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Amorphous chalcogenides enable ultrafast threshold switching, yet their switching mechanism remains debated between electronic and structural models. Song et al. reveal an electric field induced atomic displacement and dipolar ordering, which exhibit a non-Arrhenius structural transition and guide conductive filament formation.

While AI has the potential to improve accuracy and efficiency in breast cancer diagnosis, it remains to be sufficiently tested in complex real-world clinical scenarios. Here, the authors develop BIRD, an end-to-end AI system for breast cancer recognition from ultrasound images, which is tested across large, diverse, and international cohorts.

ZAT-DNA encodes data in A/Z base patterns that PCR erases, ensuring molecular non-replicability. It enables secure 32/64-bit key storage and nanopore retrieval, blocks copying, and protects NFTs. The Babel-DNA hybrid allows selective access to multiple encrypted datasets from a single DNA pool using unique ZAT-DNA keys.

Designing high performance elastomers are promising for multifunctional materials, though existing materials have unfavorable mechanical properties. Here the others design a cellulose based liquid crystal elastomer system affording a biodegradable material with mechanochromic properties.

A multiphase-flow-guided solar evaporator integrates water replenishment, vapor dissipation, salt reflux, and heat management, enabling ultrahigh-efficiency solar desalination with stable operation in ~15 wt.% saline water and high daily freshwater production under natural sunlight.

This study reports a paralog-selective p300 degrader with potent anti-cancer activity in hematological malignancies, demonstrating a strategy to selectively target transcriptional coactivators through protein degradation.

This work develops laser-engraved Janus microcavity surfaces to overcome the angular limitation of photothermal de-icing. The structure enables ice removal under oblique or weak sunlight and sustains superhydrophobicity, offering a thermal management solution for nonplanar infrastructures in extreme environments.

Global analysis of obesity trends from 1980 to 2024 in 200 countries and territories using data from 4,050 population-based studies reveals that framing obesity as a single global epidemic masks the highly varied dynamics across countries and age groups.

Traditional bisphenol A diglycidyl ether (BADGE) synthesis from bisphenol A and epichlorohydrin using NaOH suffers from side reactions, low purity product and high viscosity. Here, the authors report an organocatalytic NaOH-free route, yielding higher purity BADGE and improved epoxy resins.

Gate residues, acting in concert with distal dynamic networks, are important yet underexploited regulators of enzymatic catalysis. Here, the authors report conformational dynamics analysis of fluoroacetate dehalogenase RPA1163, which reveals a gate-based allosteric pair (K181–W185) that governs substrate access and reactivity, and engineer this pair to obtain a highly active variant for turnover of α-fluorophenylpropionic acid.

Triticum urartu is the diploid progenitor of polyploid wheat A subgenome. Here, the authors report an improved genome assembly of T. urartu and uncover a lipoxygenase gene that shapes T. urartu gene pools and their contributions to polyploid wheat A subgenome by regulating growth-defense trade offs.

Treatment failure exists in Induction chemotherapy followed by concurrent chemoradiotherapy (CCRT) for locoregionally advanced nasopharyngeal carcinoma (LA-NPC) patients. Here this group reports a phase 2 randomized trial evaluating the efficacy and safety of adding nimotuzumab, to CCRT on 246 patients with untreated, non-keratinising, stage II–IVA LA-NPC.

Despite rapid development of model algorithms, more evidence is needed on the widespread clinical implementation of auto-segmentation tools. In this prospective, multicenter, observational trial, the authors find that AI-assisted delineation performs better than manual delineation while improving time efficiency and reducing performance metrics variability across centers and physicians with varying expertise.

A Walden inversion-like transformation and multiple Feshbach resonances are observed in the Cl + NH₃ reaction, providing a complete mapping of the transition-state region for a chlorine-involved polyatomic reaction.

Current strategies for regulating enzyme activity are often enzyme-specific. Here, the authors report a spintronic approach that uses chiral gold nanohelices as electron spin polarizers to enantiospecifically modulate cyclooxygenase-2 activity for rheumatoid arthritis intervention, and explore electron spin polarization as an orthogonal mechanism for enzymatic regulation.

RNA-binding proteins (RBPs) regulate gene expression, but predicting RBP–RNA interactions across species is challenging. Here, the authors introduce MuSIC, a deep learning framework leveraging label smoothing and evolutionary conservation across 11 species to predict cross-species RBP–RNA interactions.

