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Short-circuiting during fast charging through lithium dendrite intrusion into electrolytes is a major challenge in solid-state batteries. Here, using thermally annealed 3-nm-thick Ag coatings, lithium penetration into brittle electrolyte Li_6.6La₃Zr_1.6Ta_0.4O₁₂ is inhibited at local current densities of 250 mA cm⁻² due to an increase in surface fracture toughness.

In Li-mediated electrochemical N₂ reduction to ammonia, selectivity and activity are governed by the solid electrolyte interphase (SEI). This study reveals how the applied potential shapes the SEI properties and composition, thereby influencing reaction performance.

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

Researchers report a solid that is amorphous in two dimensions but crystalline in the third, made of stacked disordered atomic layers. This shows that crystalline and amorphous order can coexist within a single material depending on direction.

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to the functional diversity among different types of neurons.

Amorphous sulfurized polyacrylonitrile suppresses polysulfide shuttling in Li–S batteries, enabling long cycle life, but the structural processes involved during synthesis and initial cycling remained unclear. An operando pair distribution function, wide-angle scattering and sulfur absorption spectroscopy reveal S–C bond formation, π–π stacking and sulfur-chain shortening, which enable reversible sulfur redox.

Here they show that FOXF2 is required for pericyte maturation and function during postnatal alveolar morphogenesis. FOXF2 is required in pericytes to induce angiogenesis after neonatal hyperoxic injury, revealing a link between pericyte-endothelial crosstalk and bronchopulmonary dysplasia pathogenesis.

Continuous monoculture of banana can result in proliferation of parasitic nematodes. Here the authors show that in the long term, soil can become suppressive to disease and this is associated with enrichment of free-living nematodes and Bacillus bacteria.

Li-metal batteries suffer from sluggish kinetics at low temperatures. Here, authors propose a guideline for rational electrolyte solvent screening and design a class of asymmetric ethers, which bestows the Li metal pouch cell with a high specific energy of 345.3 Wh kg⁻¹ over 40 cycles at −40 °C.

Rafting dispersal can facilitate responses to environmental change. Here, authors integrate dispersal simulations, ecological genomics, and salinity stress experiments to elucidate the rafting dynamics and adaptive shifts of crustaceans.

Continuously trapped atoms provide advantage for atom interferometry, yet current schemes are limited by dephasing. Here, the authors develop a Floquet-engineered atom interferometry platform for quantum force sensing purposes, unveiling regimes where the interferometric phase is insensitive to noise.

Gestational exposure of mice to the obesogen tributyltin alters 3-D chromatin interactions in primordial germ cells leading to stable reduction of hepatic Ide expression and predisposing male descendants to insulin dysregulation and obesity.

Here, the authors show that 2’-O-methylated RNA fragments from ribosomal RNA naturally block TLR7 and TLR8, helping to avoid avoid harmful self-RNA detection and autoimmunity.

Heparan sulfate proteoglycans facilitate the assembly of clusters of glycoRNAs and cell surface RNA-binding proteins, which negatively modulate VEGF-A signalling and angiogenesis.

Producing valuable hydrocarbons electrochemically from carbon monoxide (CO) is an energy-efficient pathway, but reliance on costly pure CO as a feedstock limits its economic viability. This article shows that abundant CO-rich syngas can be directly used to synthesize ethylene.

Lithium-ion battery cathode lifetime is limited by large expansion and contraction during cycling. This study uses electrochemical activation to suppress collapse in LiNi_0.9Mn_0.1O₂ cathodes, achieving improved capacity and cycle life.

Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Native state proteomics of PV interneurons revealed unique molecular features of high translational and metabolic activity, and enrichment of Alzheimer’s risk genes. Early amyloid pathology exerted unique effects on mitochondria, mTOR signaling and neurotransmission in PV neurons.

Jacquemyn et al. identify key lipid determinants controlling ectosome shedding from neurons. They find that ectosomes are a major route for the intercellular transport of misfolded α-synuclein, with relevance to Parkinson’s disease pathology.

This study finds that plastic mulch substantially increases crop yields but also contaminates soils and pollutes the environment. The authors propose biodegradable films, AI-driven farming, and policy reforms to address the productivity–sustainability trade-offs.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

Large-effect variants in autism remain elusive. Here, the authors use long-read sequencing to assemble phased genomes for 189 individuals, identifying pathogenic variants in TBL1XR1, MECP2, and SYNGAP1, plus nine candidate structural variants missed by short-read methods.

Therapies combining chemotherapy and immune checkpoint inhibitors have shown limited efficacy in patients with advanced pancreatic ductal adenocarcinoma (PDAC). Here the authors report the results of a pilot phase 1 trial of neoadjuvant modified Folfirinox plus nivolumab in borderline-resectable PDAC, including safety, efficacy and immunological correlates.

A human spinal cord organoid model can replicate two different types of spinal cord injury and can be used as an in vitro system to evaluate therapeutics and inflammatory reactions to treatments.

