum (Mo). Here it is found that the their isotopic composition is heavier than typical endmembers; refining the global Mo budget, and improving reconstructions of past ocean oxygen levels.

The authors present a federated learning framework for battery fault detection in electric vehicles using charging station data. It enables privacy-preserving collaboration among data owners, creating customized models that improve fault detection accuracy and generalization across diverse data distributions.

Liang, Ruan, Wang, and colleagues present a serum-stable, red-fluorescent nanoparticle that targets mitochondria, induces mitophagy, and effectively reduces atherosclerotic plaques in mice, constituting a promising nanomedicine for cardiovascular diseases.

Mercury isotopes in Northeast Asia intraplate basalts indicate that the EM1 mantle source contains recycled ancient terrigenous sediments stored in the mantle transition zone for over a billion years, recording long-term deep-Earth volatile cycling.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.