Single-ended spin logic devices offer a route to simpler and more energy-efficient logic-in-memory computing. Here, the authors show that obliquely sputtered Fe_xGd_100-x ferrimagnetic films enable field-free spin-orbit torque-driven magnetization switching and support six programmable logic functions in a single-ended device via a double-pulse time-delay coupled scheme.

Oocyte-specific isoforms play crucial roles in oocyte maturation. This study utilizes single-cell full-length isoform sequencing to unveil the diversity of RNA isoforms, as well as TE co-option for novel isoform generation and isoform stability during human and mouse oocyte maturation.

By introducing local ferroelectric regions into a high-entropy superparaelectric, researchers develop a design strategy for high-performance energy storage ceramics. They incorporate ferroelectric PbTiO₃ into a high-entropy matrix, achieving a high recoverable energy density.

Organic solar cells need acceptor molecules with long exciton diffusion lengths, but most available materials fail in thick films. The authors design new fluorinated quinoxaline acceptors that significantly improve carrier mobilities resulting in superior efficiency in both binary and ternary devices.

A programmable photonic quantum processor, Jiuzhang 4.0, incorporates 1,024 high-efficiency squeezed states into a hybrid spatial–temporal encoded 8,176-mode circuit.

A hierarchically integrated 1D@3D covalent organic framework heterostructure is constructed via a one-pot synthesis, leading to the formation of an S-scheme heterojunction with a built-in electric field. The heterostructure has a photocatalytic H₂ evolution rate of 45.7 mmol g⁻¹ h⁻¹, outperforming both of the constituent single-component COFs.

High-latitude soils are future soil organic carbon loss hotspots, with losses dominated by particulate organic carbon (POC). The fraction of POC in total SOC (f_POC) is a key indicator, emphasizing the climate importance of preserving POC.

A fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

After being internalized by cells, nanoparticles can, in rare events, acquire a biomolecular condensate corona. These complexes can reach the extracellular space, where they can deliver their acquired proteins and RNA content to other cells.

This study reveals that TOPOISOMERASE1 ALPHA inhibits lateral root primordium initiation in Arabidopsis by stabilizing a DNA G-quadruplex in CYP82C4, uncovering an epigenetic control over the reprogramming of pericycle cells into stem cells.

Hu et al. show that the transmembrane glycoprotein CD98hc in cerebral endothelial cells regulates the integrin–FAK signaling pathway, thereby promoting angiogenesis and maintaining blood–brain barrier integrity.

Complex motor behaviors such as birdsong are learned through practice and are thought to depend on specific excitatory connectivity in premotor circuits. Here the authors show that song learning in Bengalese Finches is associated with enrichment of inhibitory network connectivity that can affect specific song features.

Ma et al. report a laser polishing and surface reconstruction strategy to improve the surface quality of micron-thick Pb-Sn narrow-bandgap perovskites, enabling single-junction and all-perovskite tandem solar cells with efficiencies of 23.47% (certified) and 29.80%, respectively, by the antisolvent-free method.

The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with >99.999% confidence.

An Sb₂O₃ interlayer at the perovskite/electron transport layer interface increases the reverse-bias resistance of the cells to −22.3 V. Modules with an area of 62.37 cm² achieved a certified power conversion efficiency of 23.1%, 96% of which was maintained after 1,000 h of operation at 65 °C.

The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in line with standard model predictions and at odds with recent anomalous measurements.

Large-scale atmospheric circulation patterns modulate surface meteorology, enhancing isoprene production and transfer from the sea-surface microlayer to the atmosphere, according to combined emissions and cruise observations.

Prime editing using non-canonical prime editing guide RNAs, where the reverse transcription template and primer binding site is integrated within the single guide RNA loops rather than attached to the 3′ ends of CRISPR–Cas guide RNAs, increases editing efficiency.

Among sorbents used in atmospheric water harvesting, hydrogel salt-composites show exceptional performance at a low cost, but their durability remains unexplored. Here the authors systematically study hydrogel-salt composite degradation and its mechanisms under different conditions.

Structured social hierarchies, in which individuals differ in their access to resources and influence over other group members, are a characteristic of many social species. Rongzhen Yan and Dayu Lin describe the diverse routes through which social hierarchies arise in different species and outline our current understanding of the underlying neural mechanisms.

A genetically engineered pig model carrying the human huntingtin mutation with an expanded cytosine–adenine–guanine repeat reveals microglia-driven recruitment of T cells that accelerates striatal neurodegeneration in Huntington’s disease.