Photocatalytic water splitting using a single particulate photocatalyst is a cost-efficient approach for sustainable hydrogen production. Here, the authors report a nanoscale Ba_xSr_1-xTaO₂N solid-solution photocatalyst exhibits an apparent quantum efficiency of 13.5% for H₂ evolution at 420 nm.

Polarons play a crucial role in determining the (photo)electrocatalytic activity of semiconductors. Here, the authors report a reversible, potential-driven method to generate Ti³⁺ polarons on TiO₂, creating dynamic active sites that break the adsorption-potential linearity and boost hydrogen evolution.

Hexokinase detachment from the outer mitochondrial membrane is shown to support aerobic glycolysis in cancer cells. Differential localization of the HK1 isoform to the outer mitochondrial membrane, compared to the HK2 isoform, explains the conditional essentiality of HK2 in cancer cells cultured in physiologic media.

A technique called condense-seq has been developed to measure nucleosome condensability and used to show that mononucleosomes contain sufficient information to condense into large-scale compartments without requiring any external factors.

The authors describe the discovery of a series of potent non-competitive allosteric inhibitors of the ZIKV NS2B-NS3 protease, which exhibit antiviral activity in vitro and robust oral efficacy against ZIKV infections in a mouse model.

The isolation of catenated nitrogen compounds is difficult, in part because these chains can readily lose nitrogen, creating a strong thermodynamic push towards decomposition. Now, a series of molecules containing radical anions of four-atom nitrogen chains have been synthesized and studied under ambient conditions; the chain can cleave into N1 and N3 fragments, and can act as a source of nitrene radical anion.

This study applies machine learning to fMRI data to map developmental variations in functional connectivity, uncovering heterogeneity across individuals and cortical regions that predicts neurocognitive maturation in youth.

The herpes simplex virus lytic-latent balance is incompletely understood. In this study, the authors show that it is controlled by the relative abundance of host activating and repressive forkhead box (FOX) transcription factors that recruit epigenetic cofactors to the viral genome to remodel viral chromatin.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

In a study of four brain-dead human decedents, extracorporeal liver cross-circulation using genetically modified pig livers provides essential hepatic functions, supporting the feasibility of this approach for temporary liver support as a bridge to organ transplantation.

Present Li-ion batteries for portable electronics are based on inorganic electrodes made through non-ecological processes. Sustainable conjugated dicarboxylate organic salt anodes showing advantageous reversible capacities and thermal stability are now reported.

Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

Stretchable electrodes are essential for wearable electronics and soft robots, yet their performance always degrades under strain. Here, authors use robotics- and machine learning integrated workflow to design microtextured nanocomposites for strain-insensitive gold conductors and zinc batteries.

This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell composition and cell states that correlate with clinical features are highlighted.

The use of antimicrobial agents can exacerbate the proliferation of antimicrobial resistance genes, which can put public health at risk; evaluating this risk requires proper monitoring. An extensive investigation of Australian wastewater reveals a distinct correlation between the type of antimicrobial used and the socioeconomic status of the population.

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

An algorithm that combines deep learning, Bayesian optimization and computer vision techniques can be used to autonomously tune a semiconductor spin qubit from a grounded device to Rabi oscillations.

Despite high morbidity and mortality, there are currently no approved vaccines for protection against Middle East respiratory syndrome (MERS) coronavirus. Here the authors develop a ferritin nanoparticle-based MERS-CoV vaccine that elicits high levels of neutralizing antibodies in mice, non-human primates, and alpacas and prevents infection in an alpaca challenge model.

During the Last Glacial Maximum, the deep Northwest Atlantic was only about 2 °C colder than today, suggesting sustained production of relatively warm North Atlantic Deep Water during the Last Glacial Maximum.

Population-based studies from Sweden with replication in Norway identify associations between host genetic variants and gut microbial composition and implicate short-chain fatty acid chemosensors as modulators of gut microbial richness.

Pseudaminic acids (Pse) are a family of carbohydrates found within bacterial lipopolysaccharides, capsular polysaccharides and glycoproteins. Now, monoclonal antibodies have been developed that recognize diverse Pse across several bacterial species, enabling mapping of the Pse glycoproteome and demonstrating therapeutic potential against multidrug-resistant Acinetobacter baumanii in in vitro and in vivo infection models.

Ferromagnetic systems produced by the transition metal doping of semiconductors may be used as components of spintronic devices. Here, a new ferromagnet, Li_1+y(Zn_1-xMn_x)As, is prepared in bulk quantities and shown to have a critical temperature approaching 50 K.

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

Electron transfer in molecular wires is typically dominated by tunnelling at short lengths. Now it is shown that conjugated molecular wires anchored to indium tin oxide electrodes exhibit a hopping mechanism even at 1-nm lengths, enabling charge extraction in tin perovskite solar cells and improved device performance.

EGFR inhibitors are standard of care in patients with EGFR-mutant non-small cell lung cancer (NSCLC) but resistance often develops. Here the authors report that the evolution of EGFR inhibitor resistance in EGFR-mutant NSCLC results in a sensitivity to the compound, MCB-613, and investigate the underlying mechanism of action.

Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.